1,355 research outputs found
State and Institutional Policies on In-State Resident Tuition and Financial Aid for Undocumented Students: Examining Constraints and Opportunities
In this article, we examine policies related to in-state resident tuition and state financial aid policies aimed at undocumented students. To help frame the discussion and spark further debate and research in this area the article seeks to do three things. First, it provides a comprehensive review of state and institutional in-state tuition policies aimed at undocumented students as well as state college or university system responses. Second, it charts the policy landscape for state financial aid access for this population. Third, it examines the numerous implications that such policies engender and highlights the role of the federal government and the proposed Dream Act in mitigating some of these concerns. It closes by underscoring the important financial role played by the critical interaction of state, institutional, and federal policies in making college going a reality for these students while proposing avenues for future study around the issue
Recommended from our members
Phase II prospective randomized trial of weight loss prior to radical prostatectomy.
BACKGROUND:Obesity is associated with poorly differentiated and advanced prostate cancer and increased mortality. In preclinical models, caloric restriction delays prostate cancer progression and prolongs survival. We sought to determine if weight loss (WL) in men with prostate cancer prior to radical prostatectomy affects tumor apoptosis and proliferation, and if WL effects other metabolic biomarkers. METHODS:In this Phase II prospective trial, overweight and obese men scheduled for radical prostatectomy were randomized to a 5-8 week WL program consisting of standard structured energy-restricted meal plans (1200-1500 Kcal/day) and physical activity or to a control group. The primary endpoint was apoptotic index in the radical prostatectomy malignant epithelium. Secondary endpoints were proliferation (Ki67) in the radical prostatectomy tissue, body weight, body mass index (BMI), waist to hip ratio, body composition, and serum PSA, insulin, triglyceride, cholesterol, testosterone, estradiol, leptin, adiponectin, interleukin 6, interleukin 8, insulin-like growth factor 1, and IGF binding protein 1. RESULTS:In total 23 patients were randomized to the WL intervention and 21 patients to the control group. Subjects in the intervention group had significantly more weight loss (WL:-3.7 ± 0.5 kg; Control:-1.6 ± 0.5 kg; p = 0.007) than the control group and total fat mass was significantly reduced (WL:-2.1 ± 0.4; Control: 0.1 ± 0.3; p = 0.015). There was no significant difference in apoptotic or proliferation index between the groups. Among the other biomarkers, triglyceride, and insulin levels were significantly decreased in the WL compared with the control group. CONCLUSIONS:In summary, this short-term WL program prior to radical prostatectomy resulted in significantly more WL in the intervention vs. the control group and was accompanied by significant reductions in body fat mass, circulating triglycerides, and insulin. However, no significant changes were observed in malignant epithelium apoptosis or proliferation. Future studies should consider a longer term or more intensive weight loss intervention
Recommended from our members
One Year Follow-up of a Randomized, Double-Blind, Placebo-Controlled Trial of Percutaneous Peripheral Nerve Stimulation for Chronic Neuropathic Pain Following Amputation
Abstract
INTRODUCTION
Over 85% of patients experience residual limb (RLP) and/or phantom limb (PLP) pain following amputation. Peripheral nerve stimulation (PNS) is a non-opioid approach to relieve postamputation neuropathic pain. A recent multicenter, randomized, double-blind, placebo-controlled study using a novel percutaneous PNS system demonstrated clinically and statistically significant improvements in pain and pain interference with PNS compared to placebo (Gilmore et al, 2019). This work presents prospective 1-yr follow-up to assess durability of pain relief and functional improvements.
METHODS
Over 85% of patients experience residual limb (RLP) and/or phantom limb (PLP) pain following amputation. Peripheral nerve stimulation (PNS) is a non-opioid approach to relieve post-amputation neuropathic pain. A recent multicenter, randomized, double-blind, placebo-controlled study using a novel percutaneous PNS system demonstrated clinically and statistically significant improvements in pain and pain interference with PNS compared to placebo (Gilmore et al, 2019). This work presents prospective one-year follow-up to assess durability of pain relief and functional improvements.
RESULTS
A significantly greater proportion of subjects who completed the 12-mo visit reported = 50% pain relief on the BPI-SF (5/8, 63%; average pain relief = 73% among responders) compared to the placebo group at the time of crossover (0/14, 0%, P = .003; average pain relief = 23%). A majority of subjects also reported = 50% reductions in pain interference at 12 mo (5/8, 63%). Two of 13 (15%) subjects in the placebo group reported sustained improvements in pain interference (P = .06). Average reduction in pain interference among responders in the PNS group was 87%.
CONCLUSION
This work suggests that PNS delivered over 60 d may provide clinically significant and enduring pain relief, enabling improved function and potentially reducing the need for a permanently implanted system
Tyrosine-phosphorylated and nonphosphorylated isoforms of α-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions
α-Dystrobrevin (DB), a cytoplasmic component of the dystrophin–glycoprotein complex, is found throughout the sarcolemma of muscle cells. Mice lacking αDB exhibit muscular dystrophy, defects in maturation of neuromuscular junctions (NMJs) and, as shown here, abnormal myotendinous junctions (MTJs). In normal muscle, alternative splicing produces two main αDB isoforms, αDB1 and αDB2, with common NH2-terminal but distinct COOH-terminal domains. αDB1, whose COOH-terminal extension can be tyrosine phosphorylated, is concentrated at the NMJs and MTJs. αDB2, which is not tyrosine phosphorylated, is the predominant isoform in extrajunctional regions, and is also present at NMJs and MTJs. Transgenic expression of either isoform in αDB−/− mice prevented muscle fiber degeneration; however, only αDB1 completely corrected defects at the NMJs (abnormal acetylcholine receptor patterning, rapid turnover, and low density) and MTJs (shortened junctional folds). Site-directed mutagenesis revealed that the effectiveness of αDB1 in stabilizing the NMJ depends in part on its ability to serve as a tyrosine kinase substrate. Thus, αDB1 phosphorylation may be a key regulatory point for synaptic remodeling. More generally, αDB may play multiple roles in muscle by means of differential distribution of isoforms with distinct signaling or structural properties
Multi-Element Abundance Measurements from Medium-Resolution Spectra. II. Catalog of Stars in Milky Way Dwarf Satellite Galaxies
We present a catalog of Fe, Mg, Si, Ca, and Ti abundances for 2961 red giant
stars that are likely members of eight dwarf satellite galaxies of the Milky
Way (MW): Sculptor, Fornax, Leo I, Sextans, Leo II, Canes Venatici I, Ursa
Minor, and Draco. For the purposes of validating our measurements, we also
observed 445 red giants in MW globular clusters and 21 field red giants in the
MW halo. The measurements are based on Keck/DEIMOS medium-resolution
spectroscopy combined with spectral synthesis. We estimate uncertainties in
[Fe/H] by quantifying the dispersion of [Fe/H] measurements in a sample of
stars in monometallic globular clusters. We estimate uncertainties in Mg, Si,
Ca, and Ti abundances by comparing our medium-resolution spectroscopic
measurements to high-resolution spectroscopic abundances of the same stars. For
this purpose, our DEIMOS sample included 132 red giants with published
high-resolution spectroscopy in globular clusters, the MW halo field, and dwarf
galaxies. The standard deviations of the differences in [Fe/H] and [alpha/Fe]
(the average of [Mg/Fe], [Si/Fe], [Ca/Fe], and [Ti/Fe]) between the two samples
is 0.15 and 0.16, respectively. This catalog represents the largest sample of
multi-element abundances in dwarf galaxies to date. The next papers in this
series draw conclusions on the chemical evolution, gas dynamics, and star
formation histories from the catalog presented here. The wide range of dwarf
galaxy luminosity reveals the dependence of dwarf galaxy chemical evolution on
galaxy stellar mass.Comment: 26 pages, 22 figures, 4 machine-readable tables (available in the
source file; click "Other formats"); accepted for publication in ApJ
Supplements; updated acknowledgments in v
Three Dimensional N=2 Supersymmetry on the Lattice
We show how 3-dimensional, N=2 supersymmetric theories, including super QCD
with matter fields, can be put on the lattice with existing techniques, in a
way which will recover supersymmetry in the small lattice spacing limit.
Residual supersymmetry breaking effects are suppressed in the small lattice
spacing limit by at least one power of the lattice spacing a.Comment: 21 pages, 2 figures, typo corrected, reference adde
Black Diamonds at Brane Junctions
We discuss the properties of black holes in brane-world scenarios where our
universe is viewed as a four-dimensional sub-manifold of some
higher-dimensional spacetime. We consider in detail such a model where
four-dimensional spacetime lies at the junction of several domain walls in a
higher dimensional anti-de Sitter spacetime. In this model there may be any
number p of infinitely large extra dimensions transverse to the brane-world. We
present an exact solution describing a black p-brane which will induce on the
brane-world the Schwarzschild solution. This exact solution is unstable to the
Gregory-Laflamme instability, whereby long-wavelength perturbations cause the
extended horizon to fragment. We therefore argue that at late times a
non-rotating uncharged black hole in the brane-world is described by a deformed
event horizon in p+4 dimensions which will induce, to good approximation, the
Schwarzschild solution in the four-dimensional brane world. When p=2, this
deformed horizon resembles a black diamond and more generally for p>2, a
polyhedron.Comment: 13 pages, 1 figure, latex, JHEP.cl
Predicate Abstraction for Linked Data Structures
We present Alias Refinement Types (ART), a new approach to the verification
of correctness properties of linked data structures. While there are many
techniques for checking that a heap-manipulating program adheres to its
specification, they often require that the programmer annotate the behavior of
each procedure, for example, in the form of loop invariants and pre- and
post-conditions. Predicate abstraction would be an attractive abstract domain
for performing invariant inference, existing techniques are not able to reason
about the heap with enough precision to verify functional properties of data
structure manipulating programs. In this paper, we propose a technique that
lifts predicate abstraction to the heap by factoring the analysis of data
structures into two orthogonal components: (1) Alias Types, which reason about
the physical shape of heap structures, and (2) Refinement Types, which use
simple predicates from an SMT decidable theory to capture the logical or
semantic properties of the structures. We prove ART sound by translating types
into separation logic assertions, thus translating typing derivations in ART
into separation logic proofs. We evaluate ART by implementing a tool that
performs type inference for an imperative language, and empirically show, using
a suite of data-structure benchmarks, that ART requires only 21% of the
annotations needed by other state-of-the-art verification techniques
Plants, people and health: Three disciplines at work in Namaqualand
In Paulshoek, Namaqualand, three research projects focusing on medicinal plants were developed concurrently. The projects were based in the disciplines of anthropology, botany and chemistry. In this paper, we explore how these projects related to one another and describe the conversations that occurred in the process of searching for transdisciplinary knowledge. The projects ostensibly shared a common object of knowledge, but it was through working together that the medicinal plants constituted us as a community of scholars. As our insight into our respective disciplinary relationships with the plants grew, so did our understanding of the limitations of our respective disciplinary positions. The process made possible a ‘reimagination’ of both the object of study and our relationships to it and to one another. The research project, conceptualised in 2009, engaged current debates on indigenous knowledge and its historical erasures, and offered an approach that has potential to produce new knowledges while respecting the integrity of the disciplines. This approach requires a non-competitive attitude to research and one that acknowledges the contributions that can be made by multiple approaches
- …