Shock compression science: Dynamic material properties and computation

Constitutive models used in computational prediction of high-rate deformation related to SBSS are determined by validation experiments that can be interpreted with some degree of uniqueness and without ambiguity. Here we include not only material strength and fracture, but also equation-of-state information, and, in the case of reactive solids, initiation concepts related to material strength and fracture. By equation of state we mean material information derived from equilibrium thermodynamics. For fluids this is normally the p, V, E, T information necessary for high-pressure shock-wave applications. For elastic solids it can also be second- and third-order adiabatic elastic moduli for crystals of arbitrary symmetry. Material strength and fracture are generally related to the defect state of the material, and are thus distinct from equilibrium thermodynamics. Likewise, initiation of solid explosives is related to hot spots arising from defects such as porosity and cracking. Finally, by the term {open_quotes}validation{close_quotes} we mean the repeated comparison of a computational model with a set of interpretable experiments, each exercising a particular aspect of the model under well-controlled loading conditions. To be explicitly clear on the thrust of this section, emphasis is on the experimentation necessary to define and elucidate models. Here the role of computation is in the analysis of experiments. Of course, once the validity of a model is established with some confidence, large-scale computation can be used as a predictive tool

Masking Power of Dental Opaque Porcelains

A technique was developed to qualify the masking power of undiluted opaque dental porcelain by dilution of opaque powder with a clear glaze powder and by extrapolation of quantitative data gathered by reflectance spectrophotometry. Quantification of reflectance data was made on dilute opaque porcelains using the scattering and absorption coefficients in the Kubelka-Munk equation. Qualitative comparisons of undiluted opaque porcelains were made from quantitative data gathered from diluted opaque porcelains.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67998/2/10.1177_00220345840630062601.pd

Cerebrofaciothoracic dysplasia: four new patients with a recurrent TMCO1 pathogenic variant.

Biallelic loss of function variants in the TMCO1 gene have been previously demonstrated to result in cerebrofaciothoracic dysplasia (CFTD; MIM #213980). The phenotype of this condition includes severe intellectual disability, as well as distinctive craniofacial features, including brachycephaly, synophrys, arched eyebrows, "cupid's bow" upper lip, and microdontia. In addition, nonspecific skeletal anomalies are common, including bifid ribs, scoliosis, and spinal fusion. Only 19 molecularly confirmed patients have been previously described. Here, we present four patients with CFTD, including three brothers from a Pakistani background and an additional unrelated white Scottish patient. All share the characteristic craniofacial appearance, with severe intellectual disability and skeletal abnormalities. We further define the phenotype with comparison to the published literature, and present images to define the dysmorphic features in a previously unreported ethnic group. All of our patient series are homozygous for the same c.292_293del (p.Ser98*) TMCO1 pathogenic variant, which has been previously reported only in an isolated Amish population. Thus we provide evidence that CFTD may be more common than previously thought. The patients presented here further delineate the phenotypic spectrum of CFTD and provide evidence for a recurrent pathogenic variant in TMCO1

Present and Future Bounds on Non-Standard Neutrino Interactions

We consider Non-Standard neutrino Interactions (NSI), described by four-fermion operators of the form $(\bar{\nu}_{\alpha} \gamma {\nu}_{\beta}) (\bar{f} \gamma f)$, where $f$ is an electron or first generation quark. We assume these operators are generated at dimension $\geq 8$, so the related vertices involving charged leptons, obtained by an SU(2) transformation $\nu_{\delta} \to e_{\delta}$, do not appear at tree level. These related vertices necessarily arise at one loop, via $W$ exchange. We catalogue current constraints from $\sin^2 \theta_W$ measurements in neutrino scattering, from atmospheric neutrino observations, from LEP, and from bounds on the related charged lepton operators. We estimate future bounds from comparing KamLAND and solar neutrino data, and from measuring $\sin^2 \theta_W$ at the near detector of a neutrino factory. Operators constructed with $\nu_\mu$ and $\nu_e$ should not confuse the determination of oscillation parameters at a $\nu$factory, because the processes we consider are more sensitive than oscillations at the far detector. For operators involving $\nu_\tau$, we estimate similar sensitivities at the near and far detector.Comment: Erratum added at the end of the documen

Mean-field analysis of interacting boson models with random interactions

We investigate the origin of the regular features observed in numerical studies of the interacting boson model with random interactions, in particular the dominance of L=0 ground states and the occurrence of vibrational and rotational band structures. It is shown that all of these properties can be interpreted and explained in terms of a Hartree-Bose mean-field analysis, in which different regions of the parameter space are associated with geometric shapes. The same conclusions hold for the vibron model.Comment: 8 pages, 4 figures, 2 tables. Physical Review C, in pres

Designing Clinical AAC Tablet Applications with Adults who have Mild Intellectual Disabilities

Patients with mild intellectual disabilities (ID) face significant communication barriers within primary care services. This has a detrimental effect on the quality of treatment being provided, meaning the consultation process could benefit from augmentative and alternative communication (AAC) technologies. However, little research has been conducted in this area beyond that of paper-based aids. We address this by extracting design requirements for a clinical AAC tablet application from n=10 adults with mild ID. Our results show that such technologies can promote communication between general practitioners (GPs) and patients with mild ID by extracting symptoms in advance of the consultation via an accessible questionnaire. These symptoms act as a referent and assist in raising the awareness of conditions commonly overlooked by GPs. Furthermore, the application can support people with ID in identifying and accessing healthcare services. Finally, the participants identified 6 key factors that affect the clarity of medical images

Determination of steroid estrogens in wastewater by high performance liquid chromatography-tandem mass spectrometry

This paper discusses the requirement for, and presents an analytical procedure for, the determination of four unconjugated steroid hormones and a conjugated steroid (estrone-3-sulfate) in wastewaters. The method quantifies the steroids by LC/MS/MS following solid phase extraction and a two stage clean-up procedure. Samples were extracted using C18 cartridges and eluates were then purified by gel permeation chromatography, followed by a further clean-up step on an aminopropyl cartridge. The limits of detection achieved were 0.2 ng l-1 for estriol, 17β-estradiol and 17α-ethinylestradiol, and 0.1 ng l-1 for estrone and the conjugate. The robustness of the method was demonstrated by achieving recoveries of >83% for all steroids in settled sewage and final effluent samples with relative standard deviations of 0.5 - 12%. The method was used to analyse a range of samples from a wastewater treatment works in south east England which demonstrated a >80% removal for estrone, estradiol and estriol with little impact on concentrations of ethinylestradiol or the conjugate

Histogram Monte Carlo study of multicritical behavior in the hexagonal easy-axis Heisenberg antiferromagnet

The results of a detailed histogram Monte-Carlo study of critical-fluctuation effects on the magnetic-field temperature phase diagram associated with the hexagonal Heisenberg antiferromagnet with weak axial anisotropy are reported. The multiphase point where three lines of continuous transitions merge at the spin-flop boundary exhibits a structure consistent with scaling theory but without the usual umbilicus as found in the case of a bicritical point.Comment: 7 pages (RevTex 3.0), 1 figure available upon request, CRPS-93-1

Design and Test of a Forward Neutron Calorimeter for the ZEUS Experiment

A lead scintillator sandwich sampling calorimeter has been installed in the HERA tunnel 105.6 m from the central ZEUS detector in the proton beam direction. It is designed to measure the energy and scattering angle of neutrons produced in charge exchange ep collisions. Before installation the calorimeter was tested and calibrated in the H6 beam at CERN where 120 GeV electrons, muons, pions and protons were made incident on the calorimeter. In addition, the spectrum of fast neutrons from charge exchange proton-lucite collisions was measured. The design and construction of the calorimeter is described, and the results of the CERN test reported. Special attention is paid to the measurement of shower position, shower width, and the separation of electromagnetic showers from hadronic showers. The overall energy scale as determined from the energy spectrum of charge exchange neutrons is compared to that obtained from direct beam hadrons.Comment: 45 pages, 22 Encapsulated Postscript figures, submitted to Nuclear Instruments and Method