Magical Regionalism: Canadian Geography on Screen in the 1950s

Using geography and environmental history to analyze children's film in 1950s-Canada, this paper examines regionalism in a popular National Film Board of Canada series

Funny walking : the rise, fall and rise of the Anglo-American comic eccentric dancer

This article will attempt to reposition comic eccentric dance as a metamorphic form that still, surprisingly, exists, and is to be found with reasonable ubiquity, in renewed incarna-tions within twenty first century media. Tracing the origins of comic eccentric dance through examples of earlier comedy performance, and drawing from Bergson’s comic theory of body misalliance, this article will dis-cuss this particularly ludic fusion of music and comedy. Further changes to the form affected by modernist preoccupations during the new Jazz Age at the turn of the twentieth century will be suggested. Finally, ways in which the formulation lives on in twenty-first century in-carnations in the comedy work of, for instance, Jimmy Fallon and Ricky Gervase, and in popular television shows such as Strictly Come Dancing (BBC 2004 - ) and Britain’s Got Talent (ITV 2006 - ) will be posited

The effect of dorsal rim loss on the initial stability of the BioMedtrix cementless acetabular cup

BACKGROUND: Loss of dorsal acetabular rim (DAR) is a common sequela to canine hip dysplasia. The purpose of this study is to evaluate the effect of DAR loss on the initial stability of the cementless (BFX) acetabular cup. BFX cups were implanted into foam blocks reamed to resemble acetabulae with simulated 0, 25, 50, and 75% DAR loss. Models were tested in edge loading of the lateral surface of the cup with an indenter, and in centered loading with an articulated femoral prosthesis. Additionally, cups were implanted into paired cadaveric canine hemipelves with either no DAR depletion, or removal of 50% of the DAR, and acutely loaded to failure with an articulated femoral prosthesis. RESULTS: Mean load measured at 1 mm cup displacement during edge loading was not significantly different in foam blocks with loss of 0, 25, 50, and 75% DAR (360 ± 124 N, 352 ± 42 N, 330 ± 81 N, 288 ± 43 N, respectively; P = 0.425). Mean load to failure with centered loads was greatest in blocks with 0% DAR loss (2828 ± 208 N; P < 0.001), but was not significantly different between 25, 50, and 75% DAR loss (2270 ± 301 N, 1924 ± 157 N, 1745 ± 118 N). In cadaveric testing, neither mean load to failure (P = 0.067), stiffness (P = 0.707), nor energy (P = 0.228) were significantly different in control hemipelves and those with 50% depletion of the DAR. Failure in all acetabulae occurred due to acetabular bone fracture at forces in supraphysiologic ranges. CONCLUSIONS: BFX cup stability under normal physiologic loads does not appear to be compromised in acetabulae with up to 50% DAR loss

Distal femoral lateral closing wedge osteotomy as a component of comprehensive treatment of medial patellar luxation and distal femoral varus in dogs

OBJECTIVE: To describe a cohort of dogs with medial patellar luxation managed with a distal femoral lateral closing wedge ostectomy (DFO) as a component of comprehensive treatment, and to report radiographic and long-term clinical outcome of this technique. METHODS: Medical records of dogs that had a lateral closing wedge DFO as part of management of medial patellar luxation at three veterinary teaching hospitals were reviewed. Surgical reports as well as the preoperative, postoperative, and follow-up radiographs were reviewed. The anatomical lateral distal femoral angle (aLDFA) was determined. Long-term clinical outcome was assessed by telephone interview with the owner. RESULTS: A lateral closing wedge DFO was performed on 66 limbs. The mean pre- and postoperative aLDFA was 107.6° ± 5.8° and 94.1° ± 4.2°, respectively. Cranial cruciate ligament disease was identified in 28/66 affected limbs. Tibial angular deformity, torsional deformity, or both was identified in nine of the 66 limbs. Ostectomy healing was confirmed radiographically in 51/66 limbs. The mean time to union was 73 ± 37 days. All patellae were in the normal position and stable. Complications included infection (2/51), fixation failure (1/51), delayed healing (2/51), and persistent lameness (1/51). CLINICAL SIGNIFICANCE: In this cohort of cases, DFO was a highly successful and repeatable component of surgical treatment for dogs with medial patellar luxation associated with femoral varus. This study also provides more evidence of the high rate of concurrent cranial cruciate ligament disease in cases of medial patellar luxation complicated by femoral varus, and supports an association between stifle instability and medial patellar luxatio

Genomic instability in cultured stem cells: associated risks and underlying mechanisms

Embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells expanded in vitro exhibit genomic instability. Commonly reported abnormalities include aneuploidy, deletions and duplications (including regions also amplified in cancer). Genomic instability confers an increased risk of malignant transformation that may impact the safety of cultured stem cell transplantation. Possible mechanisms responsible for this genomic instability include DNA repair mechanism abnormalities, telomere crisis, mitotic spindle abnormalities and inappropriate induction of meiotic pathways. Prior to widespread use of these cells in regenerative medicine, it will be critical to gain an understanding of the mechanisms responsible for genomic instability to develop strategies to prevent the accrual of chromosomal defects during expansion in vitro