RELACIÓN DE LA MAGNITUD DE EXPOSICIÓN DEL CONTORNO GINGIVAL CON LA PROPORCIÓN DIVINA DENTARIA EN LOS PACIENTES ATENDIDOS EN LA CLÍNICA ESTOMATOLÓGICA DE LA UNIVERSIDAD DE HUÁNUCO EN EL AÑO 2019

Introducción: En nuestra boca y dientes existe una sutil variedad de partes involucradas, todas ellas presentan diferentes medidas, parecen no estar relacionadas; sin embargo, para que este sistema funcione a la perfección, debe ajustarse a una proporcionalidad. Por ello, cuando ésta no se cumple, en nuestra mente nos da el mensaje de que algo no está funcionando bien y lo percibimos como antiestético. Por este motivo se realizó dicho trabajo de investigación que tiene como propósito determinar la relación de la exposición del margen gingival con la proporción divina dentaria en los pacientes atendidos en la Universidad de Huánuco. Métodos: Se elaboró un estudio descriptivo, transversal; de alcance correlacional; con un muestreo no probabilístico, intencional, consecutivo, para la recolección de datos se obtuvo de los modelos de estudio. Resultados: La magnitud de exposición del contorno gingival no se relaciona significativamente con la proporción divina dentaria del incisivo lateral y el canino (P>0.05). Adicionalmente se ha identificado que la relación es indirecta en un -0,2% y en un -42%. Con relación al a magnitud de exposición gingival con el incisivo lateral y el Canino respectivamente. Conclusión: En nuestra investigación encontramos que a mayor discrepancia del incisivo lateral y el canino será menor la exposición de contorno gingival; presentando una relación indirecta e inversa en ambos casos.Tesi

Relación de las emociones positivas desde la perspectiva de la neurociencia con la resolución de problemas matemáticos en los estudiantes de segundo grado de primaria de la institución educativa N° 20568 “Miguel Grau”, Matucana – Perú, 2015

Este trabajo tuvo como finalidad determinar la relación existente entre las emociones positivas con la resolución de problemas matemáticos en los estudiantes de segundo grado de primaria de la Institución Educativa N° 20568 Miguel Grau, Matucana – Perú, 2015, correspondientemente a la UGEL Nº15. Esta es una investigación de Diseño Descriptivo – Correlacional, con el muestreo no probabilístico, intencional, con grupos intactos, conformado por 55 estudiantes de 2 “A” y “B”. A ellos se les aplicó dos instrumentos, un cuestionario, para medir las emociones positivas y otro para medir la resolución de problemas matemáticos, mediante los cuales recogimos la información y logramos medir la relación de dichas variables. Luego del análisis de los resultados, se concluye con un nivel de significación de 0,05, que, entre las emociones positivas y la resolución de problemas matemáticos, existe una relación significativa en los estudiantes de 2do grado de primaria de la Institución Educativa N° 20568 Miguel Grau, Matucana – Perú, 2015.The purpose of this work was to determine the relationship between positive emotions and the resolution of mathematical problems in the second grade students of the Educational Institution N ° 20568 Miguel Grau, Matucana - Peru, 2015, corresponding to UGEL Nº15. This is a Descriptive - Correlational Design research, with non-probabilistic sampling, intentional, with intact groups, consisting of 55 students of 2 "A" and "B". They were applied two instruments, a questionnaire, to measure positive emotions and another to measure the resolution of mathematical problems, through which we collected the information and we managed to measure the relationship of these variables. After the analysis of the results, it is concluded with a level of significance of 0.05, that, between the positive emotions and the resolution of mathematical problems, there is a significant relationship in the 2nd grade students of the Educational Institution N ° 20568 Miguel Grau, Matucana - Peru, 2015

Responsabilidad social universitaria en Latinoamérica: Revisión sistemática: University social responsibility in Latin America: Systematic review

Introduction: University social responsibility is present in the discourses of academics, but it fails to permeate the actions that lead to the transformation of the university, requiring a paradigm shift. At present there are conceptual confusions that make its promotion and transformative practice very difficult, in many universities it is confused with social projection, which reduces its transversal dimension.  Objective: To analyze the scientific evidence related to university social responsibility in Latin America.  Methods: Systematic review of the literature, between the months of August to December 2021; the search for articles was carried out in the databases: Scopus, Scielo, Doaj, Lilacs and Redalyc; the use of Descriptors in Health Sciences (DeCS) and the combination of the Boolean operators OR and AND were applied. Full texts in Spanish between the years 2015 and 2021 were considered.  Results: 508 articles were obtained, which were submitted to the PRISMA methodology, selecting 20 articles, grouped into four categories according to the Social Responsibility Manual of the Úrsula Model: management, training, cognitive, and social participation.  Conclusions: USR is an inalienable moral commitment, it is important in university management to promote sustainable development, with ethics and respect for human rights, the participation of committed actors is necessary, considering that it currently has a welfare and reductionist approach, scarce support, socialization and implementation and there is a need to unify criteria.Introducción: La responsabilidad social universitaria está presente en los discursos de los académicos, mas no logra permear en las acciones, que conlleven a la transformación de la universidad, por lo que es necesario un cambio de paradigma. En la actualidad, existen confusiones conceptuales que hacen muy difícil su promoción y práctica transformadora; en muchas universidades, se la confunde con proyección social, lo cual reduce su dimensión transversal.  Objetivo: Analizar la evidencia científica relacionada con la responsabilidad social universitaria en Latinoamérica.  Métodos: Revisión sistemática de la literatura; entre los meses de agosto a diciembre de 2021, se realizó la búsqueda de artículos en las bases de datos: Scopus, SCielo, Doaj, Lilacs y Redalyc; se aplicó el uso de los descriptores en ciencias de la salud (DeCS) y la combinación de los operadores booleanos OR y AND. Se consideraron textos completos en español, entre los años 2015 a 2021.  Resultados: Se obtuvo 508 artículos, los cuales fueron sometidos a la metodología PRISMA y se seleccionaron 20 artículos, agrupados en cuatro categorías, según el Manual de Responsabilidad Social del Modelo Úrsula: gestión, formación, cognitivo, y participación social.  Conclusiones: La RSU es un compromiso moral irrenunciable, es importante en la gestión universitaria para promover el desarrollo sostenible, con ética y respeto de los derechos humanos, es necesario la participación de actores comprometidos y se debe considerar que, actualmente, tiene un enfoque asistencialista y reduccionista, escaso apoyo, socialización e implementación y falta unificar criterios en su conceptualización

Experience with the use of Rituximab for the treatment of rheumatoid arthritis in a tertiary Hospital in Spain: RITAR study

There is evidence supporting that there are no relevant clinical differences between dosing rituximab 1000 mg or 2000 mg per cycle in rheumatoid arthritis (RA) patients in clinical trials, and low-dose cycles seem to have a better safety profile. Our objective was to describe the pattern of use of rituximab in real-life practice conditions. Methods: Rituximab for RA in clinical practice (RITAR) study is a retrospective cohort study from 2005 to 2015. Eligibility criteria were RA adults treated with rituximab for active articular disease. Response duration was the main outcome defined as months elapsed from the date of rituximab first infusion to the date of flare. A multivariable analysis was performed to determine the variables associated with response duration. Results: A total of 114 patients and 409 cycles were described, 93.0% seropositive and 80.7% women. Rituximab was mainly used as second-line biological therapy. On demand retreatment was used in 94.6% of cases versus fixed 6 months retreatment in 5.4%. Median response duration to on demand rituximab cycles was 10 months (interquartile range, 7–13). Multivariable analysis showed that age older than 65 years, number of rituximab cycles, seropositivity, and first- or second-line therapy were associated with longer response duration. The dose administered at each cycle was not significantly associated with response duration. Conclusions: Our experience suggests that 1000 mg rituximab single infusion on demand is a reasonable schedule for long-term treatment of those patients with good response after the first cycles, especially in seropositive patients and when it is applied as a first- or second-line biological therap

Utility of flow cytometry studies in the management of patients with multiple myeloma

Purpose of review: Although the input of multiparameter flow cytometry (MFC) into the clinical management of multiple myeloma (MM) patients has faced some reluctance, continuously growing evidence supports the utility of MFC in this disease. Recent findings: MFC immunophenotyping of bone marrow and peripheral blood plasma cells affords cost-effective assessment of clonality, and provides prognostic information on the risk of progression in smoldering MM, and the identification of active MM patients with dismal outcome (e.g.: high numbers of circulating tumor cells) or long-term survival despite sub-optimal responses through the characterization of MGUS-like phenotypes. Extensive data indicates that MRD monitoring can be used as biomarker to evaluate treatment efficacy and act as surrogate for survival. The time has come to address within clinical trials, the exact role of baseline risk factors and MRD monitoring for tailored therapy in MM, which implies systematic usage of highly sensitive cost-effective, readily available and standardized MRD techniques such as MFC. Summary: Next-generation MFC should be considered mandatory in the routine evaluation of MM patients both at diagnosis and after therapy, and represents an attractive technique to integrate with high-throughput DNA and RNA-seq methods to help understanding the mechanisms behind dissemination and chemoresistance of MM

Intermittent BRAF inhibition in advanced BRAF mutated melanoma results of a phase II randomized trial

Combination treatment with BRAF (BRAFi) plus MEK inhibitors (MEKi) has demonstrated survival benefit in patients with advanced melanoma harboring activating BRAF mutations. Previous preclinical studies suggested that an intermittent dosing of these drugs could delay the emergence of resistance. Contrary to expectations, the first published phase 2 randomized study comparing continuous versus intermittent schedule of dabrafenib (BRAFi) plus trametinib (MEKi) demonstrated a detrimental effect of the “on−off” schedule. Here we report confirmatory data from the Phase II randomized open-label clinical trial comparing the antitumoral activity of the standard schedule versus an intermittent combination of vemurafenib (BRAFi) plus cobimetinib (MEKi) in advanced BRAF mutant melanoma patients (NCT02583516). The trial did not meet its primary endpoint of progression free survival (PFS) improvement. Our results show that the antitumor activity of the experimental intermittent schedule of vemurafenib plus cobimetinib is not superior to the standard continuous schedule. Detection of BRAF mutation in cell free tumor DNA has prognostic value for survival and its dynamics has an excellent correlation with clinical response, but not with progression. NGS analysis demonstrated de novo mutations in resistant cases

Emotional Literacy in Vulnerable Contexts with Digital Drawings

The objective sought to determine the effects on emotional literacy in the elaboration of digital drawings and traditional drawings in the cooperative and individual pedagogical format. 120 schoolchildren from vulnerable contexts participated. The data was collected by a scale based on Fury's proposals. Se advierten efectos de mejora en el cambio de laalfabetización emocional, y en sus componentes de expresividad y valencia. Improvement effects are noted in the change of emotionalliteracy, and in its components of expressiveness and valence. A higherlevel was detected in the change from negative to positive emotions in thedrawings of children who used tablets collaboratively, as opposed to thosewho did so individually

Clinical implications of changing thyroglobulin and antithyroglobulin antibodies analytical methods in the follow-up of patients with differentiated thyroid carcinoma

Background and aims: Patients’ response to treatment in differentiated thyroid cancer (DTC) is classified according to serum thyroglobulin concentrations (Tg), usually using the American Thyroid Association guidelines and considering potential interfering anti-thyroglobulin antibodies (Ab-Tg). We aim to evaluate the clinical implications of changing Tg and Ab-Tg quantification method. Material and methods: Tg and Ab-Tg were quantified in 82 serum samples (60 from DTC patients) by Elecsys and Access immunoassays. Results: Elecsys immunoassay rendered higher values of Tg than Access: mean bias 5.03 ng/mL (95%CI:- 14.14–24.21). In DTC patients, there was an almost perfect agreement for response classification (kappa index = 0.833). Discrepancies appeared in patients with undetermined response, with a more tendency to subclassification with Access. Ab-Tg showed a poor correlation (r = 0.5394). When Elecsys cut-off was reduced to 43 IU/ mL, agreement for positive/negative classification improved from a kappa index of 0.607 to 0.650. Prospective study with personalized follow-up showed that only 6.3% of Tg results required an analytical confirmation, being confirmed 93% of them. Conclusions: Despite the biases observed, clinical impact of an analytical change is minimal in patients’ management. However, cautious and personalized follow-up period after the change is still mandatory, especially in patients with Tg levels between 0.2 and 1 ng/mL

Alfabetización emocional en contextos vulnerables con dibujos digitales

El objetivo buscó determinar los efectos en la alfabetización emocional en la elaboración de dibujos digitales y dibujos tradicionales en el formato pedagógico cooperativo e individual. Participaron 120 escolares de contextos vulnerables. Los datos fueron recabados por una escala basada en las propuestas de Fury. Se advierten efectos de mejora en el cambio de la alfabetización emocional, y en sus componentes de expresividad y valencia. Se detectó mayor nivel en el cambio de emociones negativas a positivas en los dibujos de niños que utilizaron tabletas de forma colaborativa a diferencia de los que lo realizaron de forma individual