145 research outputs found
BAGEL: Backdoor Attacks against Federated Contrastive Learning
Federated Contrastive Learning (FCL) is an emerging privacy-preserving
paradigm in distributed learning for unlabeled data. In FCL, distributed
parties collaboratively learn a global encoder with unlabeled data, and the
global encoder could be widely used as a feature extractor to build models for
many downstream tasks. However, FCL is also vulnerable to many security threats
(e.g., backdoor attacks) due to its distributed nature, which are seldom
investigated in existing solutions. In this paper, we study the backdoor attack
against FCL as a pioneer research, to illustrate how backdoor attacks on
distributed local clients act on downstream tasks. Specifically, in our system,
malicious clients can successfully inject a backdoor into the global encoder by
uploading poisoned local updates, thus downstream models built with this global
encoder will also inherit the backdoor. We also investigate how to inject
backdoors into multiple downstream models, in terms of two different backdoor
attacks, namely the \textit{centralized attack} and the \textit{decentralized
attack}. Experiment results show that both the centralized and the
decentralized attacks can inject backdoors into downstream models effectively
with high attack success rates. Finally, we evaluate two defense methods
against our proposed backdoor attacks in FCL, which indicates that the
decentralized backdoor attack is more stealthy and harder to defend
QoS multicast tree construction in IP/DWDM optical internet by bio-inspired algorithms
Copyright @ Elsevier Ltd. All rights reserved.In this paper, two bio-inspired Quality of Service (QoS) multicast algorithms are proposed in IP over dense wavelength division multiplexing (DWDM) optical Internet. Given a QoS multicast request and the delay interval required by the application, both algorithms are able to find a flexible QoS-based cost suboptimal routing tree. They first construct the multicast trees based on ant colony optimization and artificial immune algorithm, respectively. Then a dedicated wavelength assignment algorithm is proposed to assign wavelengths to the trees aiming to minimize the delay of the wavelength conversion. In both algorithms, multicast routing and wavelength assignment are integrated into a single process. Therefore, they can find the multicast trees on which the least wavelength conversion delay is achieved. Load balance is also considered in both algorithms. Simulation results show that these two bio-inspired algorithms can construct high performance QoS routing trees for multicast applications in IP/DWDM optical Internet.This work was supported in part ny the Program for New Century Excellent Talents in University, the Engineering and Physical Sciences Research Council (EPSRC) of UK under Grant EP/E060722/1, the National Natural Science Foundation of China under Grant no. 60673159 and 70671020, the National High-Tech Reasearch and Development Plan of China under Grant no. 2007AA041201, and the Specialized Research Fund for the Doctoral Program of Higher Education under Grant no. 20070145017
An Energy-Aware Routing Protocol in Wireless Sensor Networks
The most important issue that must be solved in designing a data gathering algorithm for wireless sensor networks (WSNS) is how to save sensor node energy while meeting the needs of applications/users. In this paper, we propose a novel energy-aware routing protocol (EAP) for a long-lived sensor network. EAP achieves a good performance in terms of lifetime by minimizing energy consumption for in-network communications and balancing the energy load among all the nodes. EAP introduces a new clustering parameter for cluster head election, which can better handle the heterogeneous energy capacities. Furthermore, it also introduces a simple but efficient approach, namely, intra-cluster coverage to cope with the area coverage problem. We use a simple temperature sensing application to evaluate the performance of EAP and results show that our protocol significantly outperforms LEACH and HEED in terms of network lifetime and the amount of data gathered
Quantum geometric-induced third-order nonlinear transport in antiferromagnetic topological insulator MnBi2Te4
Discovering the nonlinear transport features in antiferromagnets is of
fundamental interest in condensed matter physics as it offers a new frontier of
the understanding deep connections between multiple degrees of freedom,
including magnetic orders, symmetries, and band geometric properties.
Antiferromagnetic topological insulator MnBiTe has provided a
highly tunable platform for experimental explorations due to its rich magnetic
structures and striking topological band structures. Here, we experimentally
investigate the third-order nonlinear transport properties in bulk
MnBiTe flakes. The measured third-harmonic longitudinal
() and transverse () voltages show
intimate connection with magnetic transitions of MnBiTe flakes and
their magnitudes change abruptly as MnBiTe flakes go through
magnetic transitions with varying temperature and magnetic fields. In addition,
the measured exhibits an even-symmetric feature with
changing magnetic field direction and the shows an
odd-symmetric property, which are believed to be related to the quantum metric
and the emergency of non-zero Berry curvature quadrupole with broken
symmetry and non-degenerate band structures under external magnetic fields,
respectively. Our work shows great advances in the understanding of the
underlying interactions between multiple geometric quantities
Comparative mortality of hemodialysis patients at for-profit and not-for-profit dialysis facilities in the United States, 1998 to 2003: A retrospective analysis
<p>Abstract</p> <p>Background</p> <p>Concern lingers that dialysis therapy at for-profit (versus not-for-profit) hemodialysis facilities in the United States may be associated with higher mortality, even though 4 of every 5 contemporary dialysis patients receive therapy in such a setting.</p> <p>Methods</p> <p>Our primary objective was to compare the mortality hazards of patients initiating hemodialysis at for-profit and not-for-profit centers in the United States between 1998 and 2003. For-profit status of dialysis facilities was determined after subjects received 6 months of dialysis therapy, and mean follow-up was 1.7 years.</p> <p>Results</p> <p>Of the study population (<it>N </it>= 205,076), 79.9% were dialyzed in for-profit facilities after 6 months of dialysis therapy. Dialysis at for-profit facilities was associated with higher urea reduction ratios, hemoglobin levels (including levels above 12 and 13 g/dL [120 and 130 g/L]), epoetin doses, and use of intravenous iron, and less use of blood transfusions and lower proportions of patients on the transplant waiting-list (<it>P </it>< 0.05). Patients dialyzed at for-profit and at not-for-profit facilities had similar mortality risks (adjusted hazards ratio 1.02, 95% CI 0.99–1.06, <it>P </it>= 0.143).</p> <p>Conclusion</p> <p>While hemodialysis treatment at for-profit and not-for-profit dialysis facilities is associated with different patterns of clinical benchmark achievement, mortality rates are similar.</p
Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins
Central nervous system (CNS) involvement remains an important cause of morbidity and mortality in acute leukemia, the mechanisms of leukemic cell infiltration into the CNS have not yet been elucidated. The blood-brain barrier (BBB) makes CNS become a refugee to leukemic cells and serves as a resource of cells that seed extraneural sites. How can the leukemic cells disrupt this barrier and invasive the CNS, even if many of the currently available chemotherapies can not cross the BBB? Tight junction in endothelial cells occupies a central role in the function of the BBB. Except the well known role of degrading extracellular matrix in metastasis of cancer cells, here we show matrix metalloproteinase (MMP)-2 and -9, secreted by leukemic cells, mediate the BBB opening by disrupting tight junction proteins in the CNS leukemia. We demonstrated that leukemic cells impaired tight junction proteins ZO-1, claudin-5 and occludin resulting in increased permeability of the BBB. However, these alterations reduced when MMP-2 and -9 activities were inhibited by RNA interference strategy or by MMP inhibitor GM6001 in an in vitro BBB model. We also found that the disruption of the BBB in company with the down-regulation of ZO-1, claudin-5 and occludin and the up-regulation of MMP-2 and -9 in mouse brain tissues with leukemic cell infiltration by confocal imaging and the assay of in situ gelatin zymography. Besides, GM6001 protected all mice against CNS leukemia. Our findings suggest that the degradation of tight junction proteins ZO-1, claudin-5 and occludin by MMP-2 and -9 secreted by leukemic cells constitutes an important mechanism in the BBB breakdown which contributes to the invasion of leukemic cells to the CNS in acute leukemia
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