How often is a random quantum state k-entangled?

The set of trace preserving, positive maps acting on density matrices of size d forms a convex body. We investigate its nested subsets consisting of k-positive maps, where k=2,...,d. Working with the measure induced by the Hilbert-Schmidt distance we derive asymptotically tight bounds for the volumes of these sets. Our results strongly suggest that the inner set of (k+1)-positive maps forms a small fraction of the outer set of k-positive maps. These results are related to analogous bounds for the relative volume of the sets of k-entangled states describing a bipartite d X d system.Comment: 19 pages in latex, 1 figure include

Nuclear Stopping as A Probe to In-medium Nucleon-nucleon Cross Section in Intermediate Energy Heavy Ion Collisions

Using an isospin-dependent quantum molecular dynamics, nuclear stopping in intermediate heavy ion collisions has been studied. The calculation has been done for colliding systems with different neutron-proton ratios in beam energy ranging from 15MeV/u to 150MeV/u. It is found that, in the energy region from above Fermi energy to 150MeV/u, nuclear stopping is very sensitive to the isospin dependence of in-medium nucleon-nucleon cross section, but insensitive to symmetry potential. From this investigation, we propose that nuclear stopping can be used as a new probe to extract the information on the isospin dependence of in-medium nucleon-nucleon cross section in intermediate energy heavy ion collisions

SPC-P1: a pathogenicity-associated prophage of Salmonella paratyphi C

<p>Abstract</p> <p>Background</p> <p><it>Salmonella paratyphi </it>C is one of the few human-adapted pathogens along with <it>S. typhi, S. paratyphi </it>A and <it>S. paratyphi </it>B that cause typhoid, but it is not clear whether these bacteria cause the disease by the same or different pathogenic mechanisms. Notably, these typhoid agents have distinct sets of large genomic insertions, which may encode different pathogenicity factors. Previously we identified a novel prophage, SPC-P1, in <it>S. paratyphi </it>C RKS4594 and wondered whether it might be involved in pathogenicity of the bacteria.</p> <p>Results</p> <p>We analyzed the sequence of SPC-P1 and found that it is an inducible phage with an overall G+C content of 47.24%, similar to that of most <it>Salmonella </it>phages such as P22 and ST64T but significantly lower than the 52.16% average of the RKS4594 chromosome. Electron microscopy showed short-tailed phage particles very similar to the lambdoid phage CUS-3. To evaluate its roles in pathogenicity, we lysogenized <it>S. paratyphi </it>C strain CN13/87, which did not have this prophage, and infected mice with the lysogenized CN13/87. Compared to the phage-free wild type CN13/87, the lysogenized CN13/87 exhibited significantly increased virulence and caused multi-organ damages in mice at considerably lower infection doses.</p> <p>Conclusions</p> <p>SPC-P1 contributes pathogenicity to <it>S. paratyphi </it>C in animal infection models, so it is possible that this prophage is involved in typhoid pathogenesis in humans. Genetic and functional analyses of SPC-P1 may facilitate the study of pathogenic evolution of the extant typhoid agents, providing particular help in elucidating the pathogenic determinants of the typhoid agents.</p

Probabilistic optimization for conceptual rainfall-runoff models: a comparison of the shuffled complex evolution and simulated annealing algorithms

Automatic optimization algorithms are used routinely to calibrate conceptual rainfall-runoff (CRR) models. The goal of calibration is to estimate a feasible and unique (global) set of parameter estimates that best fit the observed runoff data. Most if not all optimization algorithms have difficulty in locating the global optimum because of response surfaces that contain multiple local optima with regions of attraction of differing size, discontinuities, and long ridges and valleys. Extensive research has been undertaken to develop efficient and robust global optimization algorithms over the last 10 years. This study compares the performance of two probabilistic global optimization methods: the shuffled complex evolution algorithm SCE-UA, and the three-phase simulated annealing algorithm SA-SX. Both algorithms are used to calibrate two parameter sets of a modified version of Boughtoh's [1984] SFB model using data from two Australian catchments that have low and high runoff yields. For the reduced, well-identified parameter set the algorithms have a similar efficiency for the low-yielding catchment, but SCE-UA is almost twice as robust. Although the robustness of the algorithms is similar for the high-yielding catchment, SCE-UA is six times more efficient than SA-SX. When fitting the full parameter set the performance of SA-SX deteriorated markedly for both catchments. These results indicated that SCE-UA's use of multiple complexes and shuffling provided a more effective search of the parameter space than SA-SX's single simplex with stochastic step acceptance criterion, especially when the level of parameterization is increased. Examination of the response surface for the low-yielding catchment revealed some reasons why SCE-UA outperformed SA-SX and why probabilistic optimization algorithms can experience difficulty in locating the global optimum.Mark Thyer and George Kuczera, Bryson C. Bate

Identification of osteopontin as a novel marker for early hepatocellular carcinoma

The aim of this study was to identify a biomarker that could improve alpha‐fetoprotein (AFP) performance in hepatocellular carcinoma (HCC) surveillance among patients with cirrhosis. We performed proteomic profiling of plasma from patients with cirrhosis or HCC and validated selected candidate HCC biomarkers in two geographically distinct cohorts to include HCC of different etiologies. Mass spectrometry profiling of highly fractionated plasma from 18 cirrhosis and 17 HCC patients identified osteopontin (OPN) as significantly up‐regulated in HCC cases, compared to cirrhosis controls. OPN levels were subsequently measured in 312 plasma samples collected from 131 HCC patients, 76 cirrhosis patients, 52 chronic hepatitis C (CHC) and B (CHB) patients, and 53 healthy controls in two independent cohorts. OPN plasma levels were significantly elevated in HCC patients, compared to cirrhosis, CHC, CHB, or healthy controls, in both cohorts. OPN alone or in combination with AFP had significantly better area under the receiver operating characteristic curve, compared to AFP, in comparing cirrhosis and HCC in both cohorts. OPN overall performance remained higher than AFP in comparing cirrhosis and the following HCC groups: HCV‐related HCC, HBV‐associated HCC, and early HCC. OPN also had a good sensitivity in AFP‐negative HCC. In a pilot prospective study including 22 patients who developed HCC during follow‐up, OPN was already elevated 1 year before diagnosis. Conclusion : OPN was more sensitive than AFP for the diagnosis of HCC in all studied HCC groups. In addition, OPN performance remained intact in samples collected 1 year before diagnosis. (H EPATOLOGY 2012)Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90204/1/24703_ftp.pd

Enhanced Photoluminescence Emission and Thermal Stability from Introduced Cation Disorder in Phosphors

Optimizing properties of phosphors for use in white-light-emitting diodes (WLEDs) is an important materials challenge. Most phosphors have a low level of lattice disorder due to mismatch between the host and activator cations. Here we show that deliberate introduction of high levels of cation disorder leads to significant improvements in quantum efficiency, stability to thermal quenching, and emission lifetime in Sr_{1.98–<i>x</i>}(Ca_0.55Ba_0.45)_<i>x</i>Si₅N₈:Eu_0.02 (<i>x</i> = 0–1.5) phosphors. Replacing Sr by a (Ca_0.55Ba_0.45) mixture with the same average radius increases cation size variance, resulting in photoluminescence emission increases of 20–26% for the <i>x</i> = 1.5 sample relative to the <i>x</i> = 0 parent across the 25–200 °C range that spans WLED working temperatures. Cation disorder suppresses nonradiative processes through disruption of lattice vibrations and creates deep traps that release electrons to compensate for thermal quenching. Introduction of high levels of cation disorder may thus be a very useful general approach for improving the efficiency of luminescent materials

Enantioselective synthesis of trans-2,3-Dihydro-1H-indoles through C-H Insertion of a-Diazocarbonyl compounds

A stereoselective synthesis of 2,3-dihydro-1H-indoles with a RhII-catalyzed C–H insertion is reported. The α-diazo carbonyl intermediates can be obtained by a diazo-transfer reaction of 2-aminophenylacetic acids. Optimization and kinetic studies were performed, which resulted to increased yields of the diazo transfer after mechanistic evaluation of the side-product formation. trans-2,3-Dihydro-1H-indoles were obtained in high diasteromeric excesses (up to 94 % de) and enantiomeric excesses (up to 94 % ee)

Early growth response genes 2 and 3 regulate the expression of Bcl6 and differentiation of T follicular helper cells

T follicular helper (Tfh) cells support differentiation of B cells to plasma cells and high affinity antibody production in germinal centers (GC) and Tfh differentiation requires the function of B cell lymphoma 6 (Bcl6). We have now discovered that early growth response gene (Egr) 2 and 3 directly regulate the expression of Bcl6 in Tfh cells which is required for their function in regulation of GC formation. In the absence of Egr2 and 3, the expression of Bcl6 in Tfh cells is defective leading to impaired differentiation of Tfh cells resulting in a failure to form GCs following virus infection and defects in production of anti-viral antibodies. Enforced expression of Bcl6 in Egr2/3 deficient CD4 T cells partially restored Tfh differentiation and GC formation in response to virus infection. Our findings demonstrate a novel function of Egr2/3 which is important for Tfh cell development and Tfh cell mediated B cell immune responses.This work was supported by Arthritis Research UK. The authors declare that they have no conflicts of interest with the contents of this article