A comparison of the neuroprotective efficacy of newly developed oximes (K117, K127) and currently available oxime (obidoxime) in tabun-poisoned rats

The potency of newly developed bispyridinium compounds (K117, K127) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with currently available oxime (obidoxime) using functional observational battery. The neuroprotective effects of atropine alone and atropine combined with one of three bispyridinium oximes (K117, K127, obidoxime) on rats poisoned with tabun at a sublethal dose (180 μg/kg i.m.; 80% of LD50 value) were studied. Tabun-induced neurotoxicity was monitored using a functional observational battery and automatic measurement of motor activity at 24 h following tabun challenge. The results indicated that all tested oximes combined with atropine enabled tabun-poisoned rats to survive 24 h following tabun challenge while one tabun-poisoned rats died within 24 h after tabun poisoning when the rats were treated with atropine alone. Newly developed oxime K127 combined with atropine was the most effective in decreasing tabun-induced neurotoxicity in the case of sublethal poisonings among all oximes tested. Nevertheless, the differences of neuroprotective efficacy between K127 and obidoxime are not sufficient to replace obidoxime by K127 for the treatment of acute tabun poisonings

Chromium content in the meat of male Saanen goat kids from Vojvodina (Northern Serbia)

Goats, the earliest ruminant to be domesticated, are traditional sources of meat, milk, fibre, leather, related products of animal origin and as draught and pack animals. Meat is the major product of the goat. Meat quality is the sum of all sensory, nutritive, technological and hygienic-toxicological factors of meat. The aims of this study were to investigate the chromium content of four different muscles (M. psoas major, M. longissimus dorsi, M. semimembranosus and M. triceps brachii) of Saanen goat male kids and to determine whether the chromium contents differed between the muscles. Chromium content was determined using inductively coupled plasma optical emission spectrometry (ICP-OES), after dry ashing mineralisation. The studied muscles did not significantly differ (P >0.05) with respect to chromium content. The chromium content ranged from 0.012 to 0.067 mg/100 g, with an average of 0.026 mg/100 g

Resonant Frequencies of Split Ring Resonator in Respect of Angle between Slits

Abstract In this paper we proposed the method for calculation of resonant frequencies of split-ring resonators (SRRs) as a function of the angle between slits. Method is based on transmission line (TL) approach and can be used for calculation of resonant frequencies of broadside and edge-coupled, as well as of multiple SRRs. Resonant frequencies are also calculated using 3D EM simulations based on method of moments and compared with our model. It is shown that very good agreement is achieved in case when substrate thickness is smaller. Limitations of the model are discussed

Ellipsometric data

Thin films of titanium oxides (Ti-O), titanium oxynitrides (Ti-O-N), and copper doped titanium nitride (Ti-Cu-N) were deposited on the glass substrate. Ti-O and Ti-O-N films were deposited by cathodic arc plasma evaporation while TiN-Cu films were deposited by cathodic arc evaporation and unbalanced magnetron sputtering hybrid system. Ellipsometry is a technique that uses polarized light and the relative phase change in a beam of reflected polarized light. It's a very sensitive measurement and more accurate that intensity reflectance. The extinction coefficient of Ti-O sample shows zero value at 370 nm, while the extinction coefficient of Ti-O-N has almost zero value between 700 and 1150 nm, and between 150 and 2500 nm, typical for exceptionally good capacitors. Oppositely, the extinction coefficient of Ti-N-Cu shows in the wavelength range between 1500 and 2500 nm extremely high values reaching up to 18, being typical for materials with extremely high reflectance.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Metamaterials: Characteristics, design and microwave applications

We present an overview of unique properties of metamaterials, especially negative index materials. These have allowed novel applications, concepts and devices to be developed in the past decade. A review of the progress made in this field is presented with a focus on microwave devices and applications in wireless communications. Since a metamaterial can be regarded as a continuous medium with effective dielectric permittivity and effective magnetic permeability, we present the procedure for the extraction of effective electromagnetic parameters for a guided wave structure with split-ring resonators. As examples, our own designs of bandpass and triple-band filters, which are constructed using metamaterial-inspired resonator elements, are presented and discussed.Articl

Simultaneous LC determination of tiazofurin, its acetyl and benzoyl esters and their active metabolite thiazole-4-carboxamide adenine dinucleotide in biological samples

A rapid and sensitive HPLC-RP method for simultaneous determination of tiazofurin, its 5'-O acetyl and benzoyl esters and their active metabolite thiazole-4-carboxamide adenine dinucleotide was developed and validated. The method allowed determination and quantification of nanomolar quantities of these substances in cell extracts of treated cells, and was also used in kinetic studies of cellular uptake of tiazofurin and its esters from the cultivation medium. Separation of the analyzed substances from unidentified peaks from both biological materials was achieved by gradient elution, thus reducing the possibility of interference. The mobile phase consisted of a 0.1 M sodium-hydrogen phosphate, pH 5.1 and methanol. Run time was 22 min, with 5 min equilibration time. (C) 2002 Elsevier Science B.V. All rights reserved

Kinetics and sintering mechanisms of hydro-thermally obtained hydroxyapatite

In this paper, the kinetics and sintering mechanism of hydro-thermally synthesized hydroxyapatite in the temperature range 900-1100 degrees C are presented. It was found that at 900 degrees C, the sintering process is very slow, whereas at 1000, 1050, and 1100 degrees C is much faster, caused by activated sintering with liquid phase/phase of solution on spots with concentrated material impurity and the formation of reaction/polyeutectic mixtures dominates. The activation energies of sintering were also determined. At all the investigated sintering temperatures, an approximate value of 90 kJ mol(-1) was found. (c) 2008 Elsevier B.V. All rights reserved