Therapeutic management of the odontogenic keratocyst. An energetic approach with a conservative perspective and review of the current therapeutic options

Background: Odontogenic keratocysts (OKC) are cystic lesions appearing in the jaws, usually asymptomatic with a progressive growth into the bone. Many of them are diagnosed by a routine radiological examination. Material and methods: This study reports a 12-year-old girl that presented an asymptomatic large radiolucent unilocular lesion associated to the crown of 3.8 that caused displacement of the molar and the inferior alveolar canal. Differential diagnosis included OKC, unicystic ameloblastoma, ameloblastic fibroma, dentigerous cyst and orthokeratinized odontogenic cyst. Two surgical interventions were performed; first, a marsupialization, and 10 months after, the third molar extraction plus cyst enucleation, mucosa excision and the application of Carnoy's solution. Results: The anatomopathological exam confirmed diagnosis of OKC. There was no evidence of recurrence after 2 years of follow-up. Conclusions: Marsupialization followed by surgical enucleation with mucosa excision and Carnoy's solution can help manage treatment of OKC, a lesion characterized by an aggressive behavior

Therapeutic management of the odontogenic keratocyst. An energetic approach with a conservative perspective and review of the current therapeutic options

Odontogenic keratocysts (OKC) are cystic lesions appearing in the jaws, usually asymptomatic with a progressive growth into the bone. Many of them are diagnosed by a routine radiological examination. This study reports a 12-year-old girl that presented an asymptomatic large radiolucent unilocular lesion associated to the crown of 3.8 that caused displacement of the molar and the inferior alveolar canal. Differential diagnosis included OKC, unicystic ameloblastoma, ameloblastic fibroma, dentigerous cyst and orthokeratinized odontogenic cyst. Two surgical interventions were performed; first, a marsupialization, and 10 months after, the third molar extraction plus cyst enucleation, mucosa excision and the application of Carnoy?s solution. The anatomopathological exam confirmed diagnosis of OKC. There was no evidence of recurrence after 2 years of follow-up. Marsupialization followed by surgical enucleation with mucosa excision and Carnoy?s solution can help manage treatment of OKC, a lesion characterized by an aggressive behavior

Bioactive and degradable hydrogel based on human platelet-rich plasma fibrin matrix combined with oxidized alginate in a diabetic mice wound healing model

[EN] In the present study we developed an injectable, bioactive and degradable hydrogel composed of alginate at 2.5% oxidation degree and calcium-activated platelet rich plasma (PRP) for wound healing applications (PRP-HG-2.5%). The alginate gives mechanical support to the hydrogel while the activated PRP provides growth factors that enhance wound healing and fibrin which creates an adequate microenvironment for cell migration and proliferation. The rheological and mechanical properties of the hydrogel were characterized. Further characterization revealed that PRPHG-2.5% showed a faster hydrolitic degradation rate than unmodified alginate and a similar platelet derived growth factor (PDGF-BB) release profile. In vitro efficacy studies, carried out in human fibroblasts and keratinocytes, showed that PRP-HG-2.5% was not cytotoxic and that it was able to promote cell adhesion and proliferation. Thereafter, in an in vivo full thickness wound healing study conducted in diabetic mice, no differences were found among PRP-HG-2.5% and its counterpart without PRP, likely due to the xenogeneic origin of the PRP. This hypothesis was validated in vitro, since a cytotoxic effect was observed after human PRP application to mouse fibroblasts. Therefore, PRP-HG-2.5% might be a promising strategy for chronic woundstreatment, although its effectiveness should be evaluated in a more reliable preclinical model.I. Garcia-Orue thanks University of the Basque Country (UPV/EHU) for the Dokberri grant (DOCREC19/10). The authors are thankful for the technical and human support provided by SGIker of UPV/EHU. Authors also thank ICTS "NANBIOSIS", specifically the Drug Formulation Unit (U10) of the CIBER in Bioengineering, Biomaterials and Nanomedicine (CIBERBBN) at the UPV/EHU in Vitoria-Gasteiz. Finally, the authors thank the Open Access funding provided by University of the Basque Country

Allometric Equations for Estimating Biomass and Carbon Stocks in the Temperate Forests of North-Western Mexico

This paper presents new equations for estimating above-ground biomass (AGB) and biomass components of seventeen forest species in the temperate forests of northwestern Mexico. A data set corresponding to 1336 destructively sampled oak and pine trees was used to fit the models. The generalized method of moments was used to simultaneously fit systems of equations for biomass components and AGB, to ensure additivity. In addition, the carbon content of each tree component was calculated by the dry combustion method, in a TOC analyser. The results of cross-validation indicated that the fitted equations accounted for on average 91%, 82%, 83% and 76% of the observed variance in stem wood and stem bark, branch and foliage biomass, respectively, whereas the total AGB equations explained on average 93% of the total observed variance in AGB. The inclusion of total height (h) or diameter at breast height2 × total height (d2h) as a predictor in the d-only based equations systems slightly improved estimates for stem wood, stem bark and total above-ground biomass, and greatly improved the estimates produced by the branch and foliage biomass equations. The predictive power of the proposed equations is higher than that of existing models for the study area. The fitted equations were used to estimate stand level AGB stocks from data on growing stock in 429 permanent sampling plots. Three machine-learning techniques were used to model the estimated stand level AGB and carbon contents; the selected models were used to map the AGB and carbon distributions in the study area, for which mean values of respectively 129.84 Mg ha−1 and 63.80 Mg ha−1 were obtained.This study was financially supported by the Mexican National Council for Science and Technology (CONACyT) and by the State of Durango Government (Project FOMIX- DGO-2011-C01-165681)S

Estudio de factibilidad para una microempresa de asesoría y venta de insumos para huertos familiares en Delicias, Chihuahua

En el proyecto de estudio de factibilidad para una microempresa de asesoría y venta de insumos para huertos familiares en Cd. Delicias, Chihuahua se logró desarrollar un plan de factibilidad económica de la empresa, de publicidad y comercialización de huertos familiares. Como primer paso se realizó un estudio de mercado dirigido a la población de Cd. Delicias, Chihuahua en donde la muestra fue de 400 jefes de familia encuestados. Una vez obtenida esta información se realizaron gráficas y análisis de datos para determinar la aceptación del producto y servicio; se realizó un análisis de competencia con tres empresas de la ciudad dando como resultado una ventaja competitiva derivada de la  calidad del producto y la completa variedad que se ofrece para que las familias puedan complementar su dieta alimenticia diaria, además de la adaptación de este a las necesidades del cliente sumado al precio accesible que la empresa ofrece con posible asesoría a mediano plazo para el cuidado oportuno de su producto. Se procedió a la creación de misión, visión, valores, metas organizacionales, distribución de la planta, así como una matriz FODA y el estudio de rentabilidad (TIR, VAN, beneficio-costo y punto de equilibrio) para la posible creación de la microempresa

Emergency department direct discharge compared to short-stay unit admission for selected patients with acute heart failure: analysis of short-term outcomes

Short stay unit (SSU) is an alternative to conventional hospitalization in patients with acute heart failure (AHF), but the prognosis is not known compared to direct discharge from the emergency department (ED). To determine whether direct discharge from the ED of patients diagnosed with AHF is associated with early adverse outcomes versus hospitalization in SSU. Endpoints, defined as 30-day all-cause mortality or post-discharge adverse events, were evaluated in patients diagnosed with AHF in 17 Spanish EDs with an SSU, and compared by ED discharge vs. SSU hospitalization. Endpoint risk was adjusted for baseline and AHF episode characteristics and in patients matched by propensity score (PS) for SSU hospitalization. Overall, 2358 patients were discharged home and 2003 were hospitalized in SSUs. Discharged patients were younger, more frequently men, with fewer comorbidities, had better baseline status, less infection, rapid atrial fibrillation and hypertensive emergency as the AHF trigger, and had a lower severity of AHF episode. While their 30-day mortality rate was lower than in patients hospitalized in SSU (4.4% vs. 8.1%, p < 0.001), 30-day post-discharge adverse events were similar (27.2% vs. 28.4%, p = 0.599). After adjustment, there were no differences in the 30-day risk of mortality of discharged patients (adjusted HR 0.846, 95% CI 0.637-1.107) or adverse events (1.035, 0.914-1.173). In 337 pairs of PS-matched patients, there were no differences in mortality or risk of adverse event between patients directly discharged or admitted to an SSU (0.753, 0.409-1.397; and 0.858, 0.645-1.142; respectively). Direct ED discharge of patients diagnosed with AHF provides similar outcomes compared to patients with similar characteristics and hospitalized in a SSU

Effects of exogenous enzymes and application method on nutrient intake, digestibility and growth performance of Pelibuey lambs

Pelibuey sheep is the main breed in the tropical and subtropical regions of Mexico, and high demand of sheep meat has favored the finishing of lambs in feedlots with diets containing high levels of grains. The objective of this study was to evaluate the effects of exogenous enzymes (EE) and application method on nutrient intake and digestibility and performance of growing Pelibuey lambs. Treatments were based on comparison of two different methods of adding an enzyme product (sprayed on the total mixed ration or applied orally to the lambs) versus control treatment (no added enzyme). Twenty-one Pelibuey lambs, weighing 15.7 kg (SD = 1.8 kg) initial body weight, were individually housed in shaded pens and assigned randomly to one of the three enzyme treatments. At the end of study (lasting for 45 days), three lambs from each treatment were randomly selected and adapted to a pants and harness designed for fecal collection to measure nutrient digestibilities. Total body gain and average daily gain were affected (P < 0.05) by supplemental EE. The application method of EE had significant (P < 0.05) effect on FCE and FCR, but no effects were observed on nutrient intake. Supplemental EE did improve (P < 0.05) the digestibilities of dry matter, organic matter, neutral and acid detergent fiber, but no differences were observed in crude protein digestibility. The application method of EE had significant (P < 0.05) effect on the digestibility of acid detergent fiber. Supplemental EE can improve body weight gain and nutrient digestibilities without affecting nutrient intake in Pelibuey lambs, but the results of feed conversion efficiency and acid detergent fiber digestibility depend on the application method used of the E

Taller vertical de urbanismo

Metodología docente puesta en práctica en el curso académico 2008-2009 en diferentes asignaturas de la Escuela Técnica Superior de Arquitectura de Granada.Profesores responsables: Reinoso-Bellido, Rafael; Abarca-Álvarez, Francisco Javier y Martínez-Hidalgo, Celia. Colaboradores: Sánchez Gómez, Juana; Aguirre Rodríguez, José Ignacio y Jiménez López, Diego.Se propone una metodología docente que genere la interacción entre estudiantes de diferentes cursos y de diferentes programas y asignaturas, cimentando su interés en la necesidad de no encuadrar los descriptores oficiales de las distintas asignaturas que componen el ciclo en marcos aislados de intervención, permitiendo a alumno tener una visión más general, y la libertad de interferir sus respuestas proyectuales con marcos de intervención diferentes. Es decir, facilitar la reflexión transescalar en las dos direcciones, de abajo arriba y viceversa, de manera que la mirada metropolitana y la local que afecta al crecimiento o a la de la reforma de la ciudad consolidada de manera simultánea, puedan aportar claves más completas en la resolución de los proyectos. La diferencia de madurez que muestran los alumnos de los distintos cursos ha de entenderse como una ventaja, donde aquellos que ya han superado el listón de habilidades pretendido pueden colaborar en el proceso de maduración de aquellos que pretenden alcanzarlo, acelerando, entendemos, dicho proceso

Acetonic and Methanolic Extracts of Heterotheca inuloides

The present study was designed to test the hypothesis that the acetonic and methanolic extracts of H. inuloides prevent carbon tetrachloride-(CCl4) induced oxidative stress in vital tissues. Pretreatment with both H. inuloides extracts or quercetin attenuated the increase in serum activity of alkaline phosphatase (ALP), total bilirubin (BB), creatinine (CRE), and creatine kinase (CK), and impeded the decrease of γ-globulin (γ-GLOB) and albumin (ALB) observed in CCl4-induced tissue injury. The protective effect was confirmed by histological analysis with hematoxylin-eosin and periodic acid/Schiff's reagent. Level of lipid peroxidation was higher in the organs of rats exposed to CCl4 than in those of the animals treated with Heterohteca extracts or quercetin, and these showed levels similar to the untreated group. Pretreatment of animals with either of the extracts or quercetin also prevented the increase of 4-hydroxynonenal and 3-nitrotyrosine. Pretreatment with the plant extracts or quercetin attenuated CCl4 toxic effects on the activity of several antioxidant enzymes. The present results strongly suggest that the chemopreventive effect of the extracts used and quercetin, against CCl4 toxicity, is associated with their antioxidant properties and corroborated previous results obtained in liver tissue