Fracturación y control tectosedimentario neógeno en el borde sureste de la Cuenca de Lorca

En este trabajo se estudia el control tectosedimentario ejercido por la fracturación neógena en la sedimentación en el borde suroriental de la Cuenca de Larca. El control más importante está impuesto por la actividad del Corredor Tectónico de la Falla de Alhama de Murcia. Este corredor controló la formación del borde sur de la citada cuenca a través de movimientos de carácter normal que activaron el inicio del depósito mioceno. Durante el Tortoniense y el Messiniense la cinemática sinestral e inversa del corredor controla la formación del anticlinal que estructura la Sierra de La Tercia y provoca reactivaciones de procesos erosivos en áreas emergidas

Sarcopenic osteoporosis, sarcopenic obesity, and sarcopenic osteoporotic obesity in the Camargo cohort (Cantabria, Spain)

Summary The associations of sarcopenia with osteoporosis or obesity have a very low prevalence. No trend towards an association between osteoporosis and sarcopenia is observed. Sarcopenia and obesity tend not to coincide, as if they were antagonistic disorders. Purpose To know (a) the prevalence in our region of sarcopenic osteoporosis (association of sarcopenia and osteoporosis (T-score<2.5)), sarcopenic obesity, and the association of osteoporosis, sarcopenia, and obesity; (b) the tendency of osteoporosis, sarcopenia, and obesity to associate with each other; and (c) the bone mineral density (BMD), the components of sarcopenia, and the prevalence of fragility fractures in these associations. Methods The study was performed in the Camargo cohort. Osteoporosis was diagnosed by DXA, sarcopenia by the EWGSOP-1 criteria, and obesity by body mass index (BMI) and fat percentage. Fractures were verified radiographically or by consulting the medical records. Results The prevalence of sarcopenic osteoporosis was 2.8% and the OR for this association 1.03 (p=0.89). The prevalence of sarcopenic obesity by BMI was 1.4% and by fat percentage 5.9% (corresponding ORs: 0.18 (p<0.0001) and 0.58 (p<0.003) respectively). The prevalence of the association of osteoporosis, sarcopenia, and obesity was 0.0% when assessed by BMI and 0.8% when assessed by fat percentage. Patients with sarcopenic osteoporosis have less muscle mass and more fragility fractures than sarcopenic patients overall. In patients with sarcopenic obesity by fat percentage, muscle mass and strength, as well as physical performance, were similar to those of sarcopenic patients overall. Neither BMD nor fracture prevalence showed differences between patients with sarcopenic obesity and patients with sarcopenia or obesity in general. Conclusion Our study supports the idea that the prevalence of the mixed disorders studied is low. No significant association between osteoporosis and sarcopenia was found. Sarcopenia and obesity seem to tend to occur in different people, as if suffering from one of them hinders suffering from the other.Funding: Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was funded by grants from the Instituto de Salud Carlos III (PI18/00762), Ministerio de Economía y Competitividad, Spain, which included FEDER funds from the EU

Necesidades y búsqueda de información de los estudiantes de la licenciatura en Bibliotecología modalidad presencial y a distancia en México

Summary: In the Bibliotecologico field in current times, more and more lines are developing, Extensive research to be analyzed by the professional community of the Information, which focus on studying the issues that relate to the trinomial Library-user-information This, in order to provide answers to the Demanding demands from sources and resources that the user community has to serve. This work is not the exception since it was planned to conduct a study of users The same students in the discipline who study at any of the nine schools that They imparted the disciplines in librarianship, librarianship or information sciences In the country, with the intention of identifying the needs and behavior Students who attend the first and last year of studies, I mean, what are they looking for? How are you looking for him? Where are you looking for him? Among the questions asked, a Questionnaire with open and closed questions to be able to have the opinions of the Study population and thus have a current panorama of the race

Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants

Additional files: Microsoft excel document containing the descriptions of the genes shown in Figure 2.Background Predicting antibiotic resistance before it emerges at clinical settings constitutes a novel approach for preventing and fighting resistance of bacterial pathogens. To analyse the possibility that novel plasmid-encoded quinolone resistance determinants (Qnr) can emerge and disseminate among bacterial pathogens, we searched the presence of those elements in nearly 1000 bacterial genomes and metagenomes. Results We have found a number of novel potential qnr genes in the chromosomes of aquatic bacteria and in metagenomes from marine organisms. Functional studies of the Stenotrophomonas maltophilia Smqnr gene show that plasmid-encoded SmQnr confers quinolone resistance upon its expression in a heterologous host. Conclusion Altogether, the data presented in our work support the notion that predictive studies on antibiotic resistance are feasible, using currently available information on bacterial genomes and with the aid of bioinformatic and functional tools. Our results confirm that aquatic bacteria can be the origin of plasmid-encoded Qnr, and highlight the potential role of S. maltophilia as a source of novel Qnr determinants.This work has been supported by grants BIO2005-04278, LSHM-CT-2005-518152 and LSHM-CT-2005-018705. L. M-M and J.M. R.-M. are supported by REIPI, RD06/0008 from ISCIII, Ministerio de Sanidad y Consumo, Spain.Peer reviewe

Análisis de las notas configuradoras del contrato de trabajo en los socios trabajadores de la Sociedad Laboral

El presente trabajo, está dividido en tres bloques. En el primero se analiza la Economía Social, su marco regulatorio y conceptual, los elementos y principios por los que rige, así como las entidades que la componen. En el segundo bloque se centra en una de las entidades de la economía social, la sociedad laboral, se ve su evolución normativa, su concepto, sus elementos y características principales. Por último, analiza las notas configuradoras del contrato de trabajo en los socios trabajadores de la sociedad laboral, para lo cual, se ve el concepto y las notas configuradoras del contrato de trabajo, el marco jurídico de los socios y los trabajadores de la sociedad laboral y si las notas del contrato de trabajo se dan en los socios trabajadores.Grado en Relaciones Laborales y Recursos Humano

Necesidades y búsqueda de información de los estudiantes de la licenciatura en Bibliotecología modalidad presencial y a distancia en México

Summary: In the Bibliotecologico field in current times, more and more lines are developing, Extensive research to be analyzed by the professional community of the Information, which focus on studying the issues that relate to the trinomial Library-user-information This, in order to provide answers to the Demanding demands from sources and resources that the user community has to serve. This work is not the exception since it was planned to conduct a study of users The same students in the discipline who study at any of the nine schools that They imparted the disciplines in librarianship, librarianship or information sciences In the country, with the intention of identifying the needs and behavior Students who attend the first and last year of studies, I mean, what are they looking for? How are you looking for him? Where are you looking for him? Among the questions asked, a Questionnaire with open and closed questions to be able to have the opinions of the Study population and thus have a current panorama of the race

“PACIENTES EMBARAZADAS CON VIH Y LAS ACCIONES PARA DISMINUIR EL RIESGO DE TRANSMISIÓN VERTICAL EN EL SERVICIO DE GINECOLOGÍA Y OBSTETRICIA DEL HOSPITAL GENERAL TOLUCA DR. NICOLÁS SAN JUAN DE ENERO DEL 2009 A SEPTIEMBRE DEL 2012”

Obtener y analizar la información de pacientes embarazadas con VIH en relación a las acciones que llevan como meta disminuir el riesgo de transmisión vertical y sus resultados en el servicio de ginecología y obstetricia del Hospital General Toluca Dr. Nicolás San Juan de enero del 2009 a septiembre del 2012

Direct Electron Transfer of Human Hemoglobin Molecules on Glass/Tin-Doped Indium Oxide

Interfacial electron transfer kinetics of the haem (FeIII/FeII) group in human hemoglobin molecules were investigated on glass/tin-doped indium oxide electrodes. Factors such as surface roughness, crystallinity, hydrophilicity and partial polarization of the working electrode played an important role to provide a more compatible microenvironment for protein adsorption. Results suggested that direct electron transfer from electrode to haem (FeIII)-H2O intermediate is coupled to proton at near physiological pH (I = 0.035, pH = 7.2)

Acute Colchicine-induced Neuromyopathy in a Patient Treated With Atorvastatin and Clarithromycin

Neuromyopathy is a rare side effect of chronic colchicine therapy, especially without renal impairment. Drugs interacting with colchicine metabolism through CYP3A4 can accelerate accumulation and toxicity. We describe a case of an interaction between atorvastatin, clarithromycin and colchicine resulting in acute neuromyopathy. Learning points: Colchicine has a narrow therapeutic window, and therefore, often produces side effects.Special caution should be adopted if patients with renal disease and concomitant medications are given colchicine.Before prescribing colchicine, the clinical history, including previous medications and conditions, should be carefully considered

Automatic learning framework for pharmaceutical record matching

Pharmaceutical manufacturers need to analyse a vast number of products in their daily activities. Many times, the same product can be registered several times by different systems using different attributes, and these companies require accurate and quality information regarding their products since these products are drugs. The central hypothesis of this research work is that machine learning can be applied to this domain to efficiently merge different data sources and match the records related to the same product. No human is able to do this in a reasonable way because the number of records to be matched is extremely high. This article presents a framework for pharmaceutical record matching based on machine learning techniques in a big data environment. The proposed framework aims to explode the well-known rules for the matching of records from different databases for training machine learning models. Then the trained models are evaluated by predicting matches with records that do not follow these known rules. Finally, the production environment is simulated by generating a huge amount of combinations of records and predicting the matches. The obtained results show that, despite the good results obtained with the training datasets, in the production environment, the average accuracy of the best model is around 85%. That shows that matches which do not follow the known rules can be predicted and, considering that there is not a human way to process this amount of data, the results are promising.This work was supported by the Research Program of the Ministry of Economy and competitiveness, Government of Spain, through the DeepEMR Project, under Grant TIN2017-87548-C2-1-