The influence of mixing water on the thermophysical properties of nanofluids based on solar salt and silica nanoparticles

The use of nanofluids (NFs) based on Solar Salt (SS) and nanoparticles (NPs), either as Thermal Energy Storage (TES) material or as Heat Transfer Fluid (HTF), is attracting great interest in recent years. Many authors [1,3] have reported important improvements on the thermophysical properties (specific heat capacity cp,thermal conductivity k) of NFs based on SS and ceramic NPs. These improvements would lead to important savings and better performance of TES facilities on new Concentrated Solar Power (CSP) plants due to lower quantities of material required and smaller storage tanks. To achieve these advantageous features in the final NFs, it is essential to avoid NP agglomeration during their preparation. Different synthesis procedures have been reported: mixing of solid NPs within a SS solution by means of ultrasounds [1-3], direct mixing of solid NPs and molten salt [4]. In this work, NFs based on SS and 1% by wt. of silica NPs were synthetized from a SS-water solution and a commercial water-silica NF called Ludox HS 30% (Sigma-Aldrich). The influence of the mixing water volume (MW) on the cp of NFs was evaluated. With this aim, the cp of these samples was measured by Differential Scanning Calorimetry (DSC) both in the solid and the liquid state. In addition, the distribution of sizes was measured during the whole preparation process by Dynamic Light Scattering (DLS). Further information about sizes and uniformity of the final NFs was obtained from Scanning Electron Microscopy (SEM) images. X-ray Diffraction (XRD) patterns of the SS and final NF were performed.Basque Government's ETORTEK 201

Preparation of nanofluids based on solar salt and boehmite nanoparticles: Characterization of starting materials

A nanofluid composed of Solar Salt (SS) and boehmite nanoparticles (A) in a concentration of 1% by weight, is proposed as thermal storage medium for Concentrated Solar Power (CSP) plants. A wide characterization of the raw materials has been done, focused on their thermal stability and the nanoparticle primary size and shape among other properties such as its specific heat and crystalline structure. Some features of the final nanofluids have been also investigated: thermal stability, nanoparticle sizes and their distribution and specific heat. The showed results confirm that these materials are thermally stable in the working temperature range both individually and combined. In addition, the synthesis procedure implemented is effective to keep the nanoparticle sizes in the nanometric range (<100 nm). These findings mean the first step to carry on research and characterization of this nanofluid.Basque Government's ETORTEK 201

Bioinformatic analysis of gene regulation in Geobacter sulfurreducens

Background Geobacteraceae are a family of microorganisms from the delta subdivision of Proteobacteria. They have potential for environmental bioremediation and electricity generation. In this presentation, we describe our recent bioinformatic analyses of gene regulation in Geobacter sulfurreducens, a model representative of this family. Results and conclusion We have developed an online database, GSEL (Geobacter Sequence Elements), which compiles regulatory information for G. sulfurreducens. We have recently completed the development of a new, significantly expanded and updated, relational version 2 of the GSEL database and its accompanying online query system, which compiles manually curated information on operon organization and transcription regulatory elements in the genome of G. sulfurreducens. GSEL v. 2 incorporates a graphical browser and provides significantly expanded search capabilities. It also includes new information on predicted and/or experimentally validated genome regulatory sites and provides links to information from microarray experiments stored in public gene expression databases, and to original publications describing how particular regulatory interactions were identified. Using sequence and gene expression analyses, we investigated target genes and promoters regulated by RpoN, an alternative RNA polymerase sigma factor, which regulates a variety of important cellular processes in G. sulfurreducens. Our current studies are focusing on an investigation of several transcription regulatory systems involved in RpoN-dependent regulatory pathways. We have investigated target regulatory sites for an enhancer binding protein, PilR, which participates in RpoN-dependent transcriptional regulation of the pilA gene encoding structural pilin. We predicted multiple PilR-regulated sites upstream of operons related to biosynthesis, assembly, and function of pili and flagella, type II secretory pathways, and cell wall biogenesis. We also investigated sequence changes and molecular classification of the TetR family of transcriptional regulators. In G. sulfurreducens, we identified RpoN-regulated promoters upstream of several operons containing tetR family genes. The genome of G. sulfurreducens contains nine tetR family genes. Some of them are located upstream of operons encoding functionally important c-type cytochromes. In order to better understand the roles of TetR family members in the ability of Geobacteraceae to participate in electron transfer, we investigated phylogenetic relationships among TetR proteins in Geobacteraceae and in other microbial species. We identified their conserved and variable domains, which may be important for the diversity of their functional roles, and classified them into subgroups based on sequence similarities

Impact of co-infection by hepatitis C virus on immunological and virological response to antiretroviral therapy in HIV-positive patients

We assessed the effect of co-infection by hepatitis C virus (HCV) on immunological and virological response at 48 weeks from initiation of antiretroviral therapy (ART).We included patients from the Cohort of Spanish HIV Research Network (CoRIS) starting ART between January 2004 and November 2014, had at least 1 CD4 T-cell count and viral load measurements both in the previous 6 months and at 48 (±12) weeks from ART initiation, and HCV serology before ART initiation. We used linear regression for mean differences in CD4 T-cell count increase from ART initiation and logistic regression to estimate odds ratios for virological response.Of 12,239 patients by November 30, 2015, 5070 met inclusion criteria: 4382 (86.4%) HIV mono-infected and 688 (13.6%) HIV/HCV co-infected. Co-infected patients were more likely to have acquired HIV through injecting drugs use (57.4% vs. 1.1%), to be women, older, and Spanish, have a lower educational level, and having started ART with lower CD4 counts and acquired immunodeficiency syndrome. CD4 T-cell count increase at 48 weeks was 229.7 cell/μL in HIV-monoinfected and 161.9 cell/μL in HIV/HCV-coinfected patients. The percentages of patients achieving a virological response at 48 weeks were 87.0% and 78.3% in mono and coinfected patients, respectively. Multivariable analyses showed that at 48 weeks, coinfected patients increased 44.5 (95% confidence interval [CI]: 24.8-64.3) cells/μL less than monoinfected and had lower probability of virological response (odds ratio: 0.62; 95% CI: 0.44-0.88).HIV/HCV-coinfected patients have lower immunological and virological responses at 48 weeks from ART initiation than monoinfected patients.This work has been supported by the Spanish Medical Fund Research (PI12/02134) and Spanish Research Network of Excellence on HIV (RD12/0017/0018, RD16CIII/0002/0006) and Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP).S

Red de revisión de metodologías docentes en Geodinámica Interna en la Universidad de Alicante

En el Grado en Geología en la Universidad de Alicante las asignaturas del área de conocimiento de Geodinámica Interna suponen un porcentaje significativo del total de créditos de la titulación. Este hecho, sumado a que el Grado cuenta ya con seis años de desarrollo desde su implantación, ha puesto de manifiesto la necesidad de llevar a cabo un análisis de las metodologías docentes utilizadas en dichas asignaturas para detectar potenciales mejoras en las mismas, con el fin último de potenciar un aprendizaje más autónomo del estudiante, una mayor interacción profesor-estudiante y estimular el trabajo colaborativo. Para ello se ha creado una Red Docente formada por todos los miembros de la citada área, cuyos métodos de trabajo y resultados preliminares se expondrán en la presente comunicación

Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction

BACKGROUND Chronotropic incompetence has shown to be associated with a decrease in exercise capacity in heart failure with preserved ejection fraction (HFpEF), yet b-blockers are commonly used in HFpEF despite the lack of robust evidence. OBJECTIVES This study aimed to evaluate the effect of b-blocker withdrawal on peak oxygen consumption (peak VO2) in patients with HFpEF and chronotropic incompetence. METHODS This is a multicenter, randomized, investigator-blinded, crossover clinical trial consisting of 2 treatment periods of 2 weeks separated by a washout period of 2 weeks. Patients with stable HFpEF, New York Heart Association functional classes II and III, previous treatment with b-blockers, and chronotropic incompetence were first randomized to withdrawing from (arm A: n ¼ 26) versus continuing (arm B: n ¼ 26) b-blocker treatment and were then crossed over to receive the opposite intervention. Changes in peak VO2 and percentage of predicted peak VO2 (peak VO2%) measured at the end of the trial were the primary outcome measures. To account for the paired-data nature of this crossover trial, linear mixed regression analysis was used. RESULTS The mean age was 72.6 13.1 years, and most of the patients were women (59.6%) in New York Heart Association functional class II (66.7%). The mean peakVO2 and peak VO2% were 12.4 2.9 mL/kg/min, and 72.4 17.8%, respectively. No significant baseline differences were found across treatment arms. Peak VO2 and peak VO2% increased significantly after b-blocker withdrawal (14.3 vs 12.2 mL/kg/min [D þ2.1 mL/kg/min]; P < 0.001 and 81.1 vs 69.4% [D þ11.7%]; P < 0.001, respectively). CONCLUSIONS b-blocker withdrawal improved maximal functional capacity in patients with HFpEF and chronotropic incompetence. b-blocker use in HFpEF deserves profound re-evaluation. (b-blockers Withdrawal in Patients With HFpEF and Chronotropic Incompetence: Effect on Functional Capacity [PRESERVE-HR]; NCT03871803; 2017-005077-39) (J Am Coll Cardiol 2021;78:2042–2056) © 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Role of targeted therapies in rheumatic patients on COVID-19 outcomes: results from the COVIDSER study

Objectives: To analyse the effect of targeted therapies, either biological (b) disease-modifying antirheumatic drugs (DMARDs), targeted synthetic (ts) DMARDs and other factors (demographics, comorbidities or COVID-19 symptoms) on the risk of COVID-19 related hospitalisation in patients with inflammatory rheumatic diseases. Methods: The COVIDSER study is an observational cohort including 7782 patients with inflammatory rheumatic diseases. Multivariable logistic regression was used to estimate ORs and 95% CIs of hospitalisation. Antirheumatic medication taken immediately prior to infection, demographic characteristics, rheumatic disease diagnosis, comorbidities and COVID-19 symptoms were analysed. Results: A total of 426 cases of symptomatic COVID-19 from 1 March 2020 to 13 April 2021 were included in the analyses: 106 (24.9%) were hospitalised and 19 (4.4%) died. In multivariate-adjusted models, bDMARDs and tsDMARDs in combination were not associated with hospitalisation compared with conventional synthetic DMARDs (OR 0.55, 95% CI 0.24 to 1.25 of b/tsDMARDs, p=0.15). Tumour necrosis factor inhibitors (TNF-i) were associated with a reduced likelihood of hospitalisation (OR 0.32, 95% CI 0.12 to 0.82, p=0.018), whereas rituximab showed a tendency to an increased risk of hospitalisation (OR 4.85, 95% CI 0.86 to 27.2). Glucocorticoid use was not associated with hospitalisation (OR 1.69, 95% CI 0.81 to 3.55). A mix of sociodemographic factors, comorbidities and COVID-19 symptoms contribute to patients' hospitalisation. Conclusions: The use of targeted therapies as a group is not associated with COVID-19 severity, except for rituximab, which shows a trend towards an increased risk of hospitalisation, while TNF-i was associated with decreased odds of hospitalisation in patients with rheumatic disease. Other factors like age, male gender, comorbidities and COVID-19 symptoms do play a role.This Project has been financed by Bristol-Myers Squibb, Galapagos Biopharma Spain SLU, Gebro Pharma, Roche Farma and Sanofi Aventis

Prevención primaria de diabetes tipo 2. Estado actual del conocimiento

La prevalencia de diabetes ti po 2 aumenta conti nuamente a nivel mundial y su control defi ciente genera complicaciones graves que reducen la calidad de vida de quienes la padecen y elevan sus costos de atención. Sería entonces razonable pensar que para disminuir su impacto socioeconómico deberíamos mejorar la calidad de atención de las personas con diabetes y simultáneamente prevenir el desarrollo de la enfermedad en personas con alto riesgo de padecerla. Para identi fi car personas en riesgo de desarrollar diabetes se han desarrollado cuesti onarios de probada sensibilidad y especifi cidad diagnósti ca. Existe acuerdo en que identi fi cación de estas personas no produce impactos psicológicos importantes o duraderos en la población encuestada. Existen además estrategias no farmacológicas y farmacológicas capaces de prevenir/retrasar el desarrollo de diabetes en las personas en riesgo. Las primeras, consistentes en adopción de un plan de alimentación saludable y prácti ca regular de acti vidad fí sica, logran hasta un 58% de prevención y han demostrado ser efecti vas en disti ntas poblaciones (Suecia, China, Finlandia, Norteamérica e India). Su efecto preventi vo se manti ene hasta 10 años después de la intervención. Dentro de las intervenciones farmacológicas, la metf ormina, inhibidores de la α-glucosidasa (acarbosa) y las ti azolidinedionas han demostrado su efi cacia preventi va, que en general es menor que la de los cambios de esti lo de vida. Los estudios económicos concuerdan que tanto la detección por encuestas como las intervenciones preventi vas son costo-efecti vas.The prevalence of type 2 diabetes (T2DM) is conti - nuously increasing worldwide, and its poor control causes serious complicati ons that reduce the quality of life of people suff ering the disease and increase medical care costs. To decrease diabetes socio-economic impact, we should improve treatment effi cacy and simultaneously prevent its development in people at high risk. Questi onnaires with proven diagnosti c sensiti vity and specifi city have been set up to identi fy people at risk of developing diabetes, without producing important or long-lasti ng psychological impact on the surveyed populati on. Also, non-pharmacological and pharmacological strategies can be used to prevent/delay the development of diabetes in people at risk. The former, consisti ng in the adopti on of a healthy dietary plan and the practi ce of regular physical acti vity, result in up to 58% of preventi on, have been eff ecti ve in diff erent populati ons (Sweden, China, Finland, North America and India), and their preventi ve eff ect persists up to 10 years aft er the interventi on. Among pharmacological interventi ons, metf ormin, α-glucosidase inhibitors (acarbose) and thiazolidinediones have preventi ve eff ecti veness, which in general is lower than that of lifestyle changes. Economic studies agree that both, diabetes detecti on by means of surveys as well as preventi ve interventi ons are cost-eff ecti ve.Fil: Álvarez, A.. Hospital Italiano; ArgentinaFil: Basile, R.. Sociedad Argentina de Nutrición; ArgentinaFil: Bertaina, V.. Ministerio de Salud. Administración Nacional de Medicamentos, Alimentos y Tecnología Médica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Caporale, Ana Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Castelli, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Confederaciones de Farmacias; ArgentinaFil: Giménez, L.. International Assistance Group; FranciaFil: Guntsche, Enrique Manuel. Universidad Nacional de Cuyo; ArgentinaFil: Litwak, L.. Sociedad Argentina de Diabetes; ArgentinaFil: Lijteroff, G.. Federación Argentina de Entidades de Lucha Contra la Diabetes; ArgentinaFil: Masciottra, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; Argentina. Ministerio de Salud. Administración Nacional de Medicamentos, Alimentos y Tecnología Médica; ArgentinaFil: Sinay, I.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; Argentina. Ministerio de Salud. Administración Nacional de Medicamentos, Alimentos y Tecnología Médica; ArgentinaFil: Gagliardino, Juan Jose. Ministerio de Salud. Administración Nacional de Medicamentos, Alimentos y Tecnología Médica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - la Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de la Plata. Facultad de Cs.médicas. Centro de Endocrinología Experimental y Aplicada; Argentin

Surgical treatment for colorectal cancer: Analysis of the influence of an enhanced recovery programme on long-term oncological outcomes-a study protocol for a prospective, multicentre, observational cohort study

Introduction The evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life. Methods and analysis A multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant. Ethics and dissemination Ethical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings.The present research study was awarded a Ministerio de Ciencia e Innovación health research project grant (PI19/00291) from the Carlos III Institute of the Spanish National Health Service as part of the 2019 call for Strategic Action in Health

Assessing Provisions and Requirements for the Sustainable Production of Plastics: Towards Achieving SDG 12 from the Consumers’ Perspective

Plastics are used widely, and modern civilization would have to behave differently without them. However, plastics pose a threat to sustainable life. This paper focuses on some of the provisions being made for sustainable production to date and focuses on one key sector-plastic manufacturing-where sustainable production patterns are urgently needed. The paper describes the latest trends related to plastic production, its environmental impacts, and how this sector is adjusting its processes in order to meet the current and forthcoming legal requirements and consumer demands. The methodological approach of the study has focused on both a literature review on the one hand and the consumers’ perspective obtained via a survey on the other. These two approaches were then crosschecked in order to assess current trends in plastic manufacturing and to understand how consumers see these trends as being consistent with the aims of the UN Sustainable Development Goal 12. The results obtained suggest that a greater engagement of consumers is needed in supporting the efforts to manage plastic more sustainably. Based on its findings, the paper provides useful insights linked to principles and tools for sustainable plastic production and design, and it demonstrates the usefulness and urgency of a sound materials management in order to tackle plastic pollution, one of today´s major environmental problems