Levantamiento de un edificio mediante la aplicación del problema de la galeria de arte

Currently, the graphical representation of our surroundings has got a great importance. In a few years there has been a breakthrough in the technology for image acquisition. In the same way that progress has been made in this regard, an investigation has been started in order to propose improvements in the procedures used by industry professionals topographical through the application of some optimization techniques based on mathematical techniques (Lighting System Problems) in order to find what is the minimum number of points of view from which a person will be able to obtain a complete sight of a building from the outside of it. This would avoid to waste time in unnecessary views of the survey, to increase the efficiency of the work and avoid wasting time. Once a methodology has been designed to minimize the number of positions, it has been put into action in a real buildin

Recomendaciones clínicas en la intervención terapéutica para el manejo del dolor lumbar crónico inespecífico: una revisión literaria

94 p.Antecedentes: El dolor lumbar (LBP) es una afección musculoesquelética que tiene una etiopatogenia multifactorial, y que, en algunos casos, pudiese generar condiciones persistentes en su sintomatología. Existe variedad de técnicas en el abordaje terapéutico del LBP, sin embargo, no hay un consenso en la elección de la intervención. Objetivo de la investigación: Identificar los distintos tipos de tratamiento kinésico actuales para el abordaje del paciente con dolor lumbar crónico inespecífico y generar recomendaciones para su intervención terapéutica. Método: Se realizó una búsqueda en 3 bases de datos; Pubmed, Sciencedirect, Google scholar, con artículos desde enero de 2015 hasta abril del 2022. Los estudios incluidos fueron ensayos clínicos aleatorizados que aplicaban programas de ejercicios terapéuticos, uso de agentes físicos, e intervención en educación asociada al manejo del dolor. Criterios de elegibilidad: (I) adultos entre 18 y 85 años; (II) Signos y síntomas de dolor lumbar inespecífico; (III) Síntomas no relacionados con un incidente traumático y/o neurológico; (IV) Descripción de dolor crónico o persistente de al menos 12 semanas. Resultados: Se incluyeron 20 estudios, las características de los ensayos clínicos aleatorizados (ECA) fueron amplios en cuanto a duración, desde una sesión única hasta 12 semanas de intervención con seguimiento de 12 y 24 meses. Se identificaron cuatro aristas de tratamiento, las cuales fueron ejercicio terapéutico, terapia Mckenzie, fisioterapia, y educación en neurociencia del dolor. Conclusiones: La presente revisión basada en la evidencia científica permite guiar las intervenciones terapéuticas para pacientes sintomáticos de dolor lumbar crónico inespecífico (CBLP). Los autores no identifican ninguna terapéutica más efectiva que otra, sin embargo, cada una puede generar cambios en las variables asociadas al dolor y funcionalidad. Por ende, puede utilizarse como asistencia para facilitar la toma de decisiones clínicas en pacientes con CBLP. // ABSTRACT: Background: Low back pain (LBP) is a musculoskeletal condition that has a multifactorial etiopathogenesis and, in some cases, could generate persistent conditions in its symptomatology. There is a variety of techniques in the therapeutic approach to LBP, however, there is no consensus in the choice of intervention. Objective of the research: To identify the different types of current kinesic treatment for the approach to patients with non-specific chronic low back pain and to generate recommendations for therapeutic intervention. Method: A search was carried out in 3 databases; Pubmed, Sciencedirect, Google scholar, with articles from January 2015 to April 2022. The included studies were randomized clinical trials applying therapeutic exercise programs, use of physical agents, and education intervention associated with pain management. Eligibility criteria: (I) adults between 18 and 85 years; (II) signs and symptoms of nonspecific low back pain; (III) symptoms not related to a traumatic and/or neurological incident; (IV) description of chronic or persistent pain of at least 12 weeks. Results: 20 studies were included, the characteristics of the randomized clinical trials (RCTs) were broad in duration, ranging from a single session to 12 weeks of intervention with 12 and 24 months follow-up. Four treatment edges were identified, which were therapeutic exercise, Mckenzie therapy, physical therapy, and pain neuroscience education. Conclusions: The present evidence-based review provides guidance for therapeutic interventions for symptomatic chronic non-specific low back pain (CBLP) patients. The authors do not identify any one therapy as more effective than another; however, each can generate changes in the variables associated with pain and functionality. Therefore, they can be used as an aid to facilitate clinical decision making in patients with CBLP

Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study

Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic low-grade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

5to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

El V Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2019, realizado del 6 al 8 de febrero de 2019 y organizado por la Universidad Politécnica Salesiana, ofreció a la comunidad académica nacional e internacional una plataforma de comunicación unificada, dirigida a cubrir los problemas teóricos y prácticos de mayor impacto en la sociedad moderna desde la ingeniería. En esta edición, dedicada a los 25 años de vida de la UPS, los ejes temáticos estuvieron relacionados con la aplicación de la ciencia, el desarrollo tecnológico y la innovación en cinco pilares fundamentales de nuestra sociedad: la industria, la movilidad, la sostenibilidad ambiental, la información y las telecomunicaciones. El comité científico estuvo conformado formado por 48 investigadores procedentes de diez países: España, Reino Unido, Italia, Bélgica, México, Venezuela, Colombia, Brasil, Estados Unidos y Ecuador. Fueron recibidas un centenar de contribuciones, de las cuales 39 fueron aprobadas en forma de ponencias y 15 en formato poster. Estas contribuciones fueron presentadas de forma oral ante toda la comunidad académica que se dio cita en el Congreso, quienes desde el aula magna, el auditorio y la sala de usos múltiples de la Universidad Politécnica Salesiana, cumplieron respetuosamente la responsabilidad de representar a toda la sociedad en la revisión, aceptación y validación del conocimiento nuevo que fue presentado en cada exposición por los investigadores. Paralelo a las sesiones técnicas, el Congreso contó con espacios de presentación de posters científicos y cinco workshops en temáticas de vanguardia que cautivaron la atención de nuestros docentes y estudiantes. También en el marco del evento se impartieron un total de ocho conferencias magistrales en temas tan actuales como la gestión del conocimiento en la universidad-ecosistema, los retos y oportunidades de la industria 4.0, los avances de la investigación básica y aplicada en mecatrónica para el estudio de robots de nueva generación, la optimización en ingeniería con técnicas multi-objetivo, el desarrollo de las redes avanzadas en Latinoamérica y los mundos, la contaminación del aire debido al tránsito vehicular, el radón y los riesgos que representa este gas radiactivo para la salud humana, entre otros

Aplicación del problema de la Galería de Arte a levantamientos arquitectónicos

En este trabajo se aplican estrategias empleadas en problemas de vigilancia a levantamientos arquitectónicos. Se da un método que proporciona un número suficiente de estacionamientos desde los cuales se puede obtener una visión completa de un edificio que se desea levanta

Optimization of laser scanner positioning networks for architectural surveys through the design of genetic algorithms

In recent decades, the use of terrestrial laser scanners has become the principal method for metric data collection in architecture. However, there are no systematic procedures in place to plan the data capture process. This means that the obtaining tasks of the clouds of points are based either on operator experience, or on the overlap register that grants a complete acquisition. In both cases, data redundancy represents a significant percentage, which forces subsequent filtration or point removal. This work describes the design and development of an automated methodology, based on genetic algorithms, for the selection of a set of positions from which to execute the data capture process. The algorithm designed herein is applied to a variety of cases, thereby attaining the best station-positioning network for data collection, which maximizes coverage and minimizes overlap between clouds of points. © 2021 Elsevier Lt

Cell Contact with Endothelial Cells Favors the In Vitro Maintenance of Human Chronic Myeloid Leukemia Stem and Progenitor Cells

Chronic Myeloid Leukemia (CML) originates in a leukemic stem cell that resides in the bone marrow microenvironment, where they coexist with cellular and non-cellular elements. The vascular microenvironment has been identified as an important element in CML development since an increase in the vascularization has been suggested to be related with poor prognosis; also, using murine models, it has been reported that bone marrow endothelium can regulate the quiescence and proliferation of leukemic stem and progenitor cells. This observation, however, has not been evaluated in primary human cells. In this report, we used a co-culture of primitive (progenitor and stem) CML cells with endothelial colony forming cells (ECFC) as an in vitro model to evaluate the effects of the vascular microenvironment in the leukemic hematopoiesis. Our results show that this interaction allows the in vitro maintenance of primitive CML cells through an inflammatory microenvironment able to regulate the proliferation of progenitor cells and the permanence in a quiescent state of leukemic stem cells

Biological translocation of parathion methyl by Pilobolus sp. In corn microsystems

Parathion methyl is a widely used organophosphorus pesticide (OPs). OPs in agroecosystems cause severe health and environmental effects. In this study, the Pilobolus inoculum’s ability to remove parathion methyl in microsystems corn crop was evaluated at the laboratory level. Agricultural soils containing Pilobolus inoculum were exposed to 50 μg/dm3 of parathion methyl. The results showed that Pilobolus inoculum can eliminate parathion methyl in 80% of microsystems, and positively influences 20% of the physiological processes of corn plants. This research into the field of myco-remediation widens the use of little-studied fungal species such as Pilobolus to remove pesticides