Sleep architecture in neonatal and infantile onset epilepsies in the first six months of life: A scoping review

AIM: Epilepsy occurs in approximately 80 per 100,000 infants in the first year of life, ranging in severity from self-limited and likely to spontaneously resolve, to severe developmental and epileptic encephalopathies. Sleep plays a key role in early brain development and the reciprocal relationship between sleep and seizures is not yet fully understood, particularly in young children. We conducted a Scoping Review to synthesise current knowledge of sleep architecture in neonates and infants with epilepsy. METHODS: Peer-reviewed publications from 2005 to 2022 describing sleep architecture in infants up to six months of age with unprovoked seizures were included. The analysis set was derived from EMBASE, Web of Science and PubMED using key terms “sleep, epilepsy and infant” and related descriptors. Inclusion criteria were prospectively described in a Scoping Review protocol. Sleep architecture was assessed as macro- and micro-structural elements. RESULTS: 21 publications were included in the qualitative analysis. In self-limited familial and genetic epilepsy, sleep macrostructure was generally preserved. In DEEs and in epileptic encephalopathies of genetic or structural aetiology, sleep architecture was significantly disrupted. INTERPRETATION: Early identification of infants with epilepsy is important to ensure early and effective treatment. In the DEE spectrum, sleep architecture is significantly impacted, and abnormal sleep architecture may be associated with compromised developmental outcome. Further research is needed to identify the sequence of events in abnormal brain development, epilepsy and sleep disruption and potentially help to predict the course of epilepsy towards a self-limited epilepsy versus a DEE

Clubbing and Digitalization of Government ID Proofs

Clubbing and Digitalization of Government ID Proofs is a software system for organizing and storing different kinds of documents required for a person�s identity proof. This software system handles digital documents, rather than paper documents, although in some instances, this system may also handle digital scanned versions of original paper documents. This system includes important legal documents like Birth Certificate, Aadhaar Card, PAN Card, Driving Licence, Passport, etc, a more general type of storage system that helps users to organize and store paper or digital documents. Each and every user can access by logging into the application using their username and password. This centralized system would help in providing the user to store a large volume of data and efficiently retrieve their data. This system will also help the users to update or edit any changes in their previously added information conveniently

Prostate cancer-specific PET radiotracers : a review on the clinical utility in recurrent disease

Prostate cancer-specific positron emission tomography (pcPET) has been shown to detect sites of disease recurrence at serum prostate-specific antigen (PSA) levels that are lower than those levels detected by conventional imaging. Commonly used pcPET radiotracers in the setting of biochemical recurrence are reviewed including carbon 11/fludeoxyglucose 18 (F-18) choline, gallium 68/F-18 prostate-specificmembrane antigen (PSMA), and F-18 fluciclovine. Review of the literature generally favors PSMA-based agents for the detection of recurrence as a function of low PSA levels. Positive gallium 68/F-18PSMA positron emission tomography/computed tomography scans detected potential sites of recurrence in a median 51.5% of patients when PSA level is 2.0 ng/mL. Review of carbon 11/fludeoxyglucose 18 (F-18) choline and F-18 fluciclovine data commonly demonstrated lower detection rates for each respective PSA cohort, although with some important caveats, despite having similar operational characteristics to PSMA-based imaging. Sensitive pcPET imaging has provided new insight into the early patterns of disease spread, which has prompted judicious reconsideration of additional local therapy after either prostatectomy, definitive radiation therapy, or postprostatectomy radiation therapy. This review discusses the literature, clinical utility, availability, and fundamental understanding of pcPET imaging needed to improve clinical practice. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of American Society for Radiation Oncology

Effect of the initial mass function on the dynamical SMBH mass estimate in the nucleated early-type galaxy FCC 47

Supermassive black holes (SMBHs) and nuclear star clusters (NSCs) co-exist in many galaxies. While the formation history of the black hole is essentially lost, NSCs preserve their evolutionary history imprinted onto their stellar populations and kinematics. Studying SMBHs and NSCs in tandem might help us to ultimately reveal the build-up of galaxy centres. In this study, we combine large-scale VLT/MUSE and high-resolution adaptive-optics-assisted VLT/SINFONI observations of the early-type galaxy FCC 47 with the goal being to assess the effect of a spatially (non-)variable initial mass function (IMF) on the determination of the mass of the putative SMBH in this galaxy. We achieve this by performing DYNAMITE Schwarzschild orbit-superposition modelling of the galaxy and its NSC. In order to properly take account of the stellar mass contribution to the galaxy potential, we create mass maps using a varying stellar mass-to-light ratio derived from single stellar population models with fixed and with spatially varying IMFs. Using the two mass maps, we estimate black hole masses of $(7.1^{+0.8}_{-1.1})\times 10^7\,M_{\odot}$ and $(4.4^{+1.2}_{-2.1}) \times 10^7\,M_{\odot}$ at $3\sigma$ signifance, respectively. Compared to models with constant stellar-mass-to-light ratio, the black hole masses decrease by 15% and 48%, respectively. Therefore, a varying IMF, both in its functional form and spatially across the galaxy, has a non-negligible effect on the SMBH mass estimate. Furthermore, we find that the SMBH in FCC 47 has probably not grown over-massive compared to its very over-massive NSC.Comment: 23 pages 19 Figures, accepted for publication in A&

LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex

Cell migration requires coordination between integrin-mediated cell adhesion to the extracellular matrix and force applied to adhesion sites. Talin plays a key role in coupling integrin receptors to the actomyosin contractile machinery, while deleted in liver cancer 1 (DLC1) is a Rho GAP that binds talin and regulates Rho, and therefore actomyosin contractility. We show that the LD motif of DLC1 forms a helix that binds to the four-helix bundle of the talin R8 domain in a canonical triple-helix arrangement. We demonstrate that the same R8 surface interacts with the paxillin LD1 and LD2 motifs. We identify key charged residues that stabilize the R8 interactions with LD motifs and demonstrate their importance in vitro and in cells. Our results suggest a network of competitive interactions in adhesion complexes that involve LD motifs, and identify mutations that can be used to analyze the biological roles of specific protein-protein interactions in cell migration

Discovery of a thin stellar stream in the SLAMS survey

We report the discovery of a thin stellar stream - which we name the Jet stream - crossing the constellations of Hydra and Pyxis. The discovery was made in data from the SLAMS survey, which comprises deep $g$ and $r$ imaging for a $650$ square degree region above the Galactic disc performed by the CTIO Blanco + DECam. SLAMS photometric catalogues will be made publicly available. The stream is approximately 0.18 degrees wide and 10 degrees long, though it is truncated by the survey footprint. Its colour-magnitude diagram is consistent with an old, metal-poor stellar population at a heliocentric distance of approximately 29 kpc. We corroborate this measurement by identifying a spatially coincident overdensity of likely blue horizontal branch stars at the same distance. There is no obvious candidate for a surviving stream progenitor.Comment: MNRAS accepted versio

A source of polarized electrons based on photoemission of GaAsP.

The source described is based on photoemission of electrons from 100-GaAs0.62P0.38 activated to negative electron affinity. It is built to inject a beam of polarized electrons into the 350 MeV linear accelerator in Mainz. It is capable of delivering a mean current of 28 μA spin-polarized longitudinally to a degree of 0.44. The lifetime of the cathode under operational conditions is better than 200 h. The source was successfully run in a parity experiment, in which the analysing power of quasielastic scattering from beryllium for longitudinally polarized electrons was measured

Improved limits on the weak, neutral, hadronic axial vector coupling constants from quasielastic scattering of polarized electrons.

In scattering polarized electrons (P1 = 44% by 9Be at an energy of 300 MeV at angles 115°⩽ϑ⩽145° a parity violating asymmetry of Acorr = (−3.5 ± 0.7 ± 0.2) × 10−6 was measured. After correction for finite electron polarization and background we deduce an experimental asymmetry of Acx = (−9.4 ± 1.8 ± 0.5) × 10−6. The quoted errors indicate the statistical and the systematic uncertainties, respectively. The asymmetry, which is dominated by the quasielastic cross section, is interpreted in terms of model-independent electron-nucleon coupling constants of the weak neutral current. The error limits in the sector of axial vector coupling constants have been improved by a factor of 3 over previous results. A model-dependent analysis for the Weinberg angle yields the result sin2θw = 0.221 ± 0.014 ± 0.004