Shifting Patterns in Marks and Registration: France, the United States and United Kingdom, 1870-1970

This paper looks at trademarks and brands, beyond the conventional interests of marketing and law, as a way to explaining the evolution of international business and economies in general. It shows that the perspective defended by many scholars such as Chandler (1990), Wilkins (1991, 1994) and Koehn’ (2001), about the Anglo-Saxon countries, and in particular the United States, leading the transition to modern trade-marks is narrow in its focus. Instead of the United States standing out as historically on the leading edge of innovation in the law and practice of trade marking, it appears from several directions to have been on the trailing edge. France and Britain have a more enduring interest in trademarking. The paper also looks at one particular subset of trade mark registration data – non durable consumer goods. These, and in particular food, are the dominant sectors in the three countries in terms of trademarking, reflecting the character of the sectors where imagery associated with the products is so central in competition. The paper relies on original data from three countries, France, the United Kingdom and the United States, in particular trade mark registrations, and the analysis spans for a period of one hundred years period 1870-1970.trade marks, brands, international business history, intellectual property rights, trademark law

Structural characterization of the Redox-Dependent differences in the Cytochrome P450cam-Putidaredoxin Complex using solution NMR spectroscopy

Complexation between proteins as part of biological electron transfer reactions is driven by precise interactions that are often characterized by short lifetimes, weak affinities and high turnover rates. These complex interactions are difficult to study structurally in physiologically relevant oxidation states due to their transient nature and/or large molecular sizes. One such protein complex in the cytochrome P450 family of enzymes that is of great interest to researchers due to its prototypical nature is the Putidaredoxin (Pdx)- cytochrome P450cam (CYP101) electron transfer complex that is involved in hydroxylation of D-camphor in the bacterium Pseudomonas putida. While the individual protein structures for Pdx and CYP101 have been known for several years in both oxidized and reduced states, high-resolution structural information for the Pdx-CYP101 complex is still lacking in either oxidation state. This structural information is critical to not only determine the electron transfer pathway between the two proteins in this complex, but also to explain the role of Pdx as an effector in substrate turnover. In this study, a solution NMR approach utilizing long-range distance restraints derived from paramagnetic relaxation effects is used to obtain structures of the Pdx-CYP101 complex in both substrate-bound oxidized and a catalytically competent reduced form. Key redox-dependent structural and dynamic differences between the two complexes have been characterized which provide insights into the mechanism of effector activity of Pdx

Learning from the pandemic, building increased international cooperation

The COVID-19 pandemic highlighted a fragile preparation by countries and regions for epidemic events, exposing exacerbated nationalisms in pandemic mitigation and control actions. Both conditions decisively compromise the effectiveness and efficiency of pandemic control capacity. It is important to develop frameworks that help overcome frailties in response to epidemics. Based on a thematic literature review and discussions with multiple national and international entities an attempt was made to build a tool for responding to future epidemics, the Pandemic Preparation Framework (2PF). The proposed 2PF tool is aligned with the Sendai Framework for Disaster Risk Reduction and with international bodies, such as the European Health Emergency Preparedness and Response Authority (HERA). It aims to be a framework for operationalizing these agreements. The response to pandemics must be based essentially on international action and closer collaboration between countries and regions. &nbsp

Learning from the pandemic, building increased international cooperation

The COVID-19 pandemic highlighted a fragile preparation by countries and regions for epidemic events, exposing exacerbated nationalisms in pandemic mitigation and control actions. Both conditions decisively compromise the effectiveness and efficiency of pandemic control capacity. It is important to develop frameworks that help overcome frailties in response to epidemics. Based on a thematic literature review and discussions with multiple national and international entities an attempt was made to build a tool for responding to future epidemics, the Pandemic Preparation Framework (2PF). The proposed 2PF tool is aligned with the Sendai Framework for Disaster Risk Reduction and with international bodies, such as the European Health Emergency Preparedness and Response Authority (HERA). It aims to be a framework for operationalizing these agreements. The response to pandemics must be based essentially on international action and closer collaboration between countries and regions.   Acknowledgments: The authors acknowledge Diogo Franco of the USP-ICS/UCP scientific secretariat for his support in this article.   Authors’ contribution: The authors contributed equally to this article.   Conflict of interest: None declared.   Sources of funding: None declared

A Correlational Analysis of Length and Nature of Relationships Between Applicant and Reference and Strength of Recommendation for CASPA Letters of Recommendation

Background: The Central Application Service for Physician Assistants (CASPA) application includes a standardized rating form in addition to the ability to submit letters of recommendation. This exploratory study examines the standardized portion of the CASPA letter of recommendation to determine whether there is a correlation between the ratings given and the relationship and length of time the writer knew the applicant. Method: Four-hundred and thirty recommendation forms were evaluated. Variables included length and nature of the relationship between the letter writer and the overall recommendation given by the writer for the applicant. Results: Almost 95% of writers highly recommended the applicant. There was a weak correlation between length of relationship and overall evaluation rating and recommendation to the program r = 0.12 and r = 0.17, respectively. A moderate correlation was found between the nature of the relationship (r = 0.34) and overall evaluation (r = 0.30). Conclusion: This study might indicate that the nature of the relationship between the writer and applicant and may provide programs with a metric to evaluate the strength of letters of recommendation

Event-Driven Network Programming

Software-defined networking (SDN) programs must simultaneously describe static forwarding behavior and dynamic updates in response to events. Event-driven updates are critical to get right, but difficult to implement correctly due to the high degree of concurrency in networks. Existing SDN platforms offer weak guarantees that can break application invariants, leading to problems such as dropped packets, degraded performance, security violations, etc. This paper introduces EVENT-DRIVEN CONSISTENT UPDATES that are guaranteed to preserve well-defined behaviors when transitioning between configurations in response to events. We propose NETWORK EVENT STRUCTURES (NESs) to model constraints on updates, such as which events can be enabled simultaneously and causal dependencies between events. We define an extension of the NetKAT language with mutable state, give semantics to stateful programs using NESs, and discuss provably-correct strategies for implementing NESs in SDNs. Finally, we evaluate our approach empirically, demonstrating that it gives well-defined consistency guarantees while avoiding expensive synchronization and packet buffering

Development of the stria vascularis and potassium regulation in the human fetal cochlea : insights into hereditary sensorineural hearing loss

Sensorineural hearing loss (SNHL) is one of the most common congenital disorders in humans, afflicting one in every thousand newborns. The majority is of heritable origin and can be divided in syndromic and nonsyndromic forms. Knowledge of the expression profile of affected genes in the human fetal cochlea is limited, and as many of the gene mutations causing SNHL likely affect the stria vascularis or cochlear potassium homeostasis (both essential to hearing), a better insight into the embryological development of this organ is needed to understand SNHL etiologies. We present an investigation on the development of the stria vascularis in the human fetal cochlea between 9 and 18 weeks of gestation (W9–W18) and show the cochlear expression dynamics of key potassium‐regulating proteins. At W12, MITF+/SOX10+/KIT+ neural‐crest‐derived melanocytes migrated into the cochlea and penetrated the basement membrane of the lateral wall epithelium, developing into the intermediate cells of the stria vascularis. These melanocytes tightly integrated with Na(+)/K(+)‐ATPase‐positive marginal cells, which started to express KCNQ1 in their apical membrane at W16. At W18, KCNJ10 and gap junction proteins GJB2/CX26 and GJB6/CX30 were expressed in the cells in the outer sulcus, but not in the spiral ligament. Finally, we investigated GJA1/CX43 and GJE1/CX23 expression, and suggest that GJE1 presents a potential new SNHL associated locus. Our study helps to better understand human cochlear development, provides more insight into multiple forms of hereditary SNHL, and suggests that human hearing does not commence before the third trimester of pregnancy. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 1219–1240, 201