868 research outputs found
Phase transition of a one-dimensional Ising model with distance-dependent connections
The critical behavior of Ising model on a one-dimensional network, which has
long-range connections at distances with the probability , is studied by using Monte Carlo simulations. Through studying the
Ising model on networks with different values, this paper discusses the
impact of the global correlation, which decays with the increase of , on the
phase transition of the Ising model. Adding the analysis of the finite-size
scaling of the order parameter , it is observed that in the whole range
of , a finite-temperature transition exists, and the critical exponents
show consistence with mean-field values, which indicates a mean-field nature of
the phase transition.Comment: 5 pages,8 figure
Entanglement and boundary critical phenomena
We investigate boundary critical phenomena from a quantum information
perspective. Bipartite entanglement in the ground state of one-dimensional
quantum systems is quantified using the Renyi entropy S_alpha, which includes
the von Neumann entropy (alpha=1) and the single-copy entanglement
(alpha=infinity) as special cases. We identify the contribution from the
boundary entropy to the Renyi entropy, and show that there is an entanglement
loss along boundary renormalization group (RG) flows. This property, which is
intimately related to the Affleck-Ludwig g-theorem, can be regarded as a
consequence of majorization relations between the spectra of the reduced
density matrix along the boundary RG flows. We also point out that the bulk
contribution to the single-copy entanglement is half of that to the von Neumann
entropy, whereas the boundary contribution is the same.Comment: 4 pages, 2 figure
Lack of self-averaging of the specific heat in the three-dimensional random-field Ising model
We apply the recently developed critical minimum energy subspace scheme for
the investigation of the random-field Ising model. We point out that this
method is well suited for the study of this model. The density of states is
obtained via the Wang-Landau and broad histogram methods in a unified
implementation by employing the N-fold version of the Wang-Landau scheme. The
random-fields are obtained from a bimodal distribution (), and the
scaling of the specific heat maxima is studied on cubic lattices with sizes
ranging from to . Observing the finite-size scaling behavior of the
maxima of the specific heats we examine the question of saturation of the
specific heat. The lack of self-averaging of this quantity is fully illustrated
and it is shown that this property may be related to the question mentioned
above.Comment: 8 pages, 7 figures, extended version with two new figures, version as
accepted for publication to Physical Review
Series expansions without diagrams
We discuss the use of recursive enumeration schemes to obtain low and high
temperature series expansions for discrete statistical systems. Using linear
combinations of generalized helical lattices, the method is competitive with
diagramatic approaches and is easily generalizable. We illustrate the approach
using the Ising model and generate low temperature series in up to five
dimensions and high temperature series in three dimensions. The method is
general and can be applied to any discrete model. We describe how it would work
for Potts models.Comment: 24 pages, IASSNS-HEP-93/1
A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression.
Predicting antidepressant response has been a clinical challenge for mood disorder. Although several genome-wide association studies have suggested a number of genetic variants to be associated with antidepressant response, the sample sizes are small and the results are difficult to replicate. Previous animal studies have shown that knockout of the serotonin receptor 7 gene (HTR7) resulted in an antidepressant-like phenotype, suggesting it was important to antidepressant action. In this report, in the first stage, we used a cost-effective pooled-sequencing strategy to sequence the entire HTR7 gene and its regulatory regions to investigate the association of common variants in HTR7 and clinical response to four selective serotonin reuptake inhibitors (SSRIs: citalopram, paroxetine, fluoxetine and sertraline) in a retrospective cohort mainly consisting of subjects with bipolar disorder (n = 359). We found 80 single-nucleotide polymorphisms (SNPs) with false discovery rate < 0.05 associated with response to paroxetine. Among the significant SNPs, rs7905446 (T/G), which is located at the promoter region, also showed nominal significance (P < 0.05) in fluoxetine group. GG/TG genotypes for rs7905446 and female gender were associated with better response to two SSRIs (paroxetine and fluoxetine). In the second stage, we replicated this association in two independent prospective samples of SSRI-treated patients with major depressive disorder: the MARS (n = 253, P = 0.0169) and GENDEP studies (n = 432, P = 0.008). The GG/TG genotypes were consistently associated with response in all three samples. Functional study of rs7905446 showed greater activity of the G allele in regulating expression of HTR7. The G allele displayed higher luciferase activity in two neuronal-related cell lines, and estrogen treatment decreased the activity of only the G allele. Electrophoretic mobility shift assay suggested that the G allele interacted with CCAAT/enhancer-binding protein beta transcription factor (TF), while the T allele did not show any interaction with any TFs. Our results provided novel pharmacogenomic evidence to support the role of HTR7 in association with antidepressant response
Neurophysiology
Contains reports on seven research projects.National Institutes of Health (Grant 5 RO1 EY01149-02)Bell Telephone Laboratories, Inc. (Grant)National Institutes of Health (Grant 1 TO1 EY00090-01
A resting EEG study of neocortical hyperexcitability and altered functional connectivity in fragile X syndrome
(A) Scalp topographies of “local coupling”, showing correlations in each electrode between relative power of activity in the theta, and lower and upper alpha power bands and gamma power for male FXS and male healthy control participants, with significant group differences presented in the bottom row (p < 0.05, corrected), with dark blue reflecting no group difference. (B) Mean and standard error of correlations for all electrodes showing group differences as are plotted in A. * denotes correlations of spectral power in theta and upper alpha bands with gamma band power that are significantly different from zero based on the results of permutation analyses at p < 0.05. (TIF 4297 kb
Quantum effects in a superconducting glass model
We study disordered Josephson junctions arrays with long-range interaction
and charging effects. The model consists of two orthogonal sets of positionally
disordered parallel filaments (or wires) Josephson coupled at each crossing
and in the presence of a homogeneous and transverse magnetic field. The large
charging energy (resulting from small self-capacitance of the ultrathin wires)
introduces important quantum fluctuations of the superconducting phase within
each filament. Positional disorder and magnetic field frustration induce
spin-glass like ground state, characterized by not having long-range order of
the phases. The stability of this phase is destroyed for sufficiently large
charging energy. We have evaluated the temperature vs charging energy phase
diagram by extending the methods developed in the theory of infinite-range spin
glasses, in the limit of large magnetic field. The phase diagram in the
different temperature regimes is evaluated by using variety of methods, to wit:
semiclassical WKB and variational methods, Rayleigh-Schr\"{o}dinger
perturbation theory and pseudospin effective Hamiltonians. Possible
experimental consequences of these results are briefly discussed.Comment: 17 pages REVTEX. Two Postscript figures can be obtained from the
authors. To appear in PR
Identification of Functionally Distinct Na-HCO3 Co-Transporters in Colon
Na-HCO3 cotransport (NBC) regulates intracellular pH (pHi) and HCO3 secretion in rat colon. NBC has been characterized as a 5,5′-diisothiocyanato-2-2′-stilbene (DIDS)-sensitive transporter in several tissues, while the colonic NBC is sensitive to both amiloride and DIDS. In addition, the colonic NBC has been identified as critical for pHi regulation as it is activated by intravesicular acid pH. Molecular studies have identified several characteristically distinct NBC isoforms [i.e. electrogenic (NBCe) and electroneutral (NBCn)] that exhibit tissue specific expression. This study was initiated to establish the molecular identity and specific function of NBC isoforms in rat colon. Northern blot and reverse transcriptase PCR (RT-PCR) analyses revealed that electrogenic NBCe1B or NBCe1C (NBCe1B/C) isoform is predominantly expressed in proximal colon, while electroneutral NBCn1C or NBCn1D (NBCn1C/D) is expressed in both proximal and distal colon. Functional analyses revealed that amiloride-insensitive, electrogenic, pH gradient-dependent NBC activity is present only in basolateral membranes of proximal colon. In contrast, amiloride-sensitive, electroneutral, [H+]-dependent NBC activity is present in both proximal and distal colon. Both electrogenic and electroneutral NBC activities are saturable processes with an apparent Km for Na of 7.3 and 4.3 mM, respectively; and are DIDS-sensitive with apparent Ki of 8.9 and 263.8 µM, respectively. In addition to Na-H exchanger isoform-1 (NHE1), pHi acidification is regulated by a HCO3-dependent mechanism that is HOE694-insensitive in colonic crypt glands. We conclude from these data that electroneutral, amiloride-sensitive NBC is encoded by NBCn1C/D and is present in both proximal and distal colon, while NBCe1B/C encodes electrogenic, amiloride-insensitive Na-HCO3 cotransport in proximal colon. We also conclude that NBCn1C/D regulates HCO3-dependent HOE694-insensitive Na-HCO3 cotransport and plays a critical role in pHi regulation in colonic epithelial cells
Critical Behaviour of Superfluid He in Aerogel
We report on Monte Carlo studies of the critical behaviour of superfluid
He in the presence of quenched disorder with long-range fractal
correlations. According to the heuristic argument by Harris, uncorrelated
disorder is irrelevant when the specific heat critical exponent is
negative, which is the case for the pure He. However, experiments on helium
in aerogel
have shown that the superfluid density critical exponent changes. We
hypothesize that this is a cross-over effect due to the fractal nature of
aerogel. Modelling the aerogel as an incipient percolating cluster in 3D and
weakening the bonds at the fractal sites, we perform XY-model simulations,
which demonstrate an increase in from
for the pure case to an apparent value of in the presence of
the fractal disorder, provided that the helium correlation length does not
exceed the fractal correlation length.Comment: 4 pages, RevTex, 3 postscript figures, LaTeX file and figures have
been uuencoded
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