197 research outputs found

    Consultoría para la determinación de brechas de seguridad en una red inalámbrica

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    Las redes inalámbricas cuentan con una excelente acogida gracias a sus características de flexibilidad y movilidad. Su falencia se encuentra en su medio de transmisión. El aire es un medio abierto que permite que cualquier receptor tenga acceso a los datos transmitidos en una WLAN. Existen muchos métodos para combatir los problemas de seguridad de las redes inalámbricas. El problema surge al momento de seleccionar la más adecuada. En este proyecto se realiza un análisis de los diferentes métodos de seguridad disponibles para las redes inalámbricas. Se realizó un caso de estudio en el cual se revisó las condiciones de seguridad de una red y se determinó e implementó un sistema de seguridad. Posteriormente se creó un procedimiento para realizar una consultoría que permita determinar las necesidades de seguridad de una WLAN para finalmente proponer tres soluciones que se ajustan a las necesidades de cada red. La implementación de una de estas soluciones más la correcta administración de la red inalámbrica permitirá una seguridad efectiva que haga posible aprovechar las ventajas de las WLAN

    Crime trends through two decades of social changes in Spain

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    "Over the last two decades, the Spanish social fabric has undergone a variety of profound changes, which in turn may explain the rise in police-recorded crime and prison population figures. Although the rise in crime reported to the police has been higher for common offences—misdemeanors—, the mainstream media concentrates overwhelmingly in serious violent crimes—felonies—. Spain does not have an official agency responsible for conducting victimization surveys to measure crime trends as directly experienced by the citizens. Based on this methodology, our study shows that contrary to information gathered from police data, and despite social fabric changes, crime in Spain is decreasing. The present study also reveals the distorted public perception of this trend, which seems to respond to a repetitive coverage of serious crime by the mainstream media." [author's abstract

    Coup-TFII expression defines two different septum transversum cell compartments crucial to cardiac septation and compact ventricular wall growth

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    COUP-TFII encodes for an orphan nuclear receptor expressed by multiple embryonic tissues. COUP-TFII functions include the regulation of mesodermal progenitor differentiation and cell fate specification, and is required for completion of cardiovascular development as shown by the early death (E9.5) of COUP-TFII-null mice. In this study, we show that COUP-TFII, which is strongly expressed in the atrial myocardium, is also expressed in two different compartments of the septum transversum (ST, E9.5), a mesodermal folding adjacent to cardiac inflow myocardium. The first ST compartment is COUP-TFII+/Isl1+; cells in this compartment concentrate in the posterior part of the ST, overlap with SHF, and are continuous with the dorsal mesenchymal protrusion (DMP, also known as spina vestibuli). The second compartment is characteristically COUP-TFII+/Isl1-, and comprises the majority of proepicardial cells. To dissect the role of COUP-TFII+ ST cells in cardiac development, we conditionally deleted COUP-TFII in the ST using two different Cre constructs (Wt1Cre; G2-Gata4Cre). We show that COUP-TFII deletion in the ST is most severe in G2-Gata4Cre;COUP-TFII-/- mice, containing various cardiovascular progenitor lineages. Mutant mice display atrial septation and atrioventricular septal defects as well as a severe disruption of compact ventricular myocardial growth and coronary vascularization. We conclude that COUP-TFII plays critical, pleiotropic, tissue-dependent roles during cardiac septation, growth and vascularization.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII

    Rehabilitación mediante las metodologías OPI y VIZIR para mejorar la condición del pavimento flexible en el tramo Huacapongo-Tomabal-Virú, 2022

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    La presente investigación se realizó en la provincia de Virú , en la Universidad Cesar Vallejo, se determinó la propuesta de rehabilitación para mejorar la condición del pavimento flexible bajo las metodologías OPI y VIZIR, para la realización de la tesis se utilizó un diseño no experimental, descriptivo, propositivo, el muestreo fue no probabilístico por juicio de expertos, la recolección de datos se realizó con la técnica de la Observación directa y la medición, el instrumento utilizado fue la ficha de recolección de datos, para analizar los datos se empleó la estadística descriptiva, el problema es la existencia de fallas en el pavimento flexible, ubicado en el tramo de Huacapongo-Tomabal-Virú y esto ocasiona la inseguridad en los transeúntes de la zona, la rehabilitación del pavimento flexible, mediante una condición regular , se realizó un 8% de parchados, 21% de renovación de la carpeta asfáltica de 2” en los deterioros graves y un 41% de sellado con Slurry Seal en los deterioros superficiales, se logró determinar la rehabilitación del pavimento flexible, realizándose parchados , renovaciones de la carpeta asfáltica y sellados con Slurry Seal, teniéndose un OPI de 45 y un VIZIR de 3, correspondiendo ambos un pavimento de condición regular

    Urokinase-type Plasminogen Activator Receptor Transcriptionally Controlled Adenoviruses Eradicate Pancreatic Tumors and Liver Metastasis in Mouse Models

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    Treatment options for pancreatic cancer have shown limited success mainly owing to poor selectivity for pancreatic tumor tissue and to a lack of activity in the tumor. In this study, we describe the ability of the urokinase-type plasminogen activator receptor (uPAR) promoter to efficiently and selectively target pancreatic tumors and metastases, which enables the successful management of pancreatic cancer. We have generated a replication-defective reporter adenovirus, AduPARLuc, and a conditionally replicating adenovirus, AduPARE1A, and we have studied the selectivity and antitumoral efficacy in pancreatic tumors and metastases. Toxicity was studied on intravascular delivery. We demonstrate that the uPAR promoter is highly active in pancreatic tumors but very weak in normal tissues. Tumor specificity is evidenced by a 100-fold increase in the tumor-to-liver ratio and by selective targeting of liver metastases (P < .001). Importantly, the AduPARE1A maintains the oncolytic activity of the wild-type virus, with reduced toxicity, and exhibits significant antitumoral activity (25% tumor eradication) and prolonged survival in pancreatic xenograft models (P < .0001). Furthermore, upon intravascular delivery, we demonstrate complete eradication of liver metastasis in 33% of mice, improving median survival (P = 5.43 x 10(-5)). The antitumoral selective activity of AduPARE1A shows the potential of uPAR promoter-based therapies in pancreatic cancer treatment

    A new and rapid micropropagation protocol for Eucalyptus grandis Hill ex Maiden

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    Aim of the study: We developed a faster micropropagation protocol specifically designed for Eucalyptus grandis. Eucalyptus breeding programs use micropropagation protocols to obtain high quality cloned seedlings, but current protocols are excessively time consuming.Area of the study: The protocol has been developed in Argentina, but it can be applied in anywhere.Materials and methods: We used nodal segments as initial explants to obtain micropropagated shoots, which were then simultaneously rooted ex vitro and acclimated in a hydroponic system. Nodal segments were cultured in a MS medium supplemented with 1 mg l-1 6-benzylaminopurine, 30 g l-1 sucrose, 1 g l-1 active charcoal and 8 g l-1 agar and incubated for four weeks at 25 ± 2°C under 16 h day photoperiod. Then, micropropagated shoots were exposed 15 seconds to 5000 ppm indol-butyric acid prior to being transferred to a hydroponic system, allowing simultaneous ex vitro rooting and acclimatization.Main results: 73 ± 9% of nodal segments grew to generate 1.73 ± 1.03 shoots per explant (length: 0.76 ± 0.44 cm). After four weeks in hydroponic system, 46 ± 4 % of micropropagated shoots developed roots, which represents an acceptable and intermediate rate of success, compared to the reported in vitro rooting rates.Research highlights: Our protocol allowed to obtain micropropagated seedlings in a total timespan of 8 weeks. Our results show that, by utilizing a hydroponic system, traditional protocols to micropropagate Eucalyptus can be substantially enhanced, allowing for improved production dynamics and potentially resulting in better organized seedling manufacturing facilities.Keywords: Woody plants; silviculture; nursery seedlings; rooting methods; hydroponics; acclimatization

    Psychosocial and Sociodemographic Determinants Related to Chronic Diseases in Immigrants Residing in Spain

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    The aim of the study is to analyze the effect of the psychosocial determinants of satisfaction with social support, resilience and satisfaction with life, and the sociodemographic determinants of age, gender and length of residence on chronic diseases in immigrants living in Spain. The sample was composed of 1131 immigrants from Africa, Eastern Europe, Latin America and Asia. 47.1% were men and 52.9% were women. Most relevant results point to age as the sociodemographic variable with the highest predictive effect in the six chronic diseases analyzed. Gender, in this case female, predicts arthrosis, chronic back pain and migraine, whereas length of residence was only significant in the case of chronic allergies. Regarding psychosocial variables, resilience is a good predictor of hypertension, chronic allergies and arthrosis. However, satisfaction with social support appears to be the best predictor for chronic back pain in the regression equation, satisfaction with life being a significant variable in migraine, arthrosis, allergies and high cholesterol. Results are notably relevant for the design of preventive health programs in immigrants, as well as in ensuring their appropriate access to the health system so that their chronic diseases can be diagnosed. Given the relevance and incidence of the chronic diseases analyzed in immigrants, preventive strategies should be improved to tackle chronic diseases that can have a serious impact on immigrants’ healthThis study was made possible by grants from the Spanish Economy and Competitiveness Ministry (Project I+D: PSI2013-40508-P). This research was supported by Grant Number HUM-590 (PAIDI, Junta de Andalucía). Partial funding for open access charge: Universidad de Málaga

    Finding Respondents from Minority Groups

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    The recruitment of respondents belonging to ethnic minorities poses important challenges in social and health research. This paper reflects on the enablers and barriers to recruitment that we encountered in our research work with persons belonging to ethnic minorities. Additionally, we applied the Matching Model of Recruitment, a theoretical framework concerning minority recruitment, to guide our reflection. We also explored its applicability as a research design tool. In assessing our research experience, we learned that minority recruitment in social and health research is influenced by the social context of all key players involved in the research. Also, there are enablers and barriers within that social context facilitating or delaying the recruitment process. The main enablers to recruit respondents belonging to ethnic minorities include working with community agencies and gatekeepers who share a common vision with researchers and the latter’s ability to gain the trust of potential respondents. The main barriers include demanding too much from these same community agencies and gatekeepers and ignoring factors that could delay the completion of the research. Although we found the Matching Model of Recruitment to be an effective tool in assessing the processes of recruiting respondents belonging to ethnic minorities, further empirical research is needed to explore its usefulness during the research planning phase

    Phytostabilization of polluted military soil supported by bioaugmentation with PGP-trace element tolerant bacteria isolated from helianthus petiolaris

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    Lead (Pb) and cadmium (Cd) are major environmental pollutants, and the accumulation of these elements in soils and plants is of great concern in agricultural production due to their toxic effects on crop growth. Also, these elements can enter into the food chain and severely affect human and animal health. Bioaugmentation with plant growth-promoting bacteria (PGPB) can contribute to an environmentally friendly and effective remediation approach by improving plant survival and promoting element phytostabilization or extraction under such harsh conditions. We isolated and characterised Pb and Cd-tolerant root-associated bacteria from Helianthus petiolaris growing on a Pb/Cd polluted soil in order to compose inoculants that can promote plant growth and also ameliorate the phytostabilization or phytoextraction efficiency. One hundred and five trace element-tolerant rhizospheric and endophytic bacterial strains belonging to eight different genera were isolated from the aromatic plant species Helianthus petiolaris. Most of the strains showed multiple PGP-capabilities, ability to immobilise trace elements on their cell wall, and promotion of seed germination. Bacillus paramycoides ST9, Bacillus wiedmannii ST29, Bacillus proteolyticus ST89, Brevibacterium frigoritolerans ST30, Cellulosimicrobium cellulans ST54 and Methylobacterium sp. ST85 were selected to perform bioaugmentation assays in greenhouse microcosms. After 2 months, seedlings of sunflower (H. annuus) grown on polluted soil and inoculated with B. proteolyticus ST89 produced 40% more biomass compared to the non-inoculated control plants and accumulated 20 % less Pb and 40% less Cd in the aboveground plant parts. In contrast, B. paramycoides ST9 increased the bioaccumulation factor (BAF) of Pb three times and of Cd six times without inhibiting plant growth. Our results indicate that, depending on the strain, bioaugmentation with specific beneficial bacteria can improve plant growth and either reduce trace element mobility or enhance plant trace element uptake.Fil: Saran, Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional La Pampa-San Luis. Estación Experimental Agropecuaria Anguil; Argentina. Hasselt University; BélgicaFil: Imperato, Valeria. Hasselt University; BélgicaFil: Fernandez, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional La Pampa-San Luis. Estación Experimental Agropecuaria Anguil; ArgentinaFil: Gkorezis, Panos. Hasselt University; BélgicaFil: d´Haen, Jan. Hasselt University; BélgicaFil: Merini, Luciano Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro Regional La Pampa-San Luis. Estación Experimental Agropecuaria Anguil; ArgentinaFil: Vangronsveld, Jaco. Hasselt University; Bélgica. Maria Curie Sklodowska University; PoloniaFil: Thijs, Sofie. Hasselt University; Bélgic
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