Shape memory alloy actuators for active disassembly using ‘smart’ materials of consumer electronic products

This paper reports the preliminary to current development of Shape Memory Alloy (SMA) actuators within their application in ‘Active Disassembly using Smart Materials’ (ADSM). This non-destructive self-dismantling process is to aid recycling of consumer electronic products. Actuators were placed in single and multi-stage hierarchical temperature regimes after being embedded into macro and sub-assemblies of electronic product assemblies. Findings include active disassembly and a hierarchical dismantling regime for product dismantling using developed SMA actuators embedded into candidate products

IN SITU LOCALIZATION OF GLOBIN MESSENGER RNA FORMATION : II. After Treatment of Friend Virus-Transformed Mouse Cells with Dimethyl Sulfoxide

Globin messenger RNA (mRNA) levels in Friend virus-transformed mouse cells have been estimated by in situ hybridization of DNA copy (cDNA) to fixed preparations of cells and by hybridization of cDNA to extracted cytoplasmic RNA in true solution. The results obtained by both methods agree in showing that a low level of globin mRNA can be detected in untreated Friend cells. The levels of hemoglobin and globin mRNA have also been correlated after treatment of Friend cells with dimethyl sulfoxide (DMSO). The results obtained by both experimental approaches show that there is a minimum period of treatment with DMSO required in order that Friend cells may become hemoglobinized, and that this period coincides with the time when globin mRNA accumulates. Moreover, bromodeoxyuridine prevents both hemoglobin and globin mRNA accumulation

Large-scale Roll Out of Electronic Longitudinal Mood-Monitoring for Research in Affective Disorders: Report From the UK Bipolar Disorder Research Network

Background Electronic longitudinal mood monitoring has been shown to be acceptable to patients with affective disorders within clinical settings, but its use in large-scale research has not yet been established. Methods Using both postal and email invitations, we invited 4080 past research participants with affective disorders who were recruited into the Bipolar Disorder Research Network (BDRN) over a 10 year period to participate in online weekly mood monitoring. In addition, since January 2015 we have invited all newly recruited BDRN research participants to participate in mood monitoring at the point they were recruited into BDRN. Results Online mood monitoring uptake among past participants was 20, and among new participants to date was 46 with participants recruited over the last year most likely to register (61). More than 90 mood monitoring participants engaged for at least one month, with mean engagement period greater than one year (58 weeks) and maximum engagement for longer than three years (165 weeks). There were no significant differences in the proportion of past and new BDRN participants providing data for at least 4 weeks (91, 92 respectively), 3 months (78, 82), 6 months (65, 54) or one year (51, 44). Limitations Our experiences with recruiting participants for electronic prospective mood monitoring may not necessarily generalise fully to research situations that are very different from those we describe. Conclusions Large-scale electronic longitudinal mood monitoring in affective disorders for research purposes is feasible with uptake highest among newly recruited participants

Theoretical analysis of strain and strain decay in InAs/GaAs(001) multilayer quantum dot growth

Published versio

Eco-innovation : tools to facilitate early-stage workshops

This thesis presents research carried out into the use of creative tools at the early stages of eco-innovation. Eco-innovation is a practical approach aiming to develop new products and processes which significantly decrease our impact on the environment. Designers are trained to develop profitable products that increase production and consumption. Eco-innovation is a new discipline in which designers can radically reduce the environmental burdens of production and consumption through the innovation of new types of products and services. The main aim of this research was to develop an approach that would promote significant environmental improvements whilst remaining a practical, design-focused discipline. Problems and under-investigated aspects of eco-innovation were identified: • Creative approaches at early stages of eco-innovation were under-investigated and few tools had been developed for use at the early stages. • Empirical design research techniques had rarely been used to assess new eco-innovation tools or to inform their subsequent development. The focus of the research work was the development and testing of tools to facilitate workshops at the early stages of eco-innovation. Not only was the goal to facilitate the generation of radical ideas but also to ensure that these were developed into appropriate solutions having the potential to be taken up in industry. The development of the tools was based on literature research, worked examples and interviews. The tools were tested in controlled workshop experiments and the results were analysed using various empirical techniques. First, an idea-recording technique to improve the efficiency of generating and harvesting ideas in a team design process was developed. This novel tool was called the Product Ideas Tree (PIT) diagram. The tool was tested for its ability to facilitate design workshops. Secondly, a structured approach to innovation - the theory of inventive problem solving (TRIZ) - was investigated. Worked examples using some of the tools from TRIZ were presented and a limited number of tools were selected and simplified for testing in team design workshops. The PIT diagram and TRIZ tools experiments established which attributes of the tools and approaches were most beneficial. The development and testing of these specific tools provided the following general contributions to eco-innovation: • A model for eco-innovation that describes the factors influencing the discipline and the attributes of good practice. • A recommended process to transform radical ideas into appropriate solutions to improve their potential to be taken up in industry. • General insights into the use of tools in early-stage workshops such as: tool selection, integration into existing processes, system-level problem solving and providing thematic information. • Suggested improvements for testing tools in controlled workshop experiments.EThOS - Electronic Theses Online ServiceEPSRCGBUnited Kingdo

A simple model for the vibrational modes in honeycomb lattices

The classical lattice dynamics of honeycomb lattices is studied in the harmonic approximation. Interactions between nearest neighbors are represented by springs connecting them. A short and necessary introduction of the lattice structure is presented. The dynamical matrix of the vibrational modes is then derived, and its eigenvalue problem is solved analytically. The solution may provide deeper insight into the nature of the vibrational modes. Numerical results for the vibrational frequencies are presented. To show that how effective our method used for the case of honeycomb lattice is, we also apply it to triangular and square lattice structures. A few suggested problems are listed in the concluding section.Comment: 9 pages, 12 figures, submitted to American Journal of Physic

Parameter dependence of magnetized CMB observables

Pre-decoupling magnetic fields affect the scalar modes of the geometry and produce observable effects which can be constrained also through the use of current (as opposed to forthcoming) data stemming from the Cosmic Microwave Background observations. The dependence of the temperature and polarization angular power spectra upon the parameters of an ambient magnetic field is encoded in the scaling properties of a set of basic integrals whose derivation is simplified in the limit of small angular scales. The magnetically-induced distortions patterns of the relevant observables can be computed analytically by employing scaling considerations which are corroborated by numerical results.Comment: 48 pages, 11 figures; corrected minor typos; discussions added; to appear in Physical Revie

Email fraud: The search for psychological predictors of susceptibility

Decisions that we make about email legitimacy can result in a pernicious threat to security of both individuals and organisations. Yet user response to phishing emails is far from uniform; some respond while others do not. What is the source of this diversity in decision-making? From a psychological perspective, we consider cognitive and situational influences that might explain why certain users are more susceptible than others. Alongside an email judgment task employed as a proxy for fraud susceptibility, 224 participants completed a range of cognitive tasks. In addition, we manipulated time pressure for email legitimacy judgments. We identify cognitive reflection and sensation seeking as significant, albeit modest, predictors of susceptibility. Further to this, participants asked to make quicker responses made more judgment errors. We conclude there are cognitive signatures that partially contribute to email fraud susceptibility, with implications for efforts to limit online security breaches and train secure behaviors

History of Premenstrual Mood Change and Postpartum Episodes are Associated with Perimenopausal Episodes in Women with Bipolar Disorder

Background and Aims: Reproductive life events are potential triggers of mood episodes in women with bipolar disorder. We aimed to establish whether a history of premenstrual mood change and postpartum episodes are associated with perimenopausal episodes in women who have bipolar disorder. Methods: Participants were 339 post-menopausal women with DSM-IV bipolar disorder recruited into the Bipolar Disorder Research Network (www.bdrn.org). Women self-reported presence (N = 200) or absence (N = 139) of an illness episode during the perimenopausal period. History of premenstrual mood change was measured using the self-report Premenstrual Symptoms Screening Tool (PSST), and history of postpartum episodes was measured via semi-structured interview (Schedules for Clinical Assessment in Neuropsychiatry, SCAN) and inspection of case-notes. Results: History of a postpartum episode within 6 months of delivery (OR = 2.13, p = 0.03) and history of moderate/severe premenstrual syndrome (OR = 6.33, p < 0.001) were significant predictors of the presence of a perimenopausal episode, even after controlling for demographic factors. When we narrowed the definition of premenstrual mood change to premenstrual dysphoric disorder, it remained significant (OR = 2.68, p = 0.007). Conclusions: Some women who have bipolar disorder may be particularly sensitive to reproductive life events. Previous mood episodes in relation to the female reproductive lifecycle may help clinicians predict individual risk for women with bipolar disorder approaching the menopause. There is a need for prospective longitudinal studies of women with bipolar disorder providing frequent contemporaneous ratings of their mood to overcome the limitations of retrospective self-report data

Single cell analysis identifies <em>CRLF2</em> rearrangements as both early and late events in Down syndrome and non-Down syndrome acute lymphoblastic leukaemia

Deregulated expression of the type I cytokine receptor, CRLF2, is observed in 5-15% of precursor B-cell acute lymphoblastic leukaemia (B-ALL). We have previously reported the genomic landscape of patients with CRLF2 rearrangements (CRLF2-r) using both whole genome and exome sequencing, which identified a number of potential clonal and sub-clonal genomic alterations. In this study, we aimed to assess when the CRLF2-r; IGH-CRLF2 or P2RY8-CRLF2, arose during the evolution of both Down syndrome-ALL (DS-ALL) and non-DS-ALL. Using fluorescence in situ hybridisation, we were able to track up to four structural variants in single cells from 47 CRLF2-r B-ALL patients, which in association with our multiplex single cell analysis of a further four patients, permitted simultaneous tracking of copy number alterations, structural and single nucleotide variants within individual cells. We observed CRLF2-r arising as both early and late events in DS and non-DS-ALL patients. Parallel evolution of discrete clones was observed in the development of CRLF2-r B-ALL, either involving the CRLF2-r or one of the other tracked abnormalities. In depth single cell analysis identified both linear and branching evolution with early clones harbouring a multitude of abnormalities, including the CRLF2-r in DS-ALL patients