Clinical and pathological characteristics of peripheral T‐cell lymphomas in a Spanish population: a retrospective study

We investigated the clinicopathological features and prognostic factors of patients with peripheral T-cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical outcomes were examined. A sizeable proportion of 175 patients had a history of immune-related disorders (autoimmune 16%, viral infections 17%, chemo/radiotherapy-treated carcinomas 19%). The median progression-free survival (PFS) and overall survival (OS) were 7·9 and 15·8 months, respectively. Prognostic indices influenced PFS and OS, with a higher number of adverse factors resulting in shorter survival (P 15% of cells were positive in anaplastic lymphoma kinase-positive and -negative anaplastic large-cell lymphoma and extranodal natural killer PTCL groups. We observed PTCL distribution across subtypes based on haematopathological re-evaluation. Poor prognosis, effect of specific prognostic indices, relevance of histopathological sub-classification, and response level to first-line treatment on outcomes were confirmed. Immune disorders amongst patients require further examination involving genetic studies and identification of associated immunosuppressive factors

Clinical and pathological characteristics of peripheral T-cell lymphomas in a Spanish population: a retrospective study

We investigated the clinicopathological features and prognostic factors of patients with peripheral T-cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical outcomes were examined. A sizeable proportion of 175 patients had a history of immune-related disorders (autoimmune 16%, viral infections 17%, chemo/radiotherapy-treated carcinomas 19%). The median progression-free survival (PFS) and overall survival (OS) were 7·9 and 15·8 months, respectively. Prognostic indices influenced PFS and OS, with a higher number of adverse factors resulting in shorter survival (P 15% of cells were positive in anaplastic lymphoma kinase-positive and -negative anaplastic large-cell lymphoma and extranodal natural killer PTCL groups. We observed PTCL distribution across subtypes based on haematopathological re-evaluation. Poor prognosis, effect of specific prognostic indices, relevance of histopathological sub-classification, and response level to first-line treatment on outcomes were confirmed. Immune disorders amongst patients require further examination involving genetic studies and identification of associated immunosuppressive factors.This study was sponsored by Takeda

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Microbiological and lipolytic changes in high-pressure-treated raw milk cheeses during refrigerated storage

International audienceAbstractHigh-pressure processing (HPP) has been used to control microorganisms and enzymes and avoid over-ripening in cheese. Excessive lipolysis is associated with over-ripening in cheese. However, little information about the effect of high pressure on microorganisms and lipolysis in mature cheese is available. For this reason, microbiological and lipolytic changes during refrigerated storage of pressurised Torta del Casar cheese (a raw ewe’s milk cheese) were studied. Mature cheeses (60 days of ripening) were high-pressure treated (200 or 600 MPa for 5 or 20 min) and stored at 6 °C. Cheese samples were analysed at day 60, just after high-pressure treatment, and during the refrigerated storage (at days 120, 180 and 240). Enterobacteriaceae counts were significantly reduced after high-pressure treatment, thus increasing the food safety of this cheese. In particular, Enterobacteriaceae showed a significant (p < 0.01) decrease of 2.18 and 2.46 log units in cheeses treated at 200 MPa for 20 min at days 120 and 180, respectively; however, treatment at 600 MPa for 20 min only caused reductions of 2.09 and 1.79 log units at days 120 and 180. Free fatty acids content was not significantly influenced by high-pressure treatment, although it increased with time of storage

Implementación del portfolio discente en las prácticas del Programa Oficial de Postgrado (Máster y Doctorado) en Biotecnología y Biomedicina

La convergencia con el Espacio Europeo de Educación Superior (EEES), implica la introducción de nuevas metodologías de trabajo en la Docencia Universitaria y este tránsito va a suponer un esfuerzo importante por parte de profesores, alumnos y demás participantes en el proceso formativo. El objetivo general de este proyecto es, utilizar el recurso del Portfolio Discente en la formación práctica de los alumnos del primer curso (2006/2007) del Programa Oficial de Postgrado en Biotecnología y Biomedicina. Para llevar a cabo el citado objetivo hemos diseñado y elaborado una serie de productos y estrategias para implementar el Portfolio Discente. Además, nos proponemos establecer la composición de créditos ECTS, de las prácticas de las distintas asignaturas, a partir de los datos obtenidos del Portfolio Discente, así como evaluar los Portfolios de distintas materias y realizar una serie de talleres para el establecimiento de criterios y estándares para la confección de Portfolios o Carpetas de alumno. Hasta este momento hemos implementado todos los objetivos, encontrándonos en la parte de evaluación de los Portfolios

Reseña de Libros

<p>Amar Rodríguez, Víctor, Las nuevas tecnologías aplicadas a la educación. Cádiz, Servicio de Publicaciones de la Universidad de Cádiz, 2006, 177 pp.  <br />Páginas 213-214 <br />Juan Casanova Correa <br /> <br /> <br />Baraibar Etxeberría, Álvaro, Extraño federalismo. La vía Navarra a la democracia (1973-1982). Madrid, Centro de Estudios Políticos y Constitucionales, 2004, 484 pp.  <br />Páginas 214-217 <br />José Joaquín Fernández Alles <br /> <br /> <br />Capellán de Miguel, Gonzalo (coord.), La Rioja. Construcción y desarrollo de una comunidad autónoma. Logroño, Gobierno de La Rioja, 2002, 418 pp.  <br />Páginas 217-218 <br />Joaquín Piñeiro Blanca <br /> <br /> <br />Cobo Romero, Francisco; Ortega López, Teresa María, Franquismo y posguerra en Andalucía Oriental. Represión, castigo a los vencidos y apoyos sociales al régimen franquista, 1936-1950. Granada, Universidad de Granada, 2005, 450 pp.  <br />Páginas 218-220 <br />David Molina Rabadán <br /> <br /> <br />Cuenca Toribio, José Manuel, Historia General de Andalucía. Córdoba, Almuzara, 2005, 1.003 pp.  <br />Páginas 220-222 <br />Fernando López Mora <br /> <br /> <br />Fandiño Pérez, Roberto Germán, Historia del movimiento ciudadano e historia local. El ejemplo del barrio de Yagüe en Logroño (1948-1975). Logroño, Instituto de Estudios Riojanos, 2005, 186 pp.  <br />Páginas 223-224 <br />Joaquín Piñeiro Blanca <br /> <br /> <br />"Bajo el franquismo", núm. monográfico de Gerónimo de Ustáriz, 19 (2004), 215 pp.  <br />Páginas 224-226 <br />Antonio Polo Blanco <br /> <br /> <br />Jiménez Gámez, Rafael, Inmigración, interculturalidad y currículum. Morón de la Frontera, Publicaciones MCEP, 2004, 322 pp.  <br />Páginas 226-227 <br />Víctor Amar Rodríguez <br /> <br /> <br />Mann, Michael, El imperio incoherente. Estados Unidos y el nuevo orden internacional. Barcelona, Paidós, 2004, 319 pp.  <br />Páginas 227-229 <br />David Molina Rabadán <br /> <br /> <br />Mussolini, Romano, Ultimo atto, le verità nascoste sulla fine del Duce. Milan, Rizzoli, 2005, 177 pp.  <br />Páginas 229-231 <br />Jan Nelis <br /> <br /> <br />Pagès i Blanc, Pelai (dir.), La transició democràtica als Països Catalans. Història i memòria.Valencia, Universidad de Valéncia, 2005, 423 pp.  <br />Páginas 231-232 <br />María José Malet <br /> <br /> <br />"La memoria del pasado", núm. monográfico de Pasado y Memoria. Revista de Historia Contemporánea, 3 (2004), 357 pp.  <br />Páginas 233-236 <br />Manuel Ortiz Heras <br /> <br /> <br />Quirosa-Cheyrouze y Muñoz, Rafael (coord.), II Congreso Internacional “Historia de la Transición. Los inicios del proceso democratizador”. Almería, Servicio de Publicaciones de la Universidad de Almería, 2005 (CD-ROM)  <br />Páginas 236-239 <br />Alfonso Pinilla García</p><p> <br />Rivera Menéndez, José; Gutiérrez Navas, Manuel (eds.), Sociedad y política almeriense durante el régimen de Franco. Almería, Instituto de Estudios Almerienses-Centro Asociado de la UNED, 2003, 214 pp.  <br />Páginas 239-241 <br />Mónica Fernández Amador</p><p> <br />Santacreu Soler, José Miguel, Historia del Parlamento Andino (1979-2003). Alicante, Temas de las Cortes Valencianas, Universidad de Alicante, 2004, 210 pp.  <br />Páginas 241-243 <br />Virgilio Francisco Candela Sevila</p><p> <br />Serra i Busquets, Sebastià, Els elements de canvi a la Mallorca del segle XX. Palma de Mallorca, Ediciones Cort, 2001, 351 pp.  <br />Páginas 244-245 <br />Alejandro Román Antequera</p><p> <br />Torres, R. C., Autarquie i estraperlo. L'economia en un espai rural del País Valencià durant el franquisme. València, Universitat, 2005, 168 pp.; Calzado, A., Entre la nit i el marasme. La Vall d’Albaida, 1939-1952. Alzira, Germania, 2005, 426 pp.  <br />Páginas 245-246 <br />José Miguel Santacreu Soler</p

An integrated prognostic model for diffuse large B‐cell lymphoma treated with immunochemotherapy

Abstract Diffuse large B‐cell lymphoma (DLBCL), the most frequent non‐Hodgkin's lymphoma subtype, is characterized by strong biological, morphological, and clinical heterogeneity, but patients are treated with immunochemotherapy in a relatively homogeneous way. Here, we have used a customized NanoString platform to analyze a series of 197 homogeneously treated DLBCL cases. The platform includes the most relevant genes or signatures known to be useful for predicting response to R‐CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) in DLBCL cases. We generated a risk score that combines the International Prognostic Index with cell of origin and double expression of MYC/BCL2, and stratified the series into three groups, yielding hazard ratios from 0.15 to 5.49 for overall survival, and from 0.17 to 5.04 for progression‐free survival. Group differences were highly significant (p < 0.0001), and the scoring system was applicable to younger patients (<60 years of age) and patients with advanced or localized stages of the disease. Results were validated in an independent dataset from 166 DLBCL patients treated in two distinct clinical trials. This risk score combines clinical and biological data in a model that can be used to integrate biological variables into the prognostic models for DLBCL cases

Comparison between the compound ETP-39010 and other pan-PIMi.

<p>(A) Selectivity profile showing the IC₅₀ values of each of the compounds for the kinase activity of the indicated enzymes. (B) Percentage of inhibition of a panel of unrelated kinases by ETP-39010 and ETP-47551. A similar profile was found for ETP-47551, ETP-47652 and ETP-46638 compounds. (C) Sensitivity of PTCL cell lines to all pan-PIMi. (D) The newly developed pan-PIMi ETP-47551 reduced cell viability in all studied PTCL cell lines (IC₅₀ values calculated after 72 h of treatment are shown). (E) The pan-PIMi ETP-47551 strongly induced apoptosis in a time-dependent manner in all studied PTCL cell lines (*, p<0.05, from comparison with DMSO-treated cells). The percentage of non-viable cells was calculated as Annexin V+/7AAD− plus Annexin V+/7AAD+ cells in the PIMi-treated condition minus the DMSO-treated control. (F) The combination of ALKi + ETP-39010 was highly synergistic only in ALK+ ALCL cell lines, as was (G) the combination of ALKi + ETP-47551 (Combination Index, CI, <1 indicates synergism between the two drugs; CI ≈1 indicates an additive effect; CI>1 indicates antagonism).</p