The role of paliperidone extended release for the treatment of bipolar disorder

Jehan Marino1, Clayton English2, Joshua Caballero1, Catherine Harrington11College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, 2College of Pharmacy, Albany College of Pharmacy and Health Sciences, Colchester, VT, USABackground: Bipolar disorder (BD) is a chronic, relapsing, episodic mental illness associated with other psychiatric comorbidities. There is a substantial economic burden with BD, which makes it challenging to treat. The aim of this review is to evaluate the pharmacology, clinical efficacy, and safety data related to paliperidone extended release (ER) for the treatment of BD.Methods: A literature search was performed from January 1966 through January 2012 using PreMEDLINE, MEDLINE, EMBASE, IPA, and ClinicalTrials.gov to identify articles in English regarding the pharmacology, clinical efficacy, and safety of paliperidone ER in acute mania or mixed episodes or in the maintenance treatment of BD I.Results: There are currently three published studies relating to the use of paliperidone ER for the treatment of BD. Two of these evaluated paliperidone ER as monotherapy for acute mania, while the other assessed its role as adjunct with a mood stabilizer.Conclusion: According to the limited available evidence, paliperidone at higher doses of ER 9–12 mg/day may be a safe and efficacious treatment option for acute episodes of mania in BD. A once-daily dose formulation may improve patient adherence to treatment; however, the cost of paliperidone ER, which is higher than that of generically available second-generation antipsychotics (such as olanzapine and risperidone), and a lack of alternative dosage forms (ie, liquid, intramuscular) compared with other agents may limit its usefulness in the treatment of BD. The role of paliperidone ER as an adjunctive agent or for long-term use requires further investigation.Keywords: paliperidone ER, bipolar disorder, clinical efficacy, safet

Analysis of Factors Affecting Farmers’ Willingness to Adopt Switchgrass Production

In the United States, biomass is the largest source of renewable energy accounting for over 3 percent of the energy consumed domestically and is currently the only source for liquid, renewable, transportation fuels. Continued development of biomass as a renewable energy source is being driven in large part by the Energy Independence and Security Act of 2007, which mandates that by 2022 at least 36 billion gallons of fuel ethanol be produced, with at least 16 billion gallons being derived from cellulose, hemi-cellulose, or lignin. However, the market for cellulosic biofuels is still under development. As such, little is known about producer response to feedstock prices paid for dedicated energy crops. While there have been some studies done on factors that determine farmers’ willingness to produce switchgrass, these have been very regional in nature. This study will provide information regarding potential switchgrass adoption by agricultural producers in twelve southeastern states. The objectives of this research are 1) to determine the likelihood of farmers growing switchgrass as a biomass feedstock and the acres they would be willing to devote to switchgrass production and 2) to evaluate some of the factors that are likely to influence these decisions, including the price of switchgrass.Switchgrass, Farmer Adoption, Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies, Resource /Energy Economics and Policy, Q12, Q16,

Optimizing the trade-off between number of cops and capture time in Cops and Robbers

The cop throttling number $th_c(G)$ of a graph $G$ for the game of Cops and Robbers is the minimum of $k + capt_k(G)$, where $k$ is the number of cops and $capt_k(G)$ is the minimum number of rounds needed for $k$ cops to capture the robber on $G$ over all possible games in which both players play optimally. In this paper, we construct a family of graphs having $th_c(G)= \Omega(n^{2/3})$, establish a sublinear upper bound on the cop throttling number, and show that the cop throttling number of chordal graphs is $O(\sqrt{n})$. We also introduce the product cop throttling number $th_c^{\times}(G)$ as a parameter that minimizes the person-hours used by the cops. This parameter extends the notion of speed-up that has been studied in the context of parallel processing and network decontamination. We establish bounds on the product cop throttling number in terms of the cop throttling number, characterize graphs with low product cop throttling number, and show that for a chordal graph $G$, $th_c^{\times}=1+rad(G)$.Comment: 19 pages, 3 figure

Dedicated Energy Crop Supply Chain and Associated Feedstock Transportation Emissions: A Case Study of Tennessee

and Bradly Wilson This study minimizes total cost for single-feedstock supply chains of two dedicated energy crops, perennial switchgrass and biomass sorghum, in Tennessee using a spatial optimization model. Greenhouse gas emissions from the transport of feedstock to the conversion facility were estimated for respective feedstock supply chains. Results show that different demand for land types from two feedstocks and the geographically diverse landscape across the state affect the economics of bioenergy crops supply chains and feedstock transportation emissions. Switchgrass is more suitable than biomass sorghum for biofuel production in Tennessee based on the supply chains cost and feedstock hauling emissions

Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells

How centrosome removal or perturbations of centrosomal proteins leads to G1 arrest in untransformed mammalian cells has been a mystery. We use microsurgery and laser ablation to remove the centrosome from two types of normal human cells. First, we find that the cells assemble centrioles de novo after centrosome removal; thus, this phenomenon is not restricted to transformed cells. Second, normal cells can progress through G1 in its entirety without centrioles. Therefore, the centrosome is not a necessary, integral part of the mechanisms that drive the cell cycle through G1 into S phase. Third, we provide evidence that centrosome loss is, functionally, a stress that can act additively with other stresses to arrest cells in G1 in a p38-dependent fashion

Cop throttling number: Bounds, values, and variants

The cop throttling number thc(G) of a graph G for the game of Cops and Robbers is the minimum of k+captk(G), where k is the number of cops and captk(G) is the minimum number of rounds needed for k cops to capture the robber on G over all possible games in which both players play optimally. In this paper, we answer in the negative a question from [Breen et al., Throttling for the game of Cops and Robbers on graphs, {\em Discrete Math.}, 341 (2018) 2418--2430.] about whether the cop throttling number of any graph is O(n−−√) by constructing a family of graphs having thc(G)=Ω(n2/3). We establish a sublinear upper bound on the cop throttling number and show that the cop throttling number of chordal graphs is O(n−−√). We also introduce the product cop throttling number th×c(G) as a parameter that minimizes the person-hours used by the cops. We establish bounds on the product cop throttling number in terms of the cop throttling number, characterize graphs with low product cop throttling number, and show that for a chordal graph G, th×c(G)=1+rad(G)

Variability Catalog of Stars Observed During the TESS Prime Mission

During its 2-year Prime Mission, TESS observed over 232,000 stars at a 2-min cadence across ~70% of the sky. These data provide a record of photometric variability across a range of astrophysically interesting time scales, probing stellar rotation, stellar binarity, and pulsations. We have analyzed the TESS 2-min light curves to identify periodic variability on timescales 0.01-13 days, and explored the results across various stellar properties. We have identified over 46,000 periodic variables with high confidence, and another 38,000 with moderate confidence. These light curves show differences in variability type across the HR diagram, with distinct groupings of rotational, eclipsing, and pulsational variables. We also see interesting patterns across period-luminosity space, with clear correlations between period and luminosity for high-mass pulsators, evolved stars, and contact binary systems, a discontinuity corresponding to the Kraft break, and a lower occurrence of periodic variability in main-sequence stars on timescales of 1.5 to 2 days. The variable stars identified in this work are cross-identified with several other variability catalogs, from which we find good agreement between the measured periods of variability. There are ~65,000 variable stars that are newly identified in this work, which includes rotation rates of low-mass stars, high-frequency pulsation periods for high-mass stars, and a variety of giant star variability.Comment: 29 pages, 17 figures, accepted to ApJS, catalog available: https://archive.stsci.edu/hlsp/tess-svc, data visualization tool: https://filtergraph.com/tessvariabilit

Assessing The Impact of Cluster Farming Initiatives on Small and Socially Disadvantaged Farmers, Ranchers, and Forestland Owners: A Case of The Southeastern Region of The United States

Farming in clusters is an economically viable practice to sustain small, limited resource, and socially disadvantaged farmers and forestland owners with their agricultural operations. The objectives of the study were to strengthen the capacity of clientele on cluster farming and to lower production and marketing costs by sharing input costs. Clusters were created and interventions were provided by project partners through several activities, including workshops, meetings, field days, loans, and materials/equipment. The results showed that 29 clusters involving 224 farmers, and 14 cooperatives involving 410 farmers were formed and strengthened. The number of farmers participating in workshops, training programs, field days, and meetings were, respectively, 4,921, 3,095, 1,426, and 1,285. The results also revealed that 190 producers received access to farm loans, mobile and stationary cold storage facilities, and marketing materials. Additionally, 930 farmers strengthened their knowledge and skills, and changed their behavior due to the implementation of the cluster farming approach

KSU Choral Ensembles present Messiah with KSU Symphony Orchestra

Kennesaw State University Choral Ensembles present Messiah by George Frideric Handel with KSU Symphony Orchestra.https://digitalcommons.kennesaw.edu/musicprograms/1123/thumbnail.jp

Mutual Control of Cholinergic and Low-Threshold Spike Interneurons in the Striatum

The striatum is the largest nucleus of the basal ganglia and is crucially involved in action selection and reward processing. Cortical and thalamic inputs to the striatum are processed by local networks in which several classes of interneurons play an important, but still poorly understood role. Here we investigated the interactions between cholinergic and low-threshold spike (LTS) interneurons. LTS interneurons were hyperpolarized by co-application of muscarinic and nicotinic receptor antagonists (atropine and mecamylamine, respectively). Mecamylamine alone also caused hyperpolarizations, while atropine alone caused depolarizations and increased firing. LTS interneurons were also under control of tonic GABA, as application of the GABAA receptor antagonist picrotoxin caused depolarizations and increased firing. Frequency of spontaneous GABAergic events in LTS interneurons was increased by co-application of atropine and mecamylamine or by atropine alone, but reduced by mecamylamine alone. In the presence of picrotoxin and tetrodotoxin (TTX), atropine and mecamylamine depolarized the LTS interneurons. We concluded that part of the excitatory effects of tonic acetylcholine (ACh) on LTS interneurons were due to cholinergic modulation of tonic GABA. We then studied the influence of LTS interneurons on cholinergic interneurons. Application of antagonists of somatostatin or neuropeptide Y (NPY) receptors or of an inhibitor of nitric oxide synthase (L-NAME) did not cause detectable effects in cholinergic interneurons. However, prolonged synchronized depolarizations of LTS interneurons (elicited with optogenetics tools) caused slow-onset depolarizations in cholinergic interneurons, which were often accompanied by strong action potential firing and were fully abolished by L-NAME. Thus, a mutual excitatory influence exists between LTS and cholinergic interneurons in the striatum, providing an opportunity for sustained activation of the two cell types. This activation may endow the striatal microcircuits with the ability to enter a high ACh/high nitric oxide regime when adequately triggered by external excitatory stimuli to these interneurons