Fosfatos organógenos en los recubrimientos de los granitos de Monte Louro

[Resumen] Se realiza la identificación por métodos químicos e instrumentales de un fosfato magnésico hidratado localizado en forma de recubrimientos y costras en las rocas graníticas de Monte Louro (La Coruña). La determinación del comportamiento de este mineral durante su deshidratación permite, comprobar el estrecho paralelismo existente entre la pérdida de agua y la destrucción de la newberyita. Teniendo ,en cuenta la escasa estabilidad de la newberyita en los medios de alteración y su frecuente asociación con la «struvita» se atribuye a este mineral un origen organógeno, discutiéndose la posibilidad de' que se encuentre estabilizado por la presencia de recubrimi'entos de fosfatos cálcicos (Brushita y/o Monetita)[Abstract] The identification of a hydrated magneslc phosphate is carried out by chemical and instrumental methods. This is found the shape of overlag and crust on the granitic rocks on Monte Lauro. The determination of its behaviour during the dehydratation 'is performend, let us check the elosed paralelism hetween the loss of water, and the destruction of the new" beryite structure. This mineral isimput,ed to have an organic origin taking into account its short ,stabilityin weatheringenvironments and its freguent assooiation with the «struviteD. It is presumend the posibility of becomíng stabilited by the pres,enc-e of calcic phosphate co,atings (Brushitaand/or Monetite)

Componentes no cristalinos y cristalinos (gibbsita y caolinita) en los productos de neoformación de rocas graníticas de Galicia.

[Resumen] El estudio de los recubrimientos y costras existentes en las diaclasas y fracturas superficiales de rocas graníticas de Galicia permite la diferenciación de dos tipos de materiales: a) Materiales con predominio de componentes con bajo grado de orden. Se localizan en las fracturas subhorizontales por las que discurre el agua que atraviesa el suelo y la saprolita. b) Materiales cristalinos de naturaleza gibbsítica y/o caolinítica. Se localizan en las fracturas verticales.[Abstract] The study of 'coatings and crust on the diaclasas and cracks on the surface of granitic rocks in Galicia, let us differenciate two kinds of materials. a) Materials in wich low order degree components are predominant. These are lacated in subhorizontal cracks through wich water flows. b) Crystalline materials with a gibbsitic and/or kaolinitic minerals, located in the vertical crack

Tsunami generation potential of a strike slip fault tip in the westernmost Mediterranean

Tsunamis are triggered by sudden seafloor displacements, and usually originate from seismic activity at faults. Nevertheless, strike-slip faults are usually disregarded as major triggers, as they are thought to be capable of generating only moderate seafloor deformation; accordingly, the tsunamigenic potential of the vertical throw at the tips of strike-slip faults is not thought to be significant. We found the active dextral NW–SE Averroes Fault in the central Alboran Sea (westernmost Mediterranean) has a historical vertical throw of up to 5.4 m at its northwestern tip corresponding to an earthquake of Mw 7.0. We modelled the tsunamigenic potential of this seafloor deformation by Tsunami-HySEA software using the Coulomb 3.3 code. Waves propagating on two main branches reach highly populated sectors of the Iberian coast with maximum arrival heights of 6 m within 21 and 35 min, which is too quick for current early-warning systems to operate successfully. These findings suggest that the tsunamigenic potential of strike-slip faults is more important than previously thought, and should be taken into account for the re-evaluation of tsunami early-warning systems.Versión del edito

Distribución y densidad de moluscos invasores de la familia Thiaridae en diferentes ambientes dulceacuícolas de Tabasco, México

Background. Melanoides tuberculata and Tarebia granifera invasive species are characterized by easily colonize and settle in new areas; in addition to displace native species. Goals. To determine the distribution and density of invasive Thiarid species in freshwater environments (streams, rivers and lakes) of Tabasco. Methods. Samples were taken at 40 locations during 2011 and 2012 through several macroinvertebrate methods: corer, Petite Ponar dredge and a pushnet, physicochemical variables were also recorded in water and sediment. Results. Physicochemical water parameters registered maximum values of pH (8.8), OD (9.6 mg/l), temperature (33.9 °C), Conductivity (664 mS cm-1) and organic matter (9.6%) in lakes, and fecal coliform (790,000 UFC) and total coliforms (781,000 UFC) in rivers. A total of 4,689 individuals of M. tuberculata and T. granifera 20.408 individuals were captured, density distribution of M. tuberculata results in 84% in lagoons, 10% in rivers and 6% in streams, while T. granifera was registered with 50% in rivers, 43% in lagoons and 7% in streams. Conclusions. Presence of these invasive species is confirmed with a wide distribution in most of the freshwater environments of Tabasco State, with preference for lagoon and river environments, the impact of these invasive species in the environment is still unknown.Antecedentes. Melanoides tuberculata y Tarebia granifera son especies invasoras que se caracterizan por colonizar y establecerse fácilmente en nuevas áreas, además de desplazar a las especies nativas. Objetivos. Determinar la distribución y densidad de las especies invasoras de Thiaridos en ambientes dulceacuícolas (arroyos, ríos y lagunas) de Tabasco, México. Métodos. Se realizó el registro de variables físico-químicas de la columna de agua y sedimento y recolecta de organismos en 40 localidades durante los años 2011 y 2012, utilizando un nucleador, draga Petite Ponar y una red de arrastre tipo D. Resultados. Las lagunas presentaron los máximos valores de pH (8.8), oxígeno disuelto (9.6 mg/l), temperatura (33.9 °C), conductividad (664 mS cm-1) y materia orgánica (9.6%). En los ríos se registraron los máximos valores de coliformes fecales (790,000 UFC) y coliformes totales (781,000 UFC). Un total de 4,689 individuos de M. tuberculata y 20,408 individuos de T. granifera fueron capturados, la distribución de la densidad por ambientes determinó que el 84% de M. tuberculata se registró en las lagunas, seguido de los ríos y arroyos con 10 y 6% respectivamente, mientras que T. granifera dominó en los ríos con un 50% de la densidad seguido de las lagunas con 43 y 7% en arroyos. Conclusiones. Se corrobora la presencia de estas especies invasoras que presentan una amplia distribución en los ambientes dulceacuícolas del estado de Tabasco, mostrando una preferencia por ambientes lagunares y ribereños. Hasta el momento se desconoce el posible impacto que estas especies ocasionan en estos ambientes

Reconocimiento de expresión facial emocional en el trastorno de déficit de atención e hiperactividad en la infancia

Abstract: Recognition of emotional facial expression in attention deficit/hyperactivity disorder in childhood. The main symptoms of attention deficit/hyperactivity disorder (ADHD) are inattention, hyperactivity and impulsivity. In addition to cognitive and behavioral deficits present in ADHD, having difficulties in social skills has also been observed in different studies. The objective of this study was to analyze performance in recognizing emotional facial expression in this group. For this, a clinical group with ADHD was compared to a control group. Emotional facial expression recognition tools were applied. No statistically significant differences were found between groups in non-contextualized static emotions. However, differences were found in non-contextualized dynamic emotions, contextualized scenarios and secondary social skills. In addition, a more comprehensive analysis identified a subgroup of children with ADHD that performed better than the other ADHD group of children and similarly to the control group.Resumen: Los síntomas principales del trastorno de déficit de atención/hiperactividad (TDAH) son la inatención, la hiperactividad y la impulsividad. Además de los déficits cognitivos y conductuales presentes en el TDAH, se ha observado en diferentes estudios la presencia de dificultades en las habilidades sociales. El objetivo de este estudio fue analizar el rendimiento en el reconocimiento de expresión facial emocional en este colectivo. Para ello, se comparó un grupo clínico con TDAH con un grupo control. Se emplearon herramientas de reconocimiento de expresión facial emocional. No se encontraron diferencias estadísticamente significativas en las emociones estáticas no contextualizadas entre los dos grupos. Sin embargo, sí se encontraron diferencias en las emociones dinámicas no contextualizadas, en escenarios contextualizados y habilidades sociales secundarias. Además, un análisis más exhaustivo identificó un subgrupo de niños con TDAH con un rendimiento similar al presentado por el grupo control y superior al resto de niños del grupo TDAH.

Real Field Deployment of a Smart Fiber Optic Surveillance System for Pipeline Integrity Threat Detection: Architectural Issues and Blind Field Test Results

This paper presents an on-line augmented surveillance system that aims to real time monitoring of activities along a pipeline. The system is deployed in a fully realistic scenario and exposed to real activities carried out in unknown places at unknown times within a given test time interval (socalled blind field tests). We describe the system architecture that includes specific modules to deal with the fact that continuous on-line monitoring needs to be carried out, while addressing the need of limiting the false alarms at reasonable rates. To the best or our knowledge, this is the first published work in which a pipeline integrity threat detection system is deployed in a realistic scenario (using a fiber optic along an active gas pipeline) and is thoroughly and objectively evaluated in realistic blind conditions. The system integrates two operation modes: The machine+activity identification mode identifies the machine that is carrying out a certain activity along the pipeline, and the threat detection mode directly identifies if the activity along the pipeline is a threat or not. The blind field tests are carried out in two different pipeline sections: The first section corresponds to the case where the sensor is close to the sensed area, while the second one places the sensed area about 35 km far from the sensor. Results of the machine+activity identification mode showed an average machine+activity classification rate of 46:6%. For the threat detection mode, 8 out of 10 threats were correctly detected, with only 1 false alarm appearing in a 55:5-hour sensed period.European CommissionMinisterio de Economía y CompetitividadComunidad de Madri

Irvalec Inserts into the Plasma Membrane Causing Rapid Loss of Integrity and Necrotic Cell Death in Tumor Cells

Irvalec is a marine-derived antitumor agent currently undergoing phase II clinical trials. In vitro, Irvalec induces a rapid loss of membrane integrity in tumor cells, accompanied of a significant Ca2+ influx, perturbations of membrane conductivity, severe swelling and the formation of giant membranous vesicles. All these effects are not observed in Irvalec-resistant cells, or are significantly delayed by pretreating the cells with Zn2+. Using fluorescent derivatives of Irvalec it was demonstrated that the compound rapidly interacts with the plasma membrane of tumor cells promoting lipid bilayer restructuration. Also, FRET experiments demonstrated that Irvalec molecules localize in the cell membrane close enough to each other as to suggest that the compound could self-organize, forming supramolecular structures that likely trigger cell death by necrosis through the disruption of membrane integrity

Adjuvant dabrafenib and trametinib for patients with resected BRAF-mutated melanoma: DESCRIBE-AD real-world retrospective observational study

BRAF and MEK inhibitor, dabrafenib plus trametinib, adjuvant therapy is effective for high-risk resected melanoma patients with BRAF-V600 mutations. However, real-world evidence is limited. We aimed to determine the feasibility of this therapy in routine clinical practice. DESCRIBE-AD, a retrospective observational study, collected real-world data from 25 hospitals in Spain. Histologically confirmed and resected BRAF-mutated melanoma patients aged & GE;18 years who were previously treated with dabrafenib plus trametinib adjuvant therapy, were included. The primary objectives were treatment discontinuation rate and time to discontinuation. The secondary objectives included safety and efficacy. From October 2020 to March 2021, 65 patients were included. Dabrafenib and trametinib discontinuation rate due to treatment-related adverse events (TRAEs) of any grade was 9%. Other reasons for discontinuation included patients' decisions (6%), physician decisions (6%), unrelated adverse events (3%), disease progression (5%), and others (5%). The median time to treatment discontinuation was 9 months [95% confidence interval (CI), 5-11]. G3-4 TRAEs occurred in 21.5% of patients, the most common being pyrexia (3%), asthenia (3%), and diarrhoea (3%). Unscheduled hospitalisations and clinical tests occurred in 6 and 22% of patients, respectively. After 20-month median follow-up (95% CI, 18-22), 9% of patients had exitus due to disease progression, with a 12-month relapse-free survival and overall survival rates of 95.3% and 100%, respectively. Dabrafenib and trametinib adjuvant therapy proved effective for melanoma patients in a real-world setting, with a manageable toxicity profile. Toxicity frequencies were low leading to low incidence of unscheduled medical visits, tests, and treatment discontinuations