Disease Progression Mediated by Egr-1 Associated Signaling in Response to Oxidative Stress

When cellular reducing enzymes fail to shield the cell from increased amounts of reactive oxygen species (ROS), oxidative stress arises. The redox state is misbalanced, DNA and proteins are damaged and cellular transcription networks are activated. This condition can lead to the initiation and/or to the progression of atherosclerosis, tumors or pulmonary hypertension; diseases that are decisively furthered by the presence of oxidizing agents. Redox sensitive genes, like the zinc finger transcription factor early growth response 1 (Egr-1), play a pivotal role in the pathophysiology of these diseases. Apart from inducing apoptosis, signaling partners like the MEK/ERK pathway or the protein kinase C (PKC) can activate salvage programs such as cell proliferation that do not ameliorate, but rather worsen their outcome. Here, we review the currently available data on Egr-1 related signal transduction cascades in response to oxidative stress in the progression of epidemiologically significant diseases. Knowing the molecular pathways behind the pathology will greatly enhance our ability to identify possible targets for the development of new therapeutic strategies

Towards BioDBcore: a community-defined information specification for biological databases

The present article proposes the adoption of a community-defined, uniform, generic description of the core attributes of biological databases, BioDBCore. The goals of these attributes are to provide a general overview of the database landscape, to encourage consistency and interoperability between resources and to promote the use of semantic and syntactic standards. BioDBCore will make it easier for users to evaluate the scope and relevance of available resources. This new resource will increase the collective impact of the information present in biological database

Recent advances in biocuration: meeting report from the Fifth International Biocuration Conference.

The 5th International Biocuration Conference brought together over 300 scientists to exchange on their work, as well as discuss issues relevant to the International Society for Biocuration's (ISB) mission. Recurring themes this year included the creation and promotion of gold standards, the need for more ontologies, and more formal interactions with journals. The conference is an essential part of the ISB's goal to support exchanges among members of the biocuration community. Next year's conference will be held in Cambridge, UK, from 7 to 10 April 2013. In the meanwhile, the ISB website provides information about the society's activities (http://biocurator.org), as well as related events of interest

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Alteridad, etnicidad y racismo en la búsqueda de orígenes de personas adoptadas. El caso de España

En España, la búsqueda de orígenes de las personas adoptadas, motivada por la necesidad de comunicar la historia previa a los/las menores provenientes principalmente de China, Rusia, Etiopía y Vietnam, transita entre lo biológico y lo cultural. Las adopciones internacionales introducen en el contexto de la adopción un replanteamiento de las nociones origen e identidad e incorporan las de etnicidad y raza. En este artículo, mediante el análisis crítico de discurso de un trabajo etnográfico, se subraya la importancia de repensar qué se está entendiendo por “orígenes”, tanto institucional como académicamente, y cuáles son las consecuencias —tanto teóricas como metodológicas y prácticas— de esta conceptualización en la construcción de otredad y diferencia en las personas adoptadas, en función de su procedenciaIn Spain, the search for the origins of adopted people, driven by the need to communicate the prior history of minors coming mainly from China, Russia, Ethiopia and Vietnam, moves between the biological and the cultural. International adoptions introduce a rethinking of the notions of origin and identity and incorporate those of ethnicity and race into the context of adoption. In this article, through the critical discourse analysis of an ethnographic paper, we highlight the importance of rethinking what is being understood as “origins”, both institutionally as well as academically, and what are the consequences —both theoretically as well as methodologically and practically— of this conceptualization in the construction of otherness and difference in adopted people, based on their provenance.El presente artículo se inscribe en el Proyecto I+D+i, “Menores migrantes en el arco mediterráneo: movilidad, sistemas de acogida e integración” (DER2017-89623-R), financiado por el Ministerio de Economía, Industria y Competitividad del Gobierno de España

The latent effect of cogency in the minority influence process

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Includes bibliographical references.This study investigated the mechanisms by which a minority's consistent behavioral style affected influence. To examine these mechanisms,, this study manipulated involvement and message cogency and obtained a number of process measures of the extent of message scrutiny. It was expected that a consistent behavioral style would function much like involvement. High levels of each would increase message scrutiny, and recipients should carefully process the message and discriminate weak from cogent arguments; more opinion change should be found with cogent rather than weak messages. Furthermore, minority influence should be found on private direct and indirect (latent) measures but not public (manifest) measures. Groups consisted of two naive subjects and one confederate of the same sex who were assigned to an Involvement (high vs. low) X Behavioral Style (consistent vs. inconsistent) by Argument Cogency (cogent vs. weak) condition. One hundred thirty-six (68 male and 68 female) introductory psychology students participated, in same sex groups, as part of course requirement. Subjects were told that they would be participating in a project that concerned how students view certain solutions to University-related problems, and were asked to give their opinions, and reasons for their opinions, on various proposals. Direct tests of the hypotheses could not be tested because manipulations of consistency and involvement were not powerful enough. on direct influence,, inconsistent minorities caused a boomerang effect, and consistent minorities had no effect. However, argument cogency affected subjects' thoughts about the communicator and message, and subjects' facial reactions to the source. Subjects' listed more positive thoughts about the source and the message, and emitted more positive than negative affective responses, when they heard cogent rather than weak arguments. The thought listings, and facial affect, are viewed as process-oriented measures of agreement with the source and provide a new means of measuring a type of indirect influence. This study provides us with a promising new approach to explore the latent (indirect) effects of an influential minority source via these process oriented measures

Keyword Mnemonic And Retention Of Second-Language Vocabulary Words

Use of the keyword mnemonic has been shown to substantially increase learning speed and immediate recall of 2nd-language vocabulary words in comparison with other learning strategies. Although the majority of researchers examining long-term retention of material acquired through the keyword method have concluded that these gains are maintained over time, most have relied on experimental designs based on within-subject comparisons. However, within-subject comparisons of retention over time are confounded by both rates of initial acquisition and level of immediate recall. In this article data are presented from 4 experiments in which the retention interval (immediate vs. delay) was treated as a between-subjects factor. The findings consistently indicated that long-term forgetting was greater for learners instructed to use the keyword mnemonic than for learners engaged in rote rehearsal. It is suggested that preexperimental associations to keywords interfere with retrieval of the interactive images established in the laboratory

Da circulação de crianças à adoção internacional: questões de pertencimento e posse From child circulation to international adoption: questions of ownership and belonging

Nesse artigo, examino uma prática local - a circulação de crianças em bairros populares de uma grande cidade brasileira - à luz do contexto mais amplo que inclui a adoção nacional e internacional. Inicio com a descrição etnográfica de redes de ajuda mútua e valores familiares de duas mulheres que, por causa de extrema miséria, confiaram seus filhos aos cuidados de outrem. Procuro entender como essas mulheres significam a "circulação" de suas crianças e, num segundo momento, pergunto se, no seu entendimento, as leis regendo a adoção legal seriam inteligíveis. Finalmente, teço uma curta reflexão sobre discursos encontrados entre europeus e norte-americanos que recorrem à adoção, questionando a aplicação diferencial desses discursos no âmbito internacional.<br>In this article, I examine a local practice - the circulation of children in working-class neighborhoods of a large Brazilian city - by situating it within a wider context which includes national and international adoption. I begin with the ethnographic description on mutual help networks and family-related values of two poverty-stricken women who have given their children to be raised by others. I then seek to understand the place child placement holds in the life experience of these women, and, by extension, the way laws governing legal adoption connect with their way of seeing the process. Finally, in the light of this ethnographic material on "child donors", I weave a short reflection on discourses held by Europeans and North Americans on adoption, questioning the particular way these discourses filter through to and operate on the international arena