Metal and Plastic Recycling Flows in a Circular Value Chain

Material efficiency in manufacturing is an enabler of circular economy and captures value in industry through decreasing the amount of material used toproduce one unit of output, generating less waste per output and improving waste segregation and management. However, material types and fractions play an important role in successfulness of recycling initiatives. This study investigates two main fractions in automotive industry, namely, metal and plastic. For both material flows, information availability and standards and regulations are pivotal to increase segregation, optimize the collection and obtain the highest possible circulation rates with high quality of recyclables. This paper presents and compares the current information flows and standards and regulations of metals and plastics in the automotive value chain

Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker

Background The molecular pathogenesis of T-cell large granular lymphocytic leukemia (T-LGLL), a mature T-cell leukemia arising commonly from T-cell receptor αβ-positive CD8+ memory cytotoxic T cells, is only partly understood. The role of deregulated methylation in T-LGLL is not well known. We analyzed the epigenetic profile of T-LGLL cells of 11 patients compared to their normal counterparts by array-based DNA methylation profiling. For identification of molecular events driving the pathogenesis of T-LGLL, we compared the differentially methylated loci between the T-LGLL cases and normal T cells with chromatin segmentation data of benign T cells from the BLUEPRINT project. Moreover, we analyzed gene expression data of T-LGLL and benign T cells and validated the results by pyrosequencing in an extended cohort of 17 patients, including five patients with sequential samples. Results We identified dysregulation of DNA methylation associated with altered gene expression in T-LGLL. Since T-LGLL is a rare disease, the samples size is low. But as confirmed for each sample, hypermethylation of T-LGLL cells at various CpG sites located at enhancer regions is a hallmark of this disease. The interaction of BLC11B and C14orf64 as suggested by in silico data analysis could provide a novel pathogenetic mechanism that needs further experimental investigation. Conclusions DNA methylation is altered in T-LGLL cells compared to benign T cells. In particular, BCL11B is highly significant differentially methylated in T-LGLL cells. Although our results have to be validated in a larger patient cohort, BCL11B could be considered as a potential biomarker for this leukemia. In addition, altered gene expression and hypermethylation of enhancer regions could serve as potential mechanisms for treatment of this disease. Gene interactions of dysregulated genes, like BLC11B and C14orf64, may play an important role in pathogenic mechanisms and should be further analyzed.Open Access funding enabled and organized by Projekt DEAL. PJ was funded by IFORES and the Dr. Werner Jackstädt Stiftung. TL and ECdSP received funding from the Spanish Ministry of Science (Plan Nacional I + D+i PID2019-110183RB-C21); RK was supported by the DFG (KU1315/9-2).Peer Reviewed"Article signat per 17 autors/es:Patricia Johansson, Teresa Laguna, Julio Ossowski, Vera Pancaldi, Martina Brauser, Ulrich Dührsen, Lara Keuneke, Ana Queiros, Julia Richter, José I. Martín-Subero, Reiner Siebert, Brigitte Schlegelberger, Ralf Küppers, Jan Dürig, Eva M. Murga Penas, Enrique Carillo-de Santa Pau & Anke K. Bergmann"Postprint (published version

''Att vara legitim utan legitimation?''- en kvalitativ studie av kuratorers professionella position inom barn- och ungdomspsykiatrin

The aim of this study is to examine how counselors working in child - and adolescent psychology assert their professional knowledge and expertise in their everyday w ork and in their teams. Previous research has described an increase of medicalization in child - and adolescent psychology and this has affected counselors’ position s within the organization. The psychosocial aspect has reduced and consequently there are fe wer counselors working in the organization. The intension is to study how counselors experience this development and which strategies they use to assert their knowledge in their teams . In relation to this the study also explores how counselors describe the ir position and function in the organization and how potential conflicts of interest affect their work . This essay is a qualitative study and the empirical material consists of semi - structured interviews that were conducted with nine different counselors i n Skåne. The theoretical framework which has been used to analyze our material are profession theori es and Bolman and Deal's political perspective. The main theoretical concepts that we have used are jurisdiction, professional - and organizational power and boundary work with other professions within the organization. The results of the study indicate that counselors are a very important profession in their teams and within the organization. Counselors’ knowledge and expertise is legitimate and respected by their colleagues and by the child - and adolescent psychology organization even though they do not have an official certifie d license. The study also shows that medicalization and rationalization within the organization entails fewer positions for counselor s, which is an effect from a structural development in society. In this development society requests a diagnostic explanation for children's abnormal behavior and this means doctors and psychologists become the main professions within the organization

Difference is Power : Virtuell handledningsmodell för professionella som jobbar med närståendevårdare till barn med funktionsnedsättning

Detta examensarbete är utvecklat som stöd för professionella i deras samarbete med personer som fungerar som närståendevårdare för barn under skolåldern med funktionsnedsättning. Examensarbetet är en del av projektet E-clubbing som pågått under tiden 2016–2017. Målet för E-clubbing är att minska känslan av utanförskap som familjerna kan uppleva. Kamratstöd är en väsentlig faktor för att förstärka familjernas resurser, vilket framgår i examensarbetet. Syftet med examensarbetet är att familjer med barn med funktionsnedsättning från olika håll i Svenskfinland skall hitta varandra, ta del av varandras erfarenheter och stöda varandra i vardagen. Arbetets frågeställningar är: Vilka är utmaningarna med att handleda närståendevårdare till barn under skolåldern med funktionsnedsättning på distans? Vad behöver den professionella för att kunna handleda närståendevårdare till barn under skolåldern med funktionsnedsättning virtuellt? Metoden som används i arbetet är tjänstedesign. Syftet med tjänstedesign är att skapa värde för klienten med hjälp av nya tjänster eller genom att utveckla redan existerande tjänster. Utgående från litteraturen har målgruppens vardag diskuterats och de redan existerande stödformerna har redogjorts. För att svara på frågeställningarna utreds utmaningarna med virtuell handledning på distans. Tekniska utmaningar, gruppkonstellationer samt handledarens kunskaper är faktorer som skiljer virtuell handledning på distans från fysisk handledning. Resultatet av examensarbetet är en checklista som professionella kan använda sig av vid uppstarten av e-klubbar. Checklistan är skapad så att den ska vara enkel att ha som grund och lätt att förstå för den professionella. Den består av tre delar: planering, utförande och utvärdering.Tämä opinnäytetyö on suunnattu omaishoitajien kanssa työskenteleville ammattilaisille. Kyseessä olevat omaishoitajat työskentelevät alle kouluikäisten toimintarajoitteisten lasten hoitajina. Opinnäytetyö on osa E-clubbing-projektia, joka on ollut käynnissä ajalla 2016-2017. Tavoite e-kerhojen järjestämiselle on vähentää perheiden kokemaa ulkopuolisuuden tunnetta. Vertaistuki on avainasemassa perheiden resurssien vahvistamisessa, ja tätä korostetaan myös opinnäytetyössä. Opinnäytetyön tarkoitus on, että perheet eri suomenruotsalaisilta alueilta, joilla on toimintarajoitteisia lapsia, löytäisivät toisensa, jakaisivat kokemuksia sekä tukisivat toisiaan arjessa. Opinnäytetyön kysymysasettelut ovat: Mitä haasteita etäohjaus sisältää ohjattaessa omaishoitajia, jotka hoitavat alle kouluikäisiä toimintarajoitteisia lapsia? Mitä ammattilaiset tarvitsevat pystyäkseen ohjaamaan virtuaalisesti omaishoitajia, jotka hoitavat alle kouluikäisiä toimintarajoitteisia lapsia? Menetelmänä opinnäytetyössä käytetään palvelumuotoilua. Palvelumuotoilun tarkoitus on luoda arvoa asiakkaalle suunnittelemalla uusia palveluita tai kehittämällä jo olemassa olevia palveluita. Kirjallisuuden yleiskatsauksen myötä kuvaillaan toissijaisen kohderyhmän arkea sekä jo olemassa olevia tukimuotoja. Jotta kysymysasetteluihin voidaan vastata, on virtuaalisen ohjauksen haasteita selvitetty. Tekniset ongelmat, erilaiset ryhmät ja ohjaajan taidot eriävät virtuaalisen ja perinteisen ohjauksen välillä. Opinnäytetyön tulos on niin sanottu tarkistuslista (eng. checklist), jota ammattilaiset voivat käyttää järjestäessään e-kerhoja. Tarkistuslista on kehitetty käytettäväksi apuvälineenä e-kerhoa perustettaessa. Se koostuu kolmesta osasta: suunnittelu, toteutus ja arviointi.This bachelor’s thesis is addressed to the professionals that are working with caregivers for under school-aged children with learning disabilities. This thesis is a part of the project E-clubbing that has taken place in 2016-2017, in Novia University of Applied Sciences. The main goal with e-clubbing is to reduce the feeling of alienation that different target groups might experience. Peer support is an important factor for strengthening the family’s resources, which is highlighted in this thesis. The purpose of the bachelor’s thesis is that families with children with learning disabilities from different parts of the Swedish-speaking region of Finland are able to find each other, take part in each other’s experiences and support each other in their everyday life. The questions at issue are: Which types of challenges come with tutoring caregivers for under school-aged children with learning disabilities, when it is done remotely? What does the professionals need for virtually tutoring caregivers for children under school age with learning disabilities? The method used in this bachelor’s thesis is service design. The purpose of service design is to create value for the clients with help of new services or through development of already existing services. The target groups have been discussed based on literature reviews and already existing forms of support have been reviewed. To present the answers to our questions at issue, the challenges that comes with virtual tutoring remotely have been investigated. Technical difficulties, group constellations and the knowledge of the tutor are factors that separate virtual tutoring from physical tutoring. The product is a checklist that the professionals can use as a guideline when starting e-clubs. The checklist is designed to be easily used and understood by a professional starting an e-club. It consists of three parts: planning, execution and evaluation

Adaptación de la atención terapéutica en poblaciones vulnerables que atraviesan situaciones de emergencia

The COVID-19 emergency brought new questions for mental health and, consequently, major challenges for the clinicalapproach of vulnerable populations. The objective of this research was to analyze the work strategies implemented by thePsychological Guidance Center located in the Padre Ricciardelli neighborhood of the City of Buenos Aires to guarantee thecontinuity of therapeutic care during the pandemic. Method: Semi-structured virtual interviews were administered to theworking team professionals and the analysis of the clinical records of patients who consulted during this period was carriedout accordingly. Results: From the coding material process, a central category called adaptation strategies was identified andassociated with seven other study categories: the exercise of leadership as a condition for the development of adaptationstrategies; the need of interdisciplinary work to respond to the emergency; the need to recognize and implement personalresources in the face of the new challenge; the importance of the therapeutic link as a condition to address new foci; thefundamental role of Logotherapy to promote the search for meaning and the inevitable use of technological tools. Conclusion:The present investigation demonstrated the effective implementation of innovative resources, together with already provenstrategies, to guarantee the continuity of therapeutic treatments providing the individual and community psychological supportthat the health emergency demanded in socioeconomically vulnerable populations.La emergencia del COVID-19 trajo nuevos interrogantes para la salud mental y, en consecuencia, grandes desafíos para los abordajes clínicos en poblaciones vulnerables. El objetivo de esta investigación consistió en analizar las estrategias de trabajo implementadas por el Centro de Orientación Psicológica que se ubica en el Barrio Padre Ricciardelli de la Ciudad de Buenos Aires, para garantizar la continuidad de la atención terapéutica durante la pandemia. Método: Se administró entrevistas virtuales semiestructuradas a los profesionales del equipo y se realizó el análisis de historias clínicas de pacientes que consultaron durante dicho período. Resultados: Del proceso de codificación del material se identifica una categoría central denominada estrategias de adaptación, asociada a otras siete categorías de estudio: el ejercicio del liderazgo como condición para el desarrollo de estrategias de adaptación; lo imprescindible del trabajo interdisciplinario para responder a emergencias; la necesidad de reconocer e implementar recursos personales ante nuevos desafíos; la importancia del vínculo terapéutico como condición para abordar nuevos focos; el papel fundamental de la Logoterapia en la promoción de la búsqueda de sentido; y el uso inevitable de herramientas tecnológicas. Conclusión: La presente investigación permitió evidenciar la implementación efectiva de nuevos recursos, junto con estrategias ya probadas, para garantizar la continuidad de tratamientos terapéuticos que brindaron la contención psicológica individual y comunitaria demandada por la emergencia sanitaria, en poblaciones socioeconómicamente vulnerables

Deterioration of air quality across Sweden due to transboundary agricultural burning emissions

Targino, A. C., Krecl, P., Johansson, C., Swietlicki, E., Massling, A., Coraiola, G. C. & Lihavainen, H. 2013: Deterioration of air quality across Sweden due to transboundary agricultural burning emissions. Boreal Env. Res. 18: 19-36. We analyzed measurements of aerosol and trace-gas concentrations from sites across Sweden before and during a series of agricultural wildland fires in eastern Europe in spring 2006. During the burning episodes, concentrations of background particulate matter (PM) and trace gases, such as carbon monoxide and ozone, increased, affecting air quality across the country and violating national air quality standards. The European Union PM10 daily limit value of 50 mu g m(-3) was exceeded during the pollution episodes even at the background stations, resulting in a nearly four-fold increase as compared with that in non-episode conditions. In relation to a non-episode period, the concentration rise in the accumulation-mode particles was from 40% at an urban site to 340% at a rural site, causing an increase in total particle number concentrations. The fires also boosted ground-level ozone, increasing concentrations of this pollutant by up to 100% at the background stations, which exceeded national air quality standards. Both elemental (EC) and organic carbon (OC) levels increased, with OC making a larger contribution to the total carbonaceous concentrations during the biomass burning episodes. The large-scale atmospheric circulation determined the strength and timing of the pollution events, with the eastern and northern sectors of Sweden experiencing two pollution pulses, whilst sites in the western and southern sectors were affected by one shorter episode. The results show that regional air quality deteriorated due to the long-range transport of pollutants emitted during agricultural wildfires

FRAX-based intervention and assessment thresholds for osteoporosis in Iran

A Summary We compared the utility of the current Iranian guidelines that recommend treatment in women with a T-score <= - 2.5 SD with a FRAX-based intervention threshold equivalent to women of average BMI with a prior fragility fracture. Whereas the FRAX-based intervention threshold identified women at high fracture probability, the T-score threshold was less sensitive, and the associated fracture risk decreased markedly with age. Introduction The fracture risk assessment algorithm FRAX (R) has been recently calibrated for Iran, but guidance is needed on how to apply fracture probabilities to clinical practice. Methods The age-specific ten-year probabilities of a major osteoporotic fracture were calculated in women with average BMI to determine fracture probabilities at two potential intervention thresholds. The first comprised the age-specific fracture probabilities associated with a femoral neck T-score of -2.5 SD, in line with current guidelines in Iran. The second approach determined age-specific fracture probabilities that were equivalent to a woman with a prior fragility fracture, without BMD. The parsimonious use of BMD was additionally explored by the computation of upper and lower assessment thresholds for BMD testing. Results When a BMD T-score <= - 2.5 SD was used as an intervention threshold, FRAX probabilities in women aged 50 years was approximately two-fold higher than in women of the same age but with an average BMD and no risk factors. The relative increase in risk associated with the BMD threshold decreased progressively with age such that, at the age of 80 years or more, a T-score of -2.5 SD was actually protective. The 10-year probability of a major osteoporotic fracture by age, equivalent to women with a previous fracture rose with age from 4.9% at the age of 50 years to 17%, at the age of 80 years, and identified women at increased risk at all ages. Conclusion Intervention thresholds based on BMD alone do not effectively target women at high fracture risk, particularly in the elderly. In contrast, intervention thresholds based on fracture probabilities equivalent to a "fracture threshold" target women at high fracture risk

First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities

ACKNOWLEDGMENTS The VHSV-infected samples were generated within the Scottish Government funded research project FC1996 and kindly provided by Marine Scotland staff. Thanks to ELANCO for providing the A. davidanieli (Renogen). FINANCIAL SUPPORT T. W. received funding from the MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland). MASTS is funded by the Scottish Funding Council (grant reference HR09011) and contributing institutions. Y.J., W.H. and Q.X. were supported financially by the National Scholarship Council of China. Z.Q. was supported by grants from the National Natural Science Foundation of China (31302221) and the overseas training plan for young and middle-aged teachers and principals of colleges and universities in Jiangsu Province, China. M.M.C. was funded by an Ángeles Alvariño postdoctoral contract from the Consejo Superior de Investigaciones Científicas and the Xunta de Galicia. P.D.-R. was funded by a European Commission (EC) Marie Curie Intra European Fellowship (FP7). J.W.H. was funded by the Biotechnology and Biological Sciences Research Council (BB/K009125/1). This work was also supported financially by the EC, under contract Nos. 222719 (LIFECYCLE) and 311993 (TargetFish), and by the European Research Council Starting Grant 2011 (contract No. 280469).Peer reviewedPublisher PD

PARTICIPAÇÃO DOS ALIMENTOS NO CONSUMO DIÁRIO COMO FONTE DE NUTRIENTES E DO MICRONUTRIENTE CÁLCIO, NO GRUPO DE IDOSOS ESTUDADOS DO MUNICÍPIO DE CURITIBA (PARANÁ/BR).

O consumo alimentar tem sido objeto de estudo sob vários aspectos e tem apresentado importante modificação, sendo explicada ora pelo próprio modelo agro-industrial brasileiro instituído ora pelo comportamento da vida urbana ora pelo nível de transferência das informações à população sobre os cuidados com a saúde e qualidade de vida. O presente estudo é o resultado de uma extensa pesquisa sobre os hábitos e consumo alimentar que, entre os dados, evidencia a participação de diversos alimentos na dieta de idosos (≥ 60 anos)selecionados em três bairros com diferentes condições de vida de Curitiba. O objetivo buscou identificar a participação e a quantificação dos alimentos no consumo diário como fonte dos nutrientes cálcio e energia. Entre os alimentos com importante participação na alimentação diária e fornecedores de cálcio foram identificados o espinafre, iogurte, pão francês, couve manteiga, mamão e leite e seus derivados. Enquanto que os alimentos consumidos que garantem a energia diária aos idosos foram o arroz branco, biscoitos, bisteca de porco, chocolate, frango assado, margarina, pão forma, vinho tinto além do açúcar refinado, leite e derivados e o pão francês. O perfil de consumo permite identificar estratégias a adequação nutricional considerando os hábitos alimentares dos idosos, como também indica o potencial ao desenvolvimento tecnológico de produtos alimentícios e alternativos nutricionais mais adequados e aceitos pelo consumidor. E, assim melhorar a qualidade nutricional da oferta de alimentos aos idosos. THE PARTICIPATION OF FOOD ON DAILY COMSUPTION AS A SOURCE OF CALCIUM AND ENERGY NUTRIENTS OF ELDERLY GROUP FROM CURITIBA CITY (PARANÁ/BR) Abstract The food consumption has been an object of study by a lot of aspects and presented as an important modification, explained sometimes by the own Brazilian agro business, sometimes by the behavior of the urban life, and sometimes explained by the of information of the population, about health care and life quality. This study is the result of a wide research about the habits and the food consumption that points the participation of a lot of nutrients on the diet of aged people (e 60 years) from three neighborhoods with different kind of life conditions from Curitiba, Brazil. The principal intention was to identify the participation and quantification of the food from the daily consumption as a source of the calcium and energy nutrients. Among all foods with an important participation on the daily consumption and the calcium sources were spinach, yogurt, bread, cabbage, papaya and milk and dairy products. The food that guarantees the daily allowance of energy to the elderly people were the white rice, cookies, pork meat, chocolate, roast chicken, bread, butter, wine, sugar, milk and dairy products. The consumption profile allows to identifier some strategies to the nutritional adequation considering the habits of the elderly, as indicates the potential to the technology development of the food products and nutritional alternatives more adequate and accepted by the consumer and with this, improve the nutritional quality of the food offer to the elderly

JAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL

T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell leukemia. Recent studies detected genomic aberrations affecting JAK and STAT genes in T-PLL. Due to the limited number of primary patient samples available, genomic analyses of the JAK/STAT pathway have been performed in rather small cohorts. Therefore, we conducted—via a primary-data based pipeline—a meta-analysis that re-evaluated the genomic landscape of T-PLL. It included all available data sets with sequence information on JAK or STAT gene loci in 275 T-PLL. We eliminated overlapping cases and determined a cumulative rate of 62.1% of cases with mutated JAK or STAT genes. Most frequently, JAK1 (6.3%), JAK3 (36.4%), and STAT5B (18.8%) carried somatic single-nucleotide variants (SNVs), with missense mutations in the SH2 or pseudokinase domains as most prevalent. Importantly, these lesions were predominantly subclonal. We did not detect any strong association between mutations of a JAK or STAT gene with clinical characteristics. Irrespective of the presence of gain-of-function (GOF) SNVs, basal phosphorylation of STAT5B was elevated in all analyzed T-PLL. Fittingly, a significant proportion of genes encoding for potential negative regulators of STAT5B showed genomic losses (in 71.4% of T-PLL in total, in 68.4% of T-PLL without any JAK or STAT mutations). They included DUSP4, CD45, TCPTP, SHP1, SOCS1, SOCS3, and HDAC9. Overall, considering such losses of negative regulators and the GOF mutations in JAK and STAT genes, a total of 89.8% of T-PLL revealed a genomic aberration potentially explaining enhanced STAT5B activity. In essence, we present a comprehensive meta-analysis on the highly prevalent genomic lesions that affect genes encoding JAK/STAT signaling components. This provides an overview of possible modes of activation of this pathway in a large cohort of T-PLL. In light of new advances in JAK/STAT inhibitor development, we also outline translational contexts for harnessing active JAK/STAT signaling, which has emerged as a ‘secondary’ hallmark of T-PLL