Otras aplicaciones docentes del Atlas Digital de Petrología Sedimentaria a través del Campus Virtual UCM (www.ucm.es/info/petrosed)

La Petrología Sedimentaria se adapta a las necesidades profesionales que demanda la sociedad y entre ellas el sector de la construcción. Preparar a los futuros profesionales plantea un reto no solo en la Facultad de CC. Geológicas (UCM) sino en otras muchas, sobre todo a la hora de diseñar y desarrollar el material y las herramientas didácticas que el alumno precisa en su autoaprendizaje. La asignatura Materiales de Construcción, impartida en la Facultad de CC. Geológicas (UCM) (Grado de Ingeniería Geológica), utiliza, a través de Campus Virtual, el Atlas de Petrología Sedimentaria: http://www.ucm.es/info/petrosed, ya que recoge un material didáctico fundamental para el desarrollo de gran parte de sus clases prácticas y teóricas. Esta asignatura muestra una gran afinidad con la temática y la metodología de trabajo que se emplea en la asignatura Petrología Sedimentaria, a pesar de pertenecer a campos científico-técnicos diferentes

Boosted protease inhibitor monotherapy in HIVinfected adults: outputs from a pan-European expert panel meeting

While the introduction of combination highly active antiretroviral therapy (HAART) regimens represents an important advance in the management of human immunodeficiency virus (HIV)-infected patients, tolerability can be an issue and the use of several different agents may produce problems. The switch of combination HAART to ritonavir-boosted protease inhibitor (PI) monotherapy may offer the opportunity to maintain antiviral efficacy while reducing treatment complexity and the risks of toxicity. Current European AIDS Clinical Society (EACS) guidelines recognise ritonavir-boosted PI monotherapy with twice-daily lopinavir/ritonavir or once-daily darunavir/ritonavir as a possible option in patients who have intolerance to nucleoside reverse transcriptase inhibitors, or for treatment simplification. Clinical trials data for PI boosted monotherapy are encouraging, showing substantial efficacy in the majority of patients; however, further data are required before this approach can be recommended as a routine treatment. Available data indicate that the most suitable candidates for the use of boosted PI monotherapy are long-term virologically suppressed patients who have demonstrated good adherence to antiretroviral therapy, who do not have chronic hepatitis B, have no history of treatment failure on PIs and are able to tolerate low-dose ritonavir

Critical Care Requirements Under Uncontrolled Transmission of SARS-CoV-2

Objectives. To estimate the critical care bed capacity that would be required to admit all critical COVID-19 cases in a setting of unchecked SARS-CoV-2 transmission, both with and without elderly-specific protection measures. Methods. Using electronic health records of all 2432 COVID-19 patients hospitalized in a large hospital in Madrid, Spain, between February 28 and April 23, 2020, we estimated the number of critical care beds needed to admit all critical care patients. To mimic a hypothetical intervention that halves SARS-CoV-2 infections among the elderly, we randomly excluded 50% of patients aged 65 years and older. Results. Critical care requirements peaked at 49 beds per 100 000 on April 1-2 weeks after the start of a national lockdown. After randomly excluding 50% of elderly patients, the estimated peak was 39 beds per 100 000. Conclusions. Under unchecked SARS-CoV-2 transmission, peak critical care requirements in Madrid were at least fivefold higher than prepandemic capacity. Under a hypothetical intervention that halves infections among the elderly, critical care peak requirements would have exceeded the prepandemic capacity of most high-income countries. Public Health Implications. Pandemic control strategies that rely exclusively on protecting the elderly are likely to overwhelm health care systems.S

Características de la canal y calidad instrumental de la carne en cabritos y corderos lechales

Meat from very young, milk-fed, small ruminants is an appreciated product in Mediterranean countries where milk is the main product derived from the herds. Nevertheless, many aspects of the quality of the products are virtually unknown for many goat breeds, especially among those that are reared for their meat. In this study, the quality from 50 animals from 5 local goat breeds (one dairy purpose and 4 meat purpose) and 19 lambs (from Churra, a dairy breed) was compared at commercial cold carcass weights of 4.4-6.6 kg. Carcass quality, ultimate pH and meat colour were assessed following standard procedures. Statistical differences (p < 0.05) were found in all of the variables analysed. Some of these differences might have been due to the influence of the genotype, the dam’s production potential, or differences in carcass weight and age, but most were species dependent. Lambs differed from the kids, especially from those of meat purpose breeds, due to their high proportion of bone (25.0 vs. 21.3 to 23.7%), and a more intense meat colour (higher hue: 29.2 vs. 23.4 to 28.7, and chroma: 14.6 vs. 12.1 to 14.6). Among the goat breeds, Murciano Granadina (dairy breed) and Blanca Celtibérica (meat breed) were the most different in terms of carcass morphology, fatness, and meat colour. The other three local meat-purpose goat breeds (Moncaína, Negra Serrana, and Pirenaica) differed little. To obtain a better understanding of goat species, the differences among breeds, in kids or in their most common products, require further studies. Additional key words: carcass morphology; colour; goat; pH; sheep; tissue composition.La carne de lechal es muy apreciada en los países mediterráneos, en los que la leche es una producción fundamental. Además, muchos aspectos de los productos de las razas caprinas locales son prácticamente desconocidos. En este estudio se analizó la calidad de 50 animales de 5 razas caprinas (una lechera y 4 de aptitud cárnica) y de 19 corderos (raza Churra de tipo lechero), a pesos comerciales de 4,4-6,6 kg de canal fría. Se evaluaron la calidad de la canal, el pH último y el color de la carne, siguiendo metodologías estandarizadas. Se encontraron diferencias significativas (p < 0,05) en todas las variables analizadas. Algunas de estas diferencias se podrían justificar por diferencias raciales, potencial lechero de las madres o peso canal final, pero la mayor parte fueron debidas a la especie considerada. Los corderos fueron diferentes, especialmente de los cabritos de razas con orientación predominantemente cárnica, en la proporción de hueso (25,0 vs. 21,3-23,7%) y color de carne más intenso (superiores valores de tono: 29,2 vs. 23,4-28,7 y saturación: 14,6 vs. 12,1-14,6). Entre las razas caprinas, la Murciano Granadina (raza de aptitud lechera) y la Blanca Celtibérica (raza cárnica) fueron las más diferentes en morfología de la canal, engrasamiento y color de carne. Las otras tres razas de aptitud cárnica (Moncaína, Negra Serrana y Pirenaica) fueron poco diferentes entre sí. Para conocer mejor a la especie caprina, las diferencias entre razas y la calidad de sus productos, son necesarios una mayor cantidad de estudios

EXPLORING THE IMPACT OF APOE POLYMORPHISM ON THE MOLECULAR, MORPHOLOGICAL AND FUNCTIONAL PROFILE OF iPSC-DERIVED ASTROCYTES FROM ALZHEIMER'S PATIENTS

Comunicación presentada a FENS Forum 2022Alzheimer¿s disease (AD) is pathologically characterised by the presence of amyloid-beta plaques, neurofibrillary tangles containing hyperphosphorylated Tau protein, neuroinflammation and neuronal death leading to progressive cognitive impairment. The ¿4 allele of the gene encoding apolipoprotein E (APOE), which is mainly expressed in glial cells, is the strongest genetic risk factor for sporadic AD. Increasing evidence has shown that APOE4 may disrupt normal astrocyte activity, potentially contributing to AD pathology, but the impact of different APOE alleles on astrocyte differentiation, maturation and function is not yet fully understood. To go in depth on these questions, we obtained induced pluripotent stem cells (iPSCs) from fibroblasts of AD patients carrying ¿3 and ¿4 alleles (in homozygosis) and from healthy patients. We also used gene-edited iPSC lines homozygous for the main APOE variants and an APOE knock-out line. iPSC-derived human astrocytes were generated by establishing a differentiation protocol through the consecutive addition of small molecules and growth factors, and the expression of typical markers (GFAP, GLT1, AQP4 and S100beta) and APOE was analysed. In addition, astrocytes exhibited functional features like glutamate uptake capacity and calcium waves production. They also responded to an inflammatory stimulus (IL-1beta and TNF-alpha) or to the presence of amyloid-beta 1-42 peptide by changing their morphology and increasing the expression levels of pro-inflammatory factors and cytokines. Our results shed light on the potential dual role of APOE polymorphism and the individual¿s genetic background in favouring or perhaps preventing AD pathology

ANALYSING THE MOLECULAR, MORPHOLOGICAL AND FUNCTIONAL PROFILE OF iPSC-DERIVED ASTROCYTES FROM ALZHEIMER'S DISEASE PATIENTS

Comunicación presentada en Global Summit on Neurodegenerative Diseases NEURO 2020/22The ε4 allele of the gene encoding apolipoprotein E (APOE), which is mainly expressed in glial cells, is the strongest genetic risk factor for sporadic AD. Increasing evidence has shown that APOE4 may disrupt normal astrocyte activity, potentially contributing to AD pathology, but the impact of different APOE alleles on astrocyte maturation and function as well as their inflammatory profile is not yet fully understood. To answer these questions, we obtained induced pluripotent stem cells (iPSCs) from fibroblasts of AD patients carrying ε3 and ε4 alleles (in homozygosis) and from healthy patients. We also used gene-edited iPSC lines homozygous for the main APOE variants and an APOE knock-out line. iPSC-derived human astrocytes were generated through the consecutive addition of small molecules and growth factors to the culture medium, and the expression of typical markers (GFAP, GLT1, AQP4 and S100beta) was analysed. In addition, astrocytes exhibited functional features like glutamate uptake capacity and calcium waves. They also responded to an inflammatory stimulus (IL-1beta and TNF-alpha) or to the presence of amyloid-beta 1-42 peptide by changing their morphology and increasing the expression levels of pro-inflammatory factors and cytokines. Our results shed light on the potential dual role of APOE polymorphism and the individual's genetic background in favouring or perhaps preventing AD pathology

Caracterización conjunta del basamento en Hontomín (España) empleando datos sísmicos y microgravimétricos

9ª Asamblea Hispano Portuguesa de Geodesia y Geofísica: Madrid 28-30 de junio 2016 / Organizado por la Comisión Española de Geodesia y Geofísica ; Secçao Portuguesa das Unios Internacionais Astronomica e Geodésica ; Universidad Complutense de MadridInstitut de Ciéncies de la Terra Jaume Almera, EspañaDepartment of Geology and Petroleum Geology, University of Aberdeen, Reino UnidoDepartamento de Geología, Universidad de Salamanca, EspañaInstituto Geológico y Minero de España, EspañaPeer reviewe