Efectos de alfa-tocoferol sobre el control metabólico y el estado oxidativo en mujeres sanas y con diabetes Mellitus tipo 2

Tesis (Doctorado en Ciencias en Investigación en Medicina), Instituto Politécnico Nacional, SEPI, ESM, 2006, 1 archivo PDF, (105 páginas). tesis.ipn.m

Tejido adiposo epicárdico: su relación con enfermedades cardiovasculares

La obesidad aumenta el riesgo de desarrollar enfermedades cardiovasculares, sin embargo, el riesgo depende significativamente de la distribución del tejido adiposo en el cuerpo. Evidencia reciente indica que cada depósito de grasa visceral es anatómica y funcionalmente diferente. Dada la proximidad al órgano, cada depósito de tejido adiposo visceral ejerce una modulación local más que un efecto sistémico. Debido a su peculiar localización y sus propiedades biomoleculares, el tejido adiposo epicárdico, se ha abierto campo como causante de arteriosclerosis. Este tejido puede ser medido con técnicas de imagen y está clínicamente relacionado con la masa del ventrículo izquierdo, la enfermedad arterial coronaria y el síndrome metabólico. Por tanto, la medición de la grasa epicárdica puede tener un papel en la estratificación del riesgo cardiometabólico y servir como blanco terapéutico

Estudio comparativo de calidad higiénico-sanitaria, fisicoquímica y microbiológica de leche bovina en el sureste mexicano

Objective. Evaluate the hygienic-sanitary, physicochemical and microbiological quality of bovine milk for sale, produced in a family stable and in three public markets in Tabasco state. Materials and methods. The hygienic-sanitary quality was determined according to general information of the farm, facilities, milking process, cleaning and disinfection. Physicochemical quality was determined by evaluating total proteins, casein, butyric fat, lactose, non-fatty solids and density. Microbiological quality was determined by titratable acidity, alcohol test, somatic cell content, oxide-reduction potential, foreign matter, bacterial inhibitors, and aerobic mesophilic bacteria. Results. The milk produced in the family stable was evaluated with the highest physicochemical and microbiological quality, in reference to the standards evaluated by the official Mexican regulations established in Mexico by the Council for the promotion of the quality of milk and its derivatives, A. C. Instead, milk in three public markets, it was considered as rejection, indicating possible contamination during milking processes, as well as handling and transport to public markets. Conclusions. Milk samples from public markets were considered not suitable for human consumption or for the production of by-products.Objetivo. Evaluar la calidad higiénico-sanitaria, fisicoquímica y microbiológica de leche cruda bovina destinada a la venta, producida en un establo familiar y en tres mercados públicos del estado de Tabasco. Materiales y métodos. La calidad higiénico-sanitaria se determinó de acuerdo con la información general del predio, instalaciones, proceso de ordeño, limpieza y desinfección. La calidad fisicoquímica se determinó evaluando proteínas totales, caseína, grasa butírica, lactosa, sólidos no grasos y densidad. La calidad microbiológica fue determinada mediante la acidez titulable, prueba de alcohol, contenido de células somáticas, potencial de óxido-reducción, materia extraña, inhibidores bacterianos y bacterias mesofílicas aerobias. Resultados. La leche producida en el establo familiar, fue evaluada con la máxima calidad fisicoquímica y microbiológica en referencia a los estándares que evalúa la normatividad oficial mexicana establecidas en México por el Consejo para el fomento de la calidad de la leche y sus derivados, A. C. En cambio, la leche en los tres mercados públicos se consideró de rechazo, indicando posible contaminación durante los procesos de ordeña, así como en el manejo y transporte hacia los mercados públicos. Conclusiones. Las muestras de leche provenientes de los mercados públicos se consideraron no aptas para consumo humano ni para elaboración de subproductos

Effects of Non-Nutritive Sweeteners on Energy Intake, Body Weight and Postprandial Glycemia in Healthy and with Altered Glycemic Response Rats

The aim of this study was to evaluate the effects of non-nutritive sweeteners (NNS) consumption on energy intake, body weight and postprandial glycemia in healthy and with altered glycemic response rats. Animals on normal diet (ND) or high-fat diet (HFD) were divided to receive NNS (sucralose, aspartame, stevia, rebaudioside A) or nutritive sweeteners (glucose, sucrose) for 8 weeks. The NNS were administered at doses equivalent to the human acceptable daily intake (ADI). A test using rapidly digestible starch was performed before and after treatments to estimate glycemic response. No effects of NNS consumption were observed on energy intake or body weight. Sucrose provoked an increased fluid consumption, however, energy intake, and weight gain were not altered. In ND, no effects of NNS on glycemic response were observed. In HFD, the glycemic response was increased after sucralose and stevia when only the final tolerance test was considered, however, after including the baseline test, these results were no longer significant compared to glucose. These findings provide further evidence suggesting that at the recommended doses, NNS do not alter feeding behavior, body weight or glycemic tolerance in healthy and with altered glycemic rats

Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study

We previously observed beneficial effects of native banana starch (NBS) with a high resistant starch (RS) content on glycemic response in lean and obese participants. Here, we aimed to determine the effects of NBS and high-amylose maize starch (HMS) on glycemic control (GC) and glycemic variability (GV) in patients with type 2 diabetes (T2D) when treatments were matched for digestible starch content. In a randomized, crossover study, continuous glucose monitoring (CGM) was performed in 17 participants (aged 28–65 years, BMI ≥ 25 kg/m2, both genders) consuming HMS, NBS, or digestible maize starch (DMS) for 4 days. HMS and NBS induced an increase in 24 h mean blood glucose during days 2 to 4 (p p p = 0.0074). In conclusion, under the experimental conditions, RS from two sources did not improve GC or GV. Future longer studies are needed to determine whether these findings were affected by a different baseline microbiota or other environmental factors

Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study

We previously observed beneficial effects of native banana starch (NBS) with a high resistant starch (RS) content on glycemic response in lean and obese participants. Here, we aimed to determine the effects of NBS and high-amylose maize starch (HMS) on glycemic control (GC) and glycemic variability (GV) in patients with type 2 diabetes (T2D) when treatments were matched for digestible starch content. In a randomized, crossover study, continuous glucose monitoring (CGM) was performed in 17 participants (aged 28–65 years, BMI ≥ 25 kg/m2, both genders) consuming HMS, NBS, or digestible maize starch (DMS) for 4 days. HMS and NBS induced an increase in 24 h mean blood glucose during days 2 to 4 (p < 0.05). CONGA, GRADE, and J-index values were higher in HMS compared with DMS only at day 4 (p < 0.05). Yet, NBS intake provoked a reduction in fasting glycemia changes from baseline compared with DMS (p = 0.0074). In conclusion, under the experimental conditions, RS from two sources did not improve GC or GV. Future longer studies are needed to determine whether these findings were affected by a different baseline microbiota or other environmental factors

Lack of Association of Coffee Consumption with the Prevalence of Self-Reported Type 2 Diabetes Mellitus in a Mexican Population: A Cross-Sectional Study

It is estimated that almost 366 million people are currently suffering from diabetes mellitus worldwide. However, it has been suggested that coffee consumption has a protective effect against the development of type 2 diabetes mellitus. This association has been observed in many regions around the world. Today, there are no reports in Mexico regarding this association. Therefore, the aim of this study was to assess the association between coffee intake and self-reported type 2 diabetes mellitus in the southeastern part of Mexico. This study included 1277 residents of Comalcalco, a municipality of Tabasco State, Mexico. We calculated the prevalence for diabetes and performed multivariate analysis using multiple logistic regressions to evaluate the combined association with type 2 diabetes mellitus. The prevalence of the diabetes was 12.52% (95% CI: 10.67–14.38). The majority of people surveyed (77.29%; 95% CI: 74.95–79.60) indicated they were coffee drinkers. The results of multivariate analysis showed a non-significant relationship between the number of cups of coffee drank and type 2 diabetes mellitus. The adjusted odds ratio gave the following values: 1.20, (95% CI: 0.59–2.41) for non-daily consumption; 1.66 (0.82–3.34), for 1 cup of coffee peer day, and 1.49 (0.78–2.86) for 2–3 cups. Subsequently, an adjustment was made for age, gender, marital status, education, alcohol consumption, and cigarette smoking. In our population, we did not observe an association between coffee intake and its protective relationship with self-reported type 2 diabetes mellitus

Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P <0.01) and previous renal failure (57.9%, P <0.01). Patients treated with cloxacillin presented higher rates of septic shock (25%, P = 0.033) and new-onset or worsening renal failure (47.3%, P = 0.024) with significantly higher rates of in-hospital mortality (38.5%, P = 0.017). One-year IE-related mortality and rate of relapses were similar between treatment groups. None of the treatments were identified as risk or protective factors. Conclusion: Our results suggest that cefazolin is a valuable option for the treatment of MSSA IE, without differences in 1-year mortality or relapses compared with cloxacillin, and might be considered equally effective