The upper critical field of filamentary Nb3Sn conductors

We have examined the upper critical field of a large and representative set of present multi-filamentary Nb3Sn wires and one bulk sample over a temperature range from 1.4 K up to the zero field critical temperature. Since all present wires use a solid-state diffusion reaction to form the A15 layers, inhomogeneities with respect to Sn content are inevitable, in contrast to some previously studied homogeneous samples. Our study emphasizes the effects that these inevitable inhomogeneities have on the field-temperature phase boundary. The property inhomogeneities are extracted from field-dependent resistive transitions which we find broaden with increasing inhomogeneity. The upper 90-99 % of the transitions clearly separates alloyed and binary wires but a pure, Cu-free binary bulk sample also exhibits a zero temperature critical field that is comparable to the ternary wires. The highest mu0Hc2 detected in the ternary wires are remarkably constant: The highest zero temperature upper critical fields and zero field critical temperatures fall within 29.5 +/- 0.3 T and 17.8 +/- 0.3 K respectively, independent of the wire layout. The complete field-temperature phase boundary can be described very well with the relatively simple Maki-DeGennes model using a two parameter fit, independent of composition, strain state, sample layout or applied critical state criterion.Comment: Accepted Journal of Applied Physics Few changes to shorten document, replaced eq. 7-

A Hybrid N-body--Coagulation Code for Planet Formation

We describe a hybrid algorithm to calculate the formation of planets from an initial ensemble of planetesimals. The algorithm uses a coagulation code to treat the growth of planetesimals into oligarchs and explicit N-body calculations to follow the evolution of oligarchs into planets. To validate the N-body portion of the algorithm, we use a battery of tests in planetary dynamics. Several complete calculations of terrestrial planet formation with the hybrid code yield good agreement with previously published calculations. These results demonstrate that the hybrid code provides an accurate treatment of the evolution of planetesimals into planets.Comment: Astronomical Journal, accepted; 33 pages + 11 figure

Productivity Standards and the Impact on Quality of Care: A National Survey of Inpatient Rehabilitation Professionals

Background: Skyrocketing health care costs have resulted in significant changes to reimbursement rates in health care. The result has increased pressure to be as efficient as possible while maintaining high-quality care. The purpose of this exploratory study was to examine health care professionals’ perceptions on whether and how productivity pressures have impacted the quality of care in therapy practice. Method: A survey was disseminated nationally to inpatient rehabilitation facilities. Results: Two hundred and fifty-seven surveys were opened. Of these completed surveys, 154 participants completed the closed-ended questions and 109 participants completed the open-ended questions. Outcomes indicated that clinicians are concerned that growing productivity pressures are impacting the quality of care that they provide. In addition, the findings are consistent with the literature that an emphasis to maintain productivity standards is resulting in unprofessional practices. Conclusion: Further research needs to be conducted to generalize these findings to the larger health care network. More advocacy for policy changes and the need for a unified strategic plan among the rehabilitation professions is indicated

Brain-age is associated with progression to dementia in memory clinic patients

Background: Biomarkers for the early detection of dementia risk hold promise for better disease monitoring and targeted interventions. However, most biomarker studies, particularly in neuroimaging, have analysed artificially ‘clean’ research groups, free from comorbidities, erroneous referrals, contraindications and from a narrow sociodemographic pool. Such biases mean that neuroimaging samples are often unrepresentative of the target population for dementia risk (e.g., people referred to a memory clinic), limiting the generalisation of these studies to real-world clinical settings. To facilitate better translation from research to the clinic, datasets that are more representative of dementia patient groups are warranted. Methods: We analysed T1-weighted MRI scans from a real-world setting of patients referred to UK memory clinic services (n = 1140; 60.2 % female and mean [SD] age of 70.0[10.8] years) to derive ‘brain-age’. Brain-age is an index of age-related brain health based on quantitative analysis of structural neuroimaging, largely reflecting brain atrophy. Brain-predicted age difference (brain-PAD) was calculated as brain-age minus chronological age. We determined which patients went on to develop dementia between three months and 7.8 years after neuroimaging assessment (n = 476) using linkage to electronic health records. Results: Survival analysis, using Cox regression, indicated a 3 % increased risk of dementia per brain-PAD year (hazard ratio [95 % CI] = 1.03 [1.02,1.04], p < 0.0001), adjusted for baseline age, age2, sex, Mini Mental State Examination (MMSE) score and normalised brain volume. In sensitivity analyses, brain-PAD remained significant when time-to-dementia was at least 3 years (hazard ratio [95 % CI] = 1.06 [1.02, 1.09], p = 0.0006), or when baseline MMSE score ≥ 27 (hazard ratio [95 % CI] = 1.03 [1.01, 1.05], p = 0.0006). Conclusions: Memory clinic patients with older‐appearing brains are more likely to receive a subsequent dementia diagnosis. Potentially, brain-age could aid decision-making during initial memory clinic assessment to improve early detection of dementia. Even when neuroimaging assessment was more than 3 years prior to diagnosis and when cognitive functioning was not clearly impaired, brain-age still proved informative. These real-world results support the use of quantitative neuroimaging biomarkers like brain-age in memory clinics

A Review of the Properties of Nb3Sn and Their Variation with A15 Composition, Morphology and Strain State

This article gives an overview of the available literature on simplified, well defined (quasi-)homogeneous laboratory samples. After more than 50 years of research on superconductivity in Nb3Sn, a significant amount of results are available, but these are scattered over a multitude of publications. Two reviews exist on the basic properties of A15 materials in general, but no specific review for Nb3Sn is available. This article is intended to provide such an overview. It starts with a basic description of the Niobium-Tin intermetallic. After this it maps the influence of Sn content on the the electron-phonon interaction strength and on the field-temperature phase boundary. The literature on the influence of Cu, Ti and Ta additions will then be briefly summarized. This is followed by a review on the effects of grain size and strain. The article is concluded with a summary of the main results.Comment: Invited Topical Review for Superconductor, Science and Technology. Provisionally scheduled for July 200

The cost-effectiveness of antenatal and postnatal education and support interventions for women aimed at promoting breastfeeding in the UK

Background: Breastfeeding is associated with health benefits to mothers and babies and cost-savings to the health service. Breastfeeding rates in the UK are low for various reasons including cultural barriers, inadequate support to initiate and sustain breastfeeding, lack of information, or choice not to breastfeed. Education and support interventions have been developed aiming at promoting breastfeeding rates. The objective of this study was to assess the cost-effectiveness of such interventions for women, initiated antenatally or in the first 8 weeks postnatally, aiming at improving breastfeeding rates, in the UK. Methods: A decision-analytic model was constructed to compare costs and quality-adjusted life-years (QALYs) of a breastfeeding intervention from the perspective of health and personal social services in England. Data on intervention effectiveness and the benefits of breastfeeding were derived from systematic reviews. Other model input parameters were obtained from published sources, supplemented by expert opinion. Results: The incremental cost-effectiveness ratio (ICER) of the modelled intervention added on standard care versus standard care was £51,946/QALY, suggesting that the intervention is not cost-effective under National Institute for Health and Care Excellence (NICE) criteria in England. Sensitivity analysis suggested that the cost-effectiveness of the intervention improved as its effectiveness increased and intervention cost decreased. At the base-case effect (increase in breastfeeding rates 16–26 weeks after birth by 19%), the intervention was cost-effective (<£20,000/QALY) if its cost per woman receiving the intervention became ≈£40–£45. At the base-case cost (£84), the intervention was cost-effective if it increased breastfeeding rates by at least 35–40%. Conclusions: Available breastfeeding interventions do not appear to be cost-effective under NICE criteria in England. Future breastfeeding interventions need to have higher effectiveness or lower cost compared with currently available interventions in order to become cost-effective. Public health and other societal interventions that protect, promote and support breastfeeding may be key in improving breastfeeding rates in the UK

Bayesian component separation and CMB estimation for the 5-year WMAP temperature data

A well-tested and validated Gibbs sampling code, that performs component separation and CMB power spectrum estimation, was applied to the {\it WMAP} 5-yr data. Using a simple model consisting of CMB, noise, monopoles and dipoles, a ``per pixel'' low-frequency power-law (fitting for both amplitude and spectral index), and a thermal dust template with fixed spectral index, we found that the low-$\ell$ ($\ell < 50$) CMB power spectrum is in good agreement with the published {\it WMAP}5 results. Residual monopoles and dipoles were found to be small ($\lesssim 3 \mu$K) or negligible in the 5-yr data. We comprehensively tested the assumptions that were made about the foregrounds (e.g. dust spectral index, power-law spectral index prior, templates), and found that the CMB power spectrum was insensitive to these choices. We confirm the asymmetry of power between the north and south ecliptic hemispheres, which appears to be robust against foreground modeling. The map of low frequency spectral indices indicates a steeper spectrum on average ($\beta=-2.97\pm0.21$) relative to those found at low ($\sim$GHz) frequencies.Comment: 18 pages, 19 figures, submitted to Ap

Seven-Year Wilkinson Microwave Anisotropy Probe (WMAP) Observations: Power Spectra and WMAP-Derived Parameters

(Abridged) We present the angular power spectra derived from the 7-year maps and discuss the cosmological conclusions that can be inferred from WMAP data alone. The third acoustic peak in the TT spectrum is now well measured by WMAP. In the context of a flat LambdaCDM model, this improvement allows us to place tighter constraints on the matter density from WMAP data alone, and on the epoch of matter-radiation equality, The temperature-polarization (TE) spectrum is detected in the 7-year data with a significance of 20 sigma, compared to 13 sigma with the 5-year data. The low-l EE spectrum, a measure of the optical depth due to reionization, is detected at 5.5 sigma significance when averaged over l = 2-7. The BB spectrum, an important probe of gravitational waves from inflation, remains consistent with zero. The upper limit on tensor modes from polarization data alone is a factor of 2 lower with the 7-year data than it was using the 5-year data (Komatsu et al. 2010). We test the parameter recovery process for bias and find that the scalar spectral index, ns, is biased high, but only by 0.09 sigma, while the remaining parameters are biased by < 0.15 sigma. The improvement in the third peak measurement leads to tighter lower limits from WMAP on the number of relativistic degrees of freedom (e.g., neutrinos) in the early universe: Neff > 2.7 (95% CL). Also, using WMAP data alone, the primordial helium mass fraction is found to be YHe = 0.28+0.14-0.15, and with data from higher-resolution CMB experiments included, we now establish the existence of pre-stellar helium at > 3 sigma (Komatsu et al. 2010).Comment: 22 pages, 14 figures, version accepted to Astrophysical Journal Supplement Series, added high-l EE detection, consolidated parameter recovery simulation