1,267 research outputs found

    Wind tunnel and numerical study of a small vertical axis wind turbine

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    This paper presents a combined experimental and computational study into the aerodynamics and performance of a small scale vertical axis wind turbine (VAWT). Wind tunnel tests were carried out to ascertain overall performance of the turbine and two- and three-dimensional unsteady computational fluid dynamics (CFD) models were generated to help understand the aerodynamics of this performance. Wind tunnel performance results are presented for cases of different wind velocity, tip-speed ratio and solidity as well as rotor blade surface finish. It is shown experimentally that the surface toughness on the turbine rotor blades has a significant effect on performance. Below a critical wind speed (Reynolds number of 30,000) the performance of the turbine is degraded by a smooth rotor surface finish but above the turbine performance is enhanced by a smooth surface finish. Both two bladed and three bladed it, rotors were tested and a significant increase in performance coefficient is observed for the higher solidity rotors (three bladed rotors) over most of the operating range. Dynamic stalling behaviour and the resulting large and rapid changes in force coefficients and the rotor torque are shown to be the likely cause of changes to rotor pitch angle that occurred during early testing. This small change in pitch angle caused significant decreases in performance. The performance coefficient predicted by the two dimensional computational model is significantly higher than that of the experimental and the three-dimensional CFD model. The predictions show that the presence of the over tip vortices in the 3D simulations is responsible for producing the large difference in efficiency compared to the 2D predictions. The dynamic behaviour of the over tip vortex as a rotor blade rotates through each revolution is also explored in the paper. (C) 2009 Elsevier Ltd. All rights reserved

    A crucial role for IL-21 in controlling CD4 T cell responses to respiratory viral infection

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    Respiratory syncytial virus (RSV) is a pneumovirus that infects almost all children by the age of three, and causes an intense pulmonary infiltrate termed bronchiolitis. The tissue damage caused by this immune response significantly reduces lung function such that hospitalisation and mechanical ventilation may be required. There is no licensed vaccine against RSV, partly because the exact immunological mechanism responsible for bronchiolitis remains unclear, though CD4 and CD8 T cells are known to be essential. Interleukin-21 (IL-21) is a recently identified member of the γc chain cytokine family, important in autoimmunity, cancer, and chronic viral infections. Produced mainly by CD4 T cells, IL-21 affects the responses of several cell types but is particularly important for enhancing activation and survival of CD8 T cells. As such, it was hypothesised that IL-21 could be targeted therapeutically to reduce anti-RSV CD8 T cell responses and reduce the incidence of bronchiolitis. This hypothesis was tested in three models of RSV disease. Here, it is shown that IL-21 is critical for control of CD4 T cell responses rather than CD8. IL-21 depletion increases T cell responses, including cell recruitment and cytokine production, thereby increasing disease. Conversely, it reduced regulatory T cell influx and antibody production. In contrast, IL-21 over-expression ablates the anti-viral T cell response and RSV disease without affecting regulatory T cells. Also, early chemokine production by infected epithelial cells is inhibited and that DC migration is affected, possibly reducing T cell activation and influx. Antibody 4 production is also reduced, and consequently lymphocyte memory development is blocked resulting in no protection against viral rechallenge. Therefore, IL-21 plays a crucial role in the development of anti-viral pulmonary immunity and should be considered as part of a therapy to alleviate primary RSV disease in conjunction with other factors to boost anti-viral memory.Open Acces

    Hydrodynamic studies of ribosomal protein S4 from Escherichia coli

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    Efficiency of a nature-like bypass channel for restoring longitudinal connectivity for a river-resident population of brown trout

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    Man-made, physical barriers have disrupted longitudinal connectivity for migratory fish in many river systems throughout the world for centuries. These barriers are considered to be a key reason for the decline of many fish species in river systems. To date, most research to ease movement of anadromous salmonids past such barriers to help dwindling populations has focused on the use of technical fishways. More recently emphasis has been placed on nature-like fishways to enable a wider range of fish species to bypass these barriers, but few studies have examined their efficacy. In this study, Passive Integrated Transponder (PIT) telemetry was used to assess the upstream-directed movements of 111 river-resident brown trout (length, 151–510-mm) into and through a 150-m long, nature-like bypass on the River Aire, England. Attraction (51%), entrance (86%), passage (78%) and exit (97%) efficiencies were high, and trout of a wide range of sizes entered and exited (197–510 mm) the pass across a wide range of flows (entrance = 3.55–67.44 m 3 s −1 and exit = 3.89–35.5 m 3 s −1 ). There was evidence that two trout inhabited the pass during the day, entering at sunrise and exiting at sunset. This information is important to improve understanding of fish pass performance, thus informing future best practice guidance of fish passage designs

    Win, win, win: Low cost baffle fish pass provides improved passage efficiency, reduced passage time and broadened passage flows over a low-head weir

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    The number of low-head barriers to fish migration far outweighs the number of large magnitude barriers and thus the cumulative negative impact on fish communities could also be far greater. Removal of man-made obstructions to fish migration is the most beneficial mitigation measure for reconnecting fragmented rivers but is not always possible and thus fish passes must be constructed. Given the large number of low-head barriers, cheap but effective fish passes must be identified. This study measured passage of brown trout (Salmo trutta L.) at a low-head gauging weir on Eshton Beck, England, before and after low cost baffle (LCB) fish pass construction using passive integrated transponder (PIT) telemetry. The LCB fish pass significantly improved overall passage efficiency from a maximum of 64% to 91%. There was a significant decrease in delay at the obstruction after the LCB fish pass was constructed and fish passed on a greater range of flows (0.08 – 5.39 m3s-1) in comparison to before (0.56 - 1.92 m3s-1). Fish ascended the fish pass through the low velocity channel (gaps in the baffles) as well as over the baffles, though a higher proportion were detected ascending over baffles at higher flows. It was therefore concluded that similar low-head structures should incorporate this style of fish pass to improve longitudinal connectivity for brown trout and other species with similar passage capabilities

    Crowdsourcing the identification of organisms: a case-study of iSpot

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    Accurate species identification is fundamental to biodiversity science, but the natural history skills required for this are neglected in formal education at all levels. In this paper we describe how the web application ispotnature.org and its sister site ispot.org.za (collectively, “iSpot”) are helping to solve this problem by combining learning technology with crowdsourcing to connect beginners with experts. Over 94% of observations submitted to iSpot receive a determination. External checking of a sample of 3,287 iSpot records verified > 92% of them. To mid 2014, iSpot crowdsourced the identification of 30,000 taxa (>80% at species level) in > 390,000 observations with a global community numbering > 42,000 registered participants. More than half the observations on ispotnature.org were named within an hour of submission. iSpot uses a unique, 9-dimensional reputation system to motivate and reward participants and to verify determinations. Taxon-specific reputation points are earned when a participant proposes an identification that achieves agreement from other participants, weighted by the agreers’ own reputation scores for the taxon. This system is able to discriminate effectively between competing determinations when two or more are proposed for the same observation. In 57% of such cases the reputation system improved the accuracy of the determination, while in the remainder it either improved precision (e.g. by adding a species name to a genus) or revealed false precision, for example where a determination to species level was not supported by the available evidence. We propose that the success of iSpot arises from the structure of its social network that efficiently connects beginners and experts, overcoming the social as well as geographic barriers that normally separate the two
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