Sistematización georreferenciada de Proyectos de Extensión: Becas y Subsidios de la Secretaría de Extensión Universitaria(UNC) 2010-2011-2012

Este trabajo consiste en una sistematización de los Proyectos de Becas y de Subsidios de Extensión que se han generado a partir de las convocatorias institucionales de la Secretaría de Extensión Universitaria, en toda la Universidad Nacional de Córdoba. El proceso descriptivo–analítico desarrollado comprende: 46 Proyectos de Becas y 19 Subsidios de Extensión del año 2010; 44 Proyectos de Becas y 16 Subsidios de Extensión de 2011; 47 Proyectos de Becas, 13 Subsidios y 12 Proyectos de Becas para Innovación Tecnológica Socio-Productiva (BITS) iniciados en 2012. Estos Proyectos desarrollados por becarios y equipos de trabajo, bajo supervisión de sus respectivos Directores y Co-directores, abordan una importante diversidad de problemáticas en diferentes espacios territoriales en Córdoba capital, interior provincial y otras provincias. El Objetivo del presente trabajo es referenciar y ubicar en el espacio geográfico, los lugares y zonas de influencia en que se desarrollan estas prácticas extensionistas. Asimismo, permite destacar características interdisciplinarias (por la diversidad de actores universitarios), trayectos formativos (participación de estudiantes y egresados), orientaciones profesionales, relaciones y articulaciones entre proyectos de investigación, extensión y equipos docentes. Finalmente, procura describir en una primera reflexión, ciertas continuidades que se observan en los temas (problemática-demanda) que abordan los proyectos, sus actores intervinientes, organizaciones sociales, instituciones públicas y los equipos de trabajo integrados –en muchos casos- por miembros de las organizaciones e instituciones involucradas en las acciones.Fil: Iribarne, Maria Clara. Universidad Nacional de Córdoba; ArgentinaFil: Genti, Miguel Angel. Universidad Nacional de Córdoba; ArgentinaFil: Navarro, Joaquin Luis. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Cordoba. Instituto de Diversidad y Ecologia Animal; Argentin

ESTUDIO PREDICA : Prevalencia de desnutrición y caquexia en pacientes ambulatorios con insuficiencia cardíaca crónica. Comparación de dos métodos de cribaje nutricional

La prevalencia de desnutrición y caquexia en pacientes ambulatorios con Insuficiencia Cardíaca Crónica es muy variable dependiendo del método utilizado para el diagnóstico. Este estudio observacional transversal pretende identificar cual de los diversos métodos de cribaje nutricional es el más sensible y específico para su detección, respecto a la Valoración Global Subjetiva. Se analizaron 48 pacientes dónde la prevalencia de desnutrición fue del 18,8%, y la de caquexia varió según el método (7,3-9,8%). La sensibilidad y especificidad del Mini Nutritional Assessment fueron elevadas en comparación con los otros métodos. Por lo tanto, puede ser el método más recomendado para el cribado nutricional.La prevalença de desnutrició i caquèxia en pacients ambulatoris amb Insuficiència Cardíaca Crònica es molt variable depenent del mètode utilitzat pel diagnòstic. Aquest estudi observacional transversal pretén identificar quin dels diversos mètodes de cribatge nutricional és el més sensible i específic per la seva detecció, respecte a la Valoració Global Subjectiva. Es van analitzar 48 pacients on la prevalença de desnutrició fou del 18,8% i la de caquèxia va variar segons el mètode (7,3-9,8%). La sensibilitat i especificitat del Mini Nutritional Assessment van ser elevades en comparació amb els altres mètodes. Per tant, pot ser un mètode recomanat pel cribatge nutricional

Assessing the impact of volcanic gases in the village of Copahue, Argentina

The village of Copahue (Neuquén Province, Argentina) is located in the Andean range, on one of the largest geothermal fields in the country: the Caviahue ? Copahue Volcanic Complex (CCVC). Copahue village was conceived and developed as a touristic destination centered on thermal baths and wellness activities. Currently, it receives more than 18,000 visitors per year.Fluid emissions in the CCVC are fed by a hydrothermal reservoir located at 800 m depth, mostly recharged by meteoric water and heated by a magma chamber, located at ~5 km depth. Thermal fluids in Copahue are discharged as fumaroles, diffuse degassing sites, boiling and bubbling pools. Diffuse emissions silently emit more than 100 tons of CO2 per day over the entire area of this town (~0.5 km2). Diffuse CO2 degassing anomalies indicate a strong structural control, with gas rising through fault planes and areas of high structural damage.Recently, members of the community expressed their concern about the increasing presence of fluid discharges nearby and under the foundations of commercial, residential and public buildings. The discharge of these thermal fluids is causing severe damage to buildings and infrastructure, and it constitutes a potential threat for human health. Considering this scenario, the aims of this work are: (i) to identify areas within the town of high fluid flow, (ii) to generate thermal emissions hazard maps and (iii) to assess the impact of volcanic gases on people as well as physical damage to buildings, caused by the thermal fluid discharges. The identification of areas with high fluid flow and the elaboration of hazard maps was carried out by combining multiple map layers (CO2 flux, soil temperature and urban maps) and sets of data points (point-based thermal emissions and damaged buildings within the urban area). The assessment of the physical damage on people and assets was evaluated by performing a visual recognition of the various impacts of hydrothermal gases on buildings, and by collecting audiovisual material along with anecdotal information provided by the Copahue community.The combination of the multiple map layers reveals two main areas of high CO2 release within the village of Copahue, located in the center and in the southern portion of the village. The overlaying of data points on the map layers shows that the damaged buildings are located within the southern-most CO2 diffuse degassing and thermal anomaly area.Numerous buildings present problems caused by outpouring of vapor and gaseous chemicals on floors and walls, infiltrations of fluids in joints and overheated rooms, among other issues. The impact of these geothermal events on human health is yet to be assessed.The results of this work will raise awareness among decision makers and civil protection authorities, and will establish a framework for planning land-use, ultimately fostering a safer coexistence between the population the active volcanic - geothermal field.Fil: Lamberti, María Clara Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Forte, Pablo Brian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Llano, Joaquin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Albite, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Trinelli, María Alcira. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Básicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Castro, J.. Johannes Gutenberg Universitat Mainz; AlemaniaFil: Agusto, Mariano Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaEGU General Assembly 2019VienaAustriaEuropean Geosciences Unio

Chitosan feasibility to retain retinal stem cell phenotype and slow proliferation for retinal transplantation

Retinal stem cells (RSCs) are promising in cell replacement strategies for retinal diseases. RSCs can migrate, differentiate, and integrate into retina. However, RSCs transplantation needs an adequate support; chitosan membrane (ChM) could be one, which can carry RSCs with high feasibility to support their integration into retina. RSCs were isolated, evaluated for phenotype, and subsequently grown on sterilized ChM and polystyrene surface for 8 hours, 1, 4, and 11 days for analysing cell adhesion, proliferation, viability, and phenotype. Isolated RSCs expressed GFAP, PKC, isolectin, recoverin, RPE65, PAX-6, cytokeratin 8/18, and nestin proteins. They adhered (28 ± 16%, 8 hours) and proliferated (40 ± 20 cells/field, day 1 and 244 ± 100 cells/field, day 4) significantly low on ChM. However, they maintained similar viability (>95%) and phenotype (cytokeratin 8/18, PAX6, and nestin proteins expression, day 11) on both surfaces (ChM and polystyrene). RSCs did not express alpha-SMA protein on both surfaces. RSCs express proteins belonging to epithelial, glial, and neural cells, confirming that they need further stimulus to reach a final destination of differentiation that could be provided in in vivo condition. ChM does not alternate RSCs behaviour and therefore can be used as a cell carrier so that slow proliferating RSCs can migrate and integrate into retina

Infants younger than 6 months old infected by SARS-CoV-2 show the highest respiratory viral loads

There is a paucity of reports on the characteristics of SARS-CoV-2 infection in infants, since most studies have grouped infants with older children. We analyzed the viral loads of 45,318 SARS-CoV-2-positive nasopharyngeal swab samples obtained in Buenos Aires, Argentina. Infants younger than 6 months old presented higher viral loads than any other age group. Children older than 6 months showed significantly lower viral loads, similar to those founds in adults. This observation raises new questions regarding the role of infants in the spreading of SARS-CoV-2 infection.Fil: Ochoa, Valeria Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Erra Diaz, Fernando Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Ramirez, Joaquin Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Fentini, María Clara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Carobene, Mauricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Geffner, Jorge Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Arruvito, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Remes Lenicov, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentin

Multimodal assessment of non-alcoholic fatty liver disease with transmission-reflection optoacoustic ultrasound

Non-alcoholic fatty liver disease (NAFLD) is an umbrella term referring to a group of conditions associated to fat deposition and damage of liver tissue. Early detection of fat accumulation is essential to avoid progression of NAFLD to serious pathological stages such as liver cirrhosis and hepatocellular carcinoma. Methods: We exploited the unique capabilities of transmission-reflection optoacoustic ultrasound (TROPUS), which combines the advantages of optical and acoustic contrasts, for an early-stage multi-parametric assessment of NAFLD in mice. Results: The multispectral optoacoustic imaging allowed for spectroscopic differentiation of lipid content, as well as the bio-distributions of oxygenated and deoxygenated hemoglobin in liver tissues in vivo. The pulse-echo (reflection) ultrasound (US) imaging further provided a valuable anatomical reference whilst transmission US facilitated the mapping of speed of sound changes in lipid-rich regions, which was consistent with the presence of macrovesicular hepatic steatosis in the NAFLD livers examined with ex vivo histological staining. Conclusion: The proposed multimodal approach facilitates quantification of liver abnormalities at early stages using a variety of optical and acoustic contrasts, laying the ground for translating the TROPUS approach toward diagnosis and monitoring NAFLD in patients

Quantitative genetic analysis of floral traits shows current limits but potential evolution in the wild

The vast variation in floral traits across angiosperms is often interpreted as the result of adaptation to pollinators. However, studies in wild populations often find no evidence of pollinator-mediated selection on flowers. Evolutionary theory predicts this could be the outcome of periods of stasis under stable conditions, followed by shorter periods of pollinator change that provide selection for innovative phenotypes. We asked if periods of stasis are caused by stabilizing selection, absence of other forms of selection or by low trait ability to respond even if selection is present. We studied a plant predominantly pollinated by one bee species across its range. We measured heritability and evolvability of traits, using genome-wide relatedness in a large wild population, and combined this with estimates of selection on the same individuals. We found evidence for both stabilizing selection and low trait heritability as potential explanations for stasis in flowers. The area of the standard petal is under stabilizing selection, but the variability is not heritable. A separate trait, floral weight, presents high heritability, but is not currently under selection. We show how a simple pollination environment coincides with the absence of current prerequisites for adaptive evolutionary change, while heritable variation remains to respond to future selection pressures

Role of light chain clearance in the recovery of renal function in multiple myeloma: another point of view

Lay Summary This is a retrospective multicenter study that evaluated the effectiveness of intensive haemodialysis (IHD) vs standards dialysis on renal recovery in patients with acute kidney injury (AKI) associated with myeloma multiple (MM). In this paper, we demonstrated that IHD for early light chain reduction was associated with a better renal prognosis. Another finding is the importance of maintenance diuresis as a marker of good prognosis of renal function. To our knowledge few studies have been focused in the comparison between IHD vs standard dialysis in MM patients with AKI. We consider that if we manage to recover the renal function, we achieve a great clinical impact since the patient with chronic kidney disease and especially in hemodialysis, an increased risk of mortality as well as poorer quality of life. Background Acute kidney injury (AKI) in patients with multiple myeloma (MM) requiring renal replacement treatment (RRT) is associated with high morbidity and mortality. Early reduction of serum free light chains (FLC) using both targeted therapy against MM and intensive hemodialysis (IHD) may improve renal outcomes. We evaluated the effectiveness of two different RRT techniques on renal recovery in an MM patient population: standard dialysis procedure vs IHD with either polymethylmethacrylate (PMMA) or hemodiafiltration with endogenous reinfusion (HFR). Methods This was a multicentric retrospective study with severe AKI related to MM, between 2011 and 2018. Twenty-five consecutive patients with AKI secondary to MM requiring RRT were included. Patients that underwent IHD received six dialysis sessions per week during the first 14 days (PMMA vs HFR). All patients were diagnosed with de novo MM or first relapsed MM. Primary outcome was renal recovery defined as dialysis-free at 6 months follow-up. Results A total of 25 patients were included. Seventeen patients received IHD and eight standard dialysis. All patients were treated with targeted therapy, 84% bortezomib-based. Of the 25 patients included, 14 (56%) became dialysis independent. We observed a higher proportion of patients who received IHD in the group who recovered kidney function compared with those who remained in HD (92.9% vs 36.4%, P = .007). In our study, the use of IHD to remove FLC had a statistically significant association with renal recovery compared with the standard dialysis group (P = .024). Conclusion Early reduction of FLC with IHD as an adjuvant treatment along with MM-targeted therapy may exert a positive impact on renal recovery