Global Advances and Frontiers of Phytochemicals in Tumor Research: A Bibliometric Study (2010-2023)

Objectives: Analysis of advances, hotspots and frontiers of tumor-related phytochemicals by scientifc bibliometric methods during 2012-2023. Background: Natural phytochemicals are abundantly found in nature and have a wide range of biological activities. Phytochem-icals have been shown to provide both curative and preventive benefts on many chronic diseases such as cancers. Tumor research on phyto-chemicals is one of the felds with the greatest potential for expansion in the world. However, there is still much to explore about the action mechanism of phytochemicals, the efcacy and safety of application in vivo, and the value of clinical practice. Methods: Atotal of 6523 arti-cles on tumor-related phytochemicals were identifed from the Web of Science Core Collection (WOSCC) database for research on tumor-re-lated phytochemicals. The bibliometric analysis was carried out using CiteSpace and the R package “Bibliometrix”. Results: The analysis includes 6523 publications from 144 nations or regions, with China leading the way. The number of annual publications increased rapidly from 2012 to 2022 and reached a maximum in 2022. China published the most articles, followed by India and the United States. There is a wide range of collaborations between countries, with Saudi Arabia and Egypt being the closest partners. LI Y has produced the most research outputs, yet Prof. Liu RH has received the most local citations. Although MOLECULES has the most articles, FOOD CHEMISTRY is the journal with the highest H-index. The main topics include phytochemical mechanisms and clinical applications in carcinogenesis and devel-opment. “Secondary metabolite”, “green synthesis”, “functional food”, and “degradation” all exhibit signifcant citation burstness between 2019-2023. Conclusions: This study is the frst to apply bibliometrics to examine the development of phytochemicals in oncology research over the period 2010-2023, which gives researchers a brief overview of advances, hotspots, and potential future trends in the feld

Co-evolving Vector Quantization for ID-based Recommendation

Category information plays a crucial role in enhancing the quality and personalization of recommendations. Nevertheless, the availability of item category information is not consistently present, particularly in the context of ID-based recommendations. In this work, we propose an alternative approach to automatically learn and generate entity (i.e., user and item) categorical information at different levels of granularity, specifically for ID-based recommendation. Specifically, we devise a co-evolving vector quantization framework, namely COVE, which enables the simultaneous learning and refinement of code representation and entity embedding in an end-to-end manner, starting from the randomly initialized states. With its high adaptability, COVE can be easily integrated into existing recommendation models. We validate the effectiveness of COVE on various recommendation tasks including list completion, collaborative filtering, and click-through rate prediction, across different recommendation models. We will publish the code and data for other researchers to reproduce our work

312-fs pulse generation from a passive C-band InAs/InP quantum dot mode-locked laser.

For the first time, we report femtosecond pulses from a passive single-section InAs/InP quantum-dot (QD) mode-locked laser (MLL) with the active length of 456 microm and ridge width of 2.5 microm at the C-band wavelength range. Without any external pulse compression, the transform-limited Gaussian-pulses are generated at the 92 GHz repetition rate with the 312 fs pulse duration, which is the shortest pulse from any directly electric-pumping semiconductor MLLs to our best knowledge. The lasing threshold injection current and external differential quantum efficiency are 17.2 mA and 38%, respectively. We have also investigated the working principles of the proposed QD MLLs

LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/stat3/akt pathway

Background: Gankyrin has shown to be overexpressed in human liver cancers and plays a complex role in hepatocarcinogenesis. Panobinostat (LBH589), a new hydroxamic acid-derived histone deacetylase inhibitor has shown promising anticancer effects recently. Here, we investigated the potential of LBH589 as a form of treatment for hepatocellular carcinoma (HCC). Methods: Gankyrin plasmid was transfected into HCC cells, and the cells were selected for more than 4 weeks by incubation with G418 for overexpression clones. The therapeutic effects of LBH589 were evaluated in vitro and in vivo. Cell proliferation, apoptosis, cell cycle, invasive potential, and epithelial-mesenchy-mal transition (EMT) were examined. Results: LBH589 significantly inhibited HCC growth and metastasis in vitro and in vivo. Western blotting analysis indicated that LBH589 could decrease the expression of gankyrin and subsequently reduced serine-phosphorylated Akt and tyrosine-phosphorylated STAT3 expression although the total Akt and STAT3 were unaffected. LBH589 inhibited metastasis in vitro via down-regulation of N-cadherin, vimentin, TWIST1, VEGF and up-regulation of E-cadherin. LBH589 also induced apoptosis and G1 phase arrest in HCC cell lines. Ectopic expression of gankyrin attenuated the effects of LBH589, which indicates that gankyrin might play an important role in LBH589 mediated anticancer effects. Lastly, in vivo study indicated that LBH589 inhibited tumor growth and metastasis, without discernable adverse effects comparing to control group, with abrogating gankyrin/STAT3/Akt pathway. Conclusions: Our results suggested that LBH589 could inhibit HCC growth and metastasis through down-regulating gankyrin/STAT3/Akt pathway. LBH589 may present itself as a novel therapeutic strategy for HCC

SPIE

NRC publication: Ye

InAs/InP Quantum Dash Semiconductor Coherent Comb Lasers and their Applications in Optical Networks

We report on the design, growth, and fabrication of InAs/InP quantum dash (QD) gain materials and their use in lasers for optical network applications. A noise performance comparison between QD and quantum well (QW) Fabry–Perot (F-P) lasers has been made. By using the QD gain material we have successfully developed and assembled C-band coherent comb laser (CCL) modules with an electrical fast feedback loop control system to ensure a targeted mode frequency spacing. The frequency spacing was maintained within ±100 ppm and the operation wavelengths locked on the desired ITU grid within 0.01 nm over a period of several months. We also investigated a 25-GHz C-band QD CCL with an external cavity self-injection feedback locking (SIFL) system to reduce the optical linewidth of each individual channel to below 200 kHz in the wavelength range from 1537.55 nm to 1545.14 nm. The RF mode beating signal 3-dB bandwidth was also reduced from 9 kHz to approximately 500 Hz with this SIFL system. These QD CCLs with ultra-low relative intensity noise (RIN), ultra-narrow optical linewidth, and ultra-low timing jitter are excellent laser sources for multi-terabit optical networks. Using a 34.2 GHz QD CCL we demonstrate 10.8 Tbit/s (16QAM 48 × 28 GBaud PDM) coherent data transmission over 100 km of standard single mode fiber (SSMF) and 5.4 Tbit/s (PAM-4 48 × 28 GBaud PDM) aggregate data transmission capacity over 25 km of SSMF with error-free operation

Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in Hepatocellular Carcinoma

Background: Arsenic trioxide has been demonstrated as an effective anti-cancer drug against leukemia and solid tumors both in vitro and in vivo. However, recent phase II trials demonstrated that single agent arsenic trioxide was poorly effective against hepatocellular carcinoma (HCC), which might be due to drug resistance. Methods: Mutation detection of p53 gene in arsenic trioxide resistant HCC cell lines was performed. The therapeutic effects of arsenic trioxide and Nutlin-3 on HCC were evaluated both in vitro and in vivo. A series of experiments including MTT, apoptosis assays, co-Immunoprecipitation, siRNA transfection, lentiviral infection, cell migration, invasion, and epithelial-mesenchy-mal transition (EMT) assays were performed to investigate the underlying mechanisms. Results: The acquisition of p53 mutation contributed to arsenic trioxide resistance and enhanced metastatic potential of HCC cells. Mutant p53 (Mutp53) silence could re-sensitize HCC resistant cells to arsenic trioxide and inhibit the metastatic activities, while mutp53 overexpression showed the opposite effects. Neither arsenic trioxide nor Nutlin-3 could exhibit obvious effects against arsenic trioxide resistant HCC cells, while combination of them showed significant effects. Nutlin-3 can not only increase the intracellular arsenicals through inhibition of p-gp but also promote the p73 activation and mutp53 degradation mediated by arsenic trioxide. In vivo experiments indicated that Nutlin-3 can potentiate the antitumor activities of arsenic trioxide in an orthotopic hepatic tumor model and inhibit the metastasis to lung. Conclusions: Acquisitions of p53 mutations contributed to the resistance of HCC to arsenic trioxide. Nutlin-3 could overcome arsenic trioxide resistance and inhibit tumor metastasis through p73 activation and promoting mutant p53 degradation mediated by arsenic trioxide

EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF COMPOUND HERBS PUXING YINYANG SAN

Background: Bovine mastitis is one of the most relevant and problematic diseases to treat and control in practice. Puxing Yinyang San (PYS) is a compound of herbs to treat bovine mastitis in China. This study was performed to evaluate the analgesic and anti-inflammatory activities of PYS in mice and rats. Materials and Methods: The analgesic and anti-inflammatory activities of PYS were determined using acetic acid-induced writhing response, hot plate test, xylene-induced ear swelling test, carrageenan-induced paw edema test, and acetic acid-induced capillary permeability and leukocyte infiltration test with oral doses of 155, 310 and 620 mg/kg·bw in mice or rats. Results: The acetic acid-induced writhing response was dose-dependently inhibited by oral administration of PYS and the latency time to thermal stimuli was increased in the hot plate test, especially 90 minutes after treatment. In the xylene-induced ear swelling, PYS significantly decreased swelling degree in a dose-dependent manner. Additionally, PYS significantly suppressed the peritoneal capillary permeability and leukocyte infiltration in mice induced by intraperitoneal injection of acetic acid. PYS also significantly reduced the carrageenan-induced rat paw edema at 2, 3, and 4 h after the carrageenan injection. The results suggested that PYS possessed significant analgesic and anti-inflammatory activities. Conclusion: This study was the first to demonstrate that oral administration of PYS might play an important role in the process of analgesia and anti-inflammation, supporting its treatment for mastitis. Future investigations will focus on the broader involvement of the ingredients and mechanisms responsible for pharmacological activities of PYS