Montane lakes (lagoons) of the New England Tablelands Bioregion

The vegetation of montane lagoons of the New England Tablelands Bioregion, New South Wales is examined using flexible UPGMA analysis of frequency scores on all vascular plant taxa, charophytes and one liverworts. Seven communities are described: 1. Hydrocotyle tripartita – Isotoma fluviatilis – Ranunculus inundatus – Lilaeopsis polyantha herbfield; 2. Eleocharis sphacelata – Potamogeton tricarinatus sedgeland; 3. Eleocharis sphacelata – Utricularia australis – Isolepis fluitans, herbfield; 4. Utricularia australis – Nitella sonderi herbfield; 5. Eleocharis sphacelata – Utricularia australis – Ricciocarpus natans sedgeland; 6. Carex gaudichaudiana – Holcus lanatus – Stellaria angustifolia sedgeland; 7. Cyperus sphaeroides – Eleocharis gracilis – Schoenus apogon – Carex gaudichaudiana sedgeland. 58 lagoons were located and identified, only 28% of which are considered to be intact and in good condition. Two threatened species (Aldovandra vesiculosa and Arthaxon hispidus) and three RoTAP-listed taxa were encountered during the survey

Microfocal X-Ray Computed Tomography Post-Processing Operations for Optimizing Reconstruction Volumes of Stented Arteries During 3D Computational Fluid Dynamics Modeling

Restenosis caused by neointimal hyperplasia (NH) remains an important clinical problem after stent implantation. Restenosis varies with stent geometry, and idealized computational fluid dynamics (CFD) models have indicated that geometric properties of the implanted stent may differentially influence NH. However, 3D studies capturing the in vivo flow domain within stented vessels have not been conducted at a resolution sufficient to detect subtle alterations in vascular geometry caused by the stent and the subsequent temporal development of NH. We present the details and limitations of a series of post-processing operations used in conjunction with microfocal X-ray CT imaging and reconstruction to generate geometrically accurate flow domains within the localized region of a stent several weeks after implantation. Microfocal X-ray CT reconstruction volumes were subjected to an automated program to perform arterial thresholding, spatial orientation, and surface smoothing of stented and unstented rabbit iliac arteries several weeks after antegrade implantation. A transfer function was obtained for the current post-processing methodology containing reconstructed 16 mm stents implanted into rabbit iliac arteries for up to 21 days after implantation and resolved at circumferential and axial resolutions of 32 and 50 μm, respectively. The results indicate that the techniques presented are sufficient to resolve distributions of WSS with 80% accuracy in segments containing 16 surface perturbations over a 16 mm stented region. These methods will be used to test the hypothesis that reductions in normalized wall shear stress (WSS) and increases in the spatial disparity of WSS immediately after stent implantation may spatially correlate with the temporal development of NH within the stented region

Participant acceptability of digital footprint data collection strategies:an exemplar approach to participant engagement and involvement in the ALSPAC birth cohort study

INTRODUCTION: Digital footprint records – the tracks and traces amassed by individuals as a result of their interactions with the internet, digital devices and services – can provide ecologically valid data on individual behaviours. These could enhance longitudinal population study databanks; but few UK longitudinal studies are attempting this. When using novel sources of data, study managers must engage with participants in order to develop ethical data processing frameworks that facilitate data sharing whilst safeguarding participant interests. OBJECTIVES: This paper aims to summarise the participant involvement approach used by the ALSPAC birth cohort study to inform the development of a framework for using linked participant digital footprint data, and provide an exemplar for other data linkage infrastructures. METHODS: The paper synthesises five qualitative forms of inquiry. Thematic analysis was used to code transcripts for common themes in relation to conditions associated with the acceptability of sharing digital footprint data for longitudinal research. RESULTS: We identified six themes: participant understanding; sensitivity of location data; concerns for third parties; clarity on data granularity; mechanisms of data sharing and consent; and trustworthiness of the organisation. For cohort members to consider the sharing of digital footprint data acceptable, they require information about the value, validity and risks; control over sharing elements of the data they consider sensitive; appropriate mechanisms to authorise or object to their records being used; and trust in the organisation. CONCLUSION: Realising the potential for using digital footprint records within longitudinal research will be subject to ensuring that this use of personal data is acceptable; and that rigorously controlled population data science benefiting the public good is distinguishable from the misuse and lack of personal control of similar data within other settings. Participant co-development informs the ethical-governance framework for these novel linkages in a manner which is acceptable and does not undermine the role of the trusted data custodian

Environmental Livelihood Security in Southeast Asia and Oceania: A Water-Energy-Food-Livelihoods Nexus Approach for Spatially Assessing Change

This document addresses the need for explicit inclusion of livelihoods within the environment nexus (water-energy-food security), not only responding to literature gaps but also addressing emerging dialogue from existing nexus consortia. We present the first conceptualization of ‘environmental livelihood security’, which combines the nexus perspective with sustainable livelihoods. The geographical focus of this paper is Southeast Asia and Oceania, a region currently wrought by the impacts of a changing climate. Climate change is the primary external forcing mechanism on the environmental livelihood security of communities in Southeast Asia and Oceania which, therefore, forms the applied crux of this paper. Finally, we provide a primer for using geospatial information to develop a spatial framework to enable geographical assessment of environmental livelihood security across the region. We conclude by linking the value of this research to ongoing sustainable development discussions, and for influencing policy agenda

Mode Competition in Relativistic Magnetrons and Injection Locking in KW Magnetrons

Both relativistic and nonrelativistic magnetrons are under experimental and theoretical investigation at U of M. Relativistic (Titan‐6‐vane) magnetron experiments (300–400 kV, 1–10 kA, 0.5 microsecond) investigate mode control with various output coupling geometries. Mode competition between the pi mode and the 2/3 pi mode has been characterized for two‐versus‐three output extractors for comparison with particle in cell simulations. Phase measurements and time‐frequency‐analysis are performed for mode identification. Peak microwave output power on the order 0.5 GW has been measured, assuming equal output from 3 waveguides. Nonrelativistic (4 kV, <1A, kW microwave power) magnetron experiments are performed on commercial oven magnetrons for an in‐depth investigation of crossed‐field injection‐locking and noise. Injection‐locking is demonstrated by utilizing an oven magnetron as a reflection amplifier. Noise generation is explored as a function of injected signal and cathode conditions. © 2003 American Institute of PhysicsPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87505/2/301_1.pd

Sustainable development and the water–energy–food nexus: A perspective on livelihoods

AbstractThe water–energy–food nexus is being promoted as a conceptual tool for achieving sustainable development. Frameworks for implementing nexus thinking, however, have failed to explicitly or adequately incorporate sustainable livelihoods perspectives. This is counterintuitive given that livelihoods are key to achieving sustainable development. In this paper we present a critical review of nexus approaches and identify potential linkages with sustainable livelihoods theory and practice, to deepen our understanding of the interrelated dynamics between human populations and the natural environment. Building upon this review, we explore the concept of ‘environmental livelihood security’ – which encompasses a balance between natural resource supply and human demand on the environment to promote sustainability – and develop an integrated nexus-livelihoods framework for examining the environmental livelihood security of a system. The outcome is an integrated framework with the capacity to measure and monitor environmental livelihood security of whole systems by accounting for the water, energy and food requisites for livelihoods at multiple spatial scales and institutional levels. We anticipate this holistic approach will not only provide a significant contribution to achieving national and regional sustainable development targets, but will also be effective for promoting equity amongst individuals and communities in local and global development agendas

Heritability and genome-wide analyses of problematic peer relationships during childhood and adolescence

Peer behaviour plays an important role in the development of social adjustment, though little is known about its genetic architecture. We conducted a twin study combined with a genome-wide complex trait analysis (GCTA) and a genome-wide screen to characterise genetic influences on problematic peer behaviour during childhood and adolescence. This included a series of longitudinal measures (parent-reported Strengths-and-Difficulties Questionnaire) from a UK population-based birth-cohort (ALSPAC, 4–17 years), and a UK twin sample (TEDS, 4–11 years). Longitudinal twin analysis (TEDS; N ≤ 7,366 twin pairs) showed that peer problems in childhood are heritable (4–11 years, 0.60 < twin-h 2 ≤ 0.71) but genetically heterogeneous from age to age (4–11 years, twin-r g = 0.30). GCTA (ALSPAC: N ≤ 5,608, TEDS: N ≤ 2,691) provided furthermore little support for the contribution of measured common genetic variants during childhood (4–12 years, 0.02<GCTA−h2Meta ≤ 0.11) though these influences become stronger in adolescence (13–17 years, 0.14<GCTA−h2ALSPAC ≤ 0.27). A subsequent cross-sectional genome-wide screen in ALSPAC (N ≤ 6,000) focussed on peer problems with the highest GCTA-heritability (10, 13 and 17 years, 0.0002 < GCTA-P ≤ 0.03). Single variant signals (P ≤ 10−5) were followed up in TEDS (N ≤ 2835, 9 and 11 years) and, in search for autism quantitative trait loci, explored within two autism samples (AGRE: N Pedigrees = 793; ACC: N Cases = 1,453/N Controls = 7,070). There was, however, no evidence for association in TEDS and little evidence for an overlap with the autistic continuum. In summary, our findings suggest that problematic peer relationships are heritable but genetically complex and heterogeneous from age to age, with an increase in common measurable genetic variation during adolescence

Gravity-darkening Analysis of the Misaligned Hot Jupiter MASCARA-4 b

MASCARA-4 b is a hot Jupiter in a highly misaligned orbit around a rapidly rotating A3V star that was observed for 54 days by the Transiting Exoplanet Survey Satellite (TESS). We perform two analyses of MASCARA-4 b using a stellar gravity-darkened model. First, we measure MASCARA-4 b's misaligned orbital configuration by modeling its TESS photometric light curve. We take advantage of the asymmetry in MASCARA-4 b's transit due to its host star's gravity-darkened surface to measure MASCARA-4 b's true spin–orbit angle to be 104°+7°-13°. We also detect a ~4σ secondary eclipse at 0.491 ± 0.007 orbital phase, proving that the orbit is slightly eccentric. Second, we model MASCARA-4 b's insolation including gravity darkening and find that the planet's received X-ray and ultraviolet flux varies by 4% throughout its orbit. MASCARA-4 b's short-period, polar orbit suggests that the planet likely underwent dramatic orbital evolution to end up in its present-day configuration and that it receives a varying stellar irradiance that perpetually forces the planet out of thermal equilibrium. These findings make MASCARA-4 b an excellent target for follow-up characterization to better understand the orbital evolution and present-day environment of planets around high-mass stars

BronchUK:protocol for an observational cohort study and biobank in bronchiectasis

Bronchiectasis has been a largely overlooked disease area in respiratory medicine. This is reflected by a shortage of large-scale studies and lack of approved therapies, in turn leading to a variation of treatment across centres. BronchUK (Bronchiectasis Observational Cohort and Biobank UK) is a multicentre, prospective, observational cohort study working collaboratively with the European Multicentre Bronchiectasis Audit and Research Collaboration project. The inclusion criteria for patients entering the study are a clinical history consistent with bronchiectasis and computed tomography demonstrating bronchiectasis. Main exclusion criteria are 1) patients unable to provide informed consent, 2) bronchiectasis due to known cystic fibrosis or where bronchiectasis is not the main or co-dominant respiratory disease, 3) age <18 years, and 4) prior lung transplantation for bronchiectasis. The study is aligned to standard UK National Health Service (NHS) practice with an aim to recruit a minimum of 1500 patients from across at least nine secondary care centres. Patient data collected at baseline includes demographics, aetiology testing, comorbidities, lung function, radiology, treatments, microbiology and quality of life. Patients are followed up annually for a maximum of 5 years and, where able, blood and/or sputa samples are collected and stored in a central biobank. BronchUK aims to collect robust longitudinal data that can be used for analysis into current NHS practice and patient outcomes, and to become an integral resource to better inform future interventional studies in bronchiectasis