The Grizzly, February 27, 2003

An Appetite for New Ideas: Hunger Activist Visits Ursinus • Blizzard 2003 • Night on the Town Ursinus Style • Black History Month Ends • Opinion: What is the Big Deal About Turning 21? • DanceBOOM: A Unique & Unforgettable Cultural Experience • Erfle, Luciano Reach 1,000 • UC Wrestling Captures Centennial Conference Championship • Good News: Women\u27s Gymnastic Teamhttps://digitalcommons.ursinus.edu/grizzlynews/1530/thumbnail.jp

The Grizzly, April 25, 2002

Pesta Appeals College\u27s Action • O\u27Flaherty Speaks to Ursinus about Human Rights • Diverse and Abundant Research Continues • Sex for Sale: What Drives the Porn Industry? • Final Exam Schedule • Jon Volkmer Named Montgomery County Poet Laureate • Greek Week Change Bad: An Opinion • Commencement and Baccalaureate Speakers Announced • Hockey Intramurals • Family or no Family: That is the Question for Many Career Womenhttps://digitalcommons.ursinus.edu/grizzlynews/1515/thumbnail.jp

The Lantern Vol. 71, No. 1, Fall 2003

• Lights of Venice • Portrait • Switzerland • Drunken • Revel Writing • Nectarines • Shifting Gears • Stogie • Reflect • In the Key of Fuchsia Minor • Jarring • Sissy • Mongols vs. Amish: X-Treme Culture Clash • Holding On • The Bethany • Creekside • The Real Thing • On Being Alone and Other Pleasures • Forced Entry • The Case of Beauty: Aesthetics of Distancehttps://digitalcommons.ursinus.edu/lantern/1163/thumbnail.jp

The Grizzly, April 4, 2002

Ursinus Students Seek an International Perspective During Model U.N. • Airband: When Your Lip-syncing Actually Helps Save a Life • Binge Drinking: When College Becomes Equivalent to the Neighborhood Bar • The Class of 2002 gets Ready for the Senior Class Gift Drive • Opinions: Want Easter Vacation? Some Schools Have it • Performer Gives Life to Short Stories of the South • Softball Turning Around for Some Wins • Comparative Pricing Report: Pedicureshttps://digitalcommons.ursinus.edu/grizzlynews/1512/thumbnail.jp

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA

HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity. The activating proteases are key components of its regulation, but controversy surrounds their identity. Using quantitative analysis we found no evidence for activation by uPA (urokinase plasminogen activator), despite reports that this is a principal activator of pro-HGF. This was unaffected by a wide range of experimental conditions, including the use of various molecular forms of both HGF and uPA, and the presence of uPAR (uPA receptor) or heparin. In contrast the catalytic domains of the TTSPs (type-II transmembrane serine proteases) matriptase and hepsin were highly efficient activators (50% activation at 0.1 and 3.4 nM respectively), at least four orders of magnitude more efficient than uPA. PS-SCL (positional-scanning synthetic combinatorial peptide libraries) were used to identify consensus sequences for the TTSPs, which in the case of hepsin corresponded to the pro-HGF activation sequence, demonstrating a high specificity for this reaction. Both TTSPs were also found to be efficient activators at the cell surface. Activation of pro-HGF by PC3 prostate carcinoma cells was abolished by both protease inhibition and matriptase-targeting siRNA (small interfering RNA), and scattering of MDCK (Madin–Darby canine kidney) cells in the presence of pro-HGF was abolished by inhibition of matriptase. Hepsin-transfected HEK (human embryonic kidney)-293 cells also activated pro-HGF. These observations demonstrate that, in contrast with the uPA/uPAR system, the TTSPs matriptase and hepsin are direct pericellular activators of pro-HGF, and that together these proteins may form a pathway contributing to their involvement in pathological situations, including cancer

The Grizzly, September 26, 2000

Family Day 2000 • Taking a Seat: Prized Furniture Borrowed from Pfahler Hall • UC on the Internet: How Slow Can it Go • A.L.M.A. Takes Part in Annual Puerto Rican Day Parade • Construction of WWII Memorial Scheduled to Start on Veteran\u27s Day • Opinions: 2 Thumbs Up for Theater Prof\u27s Fringe Work; Students Fed Up with Slow Internet Service; Are UC Students for the Dems or GOP?; Premature Closings Leave Students Hungering for More; Order Forms Subverting the Sandwich Experience; Yugoslav Elections Spotlight Lack of Foreign Policy Debate; UC International Students Sound Off on American Politics; Are Reimert Residents Overcharged for Damages?; UC Swimming Pool: Drowning in Dust • Students Have Splash at Philly College Fair • Virtual Grad School Fair and Greater Philadelphia Techlink: Connecting Students to Their Future • Philly Fringe Festival\u27s UC Debut a Smashing Success • Chinese Watercolors at Berman Through October • Phirst Phish Show Thrills UC Phreshman • Volleyball Spikes to .500 Overall Record • Field Hockey Grabs First League Win • Cross Country Steps Up at Messiah Invite • Lacrosse\u27s Fall Ball to Prepare Squad for Rigors of Spring • Soccer Blown Away by Blue Jays, 7-1 • Women\u27s Squad Falls at Feet of Diplomats • The Agony of Ecstasy: Illegal Drug Popular Among Young Adults • Cyrsky\u27s Guide to Eating Right at UC • Green Terror Spooks Grizzlies with Field Goal in Final Secondshttps://digitalcommons.ursinus.edu/grizzlynews/1473/thumbnail.jp

The Grizzly, November 9, 2000

Student Spearheads Effort to Save Local Dam • Cause of Deer\u27s Death a Concern to Police • Incident in Duryea Sparks Policy Change • Hostage Situation Unspools at Local Theater • A Nation Divided • Campus Survey Gauges Students\u27 Political Preferences • Collegeville has a New Sheriff in Town • Best Buddies Have Phantastic Time in Philly • Seniors Have Devil of a Time at Halloween Bash • GSA a Blur of Activity • Opinions: Campus Going to Waste; False Fire Alarms Annoying, Unsafe; CIE II a Must for Students at UC; Did Students Vote on Election Day?; Unwelcome Present Left for Reimert Residents; UC\u27s Athletic Internet Site not Living up to Potential; Confessions of a Political Junkie: An Intern\u27s Insights Into Y2K Campaigning • Ursinus Junior on \u27College Jeopardy!\u27 • Elijah a True Choral Masterpiece • Scudera\u27s Modern-day Everyman to Open Nov. 15th • Results are in: It\u27s Walking Woman in Runaway Victory • Rock & Roll Reception at Berman Today • Let the Winter Games Begin • Soccer Closes out Season with Loss to Mules • Deadly Virus Ravages African Population • Meningitis Vaccination to be Held on Campus Nov.15 • College Students Need Sleep • Muhlenberg Blanks Bears in Women\u27s Soccer Finale • Wrestler\u27s Quest for National Title Continues • Lacrosse\u27s McGovern Refuses to be Held Back • Centennial Conference Academic Honor Roll • Bears Blank Cougars, Keep Playoff Hopes Alive • Intramural Basketball Hoopla Already Underwayhttps://digitalcommons.ursinus.edu/grizzlynews/1478/thumbnail.jp

The Grizzly, March 28, 2002

Six Months after 9/11: Has America Really Changed? • The Ursinus Hillel Celebrates Passover • Valedictorian and Salutatorian Announced for 2002 • Room Lottery Returns to Ursinus • Omega Chi Blood Drive a Huge Success • First Ursinus Watson Fellow: Aaron Ranck to Study Agrarian Life • Post Traumatic Stress Disorder on the Rise • Opinions: Do Greek Organizations Foster Group Think ?; Educational Philosophy of Ursinus College • Women\u27s Lacrosse Continues to Tear Through their Schedule • Gymnastics Brings Home Fourth at the NCGA • Performance Enhancing Drugs Back in the Spotlight • Gymnastics Results • Bears Split with Red Devils in First Game of Conferencehttps://digitalcommons.ursinus.edu/grizzlynews/1511/thumbnail.jp

The Grizzly, September 5, 2002

143 Students Call Richter / North Hall Home • Under Construction Again: Field House Floor to be Redone • Orientation 2002 a Success for Freshmen and OAs • Bridge Program Unique and Important at Ursinus • Y100 at Ursinus • Freshmen Give Three Thumbs Up to Their So-Called Overcrowded Rooms • Opinions: Dirty Rooms Make Move-in Extra Grungy; What\u27s it Liked to be Named Bart?; Enemy Combatant Declarations: Wrong Policy for America • Bored? Get Some Brotherly Love in Your Life • Comparative Pricing Report: Snack Foods • Field Hockey Makes a Move to Centennial Conference • X-Country Boys and Girls Ranked 8th in Conference • Volleyball Jumps Out to Positive Start • Men\u27s Soccer Regroups with New Coach • Women\u27s Soccer go 2-0 in First Weekend of Play • Bearcock\u27s Rugby Returns for Second Season • Football Team Prepares for big Season Opener Against Washington & Jefferson • Roller Hockey Club to Play in PCRHL • Dougherty Sets Course Record in Brian Dennis Memorial X-Country Meethttps://digitalcommons.ursinus.edu/grizzlynews/1517/thumbnail.jp

The Grizzly, September 19, 2000

Are E-mail Messages on Ursinus Accounts Private? • Lack of Communication the Culprit in Parking Ticket Woes • From Chess to Diving: New Clubs to Make Splash at UC • 942, 944 Main Street Leave Much to be Desired • Family Day Preview: Student Achievement Takes Center Stage • Henninger and Tigget: Profiles of UC Students • Letter to the Editor • Opinion: Fun of Living Like a Freshman; How do Students Stand on Abortion?; Sink or Swim: Students React to Future Fountain; Your Body is a Temple; Campaign 2000: National Missile Defense • On The Fringe for Family Day • Film Society Gets 2 Thumbs Up for Movie Buffs • Volleyball Struggles to Dig Out a Win • Men\u27s Soccer Suffers Upsets Despite Great Effort • Women\u27s Soccer Off to Best Start Ever • Field Hockey Comes Home With First Win • Athletes of the Week: Heidi Rhodes; Kevin Mallon • UC Undiplomatic in 41-7 Drubbing of F+Mhttps://digitalcommons.ursinus.edu/grizzlynews/1472/thumbnail.jp