Measuring Nothing

Measurement is integral to quantum information processing and communication; it is how information encoded in the state of a system is transformed into classical signals for further use. In quantum optics, measurements are typically destructive, so that the state is not available afterwards for further steps - crucial for sequential measurement schemes. The development of practical methods for non-destructive measurements on optical fields is therefore an important topic for future practical quantum information processing systems. Here we show how to measure the presence or absence of the vacuum in a quantum optical field without destroying the state, implementing the ideal projections onto the respective subspaces. This not only enables sequential measurements, useful for quantum communication, but it can also be adapted to create novel states of light via bare raising and lowering operators.Comment: 7 pages, 4 figure

Effect Of Starvation On The Dynamic Properties Of Tilting Pad Journal Bearings

LectureA new 46 MW steam turbine became unstable as the load on the turbine was increased. The turbine had a relatively long slender shaft and the subsynchronous frequency was near the first critical speed of 1800 rpm. In an effort to allow the machine to reach full load a bearing redesign was undertaken. The bearing design was changed from the original 5 pad tilting pad journal (TPJ) bearings, orientated with the load on the bottom pad (LOP), to three pad TPJ’s also in the LOP configuration. Analysis indicated that the additional asymmetry in the dynamic coefficients would significantly increase the system logarithmic decrement (log dec) and allow the machine to run at full load without going unstable. With the three pad bearings installed the machine was brought up in speed and experienced subsynchronous vibration before reaching full speed. A design review of the bearings indicated that the top two pads of the three pad bearing were operating in the fully starved condition; that is they were not receiving sufficient oil to develop a hydrodynamic oil film. As such the horizontal stiffness went to near zero. This paper will present the results of the analysis work performed, including the starved bearing analysis, and the resulting redesign of the three pad bearing to run flooded. Operation as a flooded bearing allowed the machine to run fully loaded with no indications of unstable operation

Quantum Hilbert hotel

In 1924 David Hilbert conceived a paradoxical tale involving a hotel with an infinite number of rooms to illustrate some aspects of the mathematical notion of “infinity.” In continuous-variable quantum mechanics we routinely make use of infinite state spaces: here we show that such a theoretical apparatus can accommodate an analog of Hilbert’s hotel paradox. We devise a protocol that, mimicking what happens to the guests of the hotel, maps the amplitudes of an infinite eigenbasis to twice their original quantum number in a coherent and deterministic manner, producing infinitely many unoccupied levels in the process. We demonstrate the feasibility of the protocol by experimentally realizing it on the orbital angular momentum of a paraxial field. This new non-Gaussian operation may be exploited, for example, for enhancing the sensitivity of NOON states, for increasing the capacity of a channel, or for multiplexing multiple channels into a single one

Elastic Interfacial Waves in Discrete and Continuous Media

Phonon spectra of bicrystals with relaxed grain-boundary structure display a variety of localized modes including long-wavelength acoustic modes. Continuum solutions for localized waves that incorporate atomic-level elastic properties of the interface via discontinuity relations agree well with the latter modes. In contrast, classical solutions that depend only on bulk elastic properties do not. This demonstrates that the distinct atomic structure of the interface is a controlling factor, and it is shown how local, atomic-level properties can be incorporated into continuum analyses of interfacial phenomena

Mapping European ideoscapes: examining newspaper debates on the EU Constitution in seven European countries

Despite embracing the rhetoric of transnational flows and networks, comparative research on media content continues to fall prey to methodological nationalism. When it comes to empirical measurement, researchers often, despite their best intentions, fall back on techniques that assume that the discourses circulating within particular nationally bounded communicative spaces are homogenous. In this article, we developed a set of propositions and analytical approaches that should help to overcome this impasse, and used them to examine the newspaper debates on the EU Constitutional Treaty in seven European states: the Czech Republic, Germany, France, the Slovak Republic, Slovenia, Switzerland, and the UK. We suggested that instead of focusing solely on comparisons between nationally bounded communicative spheres, we should also look at differences between class-related communicative spaces. By adopting such an approach, we can acknowledge both sub-national segmentations of communicative spaces and transnational linkages, while at the same time not losing sight of the importance of the national. The results support our initial contention that the research on European mass communication ought to move beyond comparisons between national units and the levels of their respective Europeanization, and examine how European issues are conveyed in media catering to different social classes

Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation : exploring opportunities between reactive and antisolvent crystallization concepts

This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals

Photocathode Behavior During High Current Running in the Cornell ERL Photoinjector

The Cornell University Energy Recovery Linac (ERL) photoinjector has recently demonstrated operation at 20 mA for approximately 8 hours, utilizing a multialkali photocathode deposited on a Si substrate. We describe the recipe for photocathode deposition, and will detail the parameters of the run. Post-run analysis of the photocathode indicates the presence of significant damage to the substrate, perhaps due to ion back-bombardment from the residual beamline gas. While the exact cause of the substrate damage remains unknown, we describe multiple surface characterization techniques (X-ray fluorescence spectroscopy, X-ray diffraction, atomic force and scanning electron microscopy) used to study the interesting morphological and crystallographic features of the photocathode surface after its use for high current beam production. Finally, we present a simple model of crystal damage due to ion back-bombardment, which agrees qualitatively with the distribution of damage on the substrate surface.Comment: 20 pages, 15 figure

Crystallization diagram for antisolvent crystallization of lactose : using design of experiments to investigate continuous mixing- induced supersaturation

This study investigates the effects of key process parameters of continuous mixing-induced supersaturation on the antisolvent crystallization of lactose using D-optimal Design of Experiments (DoE). Aqueous solutions of lactose were mixed isothermally with antisolvents using a concentric capillary mixer. Process parameters investigated were the choice of antisolvent (acetone or isopropanol), concentration of lactose solution, total mass flow rate, and the ratio of mass flow rates of lactose solution and antisolvent. Using a D-optimal DoE a statistically significant sample set was chosen to explore and quantify the effects of these parameters. The responses measured were the solid state of the lactose crystallized, induction time, solid yield and particle size. Mixtures of α-lactose monohydrate and β-lactose were crystallized under most conditions with β-lactose content increasing with increasing amount of antisolvent. Pure α-lactose monohydrate was crystallized using acetone as the antisolvent, with mass flow ratios near 1:1, and near saturated solutions of lactose. A higher resolution DoE was adopted for acetone and was processed using multivariate methods to obtain a crystallization diagram of lactose. The model was used to create an optimized process to produce α-lactose monohydrate and predicted results agreed well with those obtained experimentally, validating the model. The solid state of lactose, induction time, and solid yield were accurately predicted

Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.

The protein kinase ATR plays pivotal roles in DNA repair, cell cycle checkpoint engagement and DNA replication. Consequently, ATR inhibitors (ATRi) are in clinical development for the treatment of cancers, including tumours harbouring mutations in the related kinase ATM. However, it still remains unclear which functions and pathways dominate long-term ATRi efficacy, and how these vary between clinically relevant genetic backgrounds. Elucidating common and genetic-background specific mechanisms of ATRi efficacy could therefore assist in patient stratification and pre-empting drug resistance. Here, we use CRISPR-Cas9 genome-wide screening in ATM-deficient and proficient mouse embryonic stem cells to interrogate cell fitness following treatment with the ATRi, ceralasertib. We identify factors that enhance or suppress ATRi efficacy, with a subset of these requiring intact ATM signalling. Strikingly, two of the strongest resistance-gene hits in both ATM-proficient and ATM-deficient cells encode Cyclin C and CDK8: members of the CDK8 kinase module for the RNA polymerase II mediator complex. We show that Cyclin C/CDK8 loss reduces S-phase DNA:RNA hybrid formation, transcription-replication stress, and ultimately micronuclei formation induced by ATRi. Overall, our work identifies novel biomarkers of ATRi efficacy in ATM-proficient and ATM-deficient cells, and highlights transcription-associated replication stress as a predominant driver of ATRi-induced cell death