1,775 research outputs found
The Apparent Fractal Conjecture: Scaling Features in Standard Cosmologies
This paper presents an analysis of the smoothness problem in cosmology by
focussing on the ambiguities originated in the simplifying hypotheses aimed at
observationally verifying if the large-scale distribution of galaxies is
homogeneous, and conjecturing that this distribution should follow a fractal
pattern in perturbed standard cosmologies. This is due to a geometrical effect,
appearing when certain types of average densities are calculated along the past
light cone. The paper starts reviewing the argument concerning the possibility
that the galaxy distribution follows such a scaling pattern, and the premises
behind the assumption that the spatial homogeneity of standard cosmology can be
observable. Next, it is argued that to discuss observable homogeneity one needs
to make a clear distinction between local and average relativistic densities,
and showing how the different distance definitions strongly affect them,
leading the various average densities to display asymptotically opposite
behaviours. Then the paper revisits Ribeiro's (1995: astro-ph/9910145) results,
showing that in a fully relativistic treatment some observational average
densities of the flat Friedmann model are not well defined at z ~ 0.1, implying
that at this range average densities behave in a fundamentally different manner
as compared to the linearity of the Hubble law, well valid for z < 1. This
conclusion brings into question the widespread assumption that relativistic
corrections can always be neglected at low z. It is also shown how some key
features of fractal cosmologies can be found in the Friedmann models. In view
of those findings, it is suggested that the so-called contradiction between the
cosmological principle, and the galaxy distribution forming an unlimited
fractal structure, may not exist.Comment: 30 pages, 2 figures, LaTeX. This paper is a follow-up to
gr-qc/9909093. Accepted for publication in "General Relativity and
Gravitation
Evaluation of the genetic diversity of Histoplasma capsulatum var. capsulatum isolates from north-eastern Brazil
Since the beginning of the HIV epidemic, there has been a significant increase in the number of histoplasmosis cases in Ceara, a state in north-east Brazil. The lack of epidemiological data on the genotypes circulating in the north-east region shows the importance of more detailed studies on the molecular epidemiology of Histoplasma capsulatum var. capsulatum in this region. Different molecular techniques have been used to better characterize the genetic profile of H. capsulatum var. capsulatum strains. The aim of this study was to analyse the genetic diversity of H. capsulatum var. capsulatum isolates in Fortaleza, the capital of Ceara, through the sequencing of the internal transcribed spacer (ITS)1-5.8S-ITS2 region, and establish the molecular profile of these isolates, along with strains from south-east Brazil, by RAPD analysis, featuring the different clusters in those regions. The isolates were grouped into two clusters. Cluster 1 included strains from the south-east and north-east regions with separation of isolates into three distinct subgroups (subgroups 1a, 1 b and 1 c). Cluster 2 included only samples from north-east Brazil. Sequencing of the ITS1 -5.8S-ITS2 region allowed the detection of two major clades, which showed geographical correlation between them and their subgroups. Therefore, it can be concluded that the H. capsulatum var. capsulatum isolates from Ceara have a high degree of genetic polymorphism. The molecular data also confirm that populations of this fungus are composed of different genotypes in Brazil and worldwide.National Council for Scientific and Technological Development (CNPq)[562296/2010-7, 552161/2011-0, 304779/2011-3, 473025/2012-4]Brazilian Federal Agency for the Support and Evaluation of Graduate Education (CAPES) [2103/2009
Thermochemical and Theoretical Study of Some Quinoxaline 1,4-Dioxides and of Pyrazine 1,4-Dioxide
Thermochemical and Theoretical Study of Some Quinoxaline 1,4-Dioxides and of Pyrazine 1,4-Dioxide
O idadismo como viés cultural: refletindo sobre a produção de sentidos para a velhice em nossos dias
Brain stimulation used as biofeedback training for recovery of motor functions deteriorated by stroke
Genomic Insights Into The Ixodes scapularis Tick Vector Of Lyme Disease
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retrotransposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing B57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick–host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host ‘questing’, prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent
Genomic Insights Into The Ixodes scapularis Tick Vector Of Lyme Disease
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retrotransposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing B57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick–host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host ‘questing’, prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent
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