Een Passende Beoordeling van de effecten van de toename van het aantal civiele vliegbewegingen in de omgeving van Den helder Airport

Waargenomen reacties van vogels op civiel vliegverkeer lunnen niet worden aangemerkt als zijnde een significante aantasting van de beschermde natuurwaarden, afgemeten naar de aantallen vogels die erbij betrokken zijn en van het gedrag en de voedselopname van ter plaatse foeragerende vogels

Peripheral blood lymphocyte cell subsets in subjects with chronic obstructive pulmonary disease: association with smoking, IgE and lung function

In contrast to the numerous studies which show that lymphocytes play an important role in the pathogenesis of asthma, few studies have investigated the role of lymphocytes in the pathogenesis of chronic obstructive pulmonary disease (COPD). The aim of the present study was to investigate lymphocyte subsets in peripheral venous blood of smoking and non-smoking COPD patients and healthy controls. The interaction of smoking and IgE has also been assessed, and it was investigated whether a lower level of FEV1 was associated with changes in lymphocyte subsets. In the present study, peripheral venous blood lymphocyte subsets were investigated in 42 smoking and non-smoking, non-atopic subjects with a clear diagnosis of COPD (43-74 years) who all used bronchodilator therapy only, and in 24 normal, healthy control subjects (40-72 years). No significant differences in lymphocyte subsets were found when either total groups or smoking subjects of both groups were compared. However, the percentage of CD8+ lymphocytes (suppressor/ cytotoxic T-cells) was significantly higher in the non-smoking COPD subjects compared with the non-smoking, healthy control subjects (P < 0.05). In addition, within the group of non-smoking COPD subjects, a higher CD4:CD8 ratio was associated with a higher FEV1 as a percentage of predicted (% pred.) (r = 0.55, P = 0.01) and a lower total serum IgE (r = -0.45, P = 0.04). Within the group of smoking COPD subjects, a higher FEV1 % pred. was associated with a higher percentage of CD19+ lymphocytes (B-cells) (r = 0.65, P < 0.01). The present study provides further evidence that the changes in the balance of T-cell subsets and IgE synthesis possibly plays a role in the pathogenesis of COPD

Поліфонічні прийоми в духовних творах Ігоря Мацієвського

У пропонованій статті розглядаються поліфонічні прийоми в деяких зразках духовної вокально-хорової та інструментальної музики сучасного представника української діаспори в Петербурзі, провідного вченого-етноінструментознавця й композитора Ігоря Мацієвського. Знання глибинних законів етномузики слов’янських народів дозволило йому стати не лише фундатором української й російської етноорганології, але й автором оригінальних композицій, у мові яких органічно поєднуються академічність, авангардизм, елементи гуцульської, лемківської, підляської, білоруської, польської та російської народної музики.В статье рассматриваются полифонические приёмы в некоторых образцах духовной вокально-хоровой и инструментальной музыки современного представителя украинськой диаспоры в Санкт-Петербурге, выдающегося учёного и композитора Игоря Мациевского.The polyphonic methods in some examples of the spiritual vocal-choral and instrumental music of Igor Matsiyevsky, a modern representative of the Ukrainian Diaspora in St. Petersburg, are studied in the article. The profound knowledge of the very nature of Slavonic ethnical music helped him to become not only a founder of the Ukrainian and Russian ethnoorganology, but also an author of the genuine compositions, in language of which academicism, avant-gardism and the elements of Guzulska, Lemkivska, Pidlyaska, Belorussian, Polish and Russian folk music are organically combined

Long-term air pollution exposure, genome-wide DNA methylation and lung function in the lifelines cohort study

BACKGROUND: Long-term air pollution exposure is negatively associated with lung function, yet the mechanisms underlying this association are not fully clear. Differential DNA methylation may explain this association. OBJECTIVES: Our main aim was to study the association between long-term air pollution exposure and DNA methylation. METHODS: We performed a genome-wide methylation study using robust linear regression models in 1,017 subjects from the LifeLines cohort study to analyze the association between exposure to nitrogen dioxide (NO2) and particulate matter (PM2.5, fine particulate ma

Realistic Model of the Nucleon Spectral Function in Few- and Many- Nucleon Systems

By analysing the high momentum features of the nucleon momentum distribution in light and complex nuclei, it is argued that the basic two-nucleon configurations generating the structure of the nucleon Spectral Function at high values of the nucleon momentum and removal energy, can be properly described by a factorised ansatz for the nuclear wave function, which leads to a nucleon Spectral Function in the form of a convolution integral involving the momentum distributions describing the relative and center-of-mass motion of a correlated nucleon-nucleon pair embedded in the medium. The Spectral Functions of $^3He$ and infinite nuclear matter resulting from the convolution formula and from many-body calculations are compared, and a very good agreement in a wide range of values of nucleon momentum and removal energy is found. Applications of the model to the analysis of inclusive and exclusive processes are presented, illustrating those features of the cross section which are sensitive to that part of the Spectral Function which is governed by short-range and tensor nucleon-nucleon correlations.Comment: 40 pages Latex , 16 ps figures available from the above e-mail address or from [email protected]

Charged-Particle Multiplicities in Charged-Current Neutrino-- and Anti-Neutrino--Nucleus Interactions

The CHORUS experiment, designed to search for $\nu_{\mu}\to\nu_{\tau}$ oscillations, consists of a nuclear emulsion target and electronic detectors. In this paper, results on the production of charged particles in a small sample of charged-current neutrino-- and anti-neutrino--nucleus interactions at high energy are presented. For each event, the emission angle and the ionization features of the charged particles produced in the interaction are recorded, while the standard kinematic variables are reconstructed using the electronic detectors. The average multiplicities for charged tracks, the pseudo-rapidity distributions, the dispersion in the multiplicity of charged particles and the KNO scaling are studied in different kinematical regions. A study of quasi-elastic topologies performed for the first time in nuclear emulsions is also reported. The results are presented in a form suitable for use in the validation of Monte Carlo generators of neutrino--nucleus interactions.Comment: 17 pages, 5 figure

Observation of hard scattering in photoproduction events with a large rapidity gap at HERA

Events with a large rapidity gap and total transverse energy greater than 5 GeV have been observed in quasi-real photoproduction at HERA with the ZEUS detector. The distribution of these events as a function of the $\gamma p$ centre of mass energy is consistent with diffractive scattering. For total transverse energies above 12 GeV, the hadronic final states show predominantly a two-jet structure with each jet having a transverse energy greater than 4 GeV. For the two-jet events, little energy flow is found outside the jets. This observation is consistent with the hard scattering of a quasi-real photon with a colourless object in the proton.Comment: 19 pages, latex, 4 figures appended as uuencoded fil

First Measurement of Z/gamma* Production in Compton Scattering of Quasi-real Photons

We report the first observation of Z/gamma* production in Compton scattering of quasi-real photons. This is a subprocess of the reaction e+e- to e+e-Z/gamma*, where one of the final state electrons is undetected. Approximately 55 pb-1 of data collected in the year 1997 at an e+e- centre-of-mass energy of 183 GeV with the OPAL detector at LEP have been analysed. The Z/gamma* from Compton scattering has been detected in the hadronic decay channel. Within well defined kinematic bounds, we measure the product of cross-section and Z/gamma* branching ratio to hadrons to be (0.9+-0.3+-0.1) pb for events with a hadronic mass larger than 60 GeV, dominated by (e)eZ production. In the hadronic mass region between 5 GeV and 60 GeV, dominated by (e)egamma* production, this product is found to be (4.1+-1.6+-0.6) pb. Our results agree with the predictions of two Monte Carlo event generators, grc4f and PYTHIA.Comment: 18 pages, LaTeX, 5 eps figures included, submitted to Physics Letters