Complete genome sequence of phocine distemper virus isolated from a harbor seal (Phoca vitulina) during the 1988 North Sea epidemic

Phocine distemper virus (PDV) was identified as the cause of a large morbillivirus outbreak among harbor seals in the North Sea in 1988. PDV is a member of the family Paramyxoviridae, genus Morbillivirus. Until now, no full-genome sequence of PDV has been available

Urban Foraging and the Relational Ecologies of Belonging

Through a discussion of urban foraging in Seattle, Washington, USA, we examine how people\u27s plant and mushroom harvesting practices in cities are linked to relationships with species, spaces, and ecologies. Bringing a relational approach to political ecology, we discuss the ways that these particular nature–society relationships are formed, legitimated, and mobilized in discursive and material ways in urban ecosystems. Engaging closely with and as foragers, we develop an ethnographically grounded ‘relational ecologies of belonging’ framework to conceptualize and examine three constituent themes: cultural belonging and identity, belonging and place, and belonging and more-than-human agency. Through this case study, we show the complex ways that urban foraging is underpinned by interconnected and multiple notions of identity, place, mobility, and agency for both humans and more-than-human interlocutors. The focus on relational ecologies of belonging illuminates important challenges for environmental management and public space planning in socioecologically diverse areas. Ultimately, these challenges reflect negotiated visions about how we organize ourselves and live together in cosmopolitan spaces such as cities

Noncommutative Electromagnetism As A Large N Gauge Theory

We map noncommutative (NC) U(1) gauge theory on R^d_C X R^{2n}_{NC} to U(N -> \infty) Yang-Mills theory on R^d_C, where R^d_C is a d-dimensional commutative spacetime while R^{2n}_{NC} is a 2n-dimensional NC space. The resulting U(N) Yang-Mills theory on R^d_C is equivalent to that obtained by the dimensional reduction of (d+2n)-dimensional U(N) Yang-Mills theory onto R^d_C. We show that the gauge-Higgs system (A_\mu,\Phi^a) in the U(N -> \infty) Yang-Mills theory on R^d_C leads to an emergent geometry in the (d+2n)-dimensional spacetime whose metric was determined by Ward a long time ago. In particular, the 10-dimensional gravity for d=4 and n=3 corresponds to the emergent geometry arising from the 4-dimensional N=4 vector multiplet in the AdS/CFT duality. We further elucidate the emergent gravity by showing that the gauge-Higgs system (A_\mu,\Phi^a) in half-BPS configurations describes self-dual Einstein gravity.Comment: 25 pages; More clarifications, to appear in Eur. Phys. J.

Oxidised cosmic acceleration

We give detailed proofs of several new no-go theorems for constructing flat four-dimensional accelerating universes from warped dimensional reduction. These new theorems improve upon previous ones by weakening the energy conditions, by including time-dependent compactifications, and by treating accelerated expansion that is not precisely de Sitter. We show that de Sitter expansion violates the higher-dimensional null energy condition (NEC) if the compactification manifold M is one-dimensional, if its intrinsic Ricci scalar R vanishes everywhere, or if R and the warp function satisfy a simple limit condition. If expansion is not de Sitter, we establish threshold equation-of-state parameters w below which accelerated expansion must be transient. Below the threshold w there are bounds on the number of e-foldings of expansion. If M is one-dimensional or R everywhere vanishing, exceeding the bound implies the NEC is violated. If R does not vanish everywhere on M, exceeding the bound implies the strong energy condition (SEC) is violated. Observationally, the w thresholds indicate that experiments with finite resolution in w can cleanly discriminate between different models which satisfy or violate the relevant energy conditions.Comment: v2: corrections, references adde

Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets

Identification of cellular receptors and characterization of viral tropism in animal models have vastly improved our understanding of morbillivirus pathogenesis. However, specific aspects of viral entry, dissemination and transmission remain difficult to recapitulate in animal models. Here, we used three virologically identical but phenotypically

On the RIP: using Relative Impact Potential to assess the ecological impacts of invasive alien species

Invasive alien species continue to arrive in new locations with no abatement in rate, and thus greater predictive powers surrounding their ecological impacts are required. In particular, we need improved means of quantifying the ecological impacts of new invasive species under different contexts. Here, we develop a suite of metrics based upon the novel Relative Impact Potential (RIP) metric, combining the functional response (consumer per capita effect), with proxies for the numerical response (consumer population response), providing quantification of invasive species ecological impact. These metrics are comparative in relation to the eco-evolutionary baseline of trophically analogous natives, as well as other invasive species and across multiple populations. Crucially, the metrics also reveal how impacts of invasive species change under abiotic and biotic contexts. While studies focused solely on functional responses have been successful in predictive invasion ecology, RIP retains these advantages while adding vital other predictive elements, principally consumer abundance. RIP can also be combined with propagule pressure to quantify overall invasion risk. By highlighting functional response and numerical response proxies, we outline a user-friendly method for assessing the impacts of invaders of all trophic levels and taxonomic groups. We apply the metric to impact assessment in the face of climate change by taking account of both changing predator consumption rates and prey reproduction rates. We proceed to outline the application of RIP to assess biotic resistance against incoming invasive species, the effect of evolution on invasive species impacts, application to interspecific competition, changing spatio-temporal patterns of invasion, and how RIP can inform biological control. We propose that RIP provides scientists and practitioners with a user-friendly, customisable and, crucially, powerful technique to inform invasive species policy and management

Generation of Primordial Cosmological Perturbations from Statistical Mechanical Models

The initial conditions describing seed fluctuations for the formation of structure in standard cosmological models, i.e.the Harrison-Zeldovich distribution, have very characteristic ``super-homogeneous'' properties: they are statistically translation invariant, isotropic, and the variance of the mass fluctuations in a region of volume V grows slower than V. We discuss the geometrical construction of distributions of points in ${\bf R}^3$ with similar properties encountered in tiling and in statistical physics, e.g. the Gibbs distribution of a one-component system of charged particles in a uniform background (OCP). Modifications of the OCP can produce equilibrium correlations of the kind assumed in the cosmological context. We then describe how such systems can be used for the generation of initial conditions in gravitational $N$-body simulations.Comment: 7 pages, 3 figures, final version with minor modifications, to appear in PR

Translation of clinical problems in osteoarthritis into pathophysiological research goals

Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent has a strongly ageing population and an obesity epidemic; obesity and age both being major risk factors for OA. No adequate therapeutic options, besides joint replacement, are available, although they are greatly needed and should be acquired by adequate research investments. However, the perspective on OA from a researcher's point of view is not always aligned with the perspective of a patient with OA. Researchers base their views on OA mainly on abnormalities in structure and function while patients consider OA as a collection of symptoms. In this viewpoint paper, we discuss the possibility of translating the most important clinical problems into pathophysiological research goals to facilitate the translation from bench to bedside and vice versa. This viewpoint is the outcome of a dialogue within the 'European League Against Rheumatism study group on OA' and People with Arthritis/Rheumatism across Europe (PARE) representatives