Análisis financiero y su impacto en la toma de decisiones estratégicas en la Gerencia de Infraestructura del Gobierno Regional de Puno, 2021

El objetivo principal de la presente investigación fue determinar de qué manera el análisis financiero impacta en la toma de decisiones estratégicas en la Gerencia de Infraestructura del Gobierno Regional de Puno, 2021, demostrando la situación actual en la que se encuentra la gerencia regional de infraestructura. Para el estudio se utilizó el diseño metodológico no experimental, descriptivo, correlacional, de enfoque cuantitativo, la población estuvo conformada por 22 trabajadores del área de la Gerencia regional de infraestructura y para la recolección de datos, se utilizó la encuesta y el instrumento fue el cuestionario, esta aportación empírica es únicamente para este caso, al no considerarse todo el universo el mismo que podría permitir que el Gerente regional de infraestructura reduzca el riesgo en la toma de decisiones y el análisis de ratios financieros, obteniendo como resultado un valor de Pearson r= 0.476, p <0.05 . Concluyendo que el análisis financiero impacta positivamente en la toma de decisiones de la Gerencia Regional de Infraestructura del Gobierno Regional de Puno, 2021

Eficiencia tecnológica y mercado laboral. Estudio e implicaciones en el crecimiento económico regional

En la sociedad de la información, en la que nos encontramos inmersos, son muchos los análisis que destacan el papel de la implantación de las tecnologías de la información y la comunicación en el crecimiento económico de los territorios. El cambio tecnológico junto a la capacidad de educar e investigar de un país, han conformado en los últimos tiempos, esencialmente, lo que se conoce como capitales intangibles o componentes del capital intelectual asociados a la productividad y, por ende, al crecimiento de un país o región a través de variaciones en la función de producción. En este trabajo, se enfatiza en el tratamiento de esta relación a partir del indicador de eficiencia tecnológica regional para determinar si dicho factor conlleva una mejor respuesta ante el escenario de desaceleración económica presente. Para ello, se proyectan y analizan las relaciones de este indicador con el mercado de trabajo regional, fijando los impactos producidos como más relevantes en destrucción de empleo en aquellas comunidades y sectores con peores marcas en generador de capital intelectual tecnológico. ABSTRACT&nbsp; Actually, in the information society where we are situated, there are many analyses and approaches that emphasize the relationship between the installation of the information and communications technologies with the economic growth of the territories. The technological change and the capacity to educate and to investigate in a country, has conformed basically, in the last times, what is known as intangible capitals or components of the intellectual capital, associated to the productivity and, in addition, with the growth of a country or region through variations in the production function.&nbsp;&nbsp; In this work, it is emphasized in the treatment of this relationship starting from the indicator of regional technological efficiency to determine if this factor bears a better answer before actual scenario of economic deceleration. So, we project and analyze the relationships of this indicator with the regional labour market, fixing the strong impacts taken place in employment destruction in those regions and sectors with lower scores in generator of technological intellectual capital.&nbsp

Detection of Changes on Parameters Related to Heart Rate Variability after Applying Current Interferential Therapy in Subjects with Non-Specific Low Back Pain

Interferential current therapy (ICT) is an electrotherapeutic intervention that combines the advantages of high permeability from middle frequency currents and efficient tissue stimulation from low frequency currents, delivering the maximum current with high tissue permeability. The aim was to evaluate the effects of ICT on heart rate variability (HRV) and on pain perception in patients with non-specific chronic low back pain (NSCLBP). In the study, 49 patients with NSCLBP were randomly divided into an experimental (EG) and a sham group (SG). All participants received a single intervention, ICT, or simulated intervention. Outcome measures including baseline (sit-down position) and postintervention (prone position) pain, heart rate (HR), time domain parameter (rMSSD), diameters of the Poincaré plot (SD1, SD2), stress score (SS), and sympathetic/parasympathetic (S/PS) ratio were investigated. In both groups, significant statistical differences were found in perceived pain and in all HRV parameters except in HRmax. Between-group comparisons showed statistically significant differences in all variables except for HRmin and HRmean in favor of the experimental group. These changes reported an increase in parasympathetic activity (rMSSD) (p < 0.05) and a decrease in sympathetic activity (increase in SD2 and decrease in SS) (p < 0.001) and perceived pain (p < 0.001), with a greater size effect (η2 = 0.44) in favor of the experimental group. In conclusion, a single session of ICT can shift the autonomic balance towards increase parasympathetic dominance and decrease the sympathetic dominance and intensity of pain perceived by patients with NSCLBP

Tau Protein is Associated with Longitudinal Memory Decline in Cognitively Healthy Subjects with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels

Background: We investigated a sample of cognitively healthy subjects with normal Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker levels to identify the earliest variables related to longitudinal memory changes. Objective: Employing a new highly demanding learning and memory test (the Ancient Farming Equipment Test; AFE-T), we aimed to investigate whether a biomarker related to neurodegeneration (i.e., CSF tau) was associated with longitudinal memory decline. Methods: Thirty-two cognitively and biologically normal (CBN) subjects underwent MRI, neuropsychological assessment, and the AFE-T at baseline and 18 months later. To explore the relationship between cognitive performance and relevant factors, a linear model was set up. For a secondary analysis that further explore the effect of tau, the subjects were divided into CBN-Tau↓ (tau  228.64 pg/ml; n = 16). We also performed voxel-based morphometry (VBM) to identify regions of grey matter volume that would predict both baseline and longitudinal cognitive performance. Results: Our main finding was an association between CSF tau and longitudinal memory decline measured with AFE-T (B = -0.17, p < 0.05; r = -0.414; p < 0.01), and further analyses showed different evolvement between subgroups, with an accelerated decline in individuals with higher tau (F(1,31) = 8.37; p < 0.01). VBM results suggested that AFE-T performance is related to grey matter volume in a medial temporal, middle frontal, and posterior cerebellar network at baseline, and that there are strategic brain areas driving the longitudinal cognitive changes. Conclusions: The present findings provide evidence for structural and biological markers linked to cognitive aging by highlighting the role of tau, a marker of neurodegeneration, which can be related with the earliest memory changes in healthy subjects

Clinical Predictors of Hyperperfusion Syndrome Following Carotid Stenting: Results From a National Prospective Multicenter Study

[Objectives] The aim of the HISPANIAS (HyperperfusIon Syndrome Post-carotid ANgIoplasty And Stenting) study was to define CHS rates and develop a clinical predictive model for cerebral hyperperfusion syndrome (CHS) after carotid artery stenting (CAS).[Background] CHS is a severe complication following CAS. The presence of clinical manifestations is estimated on the basis of retrospective reviews and is still uncertain.[Methods] The HISPANIAS study was a national prospective multicenter study with 14 recruiting hospitals. CHS was classified as mild (headache only) and moderate-severe (seizure, impaired level of consciousness, or development of focal neurological signs).[Results] A total of 757 CAS procedures were performed. CHS occurred in 22 (2.9%) patients, in which 16 (2.1%) had moderate-severe CHS and 6 (0.8%) had mild CHS (only headache). The rate of hemorrhages was 0.7% and was associated with high mortality (20%). Pre-operative predictors of moderate-severe CHS in multivariate analysis were female sex (odds ratio [OR]: 3.24; 95% confidence interval [CI]: 1.11 to 9.47; p = 0.03), older patients (OR: 1.09; 95% CI: 1.01 to 1.17; p = 0.02), left carotid artery treated (OR: 4.13; 95% CI: 1.11 to 15.40; p = 0.03), and chronic renal failure (OR: 6.29; 95% CI: 1.75 to 22.57; p = 0.005). The area under the curve of this clinical and radiological model was 0.86 (95% CI: 0.81 to 0.92; p = 0.001).[Conclusions] The rate of CHS in the HISPANIAS study was 2.9%, with moderate-severe CHS of 2.1%. CHS was independently associated with female sex, older age, history of chronic kidney disease, and a treated left carotid artery. Although further investigations are needed, the authors propose a model to identify high-risk patients and develop strategies to decrease CHS morbidity and mortality in the future.This study was supported by a Spanish grant from the Instituto de Salud Carlos III (ISCIII-FIS IP14/00971, 2014–2017). The ITRIBIS project has the registration number REGPOT-2013-1. Cooperative Cerebrovascular Disease Research Network (INVICTUS+) (RD16/0019/0015). Dr. Mancha is supported by a Río Hortega contract (CM16/00015). Abbott and Grifols have partial financial supported the conduction of the HISPANIAS project but had no role in the design of the study, interpretation of the data, or manuscript approval.Peer reviewe