Another Shipment of Six Short-Period Giant Planets from TESS

We present the discovery and characterization of six short-period, transiting giant planets from NASA's Transiting Exoplanet Survey Satellite (TESS) -- TOI-1811 (TIC 376524552), TOI-2025 (TIC 394050135), TOI-2145 (TIC 88992642), TOI-2152 (TIC 395393265), TOI-2154 (TIC 428787891), & TOI-2497 (TIC 97568467). All six planets orbit bright host stars (8.9 <G< 11.8, 7.7 <K< 10.1). Using a combination of time-series photometric and spectroscopic follow-up observations from the TESS Follow-up Observing Program (TFOP) Working Group, we have determined that the planets are Jovian-sized (R$_{P}$ = 1.00-1.45 R$_{J}$), have masses ranging from 0.92 to 5.35 M$_{J}$, and orbit F, G, and K stars (4753 $<$ T$_{eff}$ $<$ 7360 K). We detect a significant orbital eccentricity for the three longest-period systems in our sample: TOI-2025 b (P = 8.872 days, $e$ = $0.220\pm0.053$), TOI-2145 b (P = 10.261 days, $e$ = $0.182^{+0.039}_{-0.049}$), and TOI-2497 b (P = 10.656 days, $e$ = $0.196^{+0.059}_{-0.053}$). TOI-2145 b and TOI-2497 b both orbit subgiant host stars (3.8 $<$ $\log$ g $<$4.0), but these planets show no sign of inflation despite very high levels of irradiation. The lack of inflation may be explained by the high mass of the planets; $5.35^{+0.32}_{-0.35}$ M$_{\rm J}$ (TOI-2145 b) and $5.21\pm0.52$ M$_{\rm J}$ (TOI-2497 b). These six new discoveries contribute to the larger community effort to use {\it TESS} to create a magnitude-complete, self-consistent sample of giant planets with well-determined parameters for future detailed studies.Comment: 20 Pages, 6 Figures, 8 Tables, Accepted by MNRA

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Hide your pain:Social threat increases pain reports and aggression, but reduces facial pain expression and empathy

Earlier research studying the effects of social threat on the experience and expression of pain led to mixed results. In this study, female participants (N = 32) came to the lab with two confederates. Both confederates administered a total of 10 painful electrocutaneous stimuli to the participant. The framing of the administration was manipulated in a within-subjects design: In the low social threat condition the participant was told that the confederate could choose between 10 to 20 pain stimuli, thus they believed that this confederate chose to administer the minimum allowed number of pain stimuli. In the high social threat condition the confederate had a choice between 1 and 10 stimuli, thus they believed that this confederate chose to administer the maximum allowed number of stimuli. Participants reported on the intensity, unpleasantness, and threat value of the painful stimuli, and their facial expression was recorded. Moreover, aggression and empathy towards the confederates were assessed. As hypothesized, participants reported increased pain intensity, unpleasantness, and threat in the high social threat condition compared to the low social threat condition, but showed less facial pain expression. Finally, participants exhibited increased aggression and reduced empathy towards the confederate in the high social threat condition.status: publishe

TESS Spots a Hot Jupiter with an Inner Transiting Neptune

Hot Jupiters are rarely accompanied by other planets within a factor of a few in orbital distance. Previously, only two such systems have been found. Here, we report the discovery of a third system using data from the Transiting Exoplanet Survey Satellite (TESS). The host star, TOI-1130, is an eleventh magnitude K-dwarf in Gaia G-band. It has two transiting planets: A Neptune-sized planet (3.65 ± 0.10) with a 4.1 days period, and a hot Jupiter with an 8.4 days period. Precise radial-velocity observations show that the mass of the hot Jupiter is For the inner Neptune, the data provide only an upper limit on the mass of 0.17 (3σ). Nevertheless, we are confident that the inner planet is real, based on follow-up ground-based photometry and adaptive-optics imaging that rule out other plausible sources of the TESS transit signal. The unusual planetary architecture of and the brightness of the host star make TOI-1130 a good test case for planet formation theories, and an attractive target for future spectroscopic observations

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TOI 4201 b and TOI 5344 b: Discovery of Two Transiting Giant Planets around M-dwarf Stars and Revised Parameters for Three Others

peer reviewedWe present the discovery from the TESS mission of two giant planets transiting M-dwarf stars: TOI 4201 b and TOI 5344 b. We also provide precise radial velocity measurements and updated system parameters for three other M dwarfs with transiting giant planets: TOI 519, TOI 3629, and TOI 3714. We measure planetary masses of 0.525 ± 0.064 MJ, 0.243 ± 0.020 MJ, 0.689 ± 0.030 MJ, 2.57 ± 0.15 MJ, and 0.412±0.040 MJ for TOI 519 b, TOI 3629 b, TOI 3714 b, TOI 4201 b, and TOI 5344 b, respectively. The corresponding stellar masses are 0.372 ± 0.018 M☉, 0.635 ± 0.032 M☉, 0.522 ± 0.028 M☉, 0.626 ± 0.033 M☉, and 0.612 ± 0.034 M☉. All five hosts have supersolar metallicities, providing further support for recent findings that, like for solar-type stars, close-in giant planets are preferentially found around metal-rich M-dwarf host stars. Finally, we describe a procedure for accounting for systematic errors in stellar evolution models when those models are included directly in fitting a transiting planet system

TOI 4201 b and TOI 5344 b: Discovery of Two Transiting Giant Planets Around M Dwarf Stars and Revised Parameters for Three Others

We present the discovery from the TESS mission of two giant planets transiting M dwarf stars: TOI 4201 b and TOI 5344 b. We also provide precise radial velocity measurements and updated system parameters for three other M dwarfs with transiting giant planets: TOI 519, TOI 3629 and TOI 3714. We measure planetary masses of 0.525 +- 0.064 M_J, 0.243 +- 0.020 M_J, 0.689 +- 0.030 M_J, 2.57 +- 0.15 M_J, and 0.412 +- 0.040 M_J for TOI 519 b, TOI 3629 b, TOI 3714 b, TOI 4201 b, and TOI 5344 b, respectively. The corresponding stellar masses are 0.372 +- 0.018 M_s, 0.635 +- 0.032 M_s, 0.522 +- 0.028 M_s, 0.625 +- 0.033 M_s and 0.612 +- 0.034 M_s. All five hosts have super-solar metallicities, providing further support for recent findings that, like for solar-type stars, close-in giant planets are preferentially found around metal-rich M dwarf host stars. Finally, we describe a procedure for accounting for systematic errors in stellar evolution models when those models are included directly in fitting a transiting planet system.Comment: 32 pages, 9 figures, 10 tables, submitted to AAS Journals; revised to add co-autho

Discovery of a hot, transiting, Earth-sized planet and a second temperate, non-transiting planet around the M4 dwarf GJ 3473 (TOI-488)

International audienceWe present the confirmation and characterisation of GJ 3473 b (G 50–16, TOI-488.01), a hot Earth-sized planet orbiting an M4 dwarf star, whose transiting signal (P = 1.1980035 ± 0.0000018 d) was first detected by the Transiting Exoplanet Survey Satellite (TESS). Through a joint modelling of follow-up radial velocity observations with CARMENES, IRD, and HARPS together with extensive ground-based photometric follow-up observations with LCOGT, MuSCAT, and MuSCAT2, we determined a precise planetary mass, Mb = 1.86 ± 0.30 M⊕, and radius, Rb = 1.264 ± 0.050 R⊕. Additionally, we report the discovery of a second, temperate, non-transiting planet in the system, GJ 3473 c, which has a minimum mass, Mc sin i = 7.41 ± 0.91 M⊕, and orbital period, Pc = 15.509 ± 0.033 d. The inner planet of the system, GJ 3473 b, is one of the hottest transiting Earth-sized planets known thus far, accompanied by a dynamical mass measurement, which makes it a particularly attractive target for thermal emission spectroscopy