How Does Enterprise Social Software Impact on Employees’ Innovation Behavior? The Role of Symbolic Capital

Organizations are increasingly adopting new technologies, such as enterprise social software (ESS), which afford employees a repertoire of uses. They not simply focused on work but also on socialization and entertainment. Previous research suggested that the implementation of ESS in an organization had an impact on their employee’s creative behavior. However, how does it impact on is still not clear. In the present study, the generative mechanism of the impact on their employee’s innovation behavior is investigated. Based on the practice theory of Bourdieu and theory of critical realism, a large number of interviews within four small medium enterprises was conducted by the grounded theory methodology. The results indicated that the impact on their employee’s creative behavior was accomplished by four steps, i.e., ESS usage, capitals reproduced, being recognized and practice of creation. The managerial implications from our study are discussed finally. Keywords: ESS, Symbolic capital, Innovation behavior, Generative mechanis

Two-dimensional sp2 carbon–conjugated covalent organic frameworks

We synthesized a two-dimensional (2D) crystalline covalent organic framework (sp2c-COF) that was designed to be fully π-conjugated and constructed from all sp2-carbons by C=C condensation reactions of tetrakis(4-formylphenyl)pyrene and 1,4-phenylenediacetonitrile. The C=C linkages topologically connect pyrene knots at regular intervals into a 2D lattice with π-conjugations extended along both x and y directions, and develop an eclipsed layer framework rather than the more conventionally obtained disordered structures. The sp2c-COF is a semiconductor with a discrete band gap of 1.9 eV and can be chemically oxidized to enhance conductivity by 12 orders of magnitude. The generated radicals are confined on the pyrene knots, enabling the formation of a paramagnetic carbon structure with high spin density. The sp2-carbon framework induces ferromagnetic phase transition to develop spin-spin coherence and align spins unidirectionally across the material

Organization of the pronephric kidney revealed by large-scale gene expression mapping

Gene expression mapping reveals 8 functionally distinct domains in the Xenopus pronephros. Interestingly, no structure equivalent to the mammalian collecting duct is identified

High‐precision size recognition and separation in synthetic 1D nanochannels

Covalent organic frameworks (COFs) allow elaborate manufacture of ordered one‐dimensional channels in the crystal. We defined a superlattice of COFs by engineering channels with a persistent triangular shape and discrete pore size. We observed a size‐recognition regime that is different from the characteristic adsorption of COFs, whereby pore windows and walls were cooperative so that triangular apertures sorted molecules of one‐atom difference and notch nanogrooves confined them into single‐file molecular chains. The recognition and confinement were accurately described by sensitive spectroscopy and femtosecond dynamic simulations. The resulting COFs enabled instantaneous separation of mixtures at ambient temperature and pressure. This study offers an approach to merge precise recognition, selective transport, and instant separation in synthetic 1D channels

Identification of a Potential miRNA–mRNA Regulatory Network Associated With the Prognosis of HBV-ACLF

BackgroundHepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a life-threatening disease with a high mortality rate; the systemic inflammatory response plays a vital role in disease progression. We aimed to determine if a miRNA–mRNA co-regulatory network exists in the peripheral blood mononuclear cells (PBMCs) of HBV-ACLF patients, which might be important for prognosis.MethodsTranscriptome-wide microRNA (miRNA) and mRNA microarrays were used to define the miRNA and mRNA expression profiles of the PBMCs of HBV-ACLF patients in a discovery cohort. The targets of the miRNAs were predicted. We built a miRNA-mRNA regulatory network through bioinformatics analysis, and used quantitative real-time polymerase chain reaction (qRT-PCR) to assess the importance of candidate miRNAs and mRNAs. We also assessed the direct and transcriptional regulatory effects of miRNAs on target mRNAs using a dual-luciferase reporter assay.ResultsThe miRNA/mRNA PBMC expression profiles of the discovery cohort, of whom eight survived and eight died, revealed a prognostic interactive network involving 38 miRNAs and 313 mRNAs; this was constructed by identifying the target genes of the miRNAs. We validated the expression data in another cohort, of whom 43 survived and 35 died; miR-6840-3p, miR-6861-3p, JADE2, and NR3C2 were of particular interest. The levels of miR-6840-3p and miR-6861-3p were significantly increased in the PBMCs of the patients who died, and thus predicted prognosis (areas under the curve values = 0.665 and 0.700, respectively). The dual-luciferase reporter assay indicated that miR-6840-3p directly targeted JADE2.ConclusionWe identified a prognostic miRNA-mRNA co-regulatory network in the PBMCs of HBV-ACLF patients. miR-6840-3p-JADE2 is a potential miRNA–mRNA pair contributing to a poor prognosis

Genome-wide DNA methylation profiling in blood reveals epigenetic signature of incident acute coronary syndrome

DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear in cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS in two Chinese cohorts (discovery: 751 nested case-control pairs; replication: 476 nested case-control pairs). We identified and validated 26 differentially methylated positions (DMPs, false discovery rate [FDR] <0.05), including three mapped to known cardiovascular disease genes (PRKCZ, PRDM16, EHBP1L1) and four with causal evidence from Mendelian randomization (PRKCZ, TRIM27, EMC2, EHBP1L1). Two hypomethylated DMPs were negatively correlated with the expression in blood of their mapped genes (PIGG and EHBP1L1), which were further found to overexpress in leukocytes and/or atheroma plaques. Finally, our DMPs could substantially improve the prediction of ACS over traditional risk factors and polygenic scores. These findings demonstrate the importance of DNAm in the pathogenesis of ACS and highlight DNAm as potential predictive biomarkers and treatment targets

Discovery and Genomic Characterization of Noroviruses from a Gastroenteritis Outbreak in Domestic Cats in the US

Norovirus (NoV) RNA was detected in the stools of 6 out 14 (42.8%) 8–12-week-old cats with enteritis from a feline shelter, in New York State. Upon sequence analysis of the complete capsid, the six NoVs were found to be identical, suggesting the spread of a unique NoV strain in the shelter. The full-length genomic sequence (7839 nt) of one feline NoV, CU081210E/2010/US, was determined. In the capsid protein VP1 region, the virus displayed the highest amino acid identity to animal genogroup IV genotype 2 (GIV.2) NoVs: lion/Pistoia-387/06/IT (97.9%) and dog/Bari-170/07/IT (90.4%). These findings document the discovery of a novel feline calicivirus, different from vesiviruses, and extend the spectrum of NoV host range. Epidemiological studies using feline NoV-specific diagnostic tools and experimental infection of cats are required to understand whether NoVs have a pathogenic role in this species

Transcriptional regulation of axonal pathfinding: FoxB1 and the mammillothalamic tract

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Strategic Management in East Asia SMEs : The Case Study of SMEs in China and Indonesia

  Problem: Researchers argue that strategic management and its implementation has be-come the main focus in SMEs because of its role in generating economic wealth. Although, there are many advantages to use strategic management, there are still many SME organizations that resist using it, since some of them may think this process is only useful for larger organizations and they did not recognize that it‟s also very helpful for SMEs as a whole. Therefore, the organization face challenges such as how to use this strategic management, and how to recognize the importance of strategic management and so on.     Purpose: Our purpose is to find out how strategic management determines / affects / in-fluence SMEs performance in South East Asia and specifically in China and In-donesia. Moreover, its purpose is to identify the crucial factors that determine survival and growth in the two countries. Theory: The theoretical framework is divided into several major parts. We start with looking at definition of strategy and different types of strategy in organization. The chapter continues with looking at SMEs strategic Management Model (Analoui &amp; Karami, 2003), strategic choice, strategic fit and theory of firm per-formance i.e. dynamic capabilities (core capabilities). The last part of the chap-ter combine the previous theory, i.e. strategy and firm performance. More spe-cific, we use our theoretical framework of the process, regarding the effect of strategic management on SMEs performance.   Method: We chose qualitative method as our research method. We use case study to do this research and conduct interview to collect data. Qualitative is the appropriate method for this thesis since we aim to understand the phenomenon of SMEs strategic management on different levels. In order to gain more information, we conducted interview with middle management and top management of the com-pany. This method help us to explore into deeper stages of analyzing our subject and support our research.   Conclusion: We found there is no general answer on how strategic management determine / affects / influence SMEs performance in East Asia SMEs specifically in China and Indonesia. Further, the studied companies have more common characteris-tics than different characteristics. All of them are aware of the importance of us-ing strategic management. Moreover, our research indicate that understanding the role of internal &amp; external factors, and constantly combining the two factors into daily operation are the crucial factors for these companies survival and growth in the two countries