Diseño de una solución para la conducción de aguas residuales y aguas lluvias, con el fin de mitigar el riesgo en la erosión del terreno y saneamiento básico para los habitantes del barrio Cazuca en el municipio de Soacha Cundinamarca con la ayuda de la fundación Fuerza Verde

Práctica SocialLas necesidades de la comunidad de la zona alta del barrio Cazuca en el municipio de Soacha Cundinamarca son extremadamente importantes para lograr una mejora en su calidad de vida tanto para los niños habitantes como para los adultos, es por esta razón por la cual en conjunto con la fundación fuerza verde se decide llevar a cabo el proyecto de mitigación por medio de un diseño de una red de alcantarillado sanitario condominial y una red de canales de conducción de aguas lluvias con las cuales se lograrán resolver los problemas de salubridad de la comunidad.RESUMEN INTRODUCCIÓN 1. ANTECEDENTES Y JUSTIFICACIÓN. 2. OBJETIVOS 3. PLANTEAMIENTO Y FORMULACIÓN DEL PROBLEMA. 4. LEVANTAMIENTO TOPOGRÁFICO. 5. DISEÑO CANAL DE ALL Y ALCANTARILLADO SANITARIO. 6. CALCULOS. 7. DISEÑO CANAL. 8. DISEÑO ALCANTARILLADO CONDOMINIAL. 9. PROCESO CONTRUCTIVO 10. CANTIDADES DE OBRA. 12. CONCLUSIONES. 13. RECOMENDACIONES. 14. BIBLIOGRAFIA. 15. ANEXOS.PregradoIngeniero Civi

YsxC, an essential protein in Staphylococcus aureus crucial for ribosome assembly/stability

<p>Abstract</p> <p>Background</p> <p>Bacterial growth and division requires a core set of essential proteins, several of which are still of unknown function. They are also attractive targets for the development of new antibiotics. YsxC is a member of a family of GTPases highly conserved across eubacteria with a possible ribosome associated function.</p> <p>Results</p> <p>Here, we demonstrate by the creation of a conditional lethal mutant that <it>ysxC </it>is apparently essential for growth in <it>S. aureus</it>. To begin to elucidate YsxC function, a translational fusion of YsxC to the CBP-ProteinA tag in the staphylococcal chromosome was made, enabling Tandem Affinity Purification (TAP) of YsxC-interacting partners. These included the ribosomal proteins S2, S10 and L17, as well as the ^β' subunit of the RNA polymerase. YsxC was then shown to copurify with ribosomes as an accessory protein specifically localizing to the 50 S subunit. YsxC depletion led to a decrease in the presence of mature ribosomes, indicating a role in ribosome assembly and/or stability in <it>S. aureus</it>.</p> <p>Conclusions</p> <p>In this study we demonstrate that YsxC of <it>S. aureus </it>localizes to the ribosomes, is crucial for ribosomal stability and is apparently essential for the life of <it>S. aureus</it>.</p

On the Performance of One-Stage and Two-Stage Object Detectors in Autonomous Vehicles Using Camera Data

Object detection using remote sensing data is a key task of the perception systems of self-driving vehicles. While many generic deep learning architectures have been proposed for this problem, there is little guidance on their suitability when using them in a particular scenario such as autonomous driving. In this work, we aim to assess the performance of existing 2D detection systems on a multi-class problem (vehicles, pedestrians, and cyclists) with images obtained from the on-board camera sensors of a car. We evaluate several one-stage (RetinaNet, FCOS, and YOLOv3) and two-stage (Faster R-CNN) deep learning meta-architectures under different image resolutions and feature extractors (ResNet, ResNeXt, Res2Net, DarkNet, and MobileNet). These models are trained using transfer learning and compared in terms of both precision and efficiency, with special attention to the real-time requirements of this context. For the experimental study, we use theWaymo Open Dataset, which is the largest existing benchmark. Despite the rising popularity of one-stage detectors, our findings show that two-stage detectors still provide the most robust performance. Faster R-CNN models outperform one-stage detectors in accuracy, being also more reliable in the detection of minority classes. Faster R-CNN Res2Net-101 achieves the best speed/accuracy tradeoff but needs lower resolution images to reach real-time speed. Furthermore, the anchor-free FCOS detector is a slightly faster alternative to RetinaNet, with similar precision and lower memory usage.Ministerio de Economía y Competitividad TIN2017-88209-C2-2-RJunta de Andalucía US-1263341Junta de Andalucía P18-RT-277

Asynchronous dual-pipeline deep learning framework for online data stream classification

Data streaming classification has become an essential task in many fields where real-time decisions have to be made based on incoming information. Neural networks are a particularly suitable technique for the streaming scenario due to their incremental learning nature. However, the high computation cost of deep architectures limits their applicability to high-velocity streams, hence they have not yet been fully explored in the literature. Therefore, in this work, we aim to evaluate the effectiveness of complex deep neural networks for supervised classification in the streaming context. We propose an asynchronous deep learning framework in which training and testing are performed simultaneously in two different processes. The data stream entering the system is dual fed into both layers in order to concurrently provide quick predictions and update the deep learning model. This separation reduces processing time while obtaining high accuracy on classification. Several time-series datasets from the UCR repository have been simulated as streams to evaluate our proposal, which has been compared to other methods such as Hoeffding trees, drift detectors, and ensemble models. The statistical analysis carried out verifies the improvement in performance achieved with our dual-pipeline deep learning framework, that is also competitive in terms of computation time.Ministerio de Economía y Competitividad TIN2017-88209-C2-2-

Time Course and Magnitude of Tolerance to the Ergogenic Effect of Caffeine on the Second Ventilatory Threshold.

Pre‐exercise caffeine ingestion has been shown to increase the workload at ventilatory threshold, suggesting an ergogenic effect of this stimulant on submaximal aerobic exercise. However, the time course of tolerance to the effect of caffeine on ventilatory threshold is unknown. This study aimed to determine the evolution of tolerance to the ergogenic effect of caffeine on the ventilatory threshold. Methods: Eleven participants (age 32.3 ± 4.9 yrs, height 171 ± 8 cm, body mass 66.6 ± 13.6 kg, VO2max = 48.0 ± 3.8 mL/kg/min) took part in a longitudinal, double‐blind, placebocontrolled, randomized, crossover experimental design. Each participant took part in two identical treatments: in one treatment, participants ingested a capsule containing 3 mg of caffeine per kg of body mass per day (mg/kg/day) for twenty consecutive days; in the other treatment, participants ingested a capsule filled with a placebo for the same duration and frequency. During these treatments, participants performed a maximal ramp test on a cycle ergometer three times per week and the second ventilatory threshold (VT2) was assessed by using the ventilatory equivalents for oxygen and carbon dioxide. Results: A two‐way ANOVA with repeated measures (substance x time) revealed statistically significant main effects of caffeine (p < 0.01) and time (p = 0.04) on the wattage obtained at VT2, although there was no interaction (p = 0.09). In comparison to the placebo, caffeine increased the workload at VT2 on days 1, 4, 6 and 15 of ingestion (p < 0.05). The size of the ergogenic effect of caffeine over the placebo on the workload at VT2 was progressively reduced with the duration of the treatment. In addition, there were main effects of caffeine (p = 0.03) and time (p = 0.16) on VO2 obtained at VT2, with no interaction (p = 0.49). Specifically, caffeine increased oxygen uptake at VT2 on days 1 and 4 (p < 0.05), with no other caffeine–placebo differences afterwards. For heart rate obtained at VT2, there was a main effect of substance (p < 0.01), while the overall effect of time (p = 0.13) and the interaction (p = 0.22) did not reach statistical significance. Heart rate at VT2 was higher with caffeine than with the placebo on days 1 and 4 (p < 0.05). The size of the effect of caffeine on VO2 and heart at VT2 tended to decline over time. Conclusion: Pre‐exercise intake of 3 mg/kg/day of caffeine for twenty days enhanced the wattage obtained at VT2 during cycling ramp tests for ~15 days of ingestion, while there was a progressive attenuation of the size of the ergogenic effect of caffeine on this performance variable. Therefore, habituation to caffeine through daily ingestion may reduce the ergogenic effect of this stimulant on aerobic exercise of submaximal intensity.post-print501 K

Comparative analyses of holder pasteurization vs. HTST pasteurization for donor milk: a cost-minimization study applicable to human milk banks

BACKGROUND: High-temperature short-time (HTST) pasteurization (72-75 °C, 15 s) is an alternative treatment to traditional Holder pasteurization (HoP) (62ºC, 30 min) for donor milk. HTST pasteurization guarantees the milk's microbiological safety and retains more of its biologically and nutritionally active compounds, but the cost of implementing this technology for a human milk bank is unknown. METHODS: A cost-minimization study was carried out on the facilities of a regional human milk bank in a public hospital. Total production costs (fixed plus variables) were quantified using HTST pasteurization and HoP in three hypothetical scenarios: (1) costs of the first 10 L of pasteurized milk in a newly opened milk bank; (2) costs of the first 10 L of pasteurized milk in an active milk bank; and (3) costs using the maximum production capacity of both technologies in the first two years of operation. The following costs were analyzed: health care professionals, equipment and software, external services, and consumables. RESULTS: In scenario 1, the total production costs were 228,097.00 for the HTST method versus 154,064.00 for the HoP method. In scenario 2, these costs were similar ( 6,594.00 for HTST pasteurization versus 5,912.00 for HoP). The cost of healthcare professionals was reduced by more than half when pasteurization was carried out by the HTST method versus the Holder method ( 84.00 and 191.00, respectively). In scenario 3, the unit cost of milk pasteurized by the HTST method decreased from the first to the second year by 43.5%, while for the HoP method, it decreased by 30%. CONCLUSIONS: HTST pasteurization requires a high initial investment in equipment; however, it provides a significant minimization of production costs in the long term, pasteurizes large quantities of donor milk per working day and achieves a more efficient management of the time of the health care professionals in charge of the bank's operation compared to HoP

Evaluation of Different Concentrations of Nitrogen for Tomato Seedling Production (Lycopersicon esculentum Mill.)

This study was aimed at evaluating the different concentrations of nitrogen for tomato seedling production (Lycopersicon esculentum Mill.), hybrid Loreto. Five concentrations of nitrogen were analyzed: 0, 4, 8, 12 and 16 mEq / L, using as a basis the Steiner nutrient solution. A pilot randomized block design was used with six replications and five treatments. Thirty-five days after sowing, the following variables were analyzed: seedling height, stem diameter, fresh stem weight, fresh leaf weight, leaf area, dry steam weight, dry leaf weight, dry root weight and total nitrogen content. An ANOVA analysis (p <0.05) with post-hoc Tukey test was performed to compare each treatment variables. The results showed that the increase in the concentration of nitrogen has a positive effect on organ growth. The treatment with the highest values in the morphological variables was 16 mEq / L, which shortened the production time of seedlings ready for transplant

Evaluation of Different Concentrations of Nitrogen for Tomato Seedling Production (Lycopersicon esculentum Mill.)

This study was aimed at evaluating the different concentrations of nitrogen for tomato seedling production (Lycopersicon esculentum Mill.), hybrid Loreto. Five concentrations of nitrogen were analyzed: 0, 4, 8, 12 and 16 mEq / L, using as a basis the Steiner nutrient solution. A pilot randomized block design was used with six replications and five treatments. Thirty-five days after sowing, the following variables were analyzed: seedling height, stem diameter, fresh stem weight, fresh leaf weight, leaf area, dry steam weight, dry leaf weight, dry root weight and total nitrogen content. An ANOVA analysis (p <0.05) with post-hoc Tukey test was performed to compare each treatment variables. The results showed that the increase in the concentration of nitrogen has a positive effect on organ growth. The treatment with the highest values in the morphological variables was 16 mEq / L, which shortened the production time of seedlings ready for transplant

UNA ESTRATEGIA METODOLÓGICA DE LA MATEMÁTICA PARA CONTABILIDAD Y FINANZAS EN EL CENTRO UNIVERSITARIO MUNICIPAL DE MORÓN

Se toma como punto de partida el problema relacionado con las insuficiencias que presentan los estudiantes de la carrera de Licenciatura en Contabilidad y Finanzas del Centro Universitario Municipal (CUM) de Morón en relación a la gestión de costos. Es por ello que se propone una estrategia metodológica para el desarrollo del proceso docente educativo de la Matemática Superior I de la carrera. Estrategia que se encuentra en fase de ejecución en el CUM de Morón, la misma se ha estructurado en tres fases, primeramente la de orientación, luego la de organización y planificación para luego la fase de ejecución. En el 2016 se reinició en este CUM esta carrera, pues ya existe un antecedente con resultados positivo

Postnatal administration of allopregnanolone modifies glutamate release but Not BDNF content in striatum samples of rats prenatally exposed to ethanol

Ethanol consumption during pregnancy may induce profound changes in fetal CNS development. We postulate that some of the effects of ethanol on striatal glutamatergic transmission and neurotrophin expression could be modulated by allopregnanolone, a neurosteroid modulator of GABA A receptor activity. We describe the acute pharmacological effect of allopregnanolone (65 μg/kg, s.c.) administered to juvenile male rats (day 21 of age) on the corticostriatal glutamatergic pathway, in both control and prenatally ethanol-exposed rats (two ip injections of 2.9 g/kg in 24% v/v saline solution on gestational day 8). Prenatal ethanol administration decreased the K+-induced release of glutamate regarding the control group. Interestingly, this effect was reverted by allopregnanolone. Regarding BDNF, allopregnanolone decreases the content of this neurotrophic factor in the striatum of control groups. However, both ethanol alone and ethanol plus allopregnanolone treated animals did not show any change regarding control values. We suggest that prenatal ethanol exposure may produce an alteration of GABA A receptors which blocks the GABA agonist-like effect of allopregnanolone on rapid glutamate release, thus disturbing normal neural transmission. Furthermore, the reciprocal interactions found between GABAergic neurosteroids and BDNF could underlie mechanisms operating during the neuronal plasticity of fetal development.Fil: Yunes, Roberto Miguel Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas; ArgentinaFil: Estrella, Cecilia R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: García Menéndez, Sebastián Marcelo Manuel. Universidad Nacional de Cuyo. Facultad de Ciencias Medicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Lara, Hernán E.. Universidad de Chile; ChileFil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentin