A comparative study of the evolution of prestige formations and of speakers' attitudes in Occitan and Catalan

This thesis explores the nature and the mechanism of change of language prestige and language attitudes in two neighbouring languages: Occitan and Catalan. These two Romance minority languages show great similarities in their early external history and striking differences in their more recent past. The concepts of language attitudes and prestige call for a multidisciplinary approach which incorporates aspects from social psychology, ethnography, historical sociolinguistics and sociology to enable the author to depict in a comprehensive manner the interaction between the formation of the perception of language prestige and the declaration of language attitudes.An important rationale in this thesis is the search for an understanding of the patterns of change in prestige descriptions. Prestige and attitudes are generally interpreted as static entities but a diachronic overview of the values attached to Catalan and Occitan displays signs of disparity and evolution which are scrutinised through the analysis of selected Occitan and Catalan grammars from different periods. The data collected through semi-structured interviews with Occitan and Catalan speakers and processed with the method of Critical Discourse Analysis provides an enlightening synchronic perspective on the language situations. The combination of diachronic and present-day approaches to language representations fosters an original apparatus to investigate the gradually developing contrasts between the symbolisation of the two languages. A second point of focus for the comparison of the Occitan and Catalan linguistic situations resides in the transnational position of their linguistic communities. Since Occitan and Catalan are both spoken in France and Spain, the fascinating mismatch between the linguistic borders and the political territories provide an original and supplementary instrument of analysis of the influences of the national policies on individual attitudes. The bi-national division of Catalan and Occitan offers an examination of the inter-relation between macro-level representations and micro-level perceptions and a clarification of the dynamicity of the power relations between minority and majority groups.The objective of the study is primarily to contribute to a theorisation of language prestige through its conceptualisation as a process, and not an inherent quality, influencing, renewing or destroying, positive language attitudes which, in turn, can reinforce or challenge the preconceived and established form of prestige. The dynamic and malleable forms of prestige and attitudes need the explanatory help of the concept of language ideologies which, taken as beliefs about a language, embodies the modern and growing differentiation in the attribution of language values to Catalan and Occitan. Language ideologies as well as constituting a link between the macro and micro-domains reflect the emblematic discrepancies between a growingly powerful and confrontational Catalan prestige and a compartmentalised and disunited Occitan prestige.EThOS - Electronic Theses Online ServiceAHRCGBUnited Kingdo

A comparative study of the evolution of prestige formations and of speakers' attitudes in Occitan and Catalan

This thesis explores the nature and the mechanism of change of language prestige and language attitudes in two neighbouring languages: Occitan and Catalan. These two Romance minority languages show great similarities in their early external history and striking differences in their more recent past. The concepts of language attitudes and prestige call for a multidisciplinary approach which incorporates aspects from social psychology, ethnography, historical sociolinguistics and sociology to enable the author to depict in a comprehensive manner the interaction between the formation of the perception of language prestige and the declaration of language attitudes.An important rationale in this thesis is the search for an understanding of the patterns of change in prestige descriptions. Prestige and attitudes are generally interpreted as static entities but a diachronic overview of the values attached to Catalan and Occitan displays signs of disparity and evolution which are scrutinised through the analysis of selected Occitan and Catalan grammars from different periods. The data collected through semi-structured interviews with Occitan and Catalan speakers and processed with the method of Critical Discourse Analysis provides an enlightening synchronic perspective on the language situations. The combination of diachronic and present-day approaches to language representations fosters an original apparatus to investigate the gradually developing contrasts between the symbolisation of the two languages. A second point of focus for the comparison of the Occitan and Catalan linguistic situations resides in the transnational position of their linguistic communities. Since Occitan and Catalan are both spoken in France and Spain, the fascinating mismatch between the linguistic borders and the political territories provide an original and supplementary instrument of analysis of the influences of the national policies on individual attitudes. The bi-national division of Catalan and Occitan offers an examination of the inter-relation between macro-level representations and micro-level perceptions and a clarification of the dynamicity of the power relations between minority and majority groups.The objective of the study is primarily to contribute to a theorisation of language prestige through its conceptualisation as a process, and not an inherent quality, influencing, renewing or destroying, positive language attitudes which, in turn, can reinforce or challenge the preconceived and established form of prestige. The dynamic and malleable forms of prestige and attitudes need the explanatory help of the concept of language ideologies which, taken as beliefs about a language, embodies the modern and growing differentiation in the attribution of language values to Catalan and Occitan. Language ideologies as well as constituting a link between the macro and micro-domains reflect the emblematic discrepancies between a growingly powerful and confrontational Catalan prestige and a compartmentalised and disunited Occitan prestige.EThOS - Electronic Theses Online ServiceAHRCGBUnited Kingdo

Construction of a semi-automated ICD-10 coding help system to optimize medical and economic coding

International audienc

Evaluation of a simple method for the automatic assignment of MeSH descriptors to health resources in a French online catalogue

International audienc

Visualization of the role of host heme on the virulence of the heme auxotroph Streptococcus agalactiae

International audienceHeme is essential for several cellular key functions but is also toxic. Whereas most bacterial pathogens utilize heme as a metabolic cofactor and iron source, the impact of host heme during bacterial infection remains elusive. The opportunist pathogen Streptococcus agalactiae does not synthesize heme but still uses it to activate a respiration metabolism. Concomitantly, heme toxicity is mainly controlled by the HrtBA efflux transporter. Here we investigate how S. agalactiae manages heme toxicity versus benefits in the living host. Using bioluminescent bacteria and heme-responsive reporters for in vivo imaging, we show that the capacity of S. agalactiae to overcome heme toxicity is required for successful infection, particularly in blood-rich organs. Host heme is simultaneously required, as visualized by a generalized infection defect of a respiration-negative mutant. In S. agalactiae, HrtBA expression responds to an intracellular heme signal via activation of the two-component system HssRS. A hssRS promoter-driven intracellular luminescent heme sensor was designed to identify host compartments that supply S. agalactiae with heme. S. agalactiae acquires heme in heart, kidneys, and liver, but not in the brain. We conclude that S. agalactiae response to heme is organ-dependent, and its efflux may be particularly relevant in late stages of infection

Ultrasonographic, endoscopic and histological appearances of the caecum in cats presenting with chronic clinical signs of caecocolic disease

Objectives This study aimed to describe the ultrasonographic, endoscopic and histological characteristics of the caecum and ileocaecocolic junction in cats suffering from chronic clinical signs compatible with caecocolic disease. Methods Cats presenting with clinical signs suggestive of a caecocolic disease were prospectively recruited. All cats underwent an ultrasonographic examination of the caecum, ileum, colon, ileocolic lymph nodes and local mesenteric fat, in addition to comprehensive abdominal ultrasonography. This was followed by a colonoscopy with a macroscopic assessment of the caecocolic mucosa; caecocolic tissue samples were systematically collected for histologic analysis. Results Eighteen cats were included. Eleven of 18 cats had ultrasonographic abnormalities adjacent to the ileocaecocolic junction (lymphadenopathy, local steatitis) and 13/18 cats had abnormalities directly related to the junction (wall thickening, loss of wall layering). Seventeen of 18 cats had at least one ultrasonographic abnormality. Endoscopically, hyperaemia, oedema, discoloration and/or erosions were found in all cats. Each cat was classified as having mild or moderate-to-severe lesions according to endoscopic results; no classification could be established statistically for ultrasonographic results. The accentuation of the dimpled pattern tended to be inversely related to the severity of endoscopic lesion scoring. Histologically, a large proportion of cats showed typhlitis (13/16), one had lymphoma and two were normal. All cats with typhlitis also had colitis. There was only slight agreement between endoscopic and histological caecal results regarding the severity of lesions. Loss of caecal wall layering on ultrasound was found in 7/18 cats and, surprisingly, did not appear as a reliable predictor of the severity of inflammation or of malignancy; neither did local steatitis nor lymph node size. Conclusions and relevance Ultrasonography and endoscopy should not be used as the sole methods to investigate the ileocaecocolic region in cats with clinical signs suggestive of caecocolic disease. The presence of chronic clinical signs should routinely prompt histological biopsy

Sensitivity variation of doped Fricke gel irradiated with monochromatic synchrotron X-rays between 33.5 and 80 keV

An experimental binary radiotherapy proposes the concomitant use of a high-Z compound and synchrotron X rays for enhancing radiation dose selectively in tumours by a photoelectric effect. This study aimed at measuring the resulting dose enhancement in irradiated material. A doped Fricke gel dosemeter model was manufactured with 10 mg ml1 of iodine (Telebrix) or barium (Micropaque). Samples were irradiated with a monochromatic synchrotron beam at 33.5, 50, 65 and 80 keV. The ensuing enhancement of the sensitivity of the dosemeter was derived from the nuclear magnetic resonance relaxation rates measured at different X-ray doses. Our results demonstrate (1) the preservation of a linear relationship between relaxation rates and X-ray doses for dosemeters doped with high-Z atoms and (2) a clear energy-dependent sensitivity enhancement for barium-doped Fricke gels. This enhancement was neither reproducible with iodinated compounds nor clearly related to the expected dose enhancement factor. However 1% barium sulphate in the gel could significantly improve the gel\u27s response when it was irradiated by low-energy X rays

Added value of functional neuroimaging to assess decision-making capacity of older adults with neurocognitive disorders: protocol for a prospective, monocentric, single-arm study (IMAGISION)

International audienceIntroduction Assessment of decision-making capacity (DMC) is essential in daily life as well as for defining a person-centred care plan. Nevertheless, in ageing, especially if signs of dementia appear, it becomes difficult to assess decision-making ability and raises ethical questions. Currently, the assessment of DMC is based on the clinician’s evaluation, completed by neuropsychological tests. Functional MRI (fMRI) could bring added value to the diagnosis of DMC in difficult situations. Methods and analysis IMAGISION is a prospective, monocentric, single-arm study evaluating fMRI compared with clinical assessment of DMC. The study will begin during Fall 2021 and should be completed by Spring 2023. Participants will be recruited from a memory clinic where they will come for an assessment of their cognitive abilities due to decision-making needs to support ageing in place. They will be older people over 70 years of age, living at home, presenting with a diagnosis of mild dementia, and no exclusion criteria of MRI. They will be clinically assessed by a geriatrician on their DMC, based on the neuropsychological tests usually performed. Participants will then perform a behavioural task in fMRI (Balloon Analogue Risk Task) to analyse the activation areas. Additional semistructured interviews will be conducted to explore real life implications. The main analysis will study concordance/discordance between the clinical classification and the activation of fMRI regions of interest. Reclassification as ‘capable’, based on fMRI, of patients for whom clinical diagnosis is ‘questionable’ will be considered as a diagnostic gain. Ethics and dissemination IMAGISION has been authorised by a research ethics board (Comité de Protection des Personnes, Bordeaux, II) in France, in accordance with French legislation on interventional biomedical research, under the reference IDRCB number 2019-A00863-54, since 30 September 2020. Participants will sign an informed consent form. The results of the study will be presented in international peer-reviewed scientific journals, international scientific conferences and public lectures. Trial registration number NCT03931148NCT03931148