Lemon car game

Abstract This article presents two versions of a negotiation game, the LEMON CAR GAME, that is used to investigate cross-cultural variation in negotiation behaviour. The game is about trading a second-hand car with a possible hidden defect. One version is a specific research set-up destined to investigate face to face negotiation between participants with different acculturation on the cultural dimension of power distance. The other is a first Web-based version of the game. Both games are described. At the time of writing there are no experimental data yet

Learning and recognition of objects inspired by early cognition

In this paper, we present a unifying approach for learning and recognition of objects in unstructured environments through exploration. Taking inspiration from how young infants learn objects, we establish four principles for object learning. First, early object detection is based on an attention mechanism detecting salient parts in the scene. Second, motion of the object allows more accurate object localization. Next, acquiring multiple observations of the object through manipulation allows a more robust representation of the object. And last, object recognition benefits from a multi-modal representation. Using these principles, we developed a unifying method including visual attention, smooth pursuit of the object, and a multi-view and multi-modal object representation. Our results indicate the effectiveness of this approach and the improvement of the system when multiple observations are acquired from active object manipulation

Microglial activation in Alzheimer's disease: an (R)-[11C]PK11195 positron emission tomography study

AbstractInflammatory mechanisms, like microglial activation, could be involved in the pathogenesis of Alzheimer's disease (AD). (R)-[11C]PK11195 (1-(2-chlorophenyl)-N-methyl-N-1(1-methylpropyl)-3-isoquinolinecarboxamide), a positron emission tomography (PET) ligand, can be used to quantify microglial activation in vivo. The purpose of this study was to assess whether increased (R)-[11C]PK11195 binding is present in AD and mild cognitive impairment (MCI), currently also known as “prodromal AD.”MethodsNineteen patients with probable AD, 10 patients with prodromal AD (MCI), and 21 healthy control subjects were analyzed. Parametric images of binding potential (BPND) of (R)-[11C]PK11195 scans were generated using receptor parametric mapping (RPM) with supervised cluster analysis. Differences between subject groups were tested using mixed model analysis, and associations between BPND and cognition were evaluated using Pearson correlation coefficients.ResultsVoxel-wise statistical parametric mapping (SPM) analysis showed small clusters of significantly increased (R)-[11C]PK11195 BPND in occipital lobe in AD dementia patients compared with healthy control subjects. Regions of interest (ROI)-based analyses showed no differences, with large overlap between groups. There were no differences in (R)-[11C]PK11195 BPND between clinically stable prodromal AD patients and those who progressed to dementia, and BPND did not correlate with cognitive function.ConclusionMicroglial activation is a subtle phenomenon occurring in AD

Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization.

Human ERCC1/XPF is a structure-specific endonuclease involved in multiple DNA repair pathways. We present the solution structure of the non-catalytic ERCC1 central domain. Although this domain shows structural homology with the catalytically active XPF nuclease domain, functional investigation reveals a completely distinct function for the ERCC1 central domain by performing interactions with both XPA and single-stranded DNA. These interactions are non-competitive and can occur simultaneously through distinct interaction surfaces. Interestingly, the XPA binding by ERCC1 and the catalytic function of XPF are dependent on a structurally homologous region of the two proteins. Although these regions are strictly conserved in each protein family, amino acid composition and surface characteristics are distinct. We discuss the possibility that after XPF gene duplication, the redundant ERCC1 central domain acquired novel functions, thereby increasing the fidelity of eukaryotic DNA repair

Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW:A quantitative dose-escalation study

Tumor-positive resection margins are present in up to 23% of head and neck cancer (HNC) surgeries, as intraoperative techniques for real-time evaluation of the resection margins are lacking. In this study, we investigated the safety and potential clinical value of fluorescence-guided imaging (FGI) for resection margin evaluation in HNC patients. We determined the optimal cetuximab-800CW dose by quantification of intrinsic fluorescence values using multi-diameter single-fiber reflectance, single-fiber fluorescence (MDSFR/SFF) spectroscopy. Methods: Five cohorts of three HNC patients received cetuximab-800CW systemically: three single dose cohorts (10, 25, 50 mg) and two cohorts pre-dosed with 75 mg unlabeled cetuximab (15 or 25 mg). Fluorescence visualization and MDSFR/SFF spectroscopy quantification was performed and were correlated to histopathology. Results: There were no study-related adverse events higher than Common Terminology Criteria for Adverse Events grade-II. Quantification of intrinsic fluorescence values showed a dose-dependent increase in background fluorescence in the single dose cohorts (p<0.001, p<0.001), which remained consistently low in the pre-dosed cohorts (p=0.6808). Resection margin status was evaluated with a sensitivity of 100% (4/4 tumor-positive margins) and specificity of 91% (10/11 tumor-negative margins). Conclusion: A pre-dose of 75 mg unlabeled cetuximab followed by 15 mg cetuximab-800CW was considered the optimal dose based on safety, fluorescence visualization and quantification of intrinsic fluorescence values. We were able to use a lower dose cetuximab-800CW than previously described, while remaining a high sensitivity for tumor detection due to application of equipment optimized for IRDye800CW detection, which was validated by quantification of intrinsic fluorescence values

La campaña experimental BLLAST 2011: Boundary Layer Late Afternoon and Sunset Turbulence

Presentación realizada para las XXXII Jornadas Científicas de la Asociación Meteorológica Española y 13º Encuentro Hispano-Luso de Meteorología celebrados en Alcobendas (Madrid), del 28 al 30 de mayo de 2012

Serviços de intermediação para crianças-testemunhas que depõem em tribunais criminais da África do Sul

Publicado em português, espanhol e inglês.Título em espanhol: Servicios de mediación para los testigos menores de edad que atestiguan ante tribunales penales sudafricanos. -- Título em inglês: Intermediary services for child witnesses testifying in south african criminal courts.Destaca que os crimes contra crianças e os subseqüentes procedimentos criminais nos quais se exige que a criança participe como testemunha ocorrem com suficiente freqüência para que se garantam serviços de intermediação a todas as crianças-testemunhas. Ele destaca as implicações práticas a fim de melhorar o processo corrente de intermediação, em nível regional, provincial e nacional. Primeiramente, o artigo faz uma reflexão sobre os serviços de intermediação oferecidos a crianças-testemunhas em algumas áreas dos subúrbios da região oeste de Johannesburgo; em segundo lugar, discute experiências práticas e literatura de apoio, assim como a experiência da Bethany House com o projeto Child in Crisis Foundation (SA)