2,580 research outputs found
A Probabilistic Model and Capturing Device for Remote Simultaneous Estimation of Spectral Emissivity and Temperature of Hot Emissive Materials
Estimating the temperature of hot emissive samples (e.g. liquid slag) in the context of harsh industrial environments such as steelmaking plants is a crucial yet challenging task, which is typically addressed by means of methods that require physical contact. Current remote methods require information on the emissivity of the sample. However, the spectral emissivity is dependent on the sample composition and temperature itself, and it is hardly measurable unless under controlled laboratory procedures. In this work, we present a portable device and associated probabilistic model that can simultaneously produce quasi real-time estimates for temperature and spectral emissivity of hot samples in the [0.2, 12.0μm ] range at distances of up to 20m . The model is robust against variable atmospheric conditions, and the device is presented together with a quick calibration procedure that allows for in field deployment in rough industrial environments, thus enabling in line measurements. We validate the temperature and emissivity estimates by our device against laboratory equipment under controlled conditions in the [550, 850∘C ] temperature range for two solid samples with well characterized spectral emissivity’s: alumina ( α−Al2O3 ) and hexagonal boron nitride ( h−BN ). The analysis of the results yields Root Mean Squared Errors of 32.3∘C and 5.7∘C respectively, and well correlated spectral emissivity’s.This work was supported in part by the Basque Government (Hazitek AURRERA B: Advanced and Useful REdesign of CSP process for new steel gRAdes) under Grant ZE-2017/00009
Is Subdural Peritoneal Shunt Placement an Effective Tool for the Management of Recurrent/Chronic Subdural Hematoma?
Objectiveæ To describe a surgical techniqueæand to report using a retrospective studyæthe efficacy of peritoneal shunts for the treatment of recurrent/chronic subdural hematoma (CSDH). We describeæthe considerations, complications, and outcomes related to this technique. Methodsæ In a retrospectiveæcohort study, 125 charts with a diagnosis of subacute/chronic subdural hematoma were assigned for evaluation. Of the charts reviewed, 18 charts were found from subjects with a diagnosis of recurrent sub-acute or chronic subdural hematoma. All patients had undergone initial surgical treatment of their condition followed by peritoneal shunt placement to help alleviate intracranial pressure. Factors including the age, size of subdural hematoma, number of previous events, BMI, complications, survival, and clinical course were analyzed. Resultsæ After subdural peritoneal shunt placement all patients had full neurological recovery with no complaints of headaches, lethargy, weakness, confusion or seizures. None of the cases had new subdural hematoma episodes after placement for a minimum of a two-year period (mean 26.1 months) (range 24.3-48.6 months). No postoperative complications were reported. The rates of postoperative hemorrhage, infection, distal catheter revision, and perioperative seizures was found to be zero percent. Shunt drainage was successful in all cases, draining 85% of the blood in the first 48 hours. There was no significant relationship between complications and the use of anticoagulants four weeks after surgery. Conclusions Peritoneal shunts, though rarely used, are a viable option in the treatment of sub-acute/chronic subdural hematomas. When pursuing this treatment, this technique is recommended to mitigate the risks of repeat surgical intervention and lessen perioperative time in high-risk patients
A solution approach for deriving alternative fuel station infrastructure requirements
When an alternative fuel is introduced, the infrastructure through which that fuel is made available to the market is often underdeveloped. Transportation service providers relying on such infrastructures are unlikely to adopt alternative fuel vehicles as it may impose long detours for refueling. In this paper, we design and apply a new solution approach to derive minimum infrastructure requirements, in terms of the number of alternative fuel stations. The effectiveness of our approach is demonstrated by applying it to the case of introducing liquefied natural gas (LNG) as a transportation fuel in The Netherlands. From this case, we learn that, depending on the driving range of the LNG trucks and the size of area on which those trucks operate, a minimum of 5-12 LNG fuel stations is necessary to render LNG trucks economically and environmentally beneficial
Frequency of ABCA4 mutations in 278 Spanish controls: an insight into the prevalence of autosomal recessive Stargardt disease
An inventory control policy for liquefied natural gas as a transportation fuel
In this paper, we study a novel stochastic inventory management problem that arises in storage and refueling facilities for Liquefied Natural Gas (LNG) as a transportation fuel. In this inventory problem, the physio-chemical properties of LNG play a key role in the design of inventory policies. These properties are: (1) LNG suffers from both quantity decay and quality deterioration and (2) the quality of on-hand LNG can be upgraded by mixing it with higher-quality LNG. Given that LNG quality can be upgraded, an inventory control policy for this problem needs to consider the removal of LNG as a decision variable. We model and solve the problem by means of a Markov Decision Process (MDP) and study the structural characteristics of the optimal policy. The insights obtained in the analysis of the optimal policy are translated into a simple, though effective, inventory control policy in which actions (i.e., replenishment and/or removal) are driven by both the quality and the quantity of the inventories. We assess the performance of our policy by means of a numerical study and show that it performs close to optimal in many numerical instances. The main conclusion of our study is that it is important to take quality into consideration when design inventory control policies for LNG, and that the most effective way to cope with quality issues in an LNG inventory system involves both the removal and the replenishment of inventories
Safety and tolerability of cell culture-derived and egg-derived trivalent influenza vaccines in 3 to < 18-year-old children and adolescents at risk of influenza-related complications
Climate drives community-wide divergence within species over a limited spatial scale: evidence from an oceanic island
Geographic isolation substantially contributes to species endemism on oceanic islands when speciation involves the colonisation of a new island. However, less is understood about the drivers of speciation within islands. What is lacking is a general understanding of the geographic scale of gene flow limitation within islands, and thus the spatial scale and drivers of geographical speciation within insular contexts. Using a community of beetle species, we show that when dispersal ability and climate tolerance are restricted, microclimatic variation over distances of only a few kilometres can maintain strong geographic isolation extending back several millions of years. Further to this, we demonstrate congruent diversification with gene flow across species, mediated by Quaternary climate oscillations that have facilitated a dynamic of isolation and secondary contact. The unprecedented scale of parallel species responses to a common environmental driver for evolutionary change has profound consequences for understanding past and future species responses to climate variation
Cocoa coproducts-based and walnut oil gelled emulsion as animal fat replacer and healthy bioactive source in beef burgers
The aim of this work was to evaluate the effects on the chemical, physic-chemical, tech-nological, and sensory properties of beef burger when replacing different quantities of fat (50 and 100%) with different levels of oil-in-water-gelled emulsion elaborated with walnut oil and cocoa bean shell flour (GECW). The chemical composition of the samples was affected by the fat replace-ment. The reformulation increased the moisture and ash content while the fat and protein content decreased with respect to the control sample. The linolenic and linolenic acid content of the beef burgers increased as the GECW replacement was augmented. The polyunsaturated fatty/saturated fatty acid ratio increased in both raw and cooked burgers, whereas the atherogenicity index and thrombogenicity index were reduced in both raw and cooked burgers with respect to the control sample. The use of GECW as a fat replacer was found to be effective in improving the cooking loss. Similarly, there were positive effects on reductions in the diameter and the increases in the thickness of the beef burgers. Regarding lipid stability, in both the raw and cooked burgers, the reformulation increased the 2-thiobarbituric acid reactive substance (TBARs) values with respect to the control sample. In both types of reformulated burgers, three bound polyphenols (mainly catechin and epicatechin) and two free polyphenols were identified, as were methylxanthines theobromine and caffeine. The sensory properties for the control and partial pork backfat replacement treatments were similar, while the sample with the total pork backfat replacement treatment showed the lowest scores. The blend of cocoa bean shell flour and walnut oil could be used as new ingredients for the development of beef burgers with a healthier nutritional profile without demeriting their sensory or cooking characteristics and physic-chemical properties.This research was funded by Programa Iberoamericano de Ciencia y TecnologÃa para el
Desarrollo CYTED: 119RT0568.info:eu-repo/semantics/publishedVersio
Spatiotemporal analysis identifies ABF2 and ABF3 as key hubs of endodermal response to nitrate
Nitrate is a nutrient and a potent signal that impacts global gene expression in plants. However, the regulatory factors controlling temporal and cell type–specific nitrate responses remain largely unknown. We assayed nitrate-responsive transcriptome changes in five major root cell types of the Arabidopsis thaliana root as a function of time. We found that gene-expression response to nitrate is dynamic and highly localized and predicted cell type–specific transcription factor (TF)–target interactions. Among cell types, the endodermis stands out as having the largest and most connected nitrate-regulatory gene network. ABF2 and ABF3 are major hubs for transcriptional responses in the endodermis cell layer. We experimentally validated TF–target interactions for ABF2 and ABF3 by chromatin immunoprecipitation followed by sequencing and a cell-based system to detect TF regulation genome-wide. Validated targets of ABF2 and ABF3 account for more than 50% of the nitrate-responsive transcriptome in the endodermis. Moreover, ABF2 and ABF3 are involved in nitrate-induced lateral root growth. Our approach offers an unprecedented spatiotemporal resolution of the root response to nitrate and identifies important components of cell-specific gene regulatory networks
Tetrahedral (T) closed-shell cluster of 29 silver atoms & 12 lipoate ligands, [Ag29(R-a-LA)12](3-): antibacterial and antifungal activity
Accepted author manuscriptHere we report on the identification and applications of an aqueous 29-atom silver cluster stabilized with 12 lipoate ligands, i.e. Ag29(R-α–LA)12 or (29,12), wherein R-α–LA = R-α-lipoic acid, a natural dithiolate. Its uniformity is checked by HPLC-ESI-MS and analytical ultracentrifugation, which confirms its small dimension (∼3 nm hydrodynamic diameter). For the first time, this cluster has been detected intact via electrospray ionization mass spectrometry, allowing one to confirm its composition, its [3-] charge-state, and the 8-electron shell configuration of its metallic silver core. Its electronic structure and bonding, including T-symmetry and profound chirality in the outer shell, have been analyzed by DFT quantum-chemical calculations, starting from the known structure of a nonaqueous homologue. The cluster is effective against Methicillin-Resistant Staphylococcus aureus bacteria (MRSA) at a minimum inhibitory concentration (MIC) of 0.6 mg-Ag/mL. A preformed Candida albicans fungal biofilm, impermeable to other antifungal agents, was also inhibited by aqueous solutions of this cluster, in a dose–response manner, with a half-maximal inhibitory concentration (IC50) of 0.94 mg-Ag/mL. Scanning electron micrographs showed the post-treatment ultrastructural changes on both MRSA and C. albicans that are characteristic of those displayed after treatment by larger silver nanoparticles.Ye
- …