Determining a regular language by glider-based structures called phases fi_1 in Rule 110

Rule 110 is a complex elementary cellular automaton able of supporting universal computation and complicated collision-based reactions between gliders. We propose a representation for coding initial conditions by means of a finite subset of regular expressions. The sequences are extracted both from de Bruijn diagrams and tiles specifying a set of phases fi_1 for each glider in Rule 110. The subset of regular expressions is explained in detail

Reproducing the cyclic tag system developed by Matthew Cook with Rule 110 using the phases f1_1

This paper implements the cyclic tag system (CTS) in Rule 110 developed by Cook in [1, 2] using regular expressions denominated phases fi_1 [3]. The main problem in CTS is coding the initial condition based in a system of gliders. In this way, we develop a method to control the periodic phases of the strings representing all gliders until now known in Rule 110, including glider guns. These strings form a subset of regular expressions implemented in a computational system to facilitate the construction of CTS. Thus, these phases are useful to establish distances and positions for every glider and then to delineate more sophisticated components or packages of gliders. In this manuscript, it is possible to find differences with the results exposed in Wolfram's book [2], inclusively some mistakes which avoid to obtain an appropriated realization of CTS in Rule 110; fortunately, these irregularities were discussed and clarified by Cook

Rule 110 objects and other constructions based-collisions

The one-dimensional cellular automaton Rule 110 shows a very ample and diversified glider dynamics. The huge number of collision-based reactions presented in its evolution space are useful to implement some specific (conventional and unconventional) computable process, hence Rule 110 may be used to implement any desired simulation. Therefore there is necessity of defining some interesting objects as: solitons, eaters, black holes, flip-flops, fuses and more. For example, this work explains the construction of meta-gliders; for these constructions, we specify a regular language in Rule 110 to code in detail initial conditions with a required behavior. The paper depicts as well several experimental collision-based constructions

Influence of calcium silicate on the chemical properties of pleurotus ostreatus var. Florida (Jacq.) P. Kumm

Supplementation of mushroom substrates has been linked to a higher resistance against insect pests, although few studies show the impact of this supplementation on the different agronomical parameters of mushrooms or even their chemical composition. In this work, the variation in the biological and chemical composition of oyster mushroom (Pleurotus ostreatus var. florida (Jacq.) P. Kumm) was analysed after varying the substrate supplementation of calcium silicate (0, 0.5, 1, 2, and 4% (w/w%)) during two harvest flushes. Overall, supplementation did not change the weight, the number of fruiting bodies, biological efficiency, yield ratio, and productivity rate of the mushrooms, although the harvest flushes did show significant differences. Furthermore, slight changes were found in the chemical composition with an increase in vitamin D2 and tocopherols for the mushrooms with higher amounts of calcium silicate. Overall, the substrate supplementation did not seem to induce expressive changes or decrease production yields, and can, therefore, continue to be researched as a potential application to fight agronomical pests.This work is funded by the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project Mobilizador Norte-01-0247-FEDER-024479: ValorNatural®; and to European Agricultural Fund for Rural Development (EAFRD), through the Rural Development Program (PDR2020), within the scope of Project MicoCoating (PDR2020-101-031472). Acknowledgments: The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020), and R.V.C. Cardoso’s PhD grant (SFRH/BD/137436/2018). L. Barros and A. Fernandes also thank the national funding by FCT, P.I. through the institutional scientific employment program-contract, and M. Carocho thanks FCT, P.I. through the individual scientific employment program-contract.info:eu-repo/semantics/publishedVersio

Antioxidant and antimicrobial influence on oyster mushrooms (Pleurotus ostreatus) from substrate supplementation of calcium silicate

Supplementation of the substrate of mushrooms with calcium silicate and other minerals is usually used as a preventive measure against pests and other contaminants during the production of oyster mushrooms. Little is known of the effects of this supplementation on the quality of the mushrooms produced. In the work described herein, the supplementation of oyster mushrooms was performed with 5 supplementation levels (0%, 0.5%, 1%, 2% and 4%) on mushrooms from two different locations in Brazil, the two flushes of mushrooms produced were analysed in terms of phenolic compounds, organic acids, and the antioxidant, antibacterial and antifungal activities, and finally the data was subjected to a linear discriminant analysis to understand the discrimination of the supplementation percentages. Overall, intermediate supplementation until 1% seemed to have a positive effect on the mushrooms from Mogi-das-Cruzes region, while high supplementation favoured the mushrooms from the region of Presidente Prudente. Supplementation showed positive effects on the mushrooms by increasing the production of some secondary metabolites while not showing any negative cytotoxic effects.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES to CIMO (UIDB/00690/2020), and R.V.C. Cardoso’s PhD grant (SFRH/BD/137436/2018). L. Barros and A. Fernandes also thank the national funding by FCT, through the institutional scientific employment program-contract, and M. Carocho and J. Pinela (CEECIND/00831/2018; CEECIND/01011/2018) thank FCT, through the individual scientific employment program-contract. This work is funded by the European Regional Development Fund (ERDF) through the Regional Operational Program North 2020, within the scope of Project Mobilizador Norte-01-0247-FEDER-024479: ValorNatural®; and to European Agricultural Fund for Rural Development (EAFRD), through the Rural Development Program (PDR2020), within the scope of Project MicoCoating (PDR2020-101-031472). This work has been supported by the Ministry of Education, Science and Technological Development of Republic of Serbia (451-03-9/2021-14/200007).info:eu-repo/semantics/publishedVersio

Parametric analysis of a single alkaline membrane fuel cell

When geometric parameters, such as volume and thickness, are constraints to be considered in real applications and an increase of performance is required, other parameters must be taken into account for the optimization of fuel cells. The physical properties of bipolar plates, electrodes, and membranes are some of the parameters that can still be studied when maximum power output is sought under geometric constraint. This paper investigated the influence of porosity of the diffusive and reaction layers on the power output of an alkaline membrane fuel cell (AMFC). An experimentally validated mathematical model was used to simulate the fuel cell performance as a function of different porosities of the electrode. It was found that the change of porosity of the diffusive layer has a minimum influence in the power output of the fuel cell when the porosity of the reaction layer is kept constant. The cathode was shown to limit the performance of the fuel cell due to losses that make the polarization curve to drop to zero at the cathode faster than at the anode. The increase of the porosity of the reaction layer is verified to be an alternative to enhance the power output of the fuel cell.http://www.tandfonline.com/loi/uhte202016-07-31hb2016Mechanical and Aeronautical Engineerin

Structure of the Central High Atlas (Morocco): constraints from Potential Field Data and 3D Models

[EN] From a 3-D reconstruction based on serial cross-sections, structural observations, and potential field geophysical data we characterize the major structural frame of the Moroccan Central High Atlas. Its overall structure shows two fold-and-thrust systems (each one showing particular features) at the northern and southern borders of the chain, resulting from the inversion of the Mesozoic basin. Five more zones can be distinguished in the inner part of the chain, according to their structural features, ranging from basement-involved structures in the westernmost sector to completely detached structures in the eastern part. Most compressional structures show an ENE-WSW (atlasic) trend, also pinpointed by the orientation of pressure-solution and slaty cleavage associated with the compressional stage. Large-scale faults of crustal or lithospheric reach can be inferred from the aeromagnetic maps, that show that the gabbro intrusions (some of them showing sigmoidal shape) are aligned in an E-W direction, oblique to the main trend. The overall compressional structure is controlled by a main, low-angle, South-verging thrust involving both the Mesozoic cover and the Paleozoic basement thrusting over the southern foreland of the chain. Branching on this surface there is a series of back-thrusts and faults, some of them resulting from re-activation of extensional structures.This research was financed by projects CGL2016-77560-C2 (C21 and C22) and PID2019-108753GB-C2 (C21 and C22), funded by MICIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”.Peer reviewe

Clinical phenotypes of acute heart failure based on signs and symptoms of perfusion and congestion at emergency department presentation and their relationship with patient management and outcomes

Objective To compare the clinical characteristics and outcomes of patients with acute heart failure (AHF) according to clinical profiles based on congestion and perfusion determined in the emergency department (ED). Methods and results Overall, 11 261 unselected AHF patients from 41 Spanish EDs were classified according to perfusion (normoperfusion = warm; hypoperfusion = cold) and congestion (not = dry; yes = wet). Baseline and decompensation characteristics were recorded as were the main wards to which patients were admitted. The primary outcome was 1-year all-cause mortality; secondary outcomes were need for hospitalisation during the index AHF event, in-hospital all-cause mortality, prolonged hospitalisation, 7-day post-discharge ED revisit for AHF and 30-day post-discharge rehospitalisation for AHF. A total of 8558 patients (76.0%) were warm+ wet, 1929 (17.1%) cold+ wet, 675 (6.0%) warm+ dry, and 99 (0.9%) cold+ dry; hypoperfused (cold) patients were more frequently admitted to intensive care units and geriatrics departments, and warm+ wet patients were discharged home without admission. The four phenotypes differed in most of the baseline and decompensation characteristics. The 1-year mortality was 30.8%, and compared to warm+ dry, the adjusted hazard ratios were significantly increased for cold+ wet (1.660; 95% confidence interval 1.400-1.968) and cold+ dry (1.672; 95% confidence interval 1.189-2.351). Hypoperfused (cold) phenotypes also showed higher rates of index episode hospitalisation and in-hospital mortality, while congestive (wet) phenotypes had a higher risk of prolonged hospitalisation but decreased risk of rehospitalisation. No differences were observed among phenotypes in ED revisit risk. Conclusions Bedside clinical evaluation of congestion and perfusion of AHF patients upon ED arrival and classification according to phenotypic profiles proposed by the latest European Society of Cardiology guidelines provide useful complementary information and help to rapidly predict patient outcomes shortly after ED patient arrival

Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high-hyperdiploid B-cell acute lymphoblastic leukemia

B-cell acute lymphoblastic leukemia (B-ALL) is the commonest childhood cancer. High hyperdiploidy (HHD) identifies the most frequent cytogenetic subgroup in childhood B-ALL. Although hyperdiploidy represents an important prognostic factor in childhood B-ALL, the specific chromosome gains with prognostic value in HHD-B-ALL remain controversial, and the current knowledge about the hierarchy of chromosome gains, clonal heterogeneity and chromosomal instability in HHD-B-ALL remains very limited. We applied automated sequential-iFISH coupled with single-cell computational modeling to identify the specific chromosomal gains of the eight typically gained chromosomes in a large cohort of 72 primary diagnostic (DX, n = 62) and matched relapse (REL, n = 10) samples from HHD-B-ALL patients with either favorable or unfavorable clinical outcome in order to characterize the clonal heterogeneity, specific chromosome gains and clonal evolution. Our data show a high degree of clonal heterogeneity and a hierarchical order of chromosome gains in DX samples of HHD-B-ALL. The rates of specific chromosome gains and clonal heterogeneity found in DX samples differ between HHD-B-ALL patients with favorable or unfavorable clinical outcome. In fact, our comprehensive analyses at DX using a computationally defined risk predictor revealed low levels of trisomies +18+10 and low levels of clonal heterogeneity as robust relapse risk factors in minimal residual disease (MRD)-negative childhood HHD-B-ALL patients: relapse-free survival beyond 5 years: 22.1% versus 87.9%, P < 0.0001 and 33.3% versus 80%, P < 0.0001, respectively. Moreover, longitudinal analysis of matched DX-REL HHD-B-ALL samples revealed distinct patterns of clonal evolution at relapse. Our study offers a reliable prognostic sub-stratification of pediatric MRD-negative HHD-B-ALL patients