SOA pattern effect mitigation by neural network based pre-equalizer for 50G PON

Semiconductor optical amplifier (SOA) is widely used for power amplification in O-band, particularly for passive optical networks (PONs) which can greatly benefit its advantages of simple structure, low power consumption and integrability with photonics circuits. However, the annoying nonlinear pattern effect degrades system performance when the SOA is needed as a pre-amplifier in PONs. Conventional solutions for pattern effect mitigation are either based on optical filtering or gain clamping. They are not simple or sufficiently flexible for practical deployment. Neural network (NN) has been demonstrated for impairment compensation in optical communications thanks to its powerful nonlinear fitting ability. In this paper, for the first time, NN-based equalizer is proposed to mitigate the SOA pattern effect for 50G PON with intensity modulation and direct detection. The experimental results confirm that the NN-based equalizer can effectively mitigate the SOA nonlinear pattern effect and significantly improve the dynamic range of receiver, achieving 29-dB power budget with the FEC limit at 1e-2. Moreover, the well-trained NN model in the receiver side can be directly placed at the transmitter in the optical line terminal to pre-equalize the signal for transmission so as to simplify digital signal processing in the optical network unit

AI/ML for Beam Management in 5G-Advanced

In beamformed wireless cellular systems such as 5G New Radio (NR) networks, beam management (BM) is a crucial operation. In the second phase of 5G NR standardization, known as 5G-Advanced, which is being vigorously promoted, the key component is the use of artificial intelligence (AI) based on machine learning (ML) techniques. AI/ML for BM is selected as a representative use case. This article provides an overview of the AI/ML for BM in 5G-Advanced. The legacy non-AI and prime AI-enabled BM frameworks are first introduced and compared. Then, the main scope of AI/ML for BM is presented, including improving accuracy, reducing overhead and latency. Finally, the key challenges and open issues in the standardization of AI/ML for BM are discussed, especially the design of new protocols for AI-enabled BM. This article provides a guideline for the study of AI/ML-based BM standardization.Comment: 4 figure

100G PAM-4 PON with 34 dB Power Budget Using Joint Nonlinear Tomlinson-Harashima Precoding and Volterra Equalization

We experimentally demonstrate 100G PAM-4 passive optical network using DML-based intensity modulation and direct detection with 3-dB system bandwidth of 15 GHz in O-band. Combining nonlinear Tomlinson-Harashima precoding at the transmitter and 2nd-order Volterra at the receiver enables 34-dB power budget for PON downstream

Circulating exo-miR-154-5p regulates vascular dementia through endothelial progenitor cell-mediated angiogenesis

BackgroundVascular dementia (VaD) mainly results from cerebral vascular lesions and tissue changes, which contribute to neurodegenerative processes. Effective therapeutic approaches to targeting angiogenesis may reduce mortality of VaD. Endothelial progenitor cells (EPCs) play a key role in postnatal angiogenesis. Many exosomal microRNAs (exo-miRNAs) have been reported to involve in the development of dementia. The present study was designed to investigate whether the expression profile of the exo-miRNAs is significantly altered in patients with VaD and to reveal the function of differentially expressed miRNAs and the relevant mechanisms in EPC-mediated angiogenesis in VaD rat model.ResultsExosomes isolated from serum of patients with VaD (n = 7) and age-matched control subjects (n = 7), and miRNA sequencing and bioinformatics analysis found that circulating exosome miRNA-155-5p, miRNA-154-5p, miR-132-5p, and miR-1294 were upregulated in patients with VaD. The expression of miRNA-154-5p was further verified to be upregulated in clinical samples (n = 23) and 2-vessel occlusion-induced VaD rat model by reverse transcription quantitative PCR (RT-qPCR). Notably, miRNA-154-5p inhibition in bone marrow-EPCs (BM-EPCs) from VaD rats improved EPC functions, including tube formation, migration, and adhesion, and elevated concentrations of vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1α (SDF-1α). The mRNA levels of ICAM-1, VCAM-1, and MCP-1 were reduced in miRNA-154-5p-inhibited EPCs. In addition, miRNA-154-5p inhibition increased the level of superoxide dismutase (SOD), and decreased reactive oxygen species (ROS) in EPCs. PRKAA2 was chosen as a promising target gene of miR-154-5p, and miRNA-154-5p inhibition upregulated the protein expression of AMPKα2. Furthermore, upregulation of miR-154-5p markedly diminished EPC functions and inhibited angiogenesis following EPC transplantation in VaD rats.ConclusionCirculating exo-miR-154-5p was upregulated in patients with VaD, and miR-154-5p upregulation was associated with impaired EPC functions and angiogenesis in VaD rat model. Therefore, miR-154-5p is a promising biomarker and therapeutic strategy for VaD

Association between the triglyceride to high-density lipoprotein cholesterol ratio and the risk of type 2 diabetes mellitus among Chinese elderly: The Beijing Longitudinal Study of Aging

Objective: Time-dependent covariates are generally available as longitudinal data were collected periodically in the cohort study. To examine whether time-dependent triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio could predict the future risk of type 2 diabetes mellitus (T2DM) and assess its potential impact on the risk of T2DM incidence. Research design and methods: This study enrolled 1460 participants without T2DM aged 55 or above in 1992 in the Beijing Longitudinal Study of Aging during 25 years. The questionnaire data were collected in nine surveys from 1992 to 2017. Physical examination and blood laboratory tests including TG and HDL-C concentrations were measured in five surveys. Incident T2DM cases were confirmed via a self-reported history of T2DM or the fasting plasma glucose level. Results: 119 new cases of T2DM were identified. In the Cox regression analysis with time-dependent TG/HDL-C ratios and covariates, the adjusted hazard ratios (95% confidence interval) of T2DM incidence were 1.90 (1.12 to 3.23), 2.75 (1.58 to 4.80) and 2.84 (1.69 to 4.77), respectively, for those with TG/HDL-C ratios (both TG and HDL-C were expressed in millimole per liter) in the ranges of 0.87-1.30, 1.31-1.74 and ≥ 1.75, compared with individuals with TG/HDL-C ratios \u3c 0.87. The similar results of subdistribution hazard ratios were obtained by performing the Fine-Gray model with time-dependent TG/HDL-C ratios. This positive association and the statistically significant trend with increased risk of T2DM incidence in the three categories of elevated TG/HDL-C ratio was confirmed by multiple sensitivity analyses. Furthermore, the T2DM discriminatory power of TG/HDL-C ratio combining with other risk factors was moderately high. Conclusions: We found that time-dependent TG/HDL-C ratios were positively associated with the risk of T2DM risk. The elevated TG/HDL-C ratios increased the future risk of T2DM incidence. Lowering the TG/HDL-C ratio could assist in the prevention of diabetes for older adults. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ

Integrated Optical-Wireless Interface and Detection

This chapter elaborates on the beneficial aspects and hardware implementations of incorporating ultradense WDM-PONs (UDWDM-PONs) with hybrid optical-wireless fronthaul links and fiber to the home applications. Simulation results on the synthesis of a low-cost and low-energy consumption optoelectronic unit within the future 5G base stations (BS) are presented. In addition, an advanced neural network is investigated capable of compensating for the linear and nonlinear effects induced by semiconductor optical amplifiers (SOA)

50-Gb/s Dispersion-unmanaged DMT Transmission with Injection Locked 10G-class 1.55-mu m DML

We demonstrate 50-Gb/s DMT signal transmission over 20-km SMF by using a 10G-class 1.55-mu m DML without optical dispersion compensation. Injection locking technique is introduced, which doubles system bandwidth and greatly suppresses DML chirp. (c) 2019 The Author(s

200 Gbps/lane IM/DD Technologies for Short Reach Optical Interconnects

Client-side optics are facing an ever-increasing upgrading pace, driven by upcoming 5G related services and datacenter applications. The demand for a single lane data rate is soon approaching 200 Gbps. To meet such high-speed requirement, all segments of traditional intensity modulation direct detection (IM/DD) technologies are being challenged. The characteristics of electrical and optoelectronic components and the performance of modulation, coding, and digital signal processing (DSP) techniques are being stretched to their limits. In this context, we witnessed technological breakthroughs in several aspects, including development of broadband devices, novel modulation formats and coding, and high-performance DSP algorithms for the past few years. A great momentum has been accumulated to overcome the aforementioned challenges. In this article, we focus on IM/DD transmissions, and provide an overview of recent research and development efforts on key enabling technologies for 200 Gbps per lane and beyond. Our recent demonstrations of 200 Gbps short-reach transmissions with 4-level pulse amplitude modulation (PAM) and discrete multitone signals are also presented as examples to show the system requirements in terms of device characteristics and DSP performance. Apart from digital coherent technologies and advanced direct detection systems, such as Stokes–vector and Kramers–Kronig schemes, we expect high-speed IM/DD systems will remain advantageous in terms of system cost, power consumption, and footprint for short reach applications in the short- to mid- term perspective

Identification of avian polyomavirus and its pathogenicity to SPF chickens

The research aimed to study an Avian polyomavirus strain that was isolated in Shandong, China. To study the pathogenicity of APV in SPF chickens, and provide references for epidemiological research and disease prevention and control of APV. The genetic characterization of APV strain (termed APV-20) was analyzed and the pathogenicity of APV was investigated from two aspects: different age SPF chickens, and different infection doses. The results revealed that the APV-20 exhibits a nucleotide homology of 99% with the other three APV strains, and the evolution of APV In China was slow. In addition, the APV-20 infection in chickens caused depression, drowsiness, clustering, and fluffy feathers, but no deaths occurred in the infected chickens. The main manifestations of necropsy, and Hematoxylin and Eosin staining (HE) showed that one-day-old SPF chickens were the most susceptible, and there was a positive correlation between viral load and infection dose in the same tissue. This study showed that SPF chickens were susceptible to APV, and an experimental animal model was established. This study can provide a reference for the pathogenic mechanism of immune prevention and control of APV

Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes

YesInfection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended with metronidazole (MNA). Acetic acid (HAc) was introduced to improve the miscibility of PCL and gelatin to fabricate homogeneous hybrid nanofiber membranes. The effects of the addition of HAc and the MNA content (0, 1, 5, 10, 20, 30, and 40 wt.% of polymer) on the properties of the membranes were investigated. The membranes showed good mechanical properties, appropriate biodegradation rate and barrier function. The controlled and sustained release of MNA from the membranes significantly prevented the colonization of anaerobic bacteria. Cells could adhere to and proliferate on the membranes without cytotoxicity until the MNA content reached 30%. Subcutaneous implantation in rabbits for 8 months demonstrated that MNA-loaded membranes evoked a less severe inflammatory response depending on the dose of MNA than bare membranes. The biodegradation time of the membranes was appropriate for tissue regeneration. These results indicated the potential for using MNA-loaded PCL/gelatin electrospun membranes as anti-infective GTR/GBR membranes to optimize clinical application of GTR/GBR strategies