493 research outputs found
Análisis proteómico de la matriz exocelular (ME) de las biopelículas formadas por una cepa silvestre y por una mutante del hongo Candida albicans con una interrupción en el gen PGA10 que codifi ca para una proteína que contiene el dominio CFEM rico en cisteína
Estudio de la física de las nubes tormentosas. I: la lucha antigranizo en la región de Albacete (España)
A novel computer software for the evaluation of dynamic visual acuity
Postprint (author's final draft
Behavior of vine varieties resistant to fungal diseases in the somontano region
The vine is highly susceptible to numerous fungal diseases, the incidence and severity of which are increasing because of climate change. To fight them, large amounts of phytosanitary products are generally used, although they entail important economic and environmental costs. The new fungus resistant vine varieties (PIWI) constitute one of the most active lines of research on plant material in viticulture and are regarded as a viable solution to respond to the requirements of European Directive 2009/128/EC. In the present work, the evolution and impact of the three main fungal diseases (powdery mildew, downy mildew and botrytis bunch rot) were monitored in plots in the Somontano region (Huesca, Spain), comparing three PIWI varieties (Sauvignon Kretos, Souvignier gris and Muscaris) with a susceptible control variety (Sauvignon blanc) in real field growing conditions over three successive years (2016–2018). The main ampelographic characters of each variety were studied and a weekly follow-up was carried out to track the development of each disease, relating it to climatic variables. Regardless of the climatic conditions (one of the growing seasons was rainy and the other two corresponded to dry years, with differences in the distribution of rainfall), the three PIWI varieties hardly presented any symptoms, demonstrating a high resistance to downy mildew and powdery mildew and even to botrytis. Principal component analysis results pointed to a differential behavior versus the control and treated Sauvignon blanc plants in terms of disease resistance. Based on production results, despite the youth of the plantation, the excellent potential of Sauvignon Kretos variety was observed. However, from the analysis of the quality of wine obtained in microvinifications from these fungus resistant varieties in the second and third year, the one obtained from Muscaris seemed to have the best organoleptic properties. Apart from environmental considerations, given that these fungus resistant varieties can significantly contribute to the sustainability of wineries, they may also respond to the demand of consumers who want zero-pesticide products or of the supporters of ecological products adjusted to European regulations
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
Effects of high-intensity interval training on vascular function in patients with cardiovascular disease: a systematic review and meta-analysis
Background: Exercise training improves endothelial function in patients with
cardiovascular disease (CVD). However, the influence of training variables
remains unclear. The aim of this study was to evaluate the effect of highintensity
interval training (HIIT), compared to moderate intensity training (MIT)
and other exercise modalities (i.e., resistance and combined exercise), on
endothelial function, assessed by arterial flow-mediated dilation (FMD) or
endothelial progenitor cells (EPCs), in patients with CVD. Secondly, we
investigated the influence of other training variables (i.e., HIIT protocol).
Methods: The PICOS strategy was used to identify randomised and nonrandomised
studies comparing the effect of HIIT and other exercise modalities
(e.g., MIT) on endothelial function in patients with CVD. Electronic searches were
carried out in Pubmed, Embase, and Web of Science up to November 2022. The
TESTEX scale was used to evaluate the methodological quality of the included
studies. Random-effects models of between-group mean difference (MD) were
estimated. A positive MD indicated an effect in favour of HIIT. Heterogeneity
analyses were performed by the chi-square test and I2 index. Subgroup analyses
evaluated the influence of potential moderator variables.
Results: Fourteen studies (13; 92.9% randomised) were included. Most of the
studies trained 3 days a week for 12 weeks and performed long HIIT. No
statistically significant differences were found between HIIT and MIT for
improving brachial FMD in patients with coronary artery disease (CAD) and
heart failure with reduced ejection fraction (HFrEF) (8 studies; MD+ = 0.91%
[95% confidence interval (CI) = −0.06, 1.88]). However, subgroup analyses
showed that long HIIT (i.e., > 1 min) is better than MIT for enhancing FMD
(5 studies; MD+ = 1.46% [95% CI = 0.35, 2.57]), while no differences were
found between short HIIT (i.e., ≤ 1 min) and MIT (3 studies; MD+ = −0.41%
[95% CI = −1.64, 0.82]). Insufficient data prevented pooled analysis for EPCs,
and individual studies failed to find statistically significant differences (p > .050)
between HIIT and other exercise modalities in increasing EPCs. Discussion: Poor methodological quality could limit the precision of the current
results and increase the inconsistency. Long HIIT is superior to MIT for improving
FMD in patients with CAD or HFrEF. Future studies comparing HIIT to other exercise
modalities, as well as the effect on EPCs and in HF with preserved ejection fraction
are required
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