Multi-angle, Frequency and Polarization Radar Measurement of Ice Sheets

Radio echo sounding of polar ice sheets provides important information on the ice bed topography and internal layers. These data have been used by scientists to create 3D maps of polar ice sheets for climate modeling as well as to reconstruct the climate history that dates back to hundreds of thousands of years. In this paper, we present the design, and development of three surface-based multi-channel radars in the VHF and UHF bands. We provide results from radar data multi-frequency and polarization radar data collected over the Greenland ice sheet. All the three radars shared the same digital waveform generator and digitizer, and were installed in and operated on a tracked vehicle. The radars are operated with 3 different antenna arrays designed for operation over 170-230 MHz, 180-340 MHz and 600-900 MHz. The results we sounded more than 2.7 km thick ice with radars operating at frequencies as high as 850 MHz with more than 40 dB signal-to-noise ratio

A Mobile, Multichannel, UWB Radar for Potential Ice Core Drill Site Identification in East Antarctica: Development and First Results

We developed a high-performance, multichannel, ultra-wideband radar system for measurements of the base and interior of the East Antarctic Ice Sheet. We designed the radar to be of high power (4000-W peak) yet portable and to be able to operate with 60-MHz bandwidth at a center frequency of 200 MHz, providing high sensitivity and fine vertical resolution relative to current technology. We used the radar to perform extensive measurements as a part of a multinational collaboration. We collected data onboard a tracked vehicle outfitted with an array of high-gain antennas. We sounded 2- to 3-km thick ice near Dome Fuji. Preliminary ice thickness data match those obtained via semicoincident measurements performed with a different surface-based pulse-modulated radar system operated during the same field campaign, as well as previous airborne measurements. In addition, we mapped internal reflection horizons with fine vertical resolution from 300 m below the ice surface to ~100 m above the bed. In this article, we provide a detailed overview of the radar instrument design, implementation, and field measurement setup. We present sample data to illustrate its capabilities and discuss how the data collected with it will be valuable for the assessment of promising drilling sites to recover ice cores that are 0.9-1.5 million years old

A Mobile, Multichannel, UWB Radar for Potential Ice Core Drill Site Identification in East Antarctica: Development and First Results

We developed a high-performance, multichannel, ultra-wideband radar system for measurements of the base and interior of the East Antarctic Ice Sheet. We designed the radar to be of high power (4000-W peak) yet portable and to be able to operate with 60-MHz bandwidth at a center frequency of 200 MHz, providing high sensitivity and fine vertical resolution relative to current technology. We used the radar to perform extensive mea- surements as a part of a multinational collaboration. We collected data onboard a tracked vehicle outfitted with an array of high-gain antennas. We sounded 2- to 3-km thick ice near Dome Fuji. Prelim- inary ice thickness data match those obtained via semicoincident measurements performed with a different surface-based pulse- modulated radar system operated during the same field campaign, as well as previous airborne measurements. In addition, we mapped internal reflection horizons with fine vertical resolution from 300 m below the ice surface to ∼100 m above the bed. In this article, we provide a detailed overview of the radar instrument design, implementation, and field measurement setup. We present sample data to illustrate its capabilities and discuss how the data collected with it will be valuable for the assessment of promising drilling sites to recover ice cores that are 0.9–1.5 million years old

Brief Communication: New radar constraints support presence of ice older than 1.5 Ma at Little Dome C.

The area near Dome C, East Antarctica, is thought to be one of the most promising targets for recovering a continuous ice-core record spanning more than a million years. The European Beyond EPICA consortium has selected Little Dome C, an area ~35 km south-east of Concordia Station, to attempt to recover such a record. Here, we present the results of the final ice-penetrating radar survey used to refine the exact drill site. These data were acquired during the 2019–2020 Austral summer using a new, multi-channel high-resolution VHF radar operating in the frequency range of 170–230 MHz. This new instrument is able to detect reflections in the near-basal region, where previous surveys were unable to trace continuous horizons. The radar stratigraphy is used to transfer the timescale of the EPICA Dome C ice core (EDC) to the area of Little Dome C, using radar isochrones dating back past 600 ka. We use these data to derive the expected depth–age relationship through the ice column at the now-chosen drill site, termed BELDC. These new data indicate that the ice at BELDC is considerably older than that at EDC at the same depth, and that there is about 375 m of ice older than 600 ka at BELDC. Stratigraphy is well preserved to 2565 m, below which there is a basal unit with unknown properties. A simple ice flow model tuned to the isochrones suggests ages likely reach 1.5 Ma near 2525 m, ~40 m above the basal unit and ~240 m above the bed, with sufficient resolution (14±1 ka m−1) to resolve 41 ka glacial cycles

International studies of ice sheet and bedrock at Dome Fuji, East Antarctica

The Tenth Symposium on Polar Science/Ordinary sessions: [OM] Polar Meteorology and Glaciology, Wed. 4 Dec. / 2F Auditorium, National Institute of Polar Researc

Off-line evaluation of indoor positioning systems in different scenarios: the experiences from IPIN 2020 competition

Every year, for ten years now, the IPIN competition has aimed at evaluating real-world indoor localisation systems by testing them in a realistic environment, with realistic movement, using the EvAAL framework. The competition provided a unique overview of the state-of-the-art of systems, technologies, and methods for indoor positioning and navigation purposes. Through fair comparison of the performance achieved by each system, the competition was able to identify the most promising approaches and to pinpoint the most critical working conditions. In 2020, the competition included 5 diverse off-site off-site Tracks, each resembling real use cases and challenges for indoor positioning. The results in terms of participation and accuracy of the proposed systems have been encouraging. The best performing competitors obtained a third quartile of error of 1 m for the Smartphone Track and 0.5 m for the Foot-mounted IMU Track. While not running on physical systems, but only as algorithms, these results represent impressive achievements.Track 3 organizers were supported by the European Union’s Horizon 2020 Research and Innovation programme under the Marie Skłodowska Curie Grant 813278 (A-WEAR: A network for dynamic WEarable Applications with pRivacy constraints), MICROCEBUS (MICINN, ref. RTI2018-095168-B-C55, MCIU/AEI/FEDER UE), INSIGNIA (MICINN ref. PTQ2018-009981), and REPNIN+ (MICINN, ref. TEC2017-90808-REDT). We would like to thanks the UJI’s Library managers and employees for their support while collecting the required datasets for Track 3. Track 5 organizers were supported by JST-OPERA Program, Japan, under Grant JPMJOP1612. Track 7 organizers were supported by the Bavarian Ministry for Economic Affairs, Infrastructure, Transport and Technology through the Center for Analytics-Data-Applications (ADA-Center) within the framework of “BAYERN DIGITAL II. ” Team UMinho (Track 3) was supported by FCT—Fundação para a Ciência e Tecnologia within the R&D Units Project Scope under Grant UIDB/00319/2020, and the Ph.D. Fellowship under Grant PD/BD/137401/2018. Team YAI (Track 3) was supported by the Ministry of Science and Technology (MOST) of Taiwan under Grant MOST 109-2221-E-197-026. Team Indora (Track 3) was supported in part by the Slovak Grant Agency, Ministry of Education and Academy of Science, Slovakia, under Grant 1/0177/21, and in part by the Slovak Research and Development Agency under Contract APVV-15-0091. Team TJU (Track 3) was supported in part by the National Natural Science Foundation of China under Grant 61771338 and in part by the Tianjin Research Funding under Grant 18ZXRHSY00190. Team Next-Newbie Reckoners (Track 3) were supported by the Singapore Government through the Industry Alignment Fund—Industry Collaboration Projects Grant. This research was conducted at Singtel Cognitive and Artificial Intelligence Lab for Enterprises (SCALE@NTU), which is a collaboration between Singapore Telecommunications Limited (Singtel) and Nanyang Technological University (NTU). Team KawaguchiLab (Track 5) was supported by JSPS KAKENHI under Grant JP17H01762. Team WHU&AutoNavi (Track 6) was supported by the National Key Research and Development Program of China under Grant 2016YFB0502202. Team YAI (Tracks 6 and 7) was supported by the Ministry of Science and Technology (MOST) of Taiwan under Grant MOST 110-2634-F-155-001

Off-Line Evaluation of Indoor Positioning Systems in Different Scenarios: The Experiences From IPIN 2020 Competition

Every year, for ten years now, the IPIN competition has aimed at evaluating real-world indoor localisation systems by testing them in a realistic environment, with realistic movement, using the EvAAL framework. The competition provided a unique overview of the state-of-the-art of systems, technologies, and methods for indoor positioning and navigation purposes. Through fair comparison of the performance achieved by each system, the competition was able to identify the most promising approaches and to pinpoint the most critical working conditions. In 2020, the competition included 5 diverse off-site off-site Tracks, each resembling real use cases and challenges for indoor positioning. The results in terms of participation and accuracy of the proposed systems have been encouraging. The best performing competitors obtained a third quartile of error of 1 m for the Smartphone Track and 0.5 m for the Foot-mounted IMU Track. While not running on physical systems, but only as algorithms, these results represent impressive achievements.Track 3 organizers were supported by the European Union’s Horizon 2020 Research and Innovation programme under the Marie Skłodowska Curie Grant 813278 (A-WEAR: A network for dynamic WEarable Applications with pRivacy constraints), MICROCEBUS (MICINN, ref. RTI2018-095168-B-C55, MCIU/AEI/FEDER UE), INSIGNIA (MICINN ref. PTQ2018-009981), and REPNIN+ (MICINN, ref. TEC2017-90808-REDT). We would like to thanks the UJI’s Library managers and employees for their support while collecting the required datasets for Track 3. Track 5 organizers were supported by JST-OPERA Program, Japan, under Grant JPMJOP1612. Track 7 organizers were supported by the Bavarian Ministry for Economic Affairs, Infrastructure, Transport and Technology through the Center for Analytics-Data-Applications (ADA-Center) within the framework of “BAYERN DIGITAL II. ” Team UMinho (Track 3) was supported by FCT—Fundação para a Ciência e Tecnologia within the R&D Units Project Scope under Grant UIDB/00319/2020, and the Ph.D. Fellowship under Grant PD/BD/137401/2018. Team YAI (Track 3) was supported by the Ministry of Science and Technology (MOST) of Taiwan under Grant MOST 109-2221-E-197-026. Team Indora (Track 3) was supported in part by the Slovak Grant Agency, Ministry of Education and Academy of Science, Slovakia, under Grant 1/0177/21, and in part by the Slovak Research and Development Agency under Contract APVV-15-0091. Team TJU (Track 3) was supported in part by the National Natural Science Foundation of China under Grant 61771338 and in part by the Tianjin Research Funding under Grant 18ZXRHSY00190. Team Next-Newbie Reckoners (Track 3) were supported by the Singapore Government through the Industry Alignment Fund—Industry Collaboration Projects Grant. This research was conducted at Singtel Cognitive and Artificial Intelligence Lab for Enterprises (SCALE@NTU), which is a collaboration between Singapore Telecommunications Limited (Singtel) and Nanyang Technological University (NTU). Team KawaguchiLab (Track 5) was supported by JSPS KAKENHI under Grant JP17H01762. Team WHU&AutoNavi (Track 6) was supported by the National Key Research and Development Program of China under Grant 2016YFB0502202. Team YAI (Tracks 6 and 7) was supported by the Ministry of Science and Technology (MOST) of Taiwan under Grant MOST 110-2634-F-155-001.Peer reviewe

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival