The ontology of repeatable artefacts

Many of those artefacts with which we are so familiar – including, for example, works of music, photographs, novels, essays, films, television adverts, and graphic designs – share a common ontological nature. I argue in this thesis that they are all repeatable, and set out to provide an ontological account of these entities that explains the phenomenon of repeatability. In a fruitful meeting of aesthetics and metaphysics, a great deal has been written recently on the ontological nature of musical works. More encompassing enquiries have sought to understand the ontology of artworks in general. I will be responding to and engaging with this body of literature insofar as it also offers accounts of the entities I describe as repeatable. However, my approach gives metaphysical concerns and the phenomenon of repeatability primacy over aesthetic concerns.Here I argue that repeatable artefacts fall into the ontological category of kinds. I develop an account of repeatable artefacts as kinds that has two key components. Firstly, on my view kinds are physical rather than abstract. Secondly, I argue that repeatable artefacts, as kinds, have essences that are purely relational and historical. The thesis begins with a discussion of method. The methodological issue has grown in prominence in recent years, as theorists have sought some higher level arbitration on the expanding number of theories and approaches being offered in response to ontological puzzles. Drawing on the work of Amie Thomasson, I defend a methodology according to which we should develop an ontological account using careful conceptual analysis that assesses our intuitions about the application of referring terms. This commitment to conceptual analysis is then defended from misunderstandings and objections. I apply this method in giving an ontological explanation for the phenomenon of repeatability. I argue that repeatable artefacts are kinds. Kinds are strongly individuated by their essences, which are the conditions that must be satisfied for the kind to be instanced. I then develop an account of kinds as physical multiply located entities, that exist when and where they have instances. This stands in contrast to the prevailing view according to which kinds are abstract. I then set out to give an account of the essences of paradigmatic repeatable artefacts. I argue that this can be done if we are willing to reject the default view according to which essences are at least partly structural, and replace it with an account of purely relational and historical essences. The essences of many paradigmatic repeatable artefacts, I claim, involve causal historical processes of copying.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Matching numerical simulations to continuum field theories: A lattice renormalization study

The study of nonlinear phenomena in systems with many degrees of freedom often relies on complex numerical simulations. In trying to model realistic situations, these systems may be coupled to an external environment which drives their dynamics. For nonlinear field theories coupled to thermal (or quantum) baths, discrete lattice formulations must be dealt with extreme care if the results of the simulations are to be interpreted in the continuum limit. Using techniques from renormalization theory, a self-consistent method is presented to match lattice results to continuum models. As an application, symmetry restoration in $\phi^4$ models is investigated.Comment: 15 pages RevTex, 12 postscript figure

Fatty acids prevent Hypoxia-Inducible Factor 1α signalling in type 2 diabetes

SUMMARYHypoxia-inducible factor (HIF)-1ais essential following a myocardial infarction (MI), and diabetic patients havepoorer prognosis post-MI. Could HIF-1aactivation be abnormal in the diabetic heart, and could metabolism becausing this? Diabetic hearts had decreased HIF-1aprotein following ischemia, and insulin-resistant cardio-myocytes had decreased HIF-1a-mediated signaling and adaptation to hypoxia. This was due to elevated fattyacid (FA) metabolism preventing HIF-1aprotein stabilization. FAs exerted their effect by decreasing succinateconcentrations, a HIF-1aactivator that inhibits the regulatory HIF hydroxylase enzymes. In vivo and in vitropharmacological HIF hydroxylase inhibition restored HIF-1aaccumulation and improved post-ischemic func-tional recovery in diabetes

What 4′33″ Is

What is John Cage's 4′33″? This paper disambiguates this question into three sub-questions concerning, respectively, the work's ontological nature, the art form to which it belongs, and the genre it is in. We shall see that the work's performances consist of silence (rather than containing environmental sounds), that it is a work of performance art (rather than music), and that it belongs to the genre of conceptual art. Seeing the work in these ways helps us to understand it better, and promises to assuage somewhat the puzzlement and irritation of those who are at first resistant to its charms

Lexicality and frequency in specific language impairment: accuracy and error data from two nonword repetition tests

Purpose: Deficits in phonological working memory and deficits in phonological processing have both been considered potential explanatory factors in Specific Language Impairment (SLI). Manipulations of the lexicality and phonotactic frequency of nonwords enable contrasting predictions to be derived from these hypotheses. Method: 18 typically developing (TD) children and 18 children with SLI completed an assessment battery that included tests of language ability, non-verbal intelligence, and two nonword repetition tests that varied in lexicality and frequency. Results: Repetition accuracy showed that children with SLI were unimpaired for short and simple high lexicality nonwords, whereas clear impairments were shown for all low lexicality nonwords. For low lexicality nonwords, greater repetition accuracy was seen for nonwords constructed from high over low frequency phoneme sequences. Children with SLI made the same proportion of errors that substituted a nonsense syllable for a lexical item as TD children, and this was stable across nonword length. Conclusions: The data show support for a phonological processing deficit in children with SLI, where long-term lexical and sub-lexical phonological knowledge mediate the interpretation of nonwords. However, the data also suggest that while phonological processing may provide a key explanation of SLI, a full account is likely to be multi-faceted

Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI.

Doxorubicin (DOX) is a widely used chemotherapeutic agent that can cause serious cardiotoxic side effects culminating in congestive heart failure (HF). There are currently no clinical imaging techniques or biomarkers available to detect DOX-cardiotoxicity before functional decline. Mitochondrial dysfunction is thought to be a key factor driving functional decline, though real-time metabolic fluxes have never been assessed in DOX-cardiotoxicity. Hyperpolarized magnetic resonance imaging (MRI) can assess real-time metabolic fluxes in vivo. Here we show that cardiac functional decline in a clinically relevant rat-model of DOX-HF is preceded by a change in oxidative mitochondrial carbohydrate metabolism, measured by hyperpolarized MRI. The decreased metabolic fluxes were predominantly due to mitochondrial loss and additional mitochondrial dysfunction, and not, as widely assumed hitherto, to oxidative stress. Since hyperpolarized MRI has been successfully translated into clinical trials this opens up the potential to test cancer patients receiving DOX for early signs of cardiotoxicity