Wind-induced pressures on canopies attached to the walls of low-rise buildings

Current knowledge regarding wind-induced pressures on attached canopies is restricted to a limited number of studies. As a result, most wind standards and codes of practice do not provide guidelines for the design of such components. This thesis consists of a parametric study that expands current knowledge by providing a better understanding on the behavior of pressure coefficients acting on canopies attached to low rise buildings. All experimental results presented on this study have been carried out in the Building Aerodynamics Laboratory of Concordia University. \ud Two canopy models have been fabricated for the purpose of this study in the form of rectangular thin plates with pressure taps equally distributed along both upper and lower faces. These canopy models were attached at different locations on an acrylic glass building model with a gable roof of 4:12 slope. A total of 63 geometrically unique configurations were selected for this parametric study. The experiments were performed in the boundary layer wind tunnel for a simulated open terrain exposure. The 63 configurations, as well as the location of pressure taps on both faces of the canopy allow a detailed investigation of the different wind loading patterns exhibited as a function of the changes in the building geometry. A total number of 28 different wind directions have been tested for every configuration. Local and area-averaged peak values of the induced pressures have been analyzed as a function of the different geometrical relationships, which are unique to each configuration. The experimental results indicate that a slight difference in the geometry of the attached canopy and the parent building can result in an 80% difference of the peak net pressure coefficient. It has also been noted that the most critical uplift forces occur in canopies located above the intermediate regions of the parent wall. In contrast, downward forces exhibit less sensitivity to changes in geometry. Following the analysis and observations of the experimental data, recommended design guidelines have been provided for implementation in wind standards and building codes of practice. Comparisons with previous experimental results and provisions of other international standards and codes of practice are provided

Propuesta de mejora de distribución de planta, para reducir tiempos en la fabricación de maquinaria en la empresa Sermeind Fabricaciones Industriales SAC Moche - Trujillo 2019

RESUMEN En estos tiempos, la competitividad empresarial es cada vez más estrecha, la cual nos lleva a realizar diferentes tipos de estudios para reducir costos en diferentes procesos y/o áreas, con el cual este estudio se basa en una propuesta de una empresa metal mecánica que brinda servicios de fabricación de maquinaria para empresas agro-industriales en el norte del Perú. Para ello, se realizará el diagnostico actual de la empresa, realizando las mediciones de tiempo de diferentes maquinas, tomando las 4 principales áreas del proceso para este estudio, las cuales se necesitará métodos de estudio como: balance de líneas, distribución física del área de trabajo y por último la distribución de instalaciones, las cuales nos darán una visión más clara de la situación en la que se encuentra la empresa. El estudio de este proyecto es mejorar tiempos de fabricación y utilizar mejores métodos que puedan llevar al objetivo principal que es reducir y optimizar los costos en diversas maquinas estandarizando procedimientos de fabricación que la empresa realiza. Estos estudios se realizarán para detallar si es factible realizar estas mejoras de tal manera que mejore el proceso de fabricación, o caso contrario dar una mejor alternativa. Concluimos con este proyecto que la propuesta dada ayudaría a mejorar el tiempo de fabricación y por ende mejoraría los precios de los equipos, sin cambiar la calidad del producto e incluso mejorándolo lo cual nos permite ser una empresa competitiva dentro del mercado.ABSTRACT In these times, the business competitiveness is increasingly narrow, which leads us to perform different types of studies to reduce costs in different processes and / or areas, with which this study is based on a proposal of a metal mechanical company that provides machinery manufacturing services for agro-industrial companies in northern Peru. For this, the current diagnosis of the company will be made, making time measurements of different machines, taking the 4 main areas of the process for this study, which will need study methods such as line balance, physical distribution of the area of work and finally the distribution of facilities, which will give us a clearer vision of the situation in which the company is located. The study of this project is to improve manufacturing times and use better methods that can lead to the main objective is to reduce and optimize costs in various machines standardizing manufacturing procedures that the company performs. These studies will be carried out to detail if it is feasible to make these improvements in such a way as to improve the manufacturing process, or otherwise to give a better alternative. We conclude with this project that the given proposal would help to improve the manufacturing time and therefore improve the prices of the equipment, without changing the quality of the product and even improving it which allows us to be a competitive company within the market

Retroalimentación formativa y aprendizaje significativo en estudiantes de secundaria de la I.E.B.R. N° 7080 de Lima Sur, 2022

La investigación se llevó a cabo bajo la pregunta: ¿Qué relación existe entre la retroalimentación formativa y el aprendizaje significativo en estudiantes de secundaria de la I.E.B.R. N°7080 de Lima Sur, 2022? A partir de ello, tuvo como objetivo determinar la relación que existe entre la retroalimentación formativa y el aprendizaje significativo en estudiantes de secundaria de la I.E.B.R. N°7080 de Lima Sur, 2022. El estudio cuantitativo fue de tipo básico, con diseño no experimental, transversal y correlacional. Los resultados mostraron que el nivel de significancia fue de 0.020 y el Rho de Spearman fue de 0.170. Por ello, se concluyó que existe una correlación positiva media entre la retroalimentación formativa y el aprendizaje significativo

Altered Nuclear Functions in Progeroid Syndromes: a Paradigm for Aging Research

Syndromes of accelerated aging could provide an entry point for identifying and dissecting the cellular pathways that are involved in the development of age-related pathologies in the general population. However, their usefulness for aging research has been controversial, as it has been argued that these diseases do not faithfully reflect the process of natural aging. Here we review recent findings on the molecular basis of two progeroid diseases, Werner syndrome (WS) and Hutchinson-Gilford progeria syndrome (HGPS), and highlight functional connections to cellular processes that may contribute to normal aging

Lavado de manos: prevención de infecciones nosocomiales en una clínica de podología

The transfer of microorganisms via the hands of medical staff has been identified as the most important factor in the transmission of infections in hospitals or Health Clinics. Health ministers, technical experts and the World Health Organization (WHO) suggest some measures to combat hospital - acquired infections, also known as nosocomial infections. One of the main measures to avoid these infections is hand washing. For the importance of this topic an inquiry was conducted in a university clinic of podiatry, to identify knowledge of the people working there, or doing practices on prevention of these infections, and to determine the frequency with which they perform hand washing and if they performed correctlyLa transferencia de microorganismos a través de las manos del personal sanitario ha sido identificada como el factor más importante en la transmisión de infecciones en medios hospitalarios. Ministros de salud y funcionarios superiores, expertos técnicos y la Organización Mundial de la Salud (OMS) sugieren una serie de medidas fundamentales para luchar contra las infecciones asociadas a la atención sanitaria, también conocidas como infecciones nosocomiales, que ponen en peligro los avances obtenidos con grandes esfuerzos en los ámbitos de la salud y la esperanza de vida. Una de las medidas primordiales para evitar estas infecciones, es el lavado de manos. Debido a su repercusión y la importancia de este tema se realiza una encuesta en una Clínica Universitaria de Podología, para identificar los conocimientos del personal que trabaja o hace practicas en esta clínica sobre la prevención de este tipo de infecciones, así como para conocer la frecuencia con la que realizan el lavado de manos y si se realiza de manera correcta

The role of an electronic alert system to detect acute kidney injury in hospitalized patients: DETECT-H Project

Background and aims: Acute kidney injury (AKI) is associated with higher mortality and length of stay (LOS) for hospitalized patients. To improve outcomes, an electronic detection system could be a useful tool for early diagnosis. Methods: A fully automated real-time system for detecting decreased glomerular filtration rate in adult patients was developed in our hospital, DETECT-H project. AKI was established according to KDIGO guidelines. Results: In six months, 1241 alerts from 11,022 admissions were issued. Overall incidence of AKI was 7.7%. Highest AKI stage reached was: stage 1 (49.8%), 2 (24.5%) and 3 (25.8%), in-hospital mortality was 10.9%, 22.7%, 33.9% respectively and 57.1% in AKI requiring dialysis; mortality in stable CKD was 4.3%. Median LOS was 8 days versus 5 days for all patients. AKI was associated with a mortality of 3.18 (95% CI 1.80–5.59) and a LOS 1.52 (1.11–2.08) times as high as that for admissions without AKI. Multivariate analysis indicated that a LOS higher than 8 days was associated with AKI. Previous CKD was noted in 31.9% and AKI in 45.3% at discharge. As compared to the use of the detect system, only one third of CKD patients and half of AKI episodes were identified. Conclusions: CKD and in-hospital AKI are under-recognized entities. Mortality and LOS are increased in-hospital patients with renal dysfunction. AKI severity was associated with higher mortality and LOS. An automated electronic detection system for identifying renal dysfunction would be a useful tool to improve renal outcomes. Resumen: Introducción y objetivos: El fracaso renal agudo (FRA) aumenta la mortalidad y la estancia hospitalarias (EH). El empleo de sistemas de detección electrónica podría ser una herramienta beneficiosa para mejorar estos resultados. Métodos: Se desarrolló un sistema de detección automático a tiempo real de pacientes ingresados con función renal alterada, denominado proyecto DETECT-H. El FRA se estableció de acuerdo con las guías KDIGO. Resultados: En 6 meses, 1.241 alertas fueron recogidas de 11.022 ingresos. La incidencia global del FRA fue del 7,7%. La distribución en función del estadio máximo del FRA alcanzado fue: estadio 1: 49,8%, estadio 2: 24,5% y estadio 3: 25,8%; con una mortalidad hospitalaria del 10,9, 22,7 y 33,9%, respectivamente. En el caso del FRA con necesidad de diálisis fue del 57,1%. La mortalidad en pacientes con enfermedad renal crónica (ERC) estable fue del 4,3%. La mediana de EH en pacientes detectados fue 8 vs. 5 días para todos los pacientes hospitalizados. El FRA se asoció con una mortalidad 3,18 (1,8-5,59) y una EH 1,52 (1,11-2,08) veces superior que aquellos ingresos sin FRA. El análisis multivariante indicó que el FRA se asociaba con la EH > 8 días.En los informes de alta, la presencia de ERC previa solo fue registrada en el 31,9% de los pacientes con ERC y el FRA hospitalario en el 45,3%. Conclusiones: La ERC y el FRA intrahospitalario son entidades infradiagnosticadas. La mortalidad y la EH están aumentadas en pacientes con disfunción renal. La gravedad del FRA se asoció con mayor mortalidad y EH. Un sistema de detección automático para identificarlos podría ser útil para mejorar estos resultados. Keywords: Acute kidney injury, Automated electronic detection system, Chronic kidney disease, Diagnosis, Health information technology, Mortality, Palabras clave: Fracaso renal agudo, Sistema de detección electrónica automática, Enfermedad renal crónica, Diagnóstico, Tecnología de información de la salud, Mortalida

Multimodal texts for the strengthening of Emotional Intelligence

La inteligencia emocional es la capacidad del ser humano de controlar sus emociones, y de esta manera mejorar las relaciones interpersonales y son éstas las que juegan un papel fundamental en la vida del ser humano. La presente investigación tiene como objetivo general fortalecer la inteligencia emocional por medio de textos multimodales en la IED Janeiro en el departamento del Magdalena. El estudio se llevó a cabo desde la mirada cualitativa, empleando la entrevista estructurada como técnica de recolección de información. Los actores participantes fueron los estudiantes del grado noveno con la participación de (30) en la investigación. Como conclusiones se puede resaltar que los participantes se motivan a aprender y participan en el manejo y control de emociones presentes al momento de entrar en contacto con los procesos de enseñanza-aprendizaje.Emotional intelligence is the ability of the human being to control their emotions, and in this way improve intra and interpersonal relationships and these are the ones that play a fundamental role in the life of the human being. The general objective of this research is to strengthen emotional intelligence through multimodal texts in IED Janeiro in the department of Magdalena. The study was carried out from the qualitative perspective, using the structured interview as a technique for gathering information. The participating actors were ninth grade students with the participation of (30) in the research. As conclusions, it can be highlighted that participants are motivated to learn and participate in the management and control of present emotions when they come into contact with the teaching-learning processes

Activity of Bradykinin B2 Receptor Is Regulated by Long-Chain Polyunsaturated Fatty Acids.

The molecular and cellular mechanisms by which long-chain polyunsaturated fatty acids (LCPUFA) exert their beneficial effects on cardiovascular health remain obscure. While both LCPUFA and bradykinin (BK) signaling pathway play a role in the cardiovascular system, any direct link between the two is yet to be established. Using picosecond time-resolved fluorescence microscopy and a genetically engineered bradykinin B2 receptor (B2R) sensor (B2K-CC), we detected LCPUFA-induced conformational responses in the B2R similar to those caused by its cognate ligand, BK. The selective B2R antagonist (HOE-140) blocked the eicosapentaenoic acid (EPA, C20∶5, n-3) induced conformational response of the B2K-CC. Further analysis suggests that LCPUFA are capable of direct, B2R-dependent activation of extracellular ligand-regulated kinases (ERK). From a wide range of fatty acids studied, varying in chain length, saturation, and position of double bonds, EPA, docosahexaenoic (DHA, C22∶6, n-3), docosadienoic (DDA, C22∶2, n-6), and dihomo-gamma linoleic (DGLA, C20∶3, n-6) fatty acids caused the highest ERK phosphorylation. EPA or DHA dependent ERK phosphorylation was inhibited by the selective B2R antagonist. We show that LCPUFA stimulates downstream signaling by B2R such as B2R-dependent phosphorylation and expression regulation of endothelial nitric-oxide synthase (eNOS). Further analysis indicated that LCPUFA also alters levels of the eNOS transcription factor, kruppel-like factor 2 (KLF2). Moreover we show that EPA increases membrane fluidity on the same time scale as B2R conformational response, suggesting that partitioning of LCPUFA into bilayer is a primary step required for receptor activation. In summary our data show that LCPUFA activate B2R receptor at nanomolar concentrations suggesting a novel molecular mechanism by which fatty acids may affect the cardiovascular system