Social determinants of health and the analysis of the hospitalization characteristics of a psychiatric unit in southern Brazil

Internações psiquiátricas são dispositivos utilizados como último recurso para lidar com a sintomática de saúde mental. Objetivou-se analisar aspectos da internação psiquiátrica a partir do perfil dos internados, comparando as internações pelo tipo de convênio utilizado para o seu tratamento, considerando este como um indicativo de Determinantes Sociais de Saúde (DSS). Realizou-se análise descritiva e transversal dos prontuários da internação psiquiátrica do Hospital de Clínicas de Porto Alegre (HCPA), nos anos 2016, 2017 e 2018, totalizando 1119 internações. Em torno de metade (53,5%) eram mulheres, que se encontravam na faixa etária entre 30 e 59 anos (52,5%) e possuíam ensino fundamental incompleto (30,3 %). Os diagnósticos mais prevalentes foram transtornos de humor (55,7%) e esquizofrenia (20,2%). Pacientes internados pelo convênio Sistema Único de Saúde (SUS) se concentravam na faixa etária adulto jovem e intermediário, tiveram maior tempo médio de internação (p=0,001) e necessitaram de mais consultorias nas especialidades de Medicina Interna, Infectologia e Psicodiagnóstico (p≤0,05) do que pacientes internados por convênios privados. Tal estudo aponta para o impacto dos DSS na manifestação e tratamento das doenças e no acesso ao tratamento. O conhecimento do perfil dos pacientes que necessitam internação favorece a formulação de políticas públicas.Psychiatric hospitalizations are one of the last resources to deal with mental health symptoms. The objective of this study was to analyze the profile of the psychiatric inpatients, comparing the hospitalizations by the type of health insurance used at the intake, as an indicator of Social Determinant of Health. It is a descriptive and cross-sectional analysis of electronic records of patients in psychiatric hospitalization at the Hospital de Clínicas de Porto Alegre (HCPA), in 2016, 2017 and 2018, summing up 1119 hospitalizations. About half (53.5%) were women, aged between 30 and 59 years (52.5%) with incomplete elementary school (30.3%). The most prevalent diagnoses were mood disorders (55.7%) and schizophrenia (20,2%). Patients that used the public health insurance were mostly young and intermediate adult, had longer hospitalization (p=0,001) and needed more specialized consultancies on Internal Medicine, Infectious Diseases and Psychological Assessment (p≤0,05) than the ones who used private health insurance. This study shows the impact of Social Determinants of Health on the manifestation and treatment of the diseases and on access to treatment. Knowing the profile of the patients helps planning of public policies

Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane

Pom121 anchors core structures of the NPC to the membrane through its binding to the β-propeller domains of Nup155 and Nup160

Genomic instability in baseal cell carcinoma revealed by repetitive sequences analysis

O CBC é o câncer mais comum hoje, causado pela UV que ao atingir a pele origina mutações no DNA que se não reparadas podem levar a tumorigênese. Este estudo avalia seqüências repetitivas (microssatélites e RAPD) na busca de marcadores moleculares e de genes envolvidos no surgimento deste tipo de tumor. Os padrões foram obtidos por PCR utilizando como molde DNA genômico de tumores, pele normal e leucócitos. Foram avaliados 34 tumores. Alterações nos microssatélites foram correlacionadas com o CBC esclerodermiforme e nos RAPD (OPB-08) com tumores micronodulares. Alterações de microssatélites e RAPDs apresentam correlação com o maior número de lesões em um mesmo paciente. Indicando um acompanhamento mais atento de pacientes mais alterados. A busca de novos genes envolvidos no CBC identificou DENND1A no cromossomo 9, putativamente menos expresso em cânceres de pele, porém com relação indeterminada com a carcinogênese e BANP/SMAR1, supressor tumoral que atua na via do p53, afeta a transcrição da ciclina D1 e inibe a sinalização da via TGFb promovendo a carcinogêneseBCC is the most common cancer today, caused by UV that generates mutation on the DNA of skin cells, which if not repaired may lead to tumorigenesis. This study evaluates repetitive sequences (microsatellites and RAPD) searching for molecular markers and genes involved in the development of this tumor. The patterns were obtained by PCR using as template genomic DNA from 34 tumors, normal skin and leucocytes. Microsatellite alterations are correlated with sclerosing BCC and RAPDs with micronodular BCC (OPB-08). Alterations in microsatellites and RAPD are correlated with an increase in the number of tumors in a patient. This indicates a more careful follow up for the more altered patients. The search for new genes involved with BCC identified DENND1A on chromosome 9, putatively less expressed in skin cancers, whose relation to carcinogenesis is undetermined and BANP/SMAR1, a tumor suppressor acting on the p53 pathway, affecting cyclin D1 transcription and inhibiting TGFb signaling pathway, promoting carcinogenesi

Nucleoplasmic Nup98 controls gene expression by regulating a DExH/D-box protein.

The nucleoporin Nup98 has been linked to the regulation of transcription and RNA metabolism, 1-3 but the mechanisms by which Nup98 contributes to these processes remains largely undefined. Recently, we uncovered interactions between Nup98 and several DExH/D-box proteins (DBPs), a protein family well-known for modulating gene expression and RNA metabolism. 4-6 Analysis of Nup98 and one of these DBPs, DHX9, showed that they directly interact, their association is facilitated by RNA, and Nup98 binding stimulates DHX9 ATPase activity. 7 Furthermore, these proteins were dependent on one another for their proper association with a subset of gene loci to control transcription and modulate mRNA splicing. 7 On the basis of these observations, we proposed that Nup98 functions to regulate DHX9 activity within the nucleoplasm. 7 Since Nup98 is associated with several DBPs, regulation of DHX9 by Nup98 may represent a paradigm for understanding how Nup98, and possibly other FG-Nup proteins, could direct the diverse cellular activities of multiple DBPs