264 research outputs found
Challenges of Deliberation and Participation
The future of sustainability is tied to the future of our ability to manage interconnectedness and interdependence,
and thus to our abilities to engage in cooperative, value-creating public deliberations and
negotiations.To understand these issues,we need a better understanding of the micro-politics of planning
and public participation, the relationships between our received theories and our practices, and in
particular, the work of public dispute resolution and its implications for democratic deliberation and
governance.We need better to understand the differences between dialogue, debate, and negotiation,
as well as the corresponding work of facilitating a dialogue, moderating a debate, and mediating an
actual negotiation. Contrasting processes and practical attitudes of dialogue, debate, and negotiation
can teach us, in the context of creating a sustainable future, that we must devise discursive and conversational
political processes and institutions that explore possible commitments so that we not only
know the right things to do but actually bring ourselves and one another to do those right things.L’avenir de la durabilité est rattaché à notre capacité future de gérer l’interconnexion et l’interdépendance,
et par conséquent nos capacités à nous engager dans des discussions et des négociations publiques
coopératives et valorisantes. Pour comprendre ces questions, nous avons besoin d’une meilleure
compréhension de la micropolitique de la planification et de la participation publique, des rapports
entre nos théories et nos pratiques et,en particulier,des pratiques de résolutions publiques de conflit et
de ses implications pour la délibération et la gouvernance démocratiques.Nous devons mieux comprendre
les diffĂ©rences entre le dialogue, la discussion et la nĂ©gociation, ainsi que du travail correspondant Ă
faciliter un dialogue, à modérer une discussion, et à faire la médiation d’une négociation réelle. La comparaison
des processus et des attitudes pratiques de dialogue, de discussion et de négociation nous
enseigne, en ce qui concerne l’objectif de créer un futur soutenable, que nous devons concevoir des processus
et des institutions politiques discursives et communicationnelles qui explorent les engagements
possibles, de sorte que nous puissions non seulement comprendre quelles sont les bonnes choses Ă
faire, mais pour nous emmener réellement les uns et les autres à faire ces bonnes choses
In the Works: Conflict in the Context of Everyday Practice
Conflict is a fascinating topic. It is personal, emotional, and an integral part of any job. But public officials, especially planners in the public sector, are party to a unique form of conflict. In the following collection, some of the planner's roles, tactics, and interactions are summarily presented. See if you can't find your own approach among these quotes
Used-habitat calibration plots: a new procedure for validating species distribution, resource selection, and step-selection models
“Species distribution modeling” was recently ranked as one of the top five “research fronts” in ecology and the environmental sciences by ISI's Essential Science Indicators (Renner and Warton 2013), reflecting the importance of predicting how species distributions will respond to anthropogenic change. Unfortunately, species distribution models (SDMs) often perform poorly when applied to novel environments. Compounding on this problem is the shortage of methods for evaluating SDMs (hence, we may be getting our predictions wrong and not even know it). Traditional methods for validating SDMs quantify a model's ability to classify locations as used or unused. Instead, we propose to focus on how well SDMs can predict the characteristics of used locations. This subtle shift in viewpoint leads to a more natural and informative evaluation and validation of models across the entire spectrum of SDMs. Through a series of examples, we show how simple graphical methods can help with three fundamental challenges of habitat modeling: identifying missing covariates, non-linearity, and multicollinearity. Identifying habitat characteristics that are not well-predicted by the model can provide insights into variables affecting the distribution of species, suggest appropriate model modifications, and ultimately improve the reliability and generality of conservation and management recommendations
Draft Function Allocation Framework and Preliminary Technical Basis for Advanced SMR Concepts of Operations
This report presents preliminary research results from the investigation in to the development of new models and guidance for concepts of operations (ConOps) in advanced small modular reactor (aSMR) designs. In support of this objective, three important research areas were included: operating principles of multi-modular plants, functional allocation models and strategies that would affect the development of new, non-traditional concept of operations, and the requiremetns for human performance, based upon work domain analysis and current regulatory requirements. As part of the approach for this report, we outline potential functions, including the theoretical and operational foundations for the development of a new functional allocation model and the identification of specific regulatory requirements that will influence the development of future concept of operations. The report also highlights changes in research strategy prompted by confirmationof the importance of applying the work domain analysis methodology to a reference aSMR design. It is described how this methodology will enrich the findings from this phase of the project in the subsequent phases and help in identification of metrics and focused studies for the determination of human performance criteria that can be used to support the design process
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A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.
Small nucleolar RNAs (snoRNAs) are a diverse group of non-coding RNAs that direct chemical modifications at specific residues on other RNA molecules, primarily on ribosomal RNA (rRNA). SnoRNAs are altered in several cancers; however, their role in cell homeostasis as well as in cellular transformation remains poorly explored. Here, we show that specific subsets of snoRNAs are differentially regulated during the earliest cellular response to oncogenic RASG12V expression. We describe a novel function for one H/ACA snoRNA, SNORA24, which guides two pseudouridine modifications within the small ribosomal subunit, in RAS-induced senescence in vivo. We find that in mouse models, loss of Snora24 cooperates with RASG12V to promote the development of liver cancer that closely resembles human steatohepatitic hepatocellular carcinoma (HCC). From a clinical perspective, we further show that human HCCs with low SNORA24 expression display increased lipid content and are associated with poor patient survival. We next asked whether ribosomes lacking SNORA24-guided pseudouridine modifications on 18S rRNA have alterations in their biophysical properties. Single-molecule Fluorescence Resonance Energy Transfer (FRET) analyses revealed that these ribosomes exhibit perturbations in aminoacyl-transfer RNA (aa-tRNA) selection and altered pre-translocation ribosome complex dynamics. Furthermore, we find that HCC cells lacking SNORA24-guided pseudouridine modifications have increased translational miscoding and stop codon readthrough frequencies. These findings highlight a role for specific snoRNAs in safeguarding against oncogenic insult and demonstrate a functional link between H/ACA snoRNAs regulated by RAS and the biophysical properties of ribosomes in cancer
An assessment of high carbon stock and high conservation value approaches to sustainable oil palm cultivation in Gabon
Industrial-scale oil palm cultivation is rapidly expanding in Gabon, where it has the potential to drive economic growth, but also threatens forest, biodiversity and carbon resources. The Gabonese government is promoting an ambitious agricultural expansion strategy, while simultaneously committing to minimize negative environmental impacts of oil palm agriculture. This study estimates the extent and location of suitable land for oil palm cultivation in Gabon, based on an analysis of recent trends in plantation permitting. We use the resulting suitability map to evaluate two proposed approaches to minimizing negative environmental impacts: a High Carbon Stock (HCS) approach, which emphasizes forest protection and climate change mitigation, and a High Conservation Value (HCV) approach, which focuses on safeguarding biodiversity and ecosystems. We quantify the forest area, carbon stock, and biodiversity resources protected under each approach, using newly developed maps of priority species distributions and forest biomass for Gabon. We find 2.7–3.9 Mha of suitable or moderately suitable land that avoid HCS areas, 4.4 million hectares (Mha) that avoid HCV areas, and 1.2–1.7 Mha that avoid both. This suggests that Gabon's oil palm production target could likely be met without compromising important ecosystem services, if appropriate safeguards are put in place. Our analysis improves understanding of suitability for oil palm in Gabon, determines how conservation strategies align with national targets for oil palm production, and informs national land use planning
Considering adaptive genetic variation in climate change vulnerability assessment reduces species range loss projections
Local adaptations can determine the potential of populations to respond to environmental changes, yet adaptive genetic variation is commonly ignored in models forecasting species vulnerability and biogeographical shifts under future climate change. Here we integrate genomic and ecological modeling approaches to identify genetic adaptations associated with climate in two cryptic forest bats. We then incorporate this information directly into forecasts of range changes under future climate change and assessment of population persistence through the spread of climate-adaptive genetic variation (evolutionary rescue potential). Considering climate-adaptive potential reduced range loss projections, suggesting that failure to account for intraspecific variability can result in overestimation of future losses. On the other hand, range overlap between species was projected to increase, indicating that interspecific competition is likely to play an important role in limiting species’ future ranges. We show that although evolutionary rescue is possible, it depends on a population’s adaptive capacity and connectivity. Hence, we stress the importance of incorporating genomic data and landscape connectivity in climate change vulnerability assessments and conservation management
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