Covariance Spectroscopy for Fissile Material Detection

Nuclear fission produces multiple prompt neutrons and gammas at each fission event. The resulting daughter nuclei continue to emit delayed radiation as neutrons boil off, beta decay occurs, etc. All of the radiations are causally connected, and therefore correlated. The correlations are generally positive, but when different decay channels compete, so that some radiations tend to exclude others, negative correlations could also be observed. A similar problem of reduced complexity is that of cascades radiation, whereby a simple radioactive decay produces two or more correlated gamma rays at each decay. Covariance is the usual means for measuring correlation, and techniques of covariance mapping may be useful to produce distinct signatures of special nuclear materials (SNM). A covariance measurement can also be used to filter data streams because uncorrelated signals are largely rejected. The technique is generally more effective than a coincidence measurement. In this poster, we concentrate on cascades and the covariance filtering problem

A Search for Early Optical Emission from Short and Long Duration Gamma-ray Bursts

Gamma-ray bursts of short duration may harbor vital clues to the range of phenomena producing bursts. However, recent progress from the observation of optical counterparts has not benefitted the study of short bursts. We have searched for early optical emission from six gamma-ray bursts using the ROTSE-I telephoto array. Three of these events were of short duration, including GRB 980527 which is among the brightest short bursts yet observed. The data consist of unfiltered CCD optical images taken in response to BATSE triggers delivered via the GCN. For the first time, we have analyzed the entire 16 degree by 16 degree field covered for five of these bursts. In addition, we discuss a search for the optical counterpart to GRB 000201, a well-localized long burst. Single image sensitivities range from 13th to 14th magnitude around 10 s after the initial burst detection, and 14 - 15.8 one hour later. No new optical counterparts were discovered in this analysis suggesting short burst optical and gamma-ray fluxes are uncorrelated.Comment: 8 pages, 2 figures, subm. to ApJ Let

Prompt Optical Observations of Gamma-ray Bursts

The Robotic Optical Transient Search Experiment (ROTSE) seeks to measure simultaneous and early afterglow optical emission from gamma-ray bursts (GRBs). A search for optical counterparts to six GRBs with localization errors of 1 square degree or better produced no detections. The earliest limiting sensitivity is m(ROTSE) > 13.1 at 10.85 seconds (5 second exposure) after the gamma-ray rise, and the best limit is m(ROTSE) > 16.0 at 62 minutes (897 second exposure). These are the most stringent limits obtained for GRB optical counterpart brightness in the first hour after the burst. Consideration of the gamma-ray fluence and peak flux for these bursts and for GRB990123 indicates that there is not a strong positive correlation between optical flux and gamma-ray emission.Comment: 4 pages, 3 figures, submitted to ApJ Letter

Evolution of Antibody Immunity to SARS-CoV-2

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with development of variable levels of antibodies with neutralizing activity that can protect against infection in animal models. Antibody levels decrease with time, but the nature and quality of the memory B cells that would be called upon to produce antibodies upon re-infection has not been examined. Here we report on the humoral memory response in a cohort of 87 individuals assessed at 1.3 and 6.2 months after infection. We find that IgM, and IgG anti-SARS-CoV-2 spike protein receptor binding domain (RBD) antibody titers decrease significantly with IgA being less affected. Concurrently, neutralizing activity in plasma decreases by five-fold in pseudotype virus assays. In contrast, the number of RBD-specific memory B cells is unchanged. Memory B cells display clonal turnover after 6.2 months, and the antibodies they express have greater somatic hypermutation, increased potency and resistance to RBD mutations, indicative of continued evolution of the humoral response. Analysis of intestinal biopsies obtained from asymptomatic individuals 4 months after coronavirus disease-2019 (COVID-19) onset, using immunofluorescence, or polymerase chain reaction, revealed persistence of SARS-CoV-2 nucleic acids and immunoreactivity in the small bowel of 7 out of 14 volunteers. We conclude that the memory B cell response to SARS-CoV-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Contributions of Muscles and External Forces to Medial Knee Load Reduction Due to Osteoarthritis Braces

Background Braces for medial knee osteoarthritis can reduce medial joint loads through a combination of three mechanisms: application of an external brace abduction moment, alteration of gait dynamics, and reduced activation of antagonistic muscles. Although the effect of knee bracing has been reported independently for each of these parameters, no previous study has quantified their relative contributions to reducing medial knee loads. Methods In this study, we used a detailed musculoskeletal model to investigate immediate changes in medial and lateral loads caused by two different knee braces: OA Assist and OA Adjuster 3 (DJO Global). Seventeen osteoarthritis subjects and eighteen healthy controls performed overground gait trials in unbraced and braced conditions. Results Across all subjects, bracing reduced medial loads by 0.1 to 0.3 times bodyweight (BW), or roughly 10%, and increased lateral loads by 0.03 to 0.2 BW. Changes in gait kinematics due to bracing were subtle, and had little effect on medial and lateral joint loads. The knee adduction moment was unaltered unless the brace moment was included in its computation. Only one muscle, biceps femoris, showed a significant change in EMG with bracing, but this did not contribute to altered peak medial contact loads. Conclusions Knee braces reduced medial tibiofemoral loads primarily by applying a direct, and substantial, abduction moment to each subject's knee. To further enhance brace effectiveness, future brace designs should seek to enhance the magnitude of this unloader moment, and possibly exploit additional kinematic or neuromuscular gait modifications

SDSS J124602.54+011318.8: A Highly Luminous Optical Transient at z=0.385

We report the discovery of a highly luminous optical transient (OT), SDSS J124602.54+011318.8, associated with a galaxy at a redshift of 0.385. In this paper we consider the possibility that the OT may be a GRB afterglow. Three sets of images and two sets of spectra were obtained as part of the normal operations of the Sloan Digital Sky Survey (SDSS). In the first two image sets, observed two nights apart, the object appears as a point source at $r^{*}\approx 17$. The third image set, observed about 410 days later, shows an extended source which is more than 2.5 magnitudes fainter. The spectra were observed about 400 and 670 days after the first two image sets, and both show an apparently normal galaxy at a redshift of 0.385. Associating the OT with the galaxy, the absolute magnitude was $M_{r^*}=-24.8$, which is over 4 magnitudes brighter than the most luminous supernova ever measured. The spectral energy distributions of the galaxy-subtracted OT derived from the first two image sets are well-fit by single power-laws with indices of $\beta_{\nu}=-0.92$ and -1.29 respectively, similar to most GRB afterglows. Based upon the luminosity of the OT, non-detections in contemporaneous ROTSE-I images, and the change in spectral slope, the OT, if an afterglow, was likely discovered early during a ``plateau'' or slowly-fading phase. The discovery of a GRB afterglow at this stage of the SDSS is consistent with expectations, but only if the optical emission is much less strongly beamed than the gamma-rays. We emphasize that other explanations for the OT cannot be ruled out; a recent follow-up study by [galyam02] provides strong evidence that this source is in fact an unusual AGN.Comment: Updated version to appear in Ap

Emergence of Xin Demarcates a Key Innovation in Heart Evolution

The mouse Xin repeat-containing proteins (mXinα and mXinβ) localize to the intercalated disc in the heart. mXinα is able to bundle actin filaments and to interact with β-catenin, suggesting a role in linking the actin cytoskeleton to N-cadherin/β-catenin adhesion. mXinα-null mouse hearts display progressively ultrastructural alterations at the intercalated discs, and develop cardiac hypertrophy and cardiomyopathy with conduction defects. The up-regulation of mXinβ in mXinα-deficient mice suggests a partial compensation for the loss of mXinα. To elucidate the evolutionary relationship between these proteins and to identify the origin of Xin, a phylogenetic analysis was done with 40 vertebrate Xins. Our results show that the ancestral Xin originated prior to the emergence of lamprey and subsequently underwent gene duplication early in the vertebrate lineage. A subsequent teleost-specific genome duplication resulted in most teleosts encoding at least three genes. All Xins contain a highly conserved β-catenin-binding domain within the Xin repeat region. Similar to mouse Xins, chicken, frog and zebrafish Xins also co-localized with β-catenin to structures that appear to be the intercalated disc. A putative DNA-binding domain in the N-terminus of all Xins is strongly conserved, whereas the previously characterized Mena/VASP-binding domain is a derived trait found only in Xinαs from placental mammals. In the C-terminus, Xinαs and Xinβs are more divergent relative to each other but each isoform from mammals shows a high degree of within-isoform sequence identity. This suggests different but conserved functions for mammalian Xinα and Xinβ. Interestingly, the origin of Xin ca. 550 million years ago coincides with the genesis of heart chambers with complete endothelial and myocardial layers. We postulate that the emergence of the Xin paralogs and their functional differentiation may have played a key role in the evolutionary development of the heart