On-nanowire spatial band gap design for white light emission.

This is the accepted manuscript. The final version is available from ACS at http://pubs.acs.org/doi/abs/10.1021/nl203529h.We demonstrated a substrate-moving vapor-liquid-solid (VLS) route for growing composition gradient ZnCdSSe alloy nanowires. Relying on temperature-selected composition deposition along their lengths, single tricolor ZnCdSSe alloy nanowires with engineerable band gap covering the entire visible range were obtained. The photometric property of these tricolor nanowires, which was determined by blue-, green-, and red-color emission intensities, can be in turn controlled by their corresponding emission lengths. More particularly, under carefully selected growth conditions, on-nanowire white light emission has been achieved. Band-gap-engineered semiconductor alloy nanowires demonstrated here may find applications in broad band light absorption and emission devices

Novel biomarkers predict prognosis and drug-induced neuroendocrine differentiation in patients with prostate cancer

BackgroundA huge focus is being placed on the development of novel signatures in the form of new combinatorial regimens to distinguish the neuroendocrine (NE) characteristics from castration resistant prostate cancer (CRPC) timely and accurately, as well as predict the disease-free survival (DFS) and progression-free survival (PFS) of prostate cancer (PCa) patients.MethodsSingle cell data of 4 normal samples, 3 CRPC samples and 3 CRPC-NE samples were obtained from GEO database, and CellChatDB was used for potential intercellular communication, Secondly, using the “limma” package (v3.52.0), we obtained the differential expressed genes between CRPC and CRPC-NE both in single-cell RNA seq and bulk RNA seq samples, and discovered 12 differential genes characterized by CRPC-NE. Then, on the one hand, the diagnosis model of CRPC-NE is developed by random forest algorithm and artificial neural network (ANN) through Cbioportal database; On the other hand, using the data in Cbioportal and GEO database, the DFS and PFS prognostic model of PCa was established and verified through univariate Cox analysis, least absolute shrinkage and selection operator (Lasso) regression and multivariate Cox regression in R software. Finally, somatic mutation and immune infiltration were also discussed.ResultsOur research shows that there exists specific intercellular communication in classified clusters. Secondly, a CRPC-NE diagnostic model of six genes (HMGN2, MLLT11, SOX4, PCSK1N, RGS16 and PTMA) has been established and verified, the area under the ROC curve (AUC) is as high as 0.952 (95% CI: 0.882−0.994). The mutation landscape shows that these six genes are rarely mutated in the CRPC and NEPC samples. In addition, NE-DFS signature (STMN1 and PCSK1N) and NE-PFS signature (STMN1, UBE2S and HMGN2) are good predictors of DFS and PFS in PCa patients and better than other clinical features. Lastly, the infiltration levels of plasma cells, T cells CD4 naive, Eosinophils and Monocytes were significantly different between the CRPC and NEPC groups.ConclusionsThis study revealed the heterogeneity between CRPC and CRPC-NE from different perspectives, and developed a reliable diagnostic model of CRPC-NE and robust prognostic models for PCa

PSR J1926-0652: A Pulsar with Interesting Emission Properties Discovered at FAST

We describe PSR J1926-0652, a pulsar recently discovered with the Five-hundred-meter Aperture Spherical radio Telescope (FAST). Using sensitive single-pulse detections from FAST and long-term timing observations from the Parkes 64-m radio telescope, we probed phenomena on both long and short time scales. The FAST observations covered a wide frequency range from 270 to 800 MHz, enabling individual pulses to be studied in detail. The pulsar exhibits at least four profile components, short-term nulling lasting from 4 to 450 pulses, complex subpulse drifting behaviours and intermittency on scales of tens of minutes. While the average band spacing P3 is relatively constant across different bursts and components, significant variations in the separation of adjacent bands are seen, especially near the beginning and end of a burst. Band shapes and slopes are quite variable, especially for the trailing components and for the shorter bursts. We show that for each burst the last detectable pulse prior to emission ceasing has different properties compared to other pulses. These complexities pose challenges for the classic carousel-type models.Comment: 13pages with 12 figure

Early Neoproterozoic (870–820 Ma) amalgamation of the Tarim craton (northwestern China) and the final assembly of Rodinia

International audienceIn the paleogeographic configuration of the Neoproterozoic supercontinent of Rodinia, the Tarim craton (northwestern China), traditionally seen as a single block, is placed either on the periphery near northern Australia or India or in a central position between Australia and Laurentia. To distinguish between these possibilities, we present here new primary paleomagnetic results from ca. 900 Ma volcanics in the Aksu region of the northwestern Tarim craton. The data reveal a ~28° latitudinal difference between the North Tarim and South Tarim blocks at ca. 900 Ma and constrain the age of amalgamation of the Tarim craton to between 870 and 820 Ma. Combining paleomagnetic poles from Tarim and major cratons of Rodinia with geological evidence, a two-stage orogenic model is proposed for the assembly of Rodinia. Late Mesoproterozoic orogenesis (1.3–1.0 Ga) led to the assembly of Australia–East Antarctica, Baltica, Umkondia, South Tarim, and Cathaysia with Laurentia, forming the core of Rodinia. Thereafter, the Jiangnan–Central Tarim Ocean separating North Tarim and Yangtze from South Tarim and Cathaysia was closed before ca. 820 Ma. This second Jiangnan–Central Tarim orogeny caused nearly coeval amalgamation of the peripheral Tarim and South China cratons by the welding of North Tarim and Yangtze to South Tarim and Cathaysia, respectively. The supercontinent of Rodinia was thus assembled by two orogenic phases separated by ~200 m.y

On-Nanowire Spatial Band Gap Design for White Light Emission

We demonstrated a substrate-moving vapor–liquid–solid (VLS) route for growing composition gradient ZnCdSSe alloy nanowires. Relying on temperature-selected composition deposition along their lengths, single tricolor ZnCdSSe alloy nanowires with engineerable band gap covering the entire visible range were obtained. The photometric property of these tricolor nanowires, which was determined by blue-, green-, and red-color emission intensities, can be in turn controlled by their corresponding emission lengths. More particularly, under carefully selected growth conditions, on-nanowire white light emission has been achieved. Band-gap-engineered semiconductor alloy nanowires demonstrated here may find applications in broad band light absorption and emission devices

Room-Temperature Near-Infrared Photodetectors Based on Single Heterojunction Nanowires

Nanoscale near-infrared photodetectors are attractive for their potential applications in integrated optoelectronic devices. Here we report the synthesis of GaSb/GaInSb p-n heterojunction semiconductor nanowires for the first time through a controllable chemical vapor deposition (CVD) route. Based on these nanowires, room-temperature, high-performance, near-infrared photodetectors were constructed. The fabricated devices show excellent light response in the infrared optical communication region (1.55 mu m), with an external quantum efficiency of 10(4), a responsivity of 10(3) A/W, and a short response time of 2 ms, which shows promising potential applications in integrated photonics and optoelectronics devices or systems

Room-Temperature Dual-Wavelength Lasing from Single-Nanoribbon Lateral Heterostructures

Nanoscale dual-wavelength lasers are attractive for their potential applications in highly integrated photonic devices. Here we report the growth of nanoribbon lateral heterostructures made of a CdS_<i>x</i>Se_1–<i>x</i> central region with epitaxial CdS lateral sides using a multistep thermal evaporation route with a moving source. Under laser excitation, the emission of these ribbons indicates sandwich-like structures along the width direction, with characteristic red emission in the center and green emission at both edges. More importantly, dual-wavelength lasing with tunable wavelengths is demonstrated at room temperature based on these single-nanoribbon heterostructures for the first time. These achievements represent a significant advance in designing nanoscale dual-wavelength lasers and have the potential to open up new and exciting opportunities for diverse applications in integrated photonics, optoelectronics, and sensing

Low-Threshold Nanowire Laser Based on Composition-Symmetric Semiconductor Nanowires

Low-threshold nanoscale lasers are attractive for their promising applications in highly integrated photonic devices and systems. Here we report the controllable growth of composition-symmetric CdS_<i>x</i>Se_1–<i>x</i> nanowires by using a multistep thermal evaporation route with moving sources. Microstructure analyses reveal the obtained wires are high-quality single crystals with the composition gradually changed from the center toward their both ends. Under laser illumination, these wires exhibit symmetrical color distribution along the length direction, with red at the center and green at the both ends. Optically pumped lasing is realized at room temperature using these composition-symmetric nanowires, with the threshold several times lower than that of composition-homogeneous wires. This new nanowire structure will have potential applications as low-threshold nanoscale lasers in integrated nanophotonics